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Article ; Online: Letter regarding: Allen, B. M., Hack, C. E., & Clewell, H. J. (2007). Use of Markov Chain Monte Carlo analysis with a physiologically based pharmacokinetic model of methylmercury to estimate exposure in U.S. women of childbearing age. Risk Analysis, 27(1), 947-959.

Carrington, Clark D / Bolger, Michael

Risk analysis : an official publication of the Society for Risk Analysis

2008 Volume 28, Issue 5, Page(s) 1137–1140

MeSH term(s)	Adult ; Environmental Exposure ; Female ; Humans ; Markov Chains ; Maternal Age ; Maternal Exposure ; Methylmercury Compounds/administration & dosage ; Methylmercury Compounds/pharmacokinetics ; Models, Biological ; Monte Carlo Method ; Pregnancy ; Risk Assessment ; United States ; Young Adult
Chemical Substances	Methylmercury Compounds ; methylmercuric chloride (RWZ4L3O1X0)
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	778660-8
ISSN	1539-6924 ; 0272-4332
ISSN (online)	1539-6924
ISSN	0272-4332
DOI	10.1111/j.1539-6924.2008.01056.x
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Article ; Online: Organ preservation in the multimodality approach to locally advanced oesophageal cancer: festina lente.

Bolger, J C / Reynolds, J V

The British journal of surgery

2021 Volume 108, Issue 10, Page(s) 1142–1144

MeSH term(s)	Chemotherapy, Adjuvant ; Clinical Decision-Making ; Clinical Trials as Topic ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/therapy ; Esophagectomy ; Humans ; Neoadjuvant Therapy ; Neoplasm, Residual ; Patient Care Team ; Radiotherapy, Adjuvant
Language	English
Publishing date	2021-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znab210
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Article: Is the use of a routine intraoperative cholangiogram necessary in laparoscopic cholecystectomy?

Temperley, Hugo C / O'Sullivan, Niall J / Grainger, Richard / Bolger, Jarlath C

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

2023 Volume 21, Issue 5, Page(s) e242–e248

Abstract: Introduction: Although laparoscopic cholecystectomy (LC) has been standard of care for symptomatic gallstone disease for almost 30 years, the use of routine intraoperative cholangiogram (IOC) remains controversial. There are marked variations in the use ...

Abstract	Introduction: Although laparoscopic cholecystectomy (LC) has been standard of care for symptomatic gallstone disease for almost 30 years, the use of routine intraoperative cholangiogram (IOC) remains controversial. There are marked variations in the use IOC during LC internationally. Debate has continued about its benefit, in part because of inconsistent benefit, time, and resources required to complete IOC. This literature review is presented as a debate to outline the arguments in favour of and against routine IOC in laparoscopic cholecystectomy. Methods: A standard literature review of PubMed, Medline, OVID, EMBASE, CINHIL and Web of Science was performed, specifically for literature pertaining to the use of IOC or alternative intra-operative methods for imaging the biliary tree in LC. Two authors assembled the evidence in favour, and two authors assembled the evidence against. Results: From this controversies piece we found that there is little discernible change in the number of BDIs requiring repair procedures. Although IOC is associated with a small absolute reduction in bile duct injury, there are other confounding factors, including a change in laparoscopic learning curves. Alternative technologies such as intra-operative ultrasound, indocyanine green imaging, and increased access to ERCP may contribute to a reduction in the need for routine IOC. Conclusions: In spite of 30 years of accumulating evidence, routine IOC remains controversial. As technology advances, it is likely that alternative methods of imaging and accessing the bile duct will supplant routine IOC.
MeSH term(s)	Humans ; Cholecystectomy, Laparoscopic ; Cholangiography/methods ; Bile Ducts/injuries ; Laparoscopy ; Indocyanine Green ; Intraoperative Care/methods
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-01-27
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	2102927-1
ISSN	1479-666X
ISSN	1479-666X
DOI	10.1016/j.surge.2023.01.002
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Article ; Online: The Instructor's Role in a Model-Based Inquiry Laboratory: Characterizing Instructor Supports and Intentions in Teaching Authentic Scientific Practices.

Cooper, A C / Southard, K M / Osness, J B / Bolger, M S

CBE life sciences education

2022 Volume 21, Issue 1, Page(s) ar9

Abstract: Limited access to undergraduate research experiences for science, technology, engineering, and mathematics students has led to creation of classroom-based opportunities for students to participate in authentic science. Revising laboratory courses to ... ...

Abstract	Limited access to undergraduate research experiences for science, technology, engineering, and mathematics students has led to creation of classroom-based opportunities for students to participate in authentic science. Revising laboratory courses to engage students in the practices of science has been shown to have many benefits for students. However, the instructor's role in successful implementation of authentic-inquiry curricula requires further investigation. Previous work has demonstrated that navigating an instructional role within the open-ended format of an inquiry curriculum is challenging for instructors. Little is known about effective strategies for supporting students in authentic scientific practices. To address this challenge, we investigated instructors with prior experience teaching Authentic Inquiry through Modeling in Biology (AIM-Bio) in order to reveal strategies that are likely to help students succeed in this context. We took a unique approach that uncovered how instructors supported students and how they intended to support students in the scientific practices of modeling and experimental design. Analysis included in vivo recordings of instructor-student interactions paired with instructor interviews over the course of a semester. Findings detail the ways in which instructors flexibly responded to students through their in-the-moment actions. Additionally, the instructor intentions provided crucial explanatory power to explain the rationale behind teaching choices made.
MeSH term(s)	Curriculum ; Engineering/education ; Humans ; Intention ; Mathematics ; Students ; Teaching
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2465176-X
ISSN	1931-7913 ; 1931-7913
ISSN (online)	1931-7913
ISSN	1931-7913
DOI	10.1187/cbe.21-07-0177
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Article ; Online: Exploring a targeted approach for public health capacity restrictions during COVID-19 using a new computational model.

Micuda, Ashley N / Anderson, Mark R / Babayan, Irina / Bolger, Erin / Cantin, Logan / Groth, Gillian / Pressman-Cyna, Ry / Reed, Charlotte Z / Rowe, Noah J / Shafiee, Mehdi / Tam, Benjamin / Vidal, Marie C / Ye, Tianai / Martin, Ryan D

Infectious Disease Modelling

2024 Volume 9, Issue 1, Page(s) 234–244

Abstract: This work introduces the Queen's University Agent-Based Outbreak Outcome Model (QUABOOM). This tool is an agent-based Monte Carlo simulation for modelling epidemics and informing public health policy. We illustrate the use of the model by examining ... ...

Abstract	This work introduces the Queen's University Agent-Based Outbreak Outcome Model (QUABOOM). This tool is an agent-based Monte Carlo simulation for modelling epidemics and informing public health policy. We illustrate the use of the model by examining capacity restrictions during a lockdown. We find that public health measures should focus on the few locations where many people interact, such as grocery stores, rather than the many locations where few people interact, such as small businesses. We also discuss a case where the results of the simulation can be scaled to larger population sizes, thereby improving computational efficiency.
Language	English
Publishing date	2024-01-12
Publishing country	China
Document type	Journal Article
ZDB-ID	3015225-2
ISSN	2468-0427 ; 2468-2152
ISSN (online)	2468-0427
ISSN	2468-2152
DOI	10.1016/j.idm.2024.01.001
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Article ; Online: Bilateral laminotomy through a unilateral approach (minimally invasive) versus open laminectomy for lumbar spinal stenosis.

Horan, Jack / Husien, Mohammed Ben / Bolger, Ciaran

British journal of neurosurgery

2020 Volume 35, Issue 2, Page(s) 161–165

Abstract: Purpose: To compare the outcomes of minimally invasive (MI) bilateral laminotomy via unilateral approach versus open laminectomy in the treatment of lumbar spinal stenosis (LSS).: Materials and methods: In this prospective study, 62 patients were ... ...

Abstract	Purpose: To compare the outcomes of minimally invasive (MI) bilateral laminotomy via unilateral approach versus open laminectomy in the treatment of lumbar spinal stenosis (LSS). Materials and methods: In this prospective study, 62 patients were treated for LSS and were assigned to one of two groups over a 6-month period. Group A comprised 37 patients that underwent MI bilateral laminotomy. Group B comprised 25 patients that underwent open laminectomy. Follow-up duration was 3 years. The primary outcomes were the visual analogue scale (VAS) pain outcome score for back and leg, the Oswestry Disability Index (ODI) and complications. Results: MI methods were superior in most primary outcomes compared to open laminectomy. VAS back pain outcome was reduced from close to 7 to 4 in both groups. VAS leg pain was reduced from 6.8 to 3.2 in MI group and from 8.7 to 3.5 in the open group ( Conclusions: Bilateral laminotomy through a unilateral approach (minimally invasive) and open laminectomy are both effective in improving pain and disability in LSS. MI procedures have an advantage in shorter hospital stays, sparing of more bony structures and lower complication rates. MI unilateral decompression is at least as good as laminectomy in the treatment of LSS.
MeSH term(s)	Decompression, Surgical ; Humans ; Laminectomy ; Lumbar Vertebrae/surgery ; Prospective Studies ; Spinal Stenosis/diagnostic imaging ; Spinal Stenosis/surgery ; Treatment Outcome
Language	English
Publishing date	2020-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2020.1777253
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Article ; Online: Technical note: Novel use of recombinant tissue plasminogen activator for the evacuation of an acute extensive spinal epidural haematoma in a patient with coagulopathy.

Koustais, Stavros / Sweeney, Kieron J / Bolger, Ciaran

British journal of neurosurgery

2020 Volume 37, Issue 3, Page(s) 495–498

Abstract: Spontaneous extensive spinal epidural haematoma poses a unique challenge for the neurosurgeon. Performing extensive laminectomies to remove all of the compressive haematoma can destabilise the patient's spinal column, which may require fixation. This is ... ...

Abstract	Spontaneous extensive spinal epidural haematoma poses a unique challenge for the neurosurgeon. Performing extensive laminectomies to remove all of the compressive haematoma can destabilise the patient's spinal column, which may require fixation. This is further complicated in patients with significant coagulopathy. We present a novel use of recombinant tissue plasminogen activator (rt-PA) in a patient with therapeutic coagulopathy, presenting with myelopathy secondary to an acute extensive spinal epidural haematoma. To the best of our knowledge, this is the first case of acute multilevel spinal epidural haematoma that has been successfully evacuated via single level laminectomy and topically applied rt-PA.
MeSH term(s)	Humans ; Tissue Plasminogen Activator/therapeutic use ; Hematoma, Epidural, Spinal/complications ; Hematoma, Epidural, Spinal/diagnostic imaging ; Hematoma, Epidural, Spinal/drug therapy ; Laminectomy/adverse effects ; Decompression, Surgical/adverse effects ; Magnetic Resonance Imaging
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2020-05-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2020.1773395
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Article ; Online: Paraganglioma in an adolescent awaiting a cardiac transplant due to unrepaired congenital cyanotic heart disease and a univentricular heart: the first reported case.

Doyle, Conor / Bolger, Jarlath / Conneely, John B / Walsh, Kevin P

BMJ case reports

2021 Volume 14, Issue 5

Abstract: We report a case of a 16-year-old adolescent male born with univentricular congenital cyanotic heart disease (CCHD) who was diagnosed with an incidental paraganglioma while awaiting a cardiac transplant. The coexistence of paraganglioma and ... ...

Abstract	We report a case of a 16-year-old adolescent male born with univentricular congenital cyanotic heart disease (CCHD) who was diagnosed with an incidental paraganglioma while awaiting a cardiac transplant. The coexistence of paraganglioma and univentricular CCHD is very rare, with no previous cases described in the literature of a patient concurrently requiring a cardiac transplant. The complex physiology associated with a common atrium, common ventricle, aortopulmonary lung perfusion and a hypoplastic left lung rendered our patient extremely vulnerable to catecholamine-mediated effects of preload, contractility and afterload. The interactions and interdependence between these systems provided unique difficulties for perioperative management with serious implications for prospective cardiac transplant.
MeSH term(s)	Adolescent ; Cyanosis/etiology ; Heart Defects, Congenital/surgery ; Heart Transplantation ; Humans ; Male ; Paraganglioma/complications ; Paraganglioma/surgery ; Prospective Studies ; Univentricular Heart
Language	English
Publishing date	2021-05-25
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-241804
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Article ; Online: COVID-19 and the treatment of acute appendicitis in Ireland: a new era or short-term pivot?

Kelly, M E / Murphy, E / Bolger, J C / Cahill, R A

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2020 Volume 22, Issue 6, Page(s) 648–649

MeSH term(s)	Appendectomy/methods ; Appendicitis/diagnostic imaging ; Appendicitis/therapy ; Betacoronavirus ; COVID-19 ; Conservative Treatment/methods ; Coronavirus Infections/epidemiology ; Humans ; Ireland/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Surveys and Questionnaires ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-05-31
Publishing country	England
Document type	Letter
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15141
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Article ; Online: PD-1 inhibitors in esophageal cancer: a systematic review of the oncological outcomes associated with PD-1 blockade and the evolving therapeutic paradigm.

Whooley, J / Alazzawi, M / Donlon, N E / Bolger, J C / Robb, W B

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2021 Volume 35, Issue 5

Abstract: Patients with esophageal or gastroesophageal junction (GEJ) cancer who fail to respond to chemoradiotherapy have a poor clinical prognosis. Recent clinical trials have investigated the use of immune checkpoint inhibitors in these patients. The use of ... ...

Abstract	Patients with esophageal or gastroesophageal junction (GEJ) cancer who fail to respond to chemoradiotherapy have a poor clinical prognosis. Recent clinical trials have investigated the use of immune checkpoint inhibitors in these patients. The use of programmed cell death protein 1 (PD-1) inhibitors has emerged as exciting therapeutic options in the curative and palliative setting of other solid tumors. We assessed the efficacy and safety of PD-1 inhibitors in esophageal and GEJ cancers. This systematic review was performed in accordance with the PRISMA guidelines. A comprehensive electronic literature search from the EMBASE, Pubmed, Scopus, MEDLINE, and Google Scholar databases was conducted up to 25 July 2021. This review identified 11 eligible studies reporting outcomes of 3451 patients treated with PD-1 blockade compared with 2286 patients treated with either a placebo or the standard regimen of chemotherapy. Clinically significant improvements in median overall survival have been demonstrated in advanced and metastatic esophageal and GEJ cancer while maintaining acceptable safety profiles. Promising survival data have also recently emerged from PD-1 blockade in the adjuvant setting. PD-1 blockade in esophageal and GEJ cancer has delivered impressive survival benefit while remaining well tolerated. Its use in the adjuvant setting will further advance treatment options, and more advancements in this area of therapy are highly anticipated. However, further characterization of the PD-1/programmed death ligand-1 pathway and elucidation of biomarkers to predict response are required to optimize patient selection.
MeSH term(s)	B7-H1 Antigen/metabolism ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/pathology ; Humans ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor/therapeutic use ; Stomach Neoplasms/pathology
Chemical Substances	B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2021-09-22
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/doab063
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