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Article: Correction: Yu et al. Rare-Earth-Metal (Nd

Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

Pharmaceutics

2023 Volume 15, Issue 12

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-12-12
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15122755
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Correction: Yu et al. Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF

Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

Pharmaceutics

2024 Volume 16, Issue 1

Abstract: There was an error in the original publication [ ... ]. ...

Abstract	There was an error in the original publication [...].
Language	English
Publishing date	2024-01-09
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16010091
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Article ; Online: Qing-Xin-Jie-Yu Granule inhibits ferroptosis and stabilizes atherosclerotic plaques by regulating the GPX4/xCT signaling pathway.

Zhang, Jie / Wang, Xinyi / Guan, Baoyi / Wang, Xue / An, Xiaojing / Wang, Tong / Chen, Xuanye / Zhao, Lin / Jia, Jundi / Song, Luxia / Ma, Dan / Li, Qiuyi / Zhang, He / Ju, Jianqing / Xu, Hao

Journal of ethnopharmacology

2022 Volume 301, Page(s) 115852

Abstract: Ethnopharmacological relevance: Qing-Xin-Jie-Yu Granule (QXJYG) is an integrated ...

Abstract	Ethnopharmacological relevance: Qing-Xin-Jie-Yu Granule (QXJYG) is an integrated traditional Chinese medicine formula used to treat atherosclerotic (AS) cardiovascular diseases. A randomized controlled trial found that QXJYG reduced cardiovascular events and experiments also verified that QXJYG attenuated AS by remodeling the intestinal flora. Aim of the study: To determine whether QXJYG would attenuate AS and plaque vulnerability by regulating ferroptosis in high-fat diet-induced atherosclerotic ApoE Methods: AS models in ApoE Results: QXJYG attenuated AS progression and plaque vulnerability. Characteristic morphological changes of ferroptosis in the QXJYG-treated animals were rare. Total iron was significantly lower in the QXJYG group than in the model group (P < 0.05); QXJYG suppressed the lipid peroxidation (LPO) levels (malondialdehyde), enhanced the antioxidant capacity (superoxide dismutase and glutathione), and reduced inflammatory factors (interleukin [IL]-6, IL-1β, tumor necrosis factor-α) associated with ferroptosis. Expression of GPX4/xCT in aorta tissues was remarkably increased in the QXJYG group. QXJYG inhibited ferroptosis in J744A.1 macrophages disturbed using RSL3. The Fe Conclusion: QXJYG inhibits ferroptosis in vulnerable AS plaques partially via the GPX4/xCT signaling pathway.
MeSH term(s)	Animals ; Mice ; Amino Acid Transport Systems, Acidic/metabolism ; Apolipoproteins E ; Ferroptosis ; Plaque, Atherosclerotic/drug therapy ; Signal Transduction
Chemical Substances	Amino Acid Transport Systems, Acidic ; Apolipoproteins E ; glutathione peroxidase 4, mouse (EC 1.11.1.9) ; qing-xin-jie-yu granules
Language	English
Publishing date	2022-10-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115852
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Zs.A 1494: Show issues

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Article ; Online: Radar Characteristics and Causal Analysis of Two Consecutive Tornado Events Associated with Heavy Precipitation during the Mei-Yu Season

Shuya Cao / Yi Wang / Guangxin He / Peifeng Shen / Yan He / Yue Wu

Remote Sensing, Vol 15, Iss 23, p

2023 Volume 5470

Abstract: ... with heavy precipitation during the Mei-yu season (a period of continuous rainy weather that occurs in the middle and lower ... on the eastern section of the Mei-yu front. (2) The presence of a gap on the front side of the reflectivity ...

Abstract	This paper comprehensively analyzed two consecutive tornado events associated with heavy precipitation during the Mei-yu season (a period of continuous rainy weather that occurs in the middle and lower reaches of the Yangtze River in China from mid-June to mid-July each year) and detailed the formation and development process of the tornadoes using Doppler weather radar, wind profiler radar, ERA5 reanalysis data, ground automatic station data and other multi-source data. The results showed that: (1) Small-scale vortices were triggered and developed during the eastward movement of the low vortex, forming two tornadoes successively on the eastern section of the Mei-yu front. (2) The presence of a gap on the front side of the reflectivity factor profile indicated that strong incoming airflow entered the updraft. Mesocyclones were detected with decreasing heights and increasing shear strengths. The bottom height of the tornado vortex signature (TVS) dropped to 0.7 km, and the shear value increased to 55.4 × 10 −3 s −1 . Tornado debris signatures (TDSs) could be seen with a low cross-correlation coefficient (CC) value area of 0.85–0.9 in the mesocyclone. The difference between the lowest-level difference velocity (LLDV) and the maximum difference velocity (MXDV) reached the largest value when a tornado occurred. (3) The continuously enhanced low-level jet propagated downward to form a super-low-level jet, and the strong wind direction and wind speed convergence in the boundary layer created a warm, moist and unstable atmosphere in Suzhou. With the entrainment of dry air, the northwest dry jet and the southeast moist jet stimulated the formation of a miniature supercell. (4) The low-level vertical wind shear of 0–1 km increased significantly upon tornado occurrence, which was more conducive to the formation and intensification of horizontal vorticity tubes. Encountering updrafts and downdrafts, the vorticity tubes might have been stretched and intensified. The first lightning jumps appeared 15 min and 66 min earlier ...
Keywords	radar observations ; tornado ; heavy rainfall supercell storm ; TVS ; dual polarization Doppler weather radar ; LLDV ; Science ; Q
Subject code	910 ; 333
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extracellular polymeric substance profiling and biophysical analysis reveal influence factors of spontaneous flocculation in rich lipid alga Heveochlorella sp. Yu.

Cui, Na / Feng, Yongjie / He, Ximeng / Gu, Hong / Zhao, Peng

The Science of the total environment

2022 Volume 847, Page(s) 157655

Abstract: ... Yu has a characteristic of spontaneous flocculation to be harvested. Heveochlorella sp. Yu has high ...

Abstract	Microalgae harvest and lipid accumulation were important factors influencing commercialized development of microalgae biodiesel. Spontaneous flocculation was an ideal method in microalgae harvest, but few rich lipid microalgae could be harvested by spontaneous flocculation. Rich lipid alga Heveochlorella sp. Yu has a characteristic of spontaneous flocculation to be harvested. Heveochlorella sp. Yu has high lipid productivity (105.24 mg L
MeSH term(s)	Biofuels ; Biomass ; Chlorophyta ; Extracellular Polymeric Substance Matrix ; Flocculation ; Fructose ; Galactose ; Glucose ; Lipids ; Mannose ; Microalgae ; Polysaccharides ; Rhamnose
Chemical Substances	Biofuels ; Lipids ; Polysaccharides ; Fructose (30237-26-4) ; Glucose (IY9XDZ35W2) ; Mannose (PHA4727WTP) ; Rhamnose (QN34XC755A) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2022-07-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.157655
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Zs.A 949: Show issues

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Article ; Online: Analysis of Carbon Emission Projections and Reduction Potential of Resource-Dependent Urban Agglomerations from the Perspective of Multiple Scenarios-A Case Study of Hu-Bao-O-Yu Urban Agglomeration.

Ning, Xuanwei / He, Yushuang / Zhang, Jiayi / Wu, Chengliang / Zhang, Yang

International journal of environmental research and public health

2023 Volume 20, Issue 5

Abstract: The Hu-Bao-O-Yu urban agglomeration is an important energy exporting and high-end chemical base ... a carbon emission system dynamics model for the Hu-Bao-O-Yu urban agglomeration, and sets up different ... further increase the investment in environmental protection to make the Hu-Bao-O-Yu urban agglomeration ...

Abstract	The Hu-Bao-O-Yu urban agglomeration is an important energy exporting and high-end chemical base in China, and is an important source of carbon emissions in China. The early achievement of peak carbon emissions in this region is particularly crucial to achieving the national carbon emission reduction targets. However, there is a lack of multi-factor system dynamics analysis of resource-dependent urban agglomerations in Northwest China, as most studies have focused on single or static aspects of developed urban agglomerations. This paper analyses the relationship between carbon emissions and their influencing factors, constructs a carbon emission system dynamics model for the Hu-Bao-O-Yu urban agglomeration, and sets up different single regulation and comprehensive regulation scenarios to simulate and predict the carbon peak time, peak value, and emission reduction potential of each city and urban agglomeration under different scenarios. The results show that: (1) Hohhot and Baotou are expected to reach peak carbon by 2033 and 2031 respectively, under the baseline scenario, while other regions and the urban agglomeration will not be able to reach peak carbon by 2035. (2) Under single regulation scenarios, the effect of factors other than the energy consumption varies across cities, but the energy consumption and environmental protection input are the main factors affecting carbon emissions in the urban agglomeration. (3) A combination of the economic growth, industrial structure, energy policy, environmental protection, and technology investment is the best measure to achieve carbon peaking and enhance the carbon emission reduction in each region as soon as possible. In the future, we need to coordinate the economic development, energy structure optimisation and transformation, low-carbon transformation of industry, strengthen research on carbon sequestration technology, and further increase the investment in environmental protection to make the Hu-Bao-O-Yu urban agglomeration a resource-saving urban agglomeration with an optimal emission reduction.
MeSH term(s)	Carbon/analysis ; Cities ; China ; Industry ; Economic Development ; Carbon Dioxide/analysis
Chemical Substances	Carbon (7440-44-0) ; Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20054250
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Article ; Online: Wu-zhu-yu Decoction reduces early brain injury following subarachnoid hemorrhage in vivo and in vitro by activating the Nrf2 antioxidant system via SIRT6 targeting.

Xu, Min / Yue, Qiyu / He, Ziyang / Ling, Xiaoyang / Wang, Wenhua / Gong, Mingjie

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 3, Page(s) 117335

Abstract: ... yu Decoction (WZYD) can treat headaches and vomiting, which are similar to the early symptoms ...

Abstract	Ethnopharmacological relevance: Early brain damage (EBI) following subarachnoid hemorrhage (SAH) is a long-lasting condition with a high occurrence. However, treatment options are restricted. Wu-zhu-yu Decoction (WZYD) can treat headaches and vomiting, which are similar to the early symptoms of subarachnoid hemorrhage (SAH). However, it is yet unknown if WZYD can reduce EBI following SAH and its underlying mechanisms. Aim of the study: This study aimed to investigate whether WZYD protects against EBI following SAH by inhibiting oxidative stress through activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling via Sirtuin 6 (SIRT6)-mediated histone H3 lysine 56 (H3K56) deacetylation. Materials and methods: In the current investigation, the principal components of WZYD were identified using high-performance liquid chromatography-diode array detection (HPLC-DAD). The SAH model in rats using the internal carotid artery plug puncture approach and the SAH model in primary neurons using hemoglobin incubation were developed. WZYD with different doses (137 mg kg Results: The WZYD treatment dramatically reduced cerebral hemorrhage and edema, and enhanced neurological results in EBI following SAH rats. WZYD administration inhibited neuronal apoptosis via reducing the expression levels of Cleaved cysteinyl aspartate specific proteinase-3(Cleaved Caspase-3), cysteinyl aspartate specific proteinase-3(caspase-3), and Bcl-2, Associated X Protein (Bax) and increasing the expression of B-cell lymphoma-2(Bal2). It also decreased reactive oxygen species and malondialdehyde levels and increased Nrf2 and HO-1 expression in the rat brain after SAH. In vitro, WZYD attenuated hemoglobin-induced cytotoxicity, oxidative stress and apoptosis in primary neurons. Mechanistically, WZYD enhanced SIRT6 expression and H3K56 deacetylation, activated Nrf2/HO-1 signaling, and promoted the interaction between SIRT6 and Nrf2. Knockdown of SIRT6 abolished WZYD-induced neuroprotection. Conclusions: WZYD attenuates EBI after SAH by activating Nrf2/HO-1 signaling through SIRT6-mediated H3K56 deacetylation, suggesting its therapeutic potential for SAH treatment.
MeSH term(s)	Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; NF-E2-Related Factor 2/metabolism ; Caspase 3 ; Rats, Sprague-Dawley ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Subarachnoid Hemorrhage/metabolism ; Aspartic Acid/pharmacology ; Aspartic Acid/therapeutic use ; Brain Injuries/drug therapy ; Apoptosis ; Sirtuins ; Hemoglobins/pharmacology ; Hemoglobins/therapeutic use ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use
Chemical Substances	Antioxidants ; NF-E2-Related Factor 2 ; Caspase 3 (EC 3.4.22.-) ; Aspartic Acid (30KYC7MIAI) ; Sirtuins (EC 3.5.1.-) ; Hemoglobins ; Neuroprotective Agents
Language	English
Publishing date	2023-10-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117335
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Zs.A 1494: Show issues

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Article ; Online: Investigations into the production of volatile compounds in Korla fragrant pears (Pyrus sinkiangensis Yu).

Chen, Jianqiu / Lü, Jiahong / He, Zishun / Zhang, Feng / Zhang, Shaoling / Zhang, Huping

Food chemistry

2019 Volume 302, Page(s) 125337

Abstract: The composition of volatile compounds in Korla fragrant pears was determined using headspace solid-phase microextraction followed by a gas chromatography-mass spectrometry analysis using fruits at 30, 90, and 150 days after bloom. Hexanal, (E)-2-hexenal, ...

Abstract	The composition of volatile compounds in Korla fragrant pears was determined using headspace solid-phase microextraction followed by a gas chromatography-mass spectrometry analysis using fruits at 30, 90, and 150 days after bloom. Hexanal, (E)-2-hexenal, 1-hexanol, (E)-2-hexen-1-ol, (Z)-3-hexen-1-ol, and hexyl acetate were identified as the major compounds. The composition of volatile compounds was associated with fatty acid concentrations and key enzyme activity in the lipoxygenase pathway. In vitro linoleic and linolenic acid feeding experiments conducted using cubes of fruit flesh demonstrated that the concentrations of volatile esters, such as hexyl acetate, in the treated fruits increased significantly after incubation for 12 h compared with those in the control fruits, which was accompanied by a reduction in aldehyde and alcohol concentrations (p < 0.05 or p < 0.01). However, the treatments did not significantly influence the enzyme activity and expression of genes encoding the enzymes.
MeSH term(s)	Aldehydes/analysis ; Esters/analysis ; Fatty Acids/analysis ; Fatty Acids/metabolism ; Food Analysis/methods ; Fruit/chemistry ; Fruit/drug effects ; Fruit/physiology ; Gas Chromatography-Mass Spectrometry/methods ; Gene Expression Regulation, Plant ; Hexanols/analysis ; Linoleic Acid/pharmacology ; Odorants/analysis ; Pyrus/chemistry ; Pyrus/drug effects ; Pyrus/physiology ; Solid Phase Microextraction/methods ; Volatile Organic Compounds/analysis ; Volatile Organic Compounds/metabolism ; alpha-Linolenic Acid/pharmacology
Chemical Substances	Aldehydes ; Esters ; Fatty Acids ; Hexanols ; Volatile Organic Compounds ; alpha-Linolenic Acid (0RBV727H71) ; 2-hexenal (505-57-7) ; 1-hexanol (6CP2QER8GS) ; n-hexanal (9DC2K31JJQ) ; Linoleic Acid (9KJL21T0QJ)
Language	English
Publishing date	2019-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2019.125337
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Article: Effects of autochthonous starter cultures on bacterial communities and metabolites during fermentation of Yu jiangsuan, a Chinese traditional fermented condiment

Jiang, Lu / Liu, Lu / Chen, Hongyan / Zhang, Wei / He, Laping / Zeng, Xuefeng

Lebensmittel-Wissenschaft + Technologie. 2022 Aug. 10,

2022

Abstract: The study on the bacterial community structure and metabolite effects of fermentation of Yu ... during the fermentation of Yu jiangsuan (YJS) by inoculation of autochthonous starter cultures ...

Abstract	The study on the bacterial community structure and metabolite effects of fermentation of Yu jiangsuan（YJS）by autochthonous starter cultures has been rarely reported. In this study, the bacterial community structure and metabolites were dynamically explored by high-throughput sequencing and LC-MS/MS during the fermentation of Yu jiangsuan (YJS) by inoculation of autochthonous starter cultures. The results demonstrated that the presence of interactions between bacterial genera accelerated the fermentation process and caused an increase in bacterial diversity and metabolite production. Firmicutes, Cyanobacteria and Proteobacteria were the dominant phyla, while Weissella, Lactobacillus and Fructobacillus were the dominant genera. The growth of Cyanobacteria and Fructobacillus was reduced in the inoculated fermentation group (HY). Totally 47 major differential metabolites were screened. Pearson correlation analysis showed that seven major bacterial genera were significantly associated with 15 differential metabolites. Carbohydrate metabolism and amino acid metabolism exerted a vital influence in the formation of metabolites. Moreover, this study contributes to the investigation of the bacterial community structure and metabolite composition in the fermentation of YJS by inoculation with autochthonous starter cultures, and helps to illuminate the potential value of core functional bacterial genera in the industrial controlled production of YJS.
Keywords	Cyanobacteria ; Fructobacillus ; Lactobacillus ; Proteobacteria ; Weissella ; amino acid metabolism ; bacterial communities ; carbohydrate metabolism ; community structure ; condiments ; fermentation ; metabolites ; starter cultures
Language	English
Dates of publication	2022-0810
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2022.113874
Database	NAL-Catalogue (AGRICOLA)

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Article: Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro.

He, Caigu / Liu, Guang / Zhuang, Shuting / Zhang, Jialin / Chen, Yangtao / Li, Hetian / Huang, Zhengping / Zheng, Yanfang

Diabetes, metabolic syndrome and obesity : targets and therapy

2020 Volume 13, Page(s) 2081–2092

Abstract: Introduction: Yu Nu compound (YNJ) is a traditional Chinese medicine widely utilized to treat type ... could result in podocyte loss in diabetics nephropathy (DN). The mechanism of Yu Nu compound in DN is still ... unclear. Therefore, the study aims to investigate the effects of Yu Nu compound and analyze the potential ...

Abstract	Introduction: Yu Nu compound (YNJ) is a traditional Chinese medicine widely utilized to treat type 2 diabetes possibly through mediating autophagy. Abnormal podocyte autophagy and apoptosis could result in podocyte loss in diabetics nephropathy (DN). The mechanism of Yu Nu compound in DN is still unclear. Therefore, the study aims to investigate the effects of Yu Nu compound and analyze the potential mechanism. Methods: Goto-Kakizaki (GK) rats were administered using YNJ with different doses once a day by gavage for 4 weeks. The renal cortex injury was observed by HE staining and electron microscope. Cell apoptosis of renal cortex was analyzed by TUNNEL staining. The mTOR, autophagy-related proteins and apoptosis-related proteins were detected by Western blot or real-time PCR in vivo and vitro. MPC5 cells were exposed to high glucose (HG, 30mM) for 12h to simulate podocyte injury in DN. MPC5 cells were treated by serum containing YNJ with different dosages. Cell activities and apoptosis were, respectively, detected through Cell Counting Kit-8 (CCK8) assay and flow cytometry. Results: The results showed that the medium dose of YNJ had better effects on decreasing blood glucose and improving renal injury in GK rats, followed by decreasing mTOR levels. The autophagy levels were enhanced in renal cortex, accompanied with the increase of cell apoptosis in vivo. Besides, the proteins regulating autophagy and apoptosis were significantly modulated by YNJ in GK rats. Then, we found that the decreasing endogenous mTOR could reverse the effects of YNJ on podocyte apoptosis and autophagy in vivo. Discussion: The study suggested that YNJ recovered normal autophagy and suppressed apoptosis through regulating mTOR. The maintenance of normal basal autophagic activity possibly based on the effect of YNJ on multiple target was essential for maintaining podocyte function.
Language	English
Publishing date	2020-06-18
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S253494
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