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Article ; Online: Review of the unprecedented impact of the COVID-19 pandemic on the occurrence of eating disorders.

Meier, Karien / van Hoeken, Daphne / Hoek, Hans W

2022 Volume 35, Issue 6, Page(s) 353–361

Abstract: Purpose of review: To review the recent literature on the impact of the coronavirus disease-2019 (COVID-19) pandemic on incidence and severity of symptoms of eating disorders (EDs).: Recent findings: A worrying increase of EDs in- and outpatients has ...

Abstract	Purpose of review: To review the recent literature on the impact of the coronavirus disease-2019 (COVID-19) pandemic on incidence and severity of symptoms of eating disorders (EDs). Recent findings: A worrying increase of EDs in- and outpatients has been reported since the COVID-19 pandemic began in 2019/2020. Restrictions implemented during the pandemic to protect populations against COVID-19 increased the risk for onset and for worsening of EDs by disrupting eating and exercise routines, social isolation, lack of support, and limited access to healthcare. Substantial increases since the start of the pandemic have been reported for overall incidence (15%), hospital admissions (48%) and emergency department visits (11%) for EDs, with even higher increases among women and children or adolescents with an ED. During the pandemic, ED patients reported increased severity of ED-specific symptoms and increased anxiety, depression and suicidal ideations and -attempts. Treatments shifted largely toward online methods for continuity of care, despite concerns about the quality of care provided and difficulties in self-monitoring. Our review provides preliminary evidence for a similar effectiveness of online treatment to prepandemic face-to-face treatment. In-person assessment remains essential for detecting EDs and for those requiring medical admission. Summary: Although the ongoing COVID-2019 pandemic affected mental health globally, research shows that it particularly affected individuals with an ED diagnosis or at risk for an ED, especially women, children and adolescents, and those with anorexia nervosa.
MeSH term(s)	Adolescent ; Anxiety ; COVID-19 ; Child ; Feeding and Eating Disorders/epidemiology ; Female ; Humans ; Mental Health ; Pandemics
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645162-7
ISSN	1473-6578 ; 0951-7367
ISSN (online)	1473-6578
ISSN	0951-7367
DOI	10.1097/YCO.0000000000000815
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Article ; Online: Gene-Environment Interplay in the Development of Overweight.

de Roo, Marthe / Hartman, Catharina / Veenstra, René / Nolte, Ilja Maria / Meier, Karien / Vrijen, Charlotte / Kretschmer, Tina

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

2023 Volume 73, Issue 3, Page(s) 574–581

Abstract: Purpose: Overweight in youth is influenced by genes and environment. Gene-environment interaction (G×E) has been demonstrated in twin studies and recent developments in genetics allow for studying G×E using individual genetic predispositions for ... ...

Abstract	Purpose: Overweight in youth is influenced by genes and environment. Gene-environment interaction (G×E) has been demonstrated in twin studies and recent developments in genetics allow for studying G×E using individual genetic predispositions for overweight. We examine genetic influence on trajectories of overweight during adolescence and early adulthood and determine whether genetic predisposition is attenuated by higher socioeconomic status and having physically active parents. Methods: Latent class growth models of overweight were fitted using data from the TRacking Adolescents' Individual Lives Survey (n = 2720). A polygenic score for body mass index (BMI) was derived using summary statistics from a genome-wide association study of adult BMI (N = ∼700,000) and tested as predictor of developmental pathways of overweight. Multinomial logistic regression models were used to examine effects of interactions of genetic predisposition with socioeconomic status and parental physical activity (n = 1675). Results: A three-class model of developmental pathways of overweight fitted the data best ("non-overweight", "adolescent-onset overweight", and "persistent overweight"). The polygenic score for BMI and socioeconomic status distinguished the persistent overweight and adolescent-onset overweight trajectories from the non-overweight trajectory. Only genetic predisposition differentiated the adolescent-onset from the persistent overweight trajectory. There was no evidence for G×E. Discussion: Higher genetic predisposition increased the risk of developing overweight during adolescence and young adulthood and was associated with an earlier age at onset. We did not find that genetic predisposition was offset by higher socioeconomic status or having physically active parents. Instead, lower socioeconomic status and higher genetic predisposition acted as additive risk factors for developing overweight.
MeSH term(s)	Adult ; Adolescent ; Humans ; Young Adult ; Longitudinal Studies ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Overweight/genetics ; Body Mass Index ; Pediatric Obesity ; Risk Factors ; Seizures
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063374-1
ISSN	1879-1972 ; 1054-139X
ISSN (online)	1879-1972
ISSN	1054-139X
DOI	10.1016/j.jadohealth.2023.04.028
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Article ; Online: Correction to: Treatment and outcomes of anticoagulated geriatric trauma patients with traumatic intracranial hemorrhage after falls.

Nederpelt, Charlie J / Naar, Leon / Meier, Karien / van Wijck, Suzanne F M / Krijnen, Pieta / Velmahos, George C / Kaafarani, Haytham M A / Rosenthal, Martin G / Schipper, Inger B

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2022 Volume 48, Issue 5, Page(s) 4305

Language	English
Publishing date	2022-06-14
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-022-02024-8
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 607: Show issues

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Book ; Thesis: Sekundärkaries - Möglichkeiten der Frühdiagnostik mit Clinpro Cario Diagnosis

Meier, Bettina

2007

Author's details	vorgelegt von Bettina Meier
Language	German
Size	77 Bl., Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Erlangen, Nürnberg, Univ., Diss., 2007
HBZ-ID	HT015579987
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Article ; Online: Malnutrition and its effects in severely injured trauma patients.

Dijkink, Suzan / Meier, Karien / Krijnen, Pieta / Yeh, D Dante / Velmahos, George C / Schipper, Inger B

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2020 Volume 46, Issue 5, Page(s) 993–1004

Abstract: Purpose: In hospitalized patients, malnutrition is associated with adverse outcomes. However, the consequences of malnutrition in trauma patients are still poorly understood. This study aims to review the current knowledge about the pathophysiology, ... ...

Abstract	Purpose: In hospitalized patients, malnutrition is associated with adverse outcomes. However, the consequences of malnutrition in trauma patients are still poorly understood. This study aims to review the current knowledge about the pathophysiology, prevalence, and effects of malnutrition in severely injured patients. Methods: A systematic literature review in PubMed and Embase was conducted according to PRISMA-guidelines. Results: Nine review articles discussed the hypermetabolic state in severely injured patients in relation to malnutrition. In these patients, malnutrition negatively influenced the metabolic response, and vice versa, thereby rendering them susceptible to adverse outcomes and further deterioration of nutritional status. Thirteen cohort studies reported on prevalences of malnutrition in severely injured patients; ten reported clinical outcomes. In severely injured patients, the prevalence of malnutrition ranged from 7 to 76%, depending upon setting, population, and nutritional assessment tool used. In the geriatric trauma population, 7-62.5% were malnourished at admission and 35.6-60% were at risk for malnutrition. Malnutrition was an independent risk factor for complications, mortality, prolonged hospital length of stay, and declined quality of life. Conclusions: Despite widespread belief about the importance of nutrition in severely injured patients, the quantity and quality of available evidence is surprisingly sparse, frequently of low-quality, and outdated. Based on the malnutrition-associated adverse outcomes, the nutritional status of trauma patients should be routinely and carefully monitored. Trials are required to better define the optimal nutritional treatment of trauma patients, but a standardized data dictionary and reasonable outcome measures are required for meaningful interpretation and application of results.
MeSH term(s)	Hospitalization ; Humans ; Length of Stay/statistics & numerical data ; Malnutrition/complications ; Malnutrition/mortality ; Malnutrition/physiopathology ; Nutrition Assessment ; Nutritional Status ; Nutritional Support ; Prevalence ; Quality of Life ; Risk Factors ; Wounds and Injuries/complications ; Wounds and Injuries/mortality
Language	English
Publishing date	2020-01-23
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-020-01304-5
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 607: Show issues

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Article ; Online: Treatment and outcomes of anticoagulated geriatric trauma patients with traumatic intracranial hemorrhage after falls.

Nederpelt, Charlie J / Naar, Leon / Meier, Karien / van Wijck, Suzanne F M / Krijnen, Pieta / Velmahos, George C / Kaafarani, Haytham M A / Rosenthal, Martin G / Schipper, Inger B

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2022 Volume 48, Issue 5, Page(s) 4297–4304

Abstract: Introduction: Emergency physicians and trauma surgeons are increasingly confronted with pre-injury direct oral anticoagulants (DOACs). The objective of this study was to assess if pre-injury DOACs, compared to vitamin K antagonists (VKA), or no oral ... ...

Abstract	Introduction: Emergency physicians and trauma surgeons are increasingly confronted with pre-injury direct oral anticoagulants (DOACs). The objective of this study was to assess if pre-injury DOACs, compared to vitamin K antagonists (VKA), or no oral anticoagulants is independently associated with differences in treatment, mortality and inpatient rehabilitation requirement. Methods: We performed a review of the prospectively maintained institutional trauma registry at an urban academic level 1 trauma center. We included all geriatric patients (aged ≥ 65 years) with tICH after a fall, admitted between January 2011 and December 2018. Multivariable logistic regression analysis controlling for demographics, comorbidities, vital signs, and tICH types were performed to identify the association between pre-injury anticoagulants and reversal agent use, neurosurgical interventions, inhospital mortality, 3-day mortality, and discharge to inpatient rehabilitation. Results: A total of 1453 tICH patients were included (52 DOAC, 376 VKA, 1025 control). DOAC use was independently associated with lower odds of receiving specific reversal agents [odds ratio (OR) 0.28, 95% confidence interval (CI) 0.15-0.54] than VKA patients. DOAC use was independently associated with requiring neurosurgical intervention (OR 3.14, 95% CI 1.36-7.28). VKA use, but not DOAC use, was independently associated with inhospital mortality, or discharge to hospice care (OR 1.62, 95% CI 1.15-2.27) compared to controls. VKA use was independently associated with higher odds of discharge to inpatient rehabilitation (OR 1.41, 95% CI 1.06-1.87) compared to controls. Conclusion: Despite the higher neurosurgical intervention rates, patients with pre-injury DOAC use were associated with comparable rates of mortality and discharge to inpatient rehabilitation as patients without anticoagulation exposure. Future research should focus on risk assessment and stratification of DOAC-exposed trauma patients.
MeSH term(s)	Administration, Oral ; Aged ; Anticoagulants ; Fibrinolytic Agents ; Humans ; Intracranial Hemorrhage, Traumatic ; Treatment Outcome ; Vitamin K
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
Language	English
Publishing date	2022-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-022-01938-7
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Necrotizing Soft Tissue Infection: Time is Crucial, and the Admitting Service Matters.

Kongkaewpaisan, Napaporn / Hwabejire, John / Lee, Jae Moo / Narueponjirakul, Natawat / Meier, Karien / Mendoza, April / Saillant, Noelle / Rosenthal, Martin / King, David / Fagenholz, Peter / Velmahos, George / Kaafarani, Haytham M A

Surgical infections

2020 Volume 21, Issue 10, Page(s) 828–833

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Comorbidity ; Fasciitis, Necrotizing ; Hospitalization ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/epidemiology
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440120-4
ISSN	1557-8674 ; 1096-2964
ISSN (online)	1557-8674
ISSN	1096-2964
DOI	10.1089/sur.2019.262
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Zs.A 5617: Show issues

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Article ; Online: A Paradigm Shift in Critical Care Infrastructure in Complex Settings: Evaluating an Ultraportable Operating Room to Improve Field Surgical Safety.

Teodorescu, Debbie L / Okajima, Stephen / Moten, Asad / Teodorescu, Mike H M / El Hechi, Majed / Gutierrez-Arango, Samantha / Meier, Karien / Smalley, Robert J / King, David R

Military medicine

2021 Volume 186, Issue Suppl 1, Page(s) 295–299

Abstract: Introduction: Scarcity of operating rooms and personal protective equipment in far-forward field settings make surgical infections a potential concern for combat mortality and morbidity. Surgical and transport personnel also face infectious risks from ... ...

Abstract	Introduction: Scarcity of operating rooms and personal protective equipment in far-forward field settings make surgical infections a potential concern for combat mortality and morbidity. Surgical and transport personnel also face infectious risks from bodily fluid exposures. Our study aimed to describe the serial, proof-of-concept testing of the SurgiBox technology: an inflatable sterile environment that addresses the aforementioned problems, fits on gurneys and backpacks, and drapes over incisions. Materials and methods: The SurgiBox environmental control unit and inflatable enclosure were optimized over five generations based on iterative feedback from stakeholders experienced in surgery in austere settings. The airflow system was developed by analytic modeling, verified through in silico modeling in SOLIDWORKS, and confirmed with prototype smoke-trail checking. Particulate counts evaluated the enclosure's ability to control and mitigate users' exposures to potentially infectious contaminants from the surgical field in various settings. SurgiBox enclosures were setup over a mannequin's torso, in a configuration and position for either thoracic or abdominal surgery. A particle counter was serially positioned in sternotomy and laparotomy positions, as well as bilateral flank positions. This setup was repeated with open ports exposing the enclosure to the external environment. To simulate stress scenarios, sampling was repeated with enclosure measurements during an increase in external particulate concentration. Results: The airflow technology effectively kept contaminants away from the incision and maintained a pressure differential to reduce particle entry. Benchtop testing demonstrated that even when ports were opened or the external environment had high contaminant burden, the enclosed surgical field consistently registered 0 particle count in all positions. Time from kit opening to incision averaged 54.5 seconds, with the rate-limiting step being connecting the environmental control unit to the enclosure. The portable kit weighted 5.9 lbs. Conclusions: Analytic, in silico, and mechanical airflow modeling and benchtop testing have helped to quantify the SurgiBox system's reliability in creating and maintaining an operating room-quality surgical field within the enclosure as well as protecting the surgical team outside the enclosure. More recent and ongoing work has focused on specifying optimal use settings in the casualty chain of care, expanding support for circumferential procedures, automating airflow control, and accelerating system setup. SurgiBox's ultimate goal is to take timely, safe surgery to patients in even the most austere of settings.
MeSH term(s)	Critical Care ; Humans ; Operating Rooms ; Personal Protective Equipment ; Reproducibility of Results ; Smoke
Chemical Substances	Smoke
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usaa311
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Article ; Online: Gallbladder wall thickness as a predictor of intraoperative events during laparoscopic cholecystectomy: A prospective study of 1089 patients.

Kokoroskos, Nikolaos / Peponis, Thomas / Lee, Jae Moo / El Hechi, Majed / Naar, Leon / Elahad, Joana Abed / Nederpelt, Charlie / Bonde, Alexander / Meier, Karien / Mendoza, April / King, David / Fagenholz, Peter / Kaafarani, Haytham / Velmahos, George / Saillant, Noelle

American journal of surgery

2020 Volume 220, Issue 4, Page(s) 1031–1037

Abstract: Background: Laparoscopic cholecystectomy (LC) has a wide range of technical difficulty. Preoperative risk stratification is essential for adequate planning and patient counseling. We hypothesized that gallbladder wall thickness (GWT) is more objective ... ...

Abstract	Background: Laparoscopic cholecystectomy (LC) has a wide range of technical difficulty. Preoperative risk stratification is essential for adequate planning and patient counseling. We hypothesized that gallbladder wall thickness (GWT) is more objective marker than symptom duration in predicting complexity, as determined by operative time (OT), intraoperative events (IE), and postoperative complications. Methods: All adult patients who underwent LC during 2010-2018 were included. GWT, measured on imaging and on the histopathologic exam, was divided into three groups: <3 mm (normal), 3-7 mm and >7 mm. Univariate and multivariable analyses were performed to determine the association between GWT and 1) operative time, 2) the incidence of IE and 3) postoperative outcomes. Results: A total of 1089 patients, subjects to LC, were included in the study. GWT was positively correlated with median OT (p < 0.001), the incidence of IE (p < 0.001) and median length of hospital stay (p < 0.001). GWT independently predicted IE (OR = 2.1 95% CI: 1.3-3.4) and outperformed symptom duration, which was not significantly associated with any of the outcomes (p = 0.7). Conclusions: GWT independently predicted IE and may serve as an objective marker of LC complexity.
MeSH term(s)	Adult ; Cholecystectomy, Laparoscopic/adverse effects ; Cholecystitis/surgery ; Female ; Follow-Up Studies ; Gallbladder/pathology ; Gallbladder/surgery ; Humans ; Incidence ; Intraoperative Complications/diagnosis ; Intraoperative Complications/epidemiology ; Intraoperative Period ; Male ; Middle Aged ; Operative Time ; Prospective Studies ; United States/epidemiology
Language	English
Publishing date	2020-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2020.03.007
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Article ; Online: Public perspectives on protective measures during the COVID-19 pandemic in the Netherlands, Germany and Italy

Meier, Karien / Glatz, Toivo / Guijt, Mathijs C. / Piccininni, Marco / van der Meulen, Merel / Atmar, Khaled / Jolink, Anne-Tess C. / Kurth, Tobias / Rohmann, Jessica L. / Zamanipoor Najafabadi, Amir H.

PLOS ONE

A survey study

2020 Volume 15, Issue 8, Page(s) e0236917

Keywords	General Biochemistry, Genetics and Molecular Biology ; General Agricultural and Biological Sciences ; General Medicine ; covid19
Language	English
Publisher	Public Library of Science (PLoS)
Publishing country	us
Document type	Article ; Online
ISSN	1932-6203
DOI	10.1371/journal.pone.0236917
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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