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Article ; Online: Granulomatosis with polyangiitis in an adolescent male with chronic cough and pulmonary nodules.

Wee, Wallace / Mehta, Kevan Dilip

BMJ case reports

2022 Volume 15, Issue 11

Abstract: Granulomatosis with polyangiitis (GPA) is a small to medium vessel vasculitis that is uncommon in paediatrics. However, with chronic cough often being the initial symptom, a common complaint and a median age of diagnosis of 14 years, it is nevertheless ... ...

Abstract	Granulomatosis with polyangiitis (GPA) is a small to medium vessel vasculitis that is uncommon in paediatrics. However, with chronic cough often being the initial symptom, a common complaint and a median age of diagnosis of 14 years, it is nevertheless an important condition for paediatricians to consider as it can otherwise go undiagnosed for a long period of time. In this case report, we discuss a paediatric patient with GPA that presented with non-specific respiratory symptoms for several months and was then found to have pulmonary nodules on chest imaging once a broader differential diagnosis was considered. We will review the common presentation of GPA, the classification criteria and its management. This will ultimately assist any providers in identifying and managing GPA cases.
MeSH term(s)	Male ; Adolescent ; Humans ; Child ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Cough/etiology ; Cough/diagnosis ; Multiple Pulmonary Nodules/diagnosis ; Diagnosis, Differential ; Diagnostic Imaging
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-252257
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Article: Gordonia

Akrami, Kevan / Coletta, Joelle / Mehta, Sanjay / Fierer, Joshua

JMM case reports

2017 Volume 4, Issue 9, Page(s) e005113

Abstract: Introduction. ...

Abstract	Introduction.
Language	English
Publishing date	2017-09-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2755673-6
ISSN	2053-3721
ISSN	2053-3721
DOI	10.1099/jmmcr.0.005113
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Article: Respiratory Diagnostic Tools in Neuromuscular Disease.

Chiang, Jackie / Mehta, Kevan / Amin, Reshma

Children (Basel, Switzerland)

2018 Volume 5, Issue 6

Abstract: Children with neuromuscular disease (NMD) are at risk of acquiring respiratory complications. Both clinical assessments and respiratory diagnostic tests are important to optimize the respiratory health and care of such children. The following respiratory ...

Abstract	Children with neuromuscular disease (NMD) are at risk of acquiring respiratory complications. Both clinical assessments and respiratory diagnostic tests are important to optimize the respiratory health and care of such children. The following respiratory diagnostic tools and their utility for evaluating children with NMD are discussed in this article: lung function testing (spirometry and lung volumes), peak cough flow (PCF), respiratory muscle strength testing, oximetry, capnography, and polysomnography.
Language	English
Publishing date	2018-06-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children5060078
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Article ; Online: How to use noninvasive positive airway pressure device data reports to guide clinical care.

Perrem, Lucy / Mehta, Kevan / Syed, Faiza / Baker, Adele / Amin, Reshma

Pediatric pulmonology

2019 Volume 55, Issue 1, Page(s) 58–67

Abstract: There has been a significant increase in the past few decades in the number of children receiving noninvasive positive airway pressure (PAP) therapy at home. At present, PAP therapy can be successfully used in children of all ages, for a variety of ... ...

Abstract	There has been a significant increase in the past few decades in the number of children receiving noninvasive positive airway pressure (PAP) therapy at home. At present, PAP therapy can be successfully used in children of all ages, for a variety of indications. Data acquired from PAP devices is clinically useful, providing objective information regarding adherence, leak, and efficacy of PAP therapy. However, guidelines outlining a standardized approach to interpretation of PAP device data in pediatrics is currently lacking. Given the rapidly expanding use of PAP therapy in pediatric practice, we aim to provide an overview of the interpretation of data reports, otherwise called "data downloads," from PAP devices and illustrate how they can be used to guide clinical care.
MeSH term(s)	Child ; Continuous Positive Airway Pressure/instrumentation ; Humans ; Research Design
Language	English
Publishing date	2019-10-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24555
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Article ; Online: Pulmonary Alveolar Microlithiasis.

Mehta, Kevan / Dell, Sharon / Birken, Catherine / Al-Saleh, Suhail

Canadian respiratory journal

2016 Volume 2016, Page(s) 4938632

Abstract: Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive condition that is often asymptomatic despite significant changes in chest imaging. Diagnosis is often made when patients become symptomatic in adulthood. There are still no proven ... ...

Abstract	Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive condition that is often asymptomatic despite significant changes in chest imaging. Diagnosis is often made when patients become symptomatic in adulthood. There are still no proven treatments, but earlier diagnosis may allow for evaluation of preventative strategies that could improve outcome. It is an important diagnosis to consider in children who have marked radiographic findings with no or very mild symptoms or physical findings. Diagnosis can be made with imaging alone but may necessitate lung biopsy for definitive diagnosis.
MeSH term(s)	Calcinosis/diagnostic imaging ; Calcinosis/pathology ; Child, Preschool ; Female ; Genetic Diseases, Inborn/diagnostic imaging ; Genetic Diseases, Inborn/pathology ; Humans ; Lung/pathology ; Lung Diseases/diagnostic imaging ; Lung Diseases/pathology ; Radiography, Thoracic ; Tomography, X-Ray Computed
Language	English
Publishing date	2016
Publishing country	Egypt
Document type	Case Reports ; Journal Article
ZDB-ID	1213103-9
ISSN	1916-7245 ; 1198-2241
ISSN (online)	1916-7245
ISSN	1198-2241
DOI	10.1155/2016/4938632
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Article ; Online: Assessing air travel safety in neuromuscular disease: standard versus prolonged hypoxic challenge tests.

Chiang, Jackie / Varadi, Robert / Snow, Nadia / Al-Saleh, Suhail / Mehta, Kevan / Al-Awadi, Aceel / Almajeed, Athari / McAdam, Laura / Goldstein, Roger / Amin, Reshma

Sleep & breathing = Schlaf & Atmung

2021 Volume 26, Issue 2, Page(s) 887–891

Abstract: Purpose: The hypoxic challenge test (HCT) is used to evaluate safety for air travel in individuals with respiratory disease by breathing in 15% oxygen for 20 min. Our aim was to determine if a prolonged HCT, lasting 120 min, identified more individuals ... ...

Abstract	Purpose: The hypoxic challenge test (HCT) is used to evaluate safety for air travel in individuals with respiratory disease by breathing in 15% oxygen for 20 min. Our aim was to determine if a prolonged HCT, lasting 120 min, identified more individuals with neuromuscular disease at potential risk than the standard HCT lasting 20 min. Methods: This was a cross-sectional study. All of the clinical testing took place at SickKids, Toronto, Canada. Patients were included in the study if they had a diagnosis of NMD, greater than 6 years of age, resting oxygen saturation ≥ 94%, and partial pressure of carbon dioxide (pCO2) ≤ 45 mmHg. Notable exclusion criteria were left ventricular ejection fraction < 30%, presence of a tracheostomy, and use of non-invasive ventilation for more than 12 h daily. Participants underwent a standard HCT as well as the prolonged HCT on the same day. Results: Twenty-three patients consented to the study. One patient was withdrawn because he was unable to follow the study procedures. The 22 study participants had a mean age of 14.9 years (standard deviation (SD) of 5 years). Seventeen (77%) participants were male. Two participants were withdrawn on the day of testing due to hypercapnia. Twenty participants completed the standard and prolonged HCTs. None of the participants had a positive standard or prolonged HCT. Conclusion: Our results suggest that performing a standard or prolonged HCT may, in fact, not be of clinical utility in individuals with less severe NMD.
MeSH term(s)	Adolescent ; Air Travel ; Cross-Sectional Studies ; Female ; Humans ; Hypoxia/diagnosis ; Hypoxia/etiology ; Male ; Neuromuscular Diseases/complications ; Neuromuscular Diseases/diagnosis ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2021-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-021-02462-5
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Article ; Online: Chronic tracheostomy care of ventilator-dependent and -independent children: Clinical practice patterns of pediatric respirologists in a publicly funded (Canadian) healthcare system.

Pediatric pulmonology

2022

Abstract: Objectives: To describe the current clinical practice patterns of Canadian pediatric respirologists at pediatric tertiary care institutions regarding chronic tracheostomy tube care and management of home invasive ventilation.: Methods: A pediatric ... ...

Abstract	Objectives: To describe the current clinical practice patterns of Canadian pediatric respirologists at pediatric tertiary care institutions regarding chronic tracheostomy tube care and management of home invasive ventilation. Methods: A pediatric respirologist/pediatrician with expertise in tracheostomy tube care and home ventilation was identified at each Canadian pediatric tertiary care center to complete a 59-item survey of multiple choice and short answer questions. Domains assessed included tracheostomy tube care, caregiver competency and home monitoring, speaking valves, medical management of tracheostomy complications, decannulation, and long-term follow-up. Results: The response rate was 100% (17/17) with all Canadian tertiary care pediatric centers represented and heterogeneity of practice was observed in all domains assessed. For example, though most centers employ Bivona™ (17/17) and Shiley™ (15/17) tracheostomy tubes, variability was observed around tube change, re-use, and cleaning practices. Most centers require two trained caregivers (14/17) and recommend 24/7 eyes on care and oxygen saturation monitoring. Discharge with an emergency tracheostomy kit was universal (17/17). Considerable heterogeneity was observed in the timing and use of speaking valves and speech-language assessment. Inhaled anti-pseudomonal antibiotics are employed by most centers (16/17) though the indication, agent, and protocol varied by center. Though decannulation practices varied considerably, the requirement of upper airway patency was universally required to proceed with decannulation (17/17) independent of ongoing ventilatory support requirements. Conclusion: Considerable variability in pediatric tracheostomy tube care practice exists across Canada. These results will serve as a starting point to standardize and evaluate tracheostomy tube care nationally.
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26171
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Article ; Online: Functional organization of the S. cerevisiae phosphorylation network.

Fiedler, Dorothea / Braberg, Hannes / Mehta, Monika / Chechik, Gal / Cagney, Gerard / Mukherjee, Paromita / Silva, Andrea C / Shales, Michael / Collins, Sean R / van Wageningen, Sake / Kemmeren, Patrick / Holstege, Frank C P / Weissman, Jonathan S / Keogh, Michael-Christopher / Koller, Daphne / Shokat, Kevan M / Krogan, Nevan J

Cell

2009 Volume 136, Issue 5, Page(s) 952–963

Abstract: Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, ... ...

Abstract	Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators. Quantitative genetic interaction mapping reveals factors working in compensatory pathways (negative genetic interactions) or those operating in linear pathways (positive genetic interactions). We found an enrichment of positive genetic interactions between kinases, phosphatases, and their substrates. In addition, we assembled a higher-order map from sets of three genes that display strong interactions with one another: triplets enriched for functional connectivity. The resulting network view provides insights into signaling pathway regulation and reveals a link between the cell-cycle kinase, Cak1, the Fus3 MAP kinase, and a pathway that regulates chromatin integrity during transcription by RNA polymerase II.
MeSH term(s)	Acetylation ; Histones/metabolism ; Phosphorylation ; Protein Kinases/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction
Chemical Substances	Histones ; Saccharomyces cerevisiae Proteins ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2009-03-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2008.12.039
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Article ; Online: Rewiring of genetic networks in response to DNA damage.

Science (New York, N.Y.)

2010 Volume 330, Issue 6009, Page(s) 1385–1389

Abstract: Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among ... ...

Abstract	Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They are very effective at identifying DNA repair pathways, highlighting new damage-dependent roles for the Slt2 kinase, Pph3 phosphatase, and histone variant Htz1. The data also reveal that protein complexes are generally stable in response to perturbation, but the functional relations between these complexes are substantially reorganized. Differential networks chart a new type of genetic landscape that is invaluable for mapping cellular responses to stimuli.
MeSH term(s)	Chromatin/metabolism ; DNA Damage ; DNA Repair/genetics ; DNA, Fungal/genetics ; Epistasis, Genetic ; Gene Regulatory Networks ; Genes, Fungal ; Histones/genetics ; Histones/metabolism ; Methyl Methanesulfonate/pharmacology ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Mutagens/pharmacology ; Mutation ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; Protein Interaction Mapping ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Chromatin ; DNA, Fungal ; Histones ; Htz1 protein, S cerevisiae ; Mutagens ; Saccharomyces cerevisiae Proteins ; Transcription Factors ; Methyl Methanesulfonate (AT5C31J09G) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; SLT2 protein, S cerevisiae (EC 2.7.11.24) ; PPH3 protein, S cerevisiae (EC 3.1.3.16) ; Phosphoprotein Phosphatases (EC 3.1.3.16)
Language	English
Publishing date	2010-12-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.1195618
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Article: Rewiring of Genetic Networks in Response to DNA Damage

Science. 2010 Dec. 3, v. 330, no. 6009

2010

Abstract	Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They are very effective at identifying DNA repair pathways, highlighting new damage-dependent roles for the Slt2 kinase, Pph3 phosphatase, and histone variant Htz1. The data also reveal that protein complexes are generally stable in response to perturbation, but the functional relations between these complexes are substantially reorganized. Differential networks chart a new type of genetic landscape that is invaluable for mapping cellular responses to stimuli.
Keywords	DNA damage ; DNA repair ; epistasis ; genes ; histones ; phosphotransferases (kinases) ; transcription factors ; yeasts
Language	English
Dates of publication	2010-1203
Size	p. 1385-1389.
Publishing place	American Association for the Advancement of Science
Document type	Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.1195618
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