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  1. Article: Mechanism of Action of Natural Dipeptidyl Peptidase-IV Inhibitors (Berberine and Mangiferin) in Experimentally Induced Diabetes with Metabolic Syndrome.

    Suman, Rajesh Kumar / Borde, Manjusha K / Mohanty, Ipseeta Ray / Singh, Hemant Kumar

    International journal of applied & basic medical research

    2023  Volume 13, Issue 3, Page(s) 133–142

    Abstract: Background: Berberine (BER) and mangiferin are known natural dipeptidyl peptidase (DPP-IV) inhibitors. Hence, the study was designed to elucidate the mechanism of action of natural DPP-IV inhibitors (BER and MNG) in experimentally induced diabetes with ... ...

    Abstract Background: Berberine (BER) and mangiferin are known natural dipeptidyl peptidase (DPP-IV) inhibitors. Hence, the study was designed to elucidate the mechanism of action of natural DPP-IV inhibitors (BER and MNG) in experimentally induced diabetes with metabolic syndrome.
    Aim: The aim of this study was to observe mechanism through which natural DPP-IV inhibitor works in diabetes with metabolic syndrome rat model.
    Materials and methods: Wistar rats were fed high-fat diet for 10 weeks and challenged with streptozotocin (STZ) (40 mg/kg) at the 3
    Results: Insulin resistance (IR) was seen in the HF-DC group as indicated by raised homeostasis model assessment of IR (HOMA-IR) in HF-DC group as compared with normal control (NC) groups. The treatment groups reduced IR as shown by a decrease in HOMA-IR as compared with HF-DC group rats. The marked reduction (
    Conclusion: The natural DPP-IV inhibitors BER and MNG treatment showed beneficial effects on various components of metabolic syndrome.
    Language English
    Publishing date 2023-09-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2645750-7
    ISSN 2248-9606 ; 2229-516X
    ISSN (online) 2248-9606
    ISSN 2229-516X
    DOI 10.4103/ijabmr.ijabmr_115_23
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  2. Article ; Online: Macrocyclic Sulfur Ligand Stabilized Trans-Palladium Dichloride Complex: Syntheses, Structure, Chlorine Rotation, and Application in α-Olefination of Nitriles by Primary Alcohols.

    Kumar, Sunil / Sharma, Ashutosh / Mahala, Suman / Gaatha, K / Reddy, S Rajagopala / Rom, Tanmay / Paul, Avijit Kumar / Roy, Partha / Joshi, Hemant

    Chemistry, an Asian journal

    2024  Volume 19, Issue 4, Page(s) e202300935

    Abstract: Herein, we have reported the synthesis of a macrocyclic organosulfur ligand (L1) having a seventeen-membered macrocyclic ring. Subsequently, the corresponding trans-palladium complex (C1) of bulky macrocyclic organosulfur ligand (L1) was synthesized by ... ...

    Abstract Herein, we have reported the synthesis of a macrocyclic organosulfur ligand (L1) having a seventeen-membered macrocyclic ring. Subsequently, the corresponding trans-palladium complex (C1) of bulky macrocyclic organosulfur ligand (L1) was synthesized by reacting it with PdCl
    Language English
    Publishing date 2024-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300935
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  3. Article ; Online: Public Transport Operations After Lockdown: How to Make It Happen?

    Suman, Hemant K / Agarwal, Amit / Bolia, Nomesh B

    Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology

    2020  Volume 5, Issue 2, Page(s) 149–156

    Abstract: Lockdown in cities across the globe has imposed severe travel restrictions to limit the spread of Coronavirus disease. The travel behavior and operations will not be the same as before due to requirements such as physical (social) distancing. This study ... ...

    Abstract Lockdown in cities across the globe has imposed severe travel restrictions to limit the spread of Coronavirus disease. The travel behavior and operations will not be the same as before due to requirements such as physical (social) distancing. This study analyzes the resulting shortage in supply of public transport (buses) that will likely widen the existing gap between demand and supply. In this work, system optimization models are developed to efficiently reallocate the bus fleet to routes for different levels of physical distancing gaps and travel demand. The proposed models are applied to a real-life network of 34 bus routes of Delhi, considering three types of scenarios: current, practical, and ideal. In the practical scenarios, the additional, idling bus fleets can be allocated to the routes efficiently while maintaining physical distancing. The results show that the Business-as-Usual (BAU) scenario involving the current allocation approach will make it impossible to use public buses even if the bare minimum physical distancing has to be maintained. Further, the models proposed in the study significantly improve the key performance indicators for all scenarios.
    Language English
    Publishing date 2020-06-12
    Publishing country Singapore
    Document type Journal Article
    ISSN 2662-5423
    ISSN (online) 2662-5423
    DOI 10.1007/s41403-020-00121-x
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  4. Article: Public Transport Operations After Lockdown: How to Make It Happen?

    Suman, Hemant K. / Agarwal, Amit / Bolia, Nomesh B.

    Transactions of the Indian National Academy of Engineering

    Abstract: Lockdown in cities across the globe has imposed severe travel restrictions to limit the spread of Coronavirus disease The travel behavior and operations will not be the same as before due to requirements such as physical (social) distancing This study ... ...

    Abstract Lockdown in cities across the globe has imposed severe travel restrictions to limit the spread of Coronavirus disease The travel behavior and operations will not be the same as before due to requirements such as physical (social) distancing This study analyzes the resulting shortage in supply of public transport (buses) that will likely widen the existing gap between demand and supply In this work, system optimization models are developed to efficiently reallocate the bus fleet to routes for different levels of physical distancing gaps and travel demand The proposed models are applied to a real-life network of 34 bus routes of Delhi, considering three types of scenarios: current, practical, and ideal In the practical scenarios, the additional, idling bus fleets can be allocated to the routes efficiently while maintaining physical distancing The results show that the Business-as-Usual (BAU) scenario involving the current allocation approach will make it impossible to use public buses even if the bare minimum physical distancing has to be maintained Further, the models proposed in the study significantly improve the key performance indicators for all scenarios
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #597148
    Database COVID19

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  5. Article ; Online: Quantitative Determination of Cannabis Terpenes Using Gas Chromatography-Flame Ionization Detector.

    Ibrahim, Elsayed A / Radwan, Mohamed M / Gul, Waseem / Majumdar, Chandrani G / Hadad, Ghada M / Abdel Salam, Randa A / Ibrahim, Amany K / Ahmed, Safwat A / Chandra, Suman / Lata, Hemant / ElSohly, Mahmoud A / Wanas, Amira S

    Cannabis and cannabinoid research

    2022  Volume 8, Issue 5, Page(s) 899–910

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2022.0188
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  6. Article: Reciprocal relation between reporter gene transcription and translation efficiency in fission yeast

    Srivastava, Suchita / Kaur, Satinderdeep / Verma, Hemant K / Rani, Suman / Thakur, Manisha / Haldar, Swati / Singh, Jagmohan

    Plasmid. 2021 May, v. 115

    2021  

    Abstract: The fission yeast, Schizosaccharomyces pombe, is an excellent model for basic research but is not useful for commercial scale protein expression due to lack of strong expression vectors. Earlier, we showed that the lsd90 promoter elicited significantly ... ...

    Abstract The fission yeast, Schizosaccharomyces pombe, is an excellent model for basic research but is not useful for commercial scale protein expression due to lack of strong expression vectors. Earlier, we showed that the lsd90 promoter elicited significantly greater GFP expression level than the adh1 and nmt1 promoters, albeit in different vector backbones. Here, we have systematically investigated the contribution of selectable markers, LEU2 and URA3m to GFP expression: while LEU2 elicited very low expression, the URA3m gene, with truncated promoter, elicited much greater GFP expression level with all promoters. Paradoxically, an inverse correlation was observed between the GFP transcription and translation efficiency. This system can be useful for understanding the factors governing recombinant gene expression and optimization of protein production.
    Keywords Schizosaccharomyces pombe ; gene expression ; models ; plasmids ; protein synthesis ; reporter genes ; transcription (genetics)
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 282384-6
    ISSN 1095-9890 ; 0147-619X
    ISSN (online) 1095-9890
    ISSN 0147-619X
    DOI 10.1016/j.plasmid.2021.102557
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Reciprocal relation between reporter gene transcription and translation efficiency in fission yeast.

    Srivastava, Suchita / Kaur, Satinderdeep / Verma, Hemant K / Rani, Suman / Thakur, Manisha / Haldar, Swati / Singh, Jagmohan

    Plasmid

    2021  Volume 115, Page(s) 102557

    Abstract: The fission yeast, Schizosaccharomyces pombe, is an excellent model for basic research but is not useful for commercial scale protein expression due to lack of strong expression vectors. Earlier, we showed that the lsd90 promoter elicited significantly ... ...

    Abstract The fission yeast, Schizosaccharomyces pombe, is an excellent model for basic research but is not useful for commercial scale protein expression due to lack of strong expression vectors. Earlier, we showed that the lsd90 promoter elicited significantly greater GFP expression level than the adh1 and nmt1 promoters, albeit in different vector backbones. Here, we have systematically investigated the contribution of selectable markers, LEU2 and URA3m to GFP expression: while LEU2 elicited very low expression, the URA3m gene, with truncated promoter, elicited much greater GFP expression level with all promoters. Paradoxically, an inverse correlation was observed between the GFP transcription and translation efficiency. This system can be useful for understanding the factors governing recombinant gene expression and optimization of protein production.
    MeSH term(s) Genes, Reporter ; Genetic Vectors/genetics ; Plasmids ; Schizosaccharomyces/genetics ; Schizosaccharomyces pombe Proteins/genetics ; Transcription, Genetic
    Chemical Substances NMT1 protein, S pombe ; Schizosaccharomyces pombe Proteins
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282384-6
    ISSN 1095-9890 ; 0147-619X
    ISSN (online) 1095-9890
    ISSN 0147-619X
    DOI 10.1016/j.plasmid.2021.102557
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  8. Article ; Online: High resolution ultra sound and color Doppler in evaluation of thyroid nodule with fine needle aspiration cytology correlation

    Suman Chaudhary / Anand Prakash Verma / Hemant K. Mishra

    International Journal of Research in Medical Sciences, Vol 4, Iss 9, Pp 4113-

    2016  Volume 4118

    Abstract: Background: Thyroid gland is the first to develop in fetal life and is largest of all the endocrine glands. It is superficial in location which helps in its excellent visualization of normal anatomy and pathologic condition by high resolution real time ... ...

    Abstract Background: Thyroid gland is the first to develop in fetal life and is largest of all the endocrine glands. It is superficial in location which helps in its excellent visualization of normal anatomy and pathologic condition by high resolution real time grey scale sonography. The purpose of this study was to evaluate the usage of grey scale ultrasound and color Doppler with FNAC correlation for differentiation of benign and malignant thyroid nodule. Methods: This prospective study was carried out on sixteen patients who came to our department from period of 1 February to 31 march 2016.Grey scale ultrasound of neck and Doppler followed by USG guided FNAC of thyroid swelling was done. Results: Out of 16 cases, 3 were malignant, 10 were benign, and 3 were indeterminate. One case was diagnosed as benign lesion on sono which came out to be malignant on pathology as follicular carcinoma. The cases were presented as hypoechoic lesion with regular margins with peripheral and internal vascularity. Due to well defined margins it was diagnosed as benign adenoma but turned out to be malignant on pathology as follicular carcinoma. Colloid goiter was most common presentation on ultrasound and it showed wide spectrum of appearance, majority being nodular with anechoic echotexture. Conclusions: High resolution grey scale ultra sound with color Doppler has emerged as initial modality of choice for evaluating the patient with thyroid enlargement. [Int J Res Med Sci 2016; 4(9.000): 4113-4118]
    Keywords Thyroid ; Ultrasonography ; Fine neddle aspiration cytology ; Color Doppler ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Medip Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Progressive Disseminated Histoplasmosis Mimicking as Anal Carcinoma - Look at the Mountain, Not at Stone: A Case Report.

    Singh, Mahaveer / Sharma, Abhishek / Sankhala, Kalpana / Bareth, Hemant / Suman, Supriya

    Journal of multidisciplinary healthcare

    2021  Volume 14, Page(s) 2749–2754

    Abstract: Disseminated histoplasmosis is a systemic disease caused by the dimorphic ... ...

    Abstract Disseminated histoplasmosis is a systemic disease caused by the dimorphic fungus
    Language English
    Publishing date 2021-10-01
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S325134
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  10. Article ; Online: Analysis of Terpenes in Cannabis sativa L. Using GC/MS: Method Development, Validation, and Application.

    Ibrahim, Elsayed A / Wang, Mei / Radwan, Mohamed M / Wanas, Amira S / Majumdar, Chandrani G / Avula, Baharthi / Wang, Yan-Hong / Khan, Ikhlas A / Chandra, Suman / Lata, Hemant / Hadad, Ghada M / Abdel Salam, Randa A / Ibrahim, Amany K / Ahmed, Safwat A / ElSohly, Mahmoud A

    Planta medica

    2019  Volume 85, Issue 5, Page(s) 431–438

    Abstract: Terpenes are the major components of the essential oils present in ... ...

    Abstract Terpenes are the major components of the essential oils present in various
    MeSH term(s) Cannabis/chemistry ; Gas Chromatography-Mass Spectrometry/methods ; Limit of Detection ; Reproducibility of Results ; Terpenes/analysis ; Terpenes/isolation & purification
    Chemical Substances Terpenes
    Language English
    Publishing date 2019-01-15
    Publishing country Germany
    Document type Journal Article ; Validation Studies
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-0828-8387
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