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  1. Article: Public-making in a pandemic: The role of street art in East African countries.

    McEwan, Cheryl / Szablewska, Lucy / Lewis, Kate V / Nabulime, Lilian M

    Political geography

    2022  Volume 98, Page(s) 102692

    Abstract: Street artists around the world have been prominent in depicting issues concerning COVID-19, but the role of street art in public-making during the pandemic is unexplored. Despite burgeoning street art scenes in many African countries since the early ... ...

    Abstract Street artists around the world have been prominent in depicting issues concerning COVID-19, but the role of street art in public-making during the pandemic is unexplored. Despite burgeoning street art scenes in many African countries since the early 2000s, African street art is relatively neglected in critical street art scholarship. In response, this paper examines street art created during the pandemic in East African countries, principally Uganda, Kenya, Rwanda, and Tanzania, and explores the ways in which it is engaged in highly distinctive forms of public-making. Drawing primarily on qualitative online interviews with East African artists creating street art, and image analysis using online search tools, the paper argues that street art in urban areas is attempting to create knowledgeable publics through countering disinformation about the pandemic, to responsiblize publics through public health messaging and, through community activism, to build resilient publics. The paper concludes that street art is potentially an important tool in tackling the COVID-19 pandemic in East African countries due to the proximity, and mutual constitution of, creative practices and publics, which emerge from the embedding of street art within the social spaces of cities and everyday experiences of the pandemic.
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ISSN 0962-6298
    ISSN 0962-6298
    DOI 10.1016/j.polgeo.2022.102692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Women-Centered Program for Women of Color (WC4WC): A Community-Based Participatory, Culturally Congruent Sexual Health Intervention in Los Angeles County, California.

    Wyatt, Gail E / Chin, Dorothy / Loeb, Tamra B / Norwood-Scott, Enricka / McEwan, Jenna A / Zhang, Muyu / Smith-Clapham, Amber M / Cooley-Strickland, Michele / Trinidad, Cheryl / Flint, Janette R / Wells, Yvette / Divinity, Rosalynd / Liu, Honghu

    American journal of public health

    2023  Volume 113, Issue S2, Page(s) S110–S114

    Abstract: The Women-Centered Program for Women of Color, a culturally congruent sexual health intervention, was implemented in 2018 in Los Angeles County, California, according to the principles of community-based participatory research: enhancing community ... ...

    Abstract The Women-Centered Program for Women of Color, a culturally congruent sexual health intervention, was implemented in 2018 in Los Angeles County, California, according to the principles of community-based participatory research: enhancing community capacity, establishing sustainable programs, and translating research findings to community settings. Participants exhibited significantly increased knowledge of and interest in preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) over time, but no significant change in condom use was evident. Booster sessions are needed to maintain interest in PrEP and PEP given concerns about reproductive and sexual health. (
    MeSH term(s) Male ; Humans ; Female ; Homosexuality, Male ; HIV Infections/prevention & control ; Los Angeles ; Sexual Health ; Skin Pigmentation ; Pre-Exposure Prophylaxis
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2023.307296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: New Insights into the Role of Zinc Acquisition and Zinc Tolerance in Group A Streptococcal Infection.

    Ong, Cheryl-Lynn Y / Berking, Olga / Walker, Mark J / McEwan, Alastair G

    Infection and immunity

    2018  Volume 86, Issue 6

    Abstract: Zinc plays an important role in host innate immune function. However, the innate immune system also utilizes zinc starvation ("nutritional immunity") to combat infections. Here, we investigate the role of zinc import and export in the protection ... ...

    Abstract Zinc plays an important role in host innate immune function. However, the innate immune system also utilizes zinc starvation ("nutritional immunity") to combat infections. Here, we investigate the role of zinc import and export in the protection of
    MeSH term(s) Animals ; DNA, Bacterial ; Gene Deletion ; Gene Expression Regulation/immunology ; Humans ; Leukocyte L1 Antigen Complex/metabolism ; Lysosomes ; Mice ; Mice, Transgenic ; Neutrophils/physiology ; Plasminogen/genetics ; Plasminogen/metabolism ; Skin/cytology ; Skin/metabolism ; Skin/microbiology ; Skin Diseases, Bacterial/metabolism ; Skin Diseases, Bacterial/microbiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/metabolism ; Streptococcus pyogenes/pathogenicity ; Virulence ; Zinc/metabolism ; Zinc/toxicity
    Chemical Substances DNA, Bacterial ; Leukocyte L1 Antigen Complex ; Plasminogen (9001-91-6) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2018-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00048-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Group A

    Turner, Andrew G / Djoko, Karrera Y / Ong, Cheryl-Lynn Y / Barnett, Timothy C / Walker, Mark J / McEwan, Alastair G

    The Biochemical journal

    2019  Volume 476, Issue 3, Page(s) 595–611

    Abstract: Bacterial pathogens encounter a variety of adverse physiological conditions during infection, including metal starvation, metal overload and oxidative stress. Here, we demonstrate that group ... ...

    Abstract Bacterial pathogens encounter a variety of adverse physiological conditions during infection, including metal starvation, metal overload and oxidative stress. Here, we demonstrate that group A
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Hydrogen Peroxide/pharmacology ; Iron/metabolism ; Manganese/metabolism ; Oxidative Stress/drug effects ; Oxidative Stress/genetics ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/metabolism ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism
    Chemical Substances Bacterial Proteins ; Manganese (42Z2K6ZL8P) ; Hydrogen Peroxide (BBX060AN9V) ; Iron (E1UOL152H7) ; SodA protein, Bacteria (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2019-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20180902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Postcolonialism and development

    McEwan, Cheryl

    (Routledge perspectives on development)

    2009  

    Author's details Cheryl McEwan
    Series title Routledge perspectives on development
    Keywords Postcolonialism ; Developing countries
    Language English
    Size XVIII, 354 S, Ill
    Publisher Routledge
    Publishing place London ;New York
    Document type Book
    Note Includes bibliographical references (p. ) and index ; Introduction -- The origins of postcolonialism -- Postcolonial theory and development -- Discourses of development and the power of representation -- Development knowledge and power -- Agency in development -- Towards a postcolonial development agenda -- Conclusions
    ISBN 0203887387 ; 0415433649 ; 0415433657 ; 9780203887387 ; 9780415433648 ; 9780415433655
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article ; Online: Two Distinct L-Lactate Dehydrogenases Play a Role in the Survival of Neisseria gonorrhoeae in Cervical Epithelial Cells.

    Chen, Nathan H / Ong, Cheryl-Lynn Y / O'sullivan, Jonathan / Ibranovic, Ines / Davey, Krystelle / Edwards, Jennifer L / McEwan, Alastair G

    The Journal of infectious diseases

    2019  Volume 221, Issue 3, Page(s) 449–453

    Abstract: L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L- ... ...

    Abstract L-lactate is an abundant metabolite in a number of niches in host organisms and represents an important carbon source for bacterial pathogens such as Neisseria gonorrhoeae. In this study, we describe an alternative, iron-sulfur cluster-containing L-lactate dehydrogenase (LutACB), that is distinct from the flavoprotein L-lactate dehydrogenase (LldD). Expression of lutACB was found to be positively regulated by iron, whereas lldD was more highly expressed under conditions of iron-limitation. The functional role of LutACB and LldD was reflected in in vitro studies of growth and in the survival of N gonorrhoeae in primary cervical epithelial cells.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cervix Uteri/cytology ; Epithelial Cells/microbiology ; Female ; Gene Deletion ; Gene Expression Regulation, Bacterial ; Gonorrhea/metabolism ; Gonorrhea/microbiology ; Humans ; Iron/metabolism ; L-Lactate Dehydrogenase/genetics ; L-Lactate Dehydrogenase/metabolism ; Microbial Viability/genetics ; Neisseria gonorrhoeae/enzymology ; Neisseria gonorrhoeae/genetics ; Neisseria gonorrhoeae/growth & development ; RNA, Viral/genetics
    Chemical Substances Bacterial Proteins ; RNA, Viral ; Iron (E1UOL152H7) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2019-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae.

    Turner, Andrew G / Ong, Cheryl-Lynn Y / Walker, Mark J / Djoko, Karrera Y / McEwan, Alastair G

    Advances in microbial physiology

    2017  Volume 70, Page(s) 123–191

    Abstract: Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions including proper innate immune function. The host immune system has complicated and coordinated mechanisms in place to either starve and/or overload invading pathogens ... ...

    Abstract Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions including proper innate immune function. The host immune system has complicated and coordinated mechanisms in place to either starve and/or overload invading pathogens with various metals to combat the infection. Here, we discuss the roles of Fe, Mn and Zn in terms of nutritional immunity, and also the roles of Cu and Zn in metal overload in relation to the physiology and pathogenesis of two human streptococcal species, Streptococcus pneumoniae and Streptococcus pyogenes. S. pneumoniae is a major human pathogen that is carried asymptomatically in the nasopharynx by up to 70% of the population; however, transition to internal sites can cause a range of diseases such as pneumonia, otitis media, meningitis and bacteraemia. S. pyogenes is a human pathogen responsible for diseases ranging from pharyngitis and impetigo, to severe invasive infections. Both species have overlapping capacity with respect to metal acquisition, export and regulation and how metal homeostasis relates to their virulence and ability to invade and survive within the host. It is becoming more apparent that metals have an important role to play in the control of infection, and with further investigations, it could lead to the potential use of metals in novel antimicrobial therapies.
    MeSH term(s) Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Homeostasis ; Host-Pathogen Interactions/drug effects ; Humans ; Immunity, Innate ; Streptococcal Infections/drug therapy ; Streptococcal Infections/metabolism ; Streptococcal Infections/microbiology ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/metabolism ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/metabolism ; Transition Elements/metabolism ; Transition Elements/pharmacology ; Virulence/drug effects
    Chemical Substances Anti-Infective Agents ; Transition Elements
    Language English
    Publishing date 2017-02-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 174-0
    ISSN 2162-5468 ; 0065-2911
    ISSN (online) 2162-5468
    ISSN 0065-2911
    DOI 10.1016/bs.ampbs.2017.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria.

    De Oliveira, David M P / Keller, Bernhard / Hayes, Andrew J / Ong, Cheryl-Lynn Y / Harbison-Price, Nichaela / El-Deeb, Ibrahim M / Li, Gen / Keller, Nadia / Bohlmann, Lisa / Brouwer, Stephan / Turner, Andrew G / Cork, Amanda J / Jones, Thomas R / Paterson, David L / McEwan, Alastair G / Davies, Mark R / McDevitt, Christopher A / Itzstein, Mark von / Walker, Mark J

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria. The safe- ... ...

    Abstract Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria. The safe-for-human-use hydroxyquinoline analog ionophore PBT2 has been previously shown to break polymyxin resistance in Gram-negative bacteria, independent of the lipopolysaccharide modification pathways that confer polymyxin resistance. Here, in combination with zinc, PBT2 was shown to break intrinsic polymyxin resistance in
    Language English
    Publishing date 2022-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11040449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.

    Ong, Cheryl-lynn Y / Walker, Mark J / McEwan, Alastair G

    Scientific reports

    2015  Volume 5, Page(s) 10799

    Abstract: Neutrophils release free zinc to eliminate the phagocytosed bacterial pathogen Streptococcus pyogenes (Group A Streptococcus; GAS). In this study, we investigated the mechanisms underpinning zinc toxicity towards this human pathogen, responsible for ... ...

    Abstract Neutrophils release free zinc to eliminate the phagocytosed bacterial pathogen Streptococcus pyogenes (Group A Streptococcus; GAS). In this study, we investigated the mechanisms underpinning zinc toxicity towards this human pathogen, responsible for diseases ranging from pharyngitis and impetigo, to severe invasive infections. Using the globally-disseminated M1T1 GAS strain, we demonstrate that zinc stress impairs glucose metabolism through the inhibition of the glycolytic enzymes phosphofructokinase and glyceraldehyde-3-phosphate dehydrogenase. In the presence of zinc, a metabolic shift to the tagatose-6-phosphate pathway allows conversion of D-galactose to dihydroxyacetone phosphate and glyceraldehyde phosphate, partially bypassing impaired glycolytic enzymes to generate pyruvate. Additionally, zinc inhibition of phosphoglucomutase results in decreased capsule biosynthesis. These data indicate that zinc exerts it toxicity via mechanisms that inhibit both GAS central carbon metabolism and virulence pathways.
    MeSH term(s) Bacterial Capsules/metabolism ; Carbon/metabolism ; Galactose/metabolism ; Gene Expression Regulation, Bacterial ; Glucose/metabolism ; Glycolysis ; Humans ; Hyaluronic Acid/biosynthesis ; Metabolic Networks and Pathways ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/metabolism ; Stress, Physiological ; Zinc/toxicity
    Chemical Substances Carbon (7440-44-0) ; Hyaluronic Acid (9004-61-9) ; Glucose (IY9XDZ35W2) ; Zinc (J41CSQ7QDS) ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2015-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep10799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Postcolonialism and development

    McEwan, Cheryl

    (Routledge perspectives on development)

    2009  

    Abstract: This book provides a valuable and unique introductory text that explains, reviews and critically evaluates recent debates about postcolonial approaches and their implications for development ... ...

    Author's details Cheryl McEwan
    Series title Routledge perspectives on development
    Abstract This book provides a valuable and unique introductory text that explains, reviews and critically evaluates recent debates about postcolonial approaches and their implications for development studies
    Keywords Postcolonialism ; Developing countries
    Language English
    Size Online-Ressource, Ill
    Publisher Routledge
    Publishing place London u.a.
    Document type Book ; Online
    Note Includes bibliographical references (p. ) and index ; Introduction -- The origins of postcolonialism -- Postcolonial theory and development -- Discourses of development and the power of representation -- Development knowledge and power -- Agency in development -- Towards a postcolonial development agenda -- Conclusions
    ISBN 9780415433648 ; 9781134080823 ; 9781281900104 ; 0415433649 ; 1134080824 ; 1281900109
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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