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  1. Article ; Online: Tissue factor pathway inhibitor and interleukin-1 receptor levels in COVID-19.

    Gorog, Diana Adrienne / Patel, Brijesh V

    Thrombosis and haemostasis

    2024  

    Abstract: No Abstract. ...

    Abstract No Abstract.
    Language English
    Publishing date 2024-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2315-8278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.192: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 433: Show issues

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  2. Article: Tissue factor pathway inhibitor and interleukin-1 receptor levels in COVID-19

    Gorog, Diana Adrienne / Patel, Brijesh V

    Thrombosis and Haemostasis

    2024  

    Abstract: ... No ... ...

    Abstract No Abstract
    Language English
    Publishing date 2024-04-27
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2315-8278
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: CLUSTERINg Circulating Histones in Sepsis.

    Patel, Brijesh V / Lee, Teresa M L / O'Dea, Kieran

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 2, Page(s) 125–127

    MeSH term(s) Humans ; Histones ; Clusterin ; Antineoplastic Agents ; Sepsis/diagnosis
    Chemical Substances Histones ; Clusterin ; Antineoplastic Agents
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202305-0935ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical practice, decision-making, and use of clinical decision support systems in invasive mechanical ventilation: a narrative review.

    Murali, Mayur / Ni, Melody / Karbing, Dan S / Rees, Stephen E / Komorowski, Matthieu / Marshall, Dominic / Ramnarayan, Padmanabhan / Patel, Brijesh V

    British journal of anaesthesia

    2024  

    Abstract: Invasive mechanical ventilation is a key supportive therapy for patients on intensive care. There is increasing emphasis on personalised ventilation strategies. Clinical decision support systems (CDSS) have been developed to support this. We conducted a ... ...

    Abstract Invasive mechanical ventilation is a key supportive therapy for patients on intensive care. There is increasing emphasis on personalised ventilation strategies. Clinical decision support systems (CDSS) have been developed to support this. We conducted a narrative review to assess evidence that could inform device implementation. A search was conducted in MEDLINE (Ovid) and EMBASE. Twenty-nine studies met the inclusion criteria. Role allocation is well described, with interprofessional collaboration dependent on culture, nurse:patient ratio, the use of protocols, and perception of responsibility. There were no descriptions of process measures, quality metrics, or clinical workflow. Nurse-led weaning is well-described, with factors grouped by patient, nurse, and system. Physician-led weaning is heterogenous, guided by subjective and objective information, and 'gestalt'. No studies explored decision-making with CDSS. Several explored facilitators and barriers to implementation, grouped by clinician (facilitators: confidence using CDSS, retaining decision-making ownership; barriers: undermining clinician's role, ambiguity moving off protocol), intervention (facilitators: user-friendly interface, ease of workflow integration, minimal training requirement; barriers: increased documentation time), and organisation (facilitators: system-level mandate; barriers: poor communication, inconsistent training, lack of technical support). One study described factors that support CDSS implementation. There are gaps in our understanding of ventilation practice. A coordinated approach grounded in implementation science is required to support CDSS implementation. Future research should describe factors that guide clinical decision-making throughout mechanical ventilation, with and without CDSS, map clinical workflow, and devise implementation toolkits. Novel research design analogous to a learning organisation, that considers the commercial aspects of device design, is required.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2024.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.80: Show issues Location:
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  5. Article ; Online: Hypoxemia Trajectory of Non-COVID-19 Acute Respiratory Distress Syndrome Patients. An Observational Study Focusing on Hypoxemia Resolver Status.

    Toal, Connor M / Fowler, Alexander J / Patel, Brijesh V / Puthucheary, Zudin / Prowle, John R

    Critical care explorations

    2023  Volume 5, Issue 10, Page(s) e0985

    Abstract: Importance: Most studies on acute respiratory distress syndrome (ARDS) group patients by severity based on their initial degree of hypoxemia. However, this grouping has limitations, including inconsistent hypoxemia trajectories and outcomes.: ... ...

    Abstract Importance: Most studies on acute respiratory distress syndrome (ARDS) group patients by severity based on their initial degree of hypoxemia. However, this grouping has limitations, including inconsistent hypoxemia trajectories and outcomes.
    Objectives: This study explores the benefits of grouping patients by resolver status based on their hypoxemia progression over the first 7 days.
    Design setting and participants: This is an observational study from a large single-center database. Medical Information Mart for Intensive Care (MIMIC)-IV and MIMIC Chest X-ray JPEG databases were used. Mechanically ventilated patients that met the Berlin ARDS criteria were included.
    Main outcomes and measures: The primary outcome was the proportion of hypoxemia resolvers vs. nonresolvers in non-COVID-19 ARDS patients. Nonresolvers were defined as those whose hypoxemia worsened or remained moderate or severe over the first 7 days. Secondary outcomes included baseline admission characteristics, initial blood gases and ventilation settings, length of invasive mechanical ventilation, length of ICU stay, and ICU survival rates across resolver groups.
    Results: A total of 894 ICU admissions were included in the study. Of these, 33.9% were hypoxemia nonresolvers. The resolver groups showed no significant difference in age, body mass index, comorbidities, or Charlson score. There was no significant difference in the percentage of those with initial severe hypoxemia between the two groups (8.1% vs. 9.2%;
    Conclusions and relevance: Our study shows that resolver status is a valuable grouping in ARDS. It has significant advantages over grouping by initial degree of hypoxemia, including better mapping of trajectory and comparable outcomes across other studies. While it may offer insights into disease-specific associations, future studies should include resolver status analysis for more definitive conclusions.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care.

    Jenkins, Timothy O / MacBean, Vicky / Poulsen, Mathias Krogh / Karbing, Dan Stieper / Rees, Stephen Edward / Patel, Brijesh V / Polkey, Michael I

    Intensive care medicine experimental

    2023  Volume 11, Issue 1, Page(s) 41

    Abstract: Background: Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet the optimal approach remains ... ...

    Abstract Background: Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet the optimal approach remains uncertain. Whilst some data on the metabolic response to whole body exercise in critical care exist, the metabolic response to IMT in critical care is yet to be investigated. This study aimed to quantify the metabolic response to IMT in critical care and its relationship to physiological variables.
    Methods: We conducted a prospective observational study on mechanically ventilated patients ventilated for ≥ 72 h and able to participate in IMT in a medical, surgical, and cardiothoracic intensive care unit. 76 measurements were taken on 26 patients performing IMT using an inspiratory threshold loading device at 4 cmH
    Results: First session mean (SD) VO
    Conclusions: IMT causes a significant load-dependent increase in VO
    Take home message: The optimal approach to IMT in ICU is uncertain; we measured VO
    Language English
    Publishing date 2023-07-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-023-00522-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of genetic introgression in introducing mutant alleles in Bos indicus cattle and prevalence of lethal genetic disorders in Bos taurus × Bos indicus and Bos indicus cattle in India.

    Sudhakar, A / Nayee, Nilesh / Saha, Sujit / Donthula, Sandeep K / Poojara, Hardik V / Gohil, Tejas / Patel, Aashish C / Maurya, Brijesh K

    Tropical animal health and production

    2023  Volume 55, Issue 6, Page(s) 399

    Abstract: Fertility is an important trait associated with reproductive performance and animal welfare concern. Lethal alleles affect fertility through early embryonic death, abortions, and stillbirth depending on the genetic expression of the allele. Holstein ... ...

    Abstract Fertility is an important trait associated with reproductive performance and animal welfare concern. Lethal alleles affect fertility through early embryonic death, abortions, and stillbirth depending on the genetic expression of the allele. Holstein Friesian and Jersey are two major Bos taurus breeds used widely for increasing milk yield along with purebreds of Bos indicus breeds like Gir, Kankrej, Sahiwal, and Tharparkar. In the present study, prevalence of lethal mutants in crossbred Holstein Friesian (CBHF, n = 2435), crossbred Jersey (CBJY, n = 2874), Gir (n = 3288), Kankrej (n = 593), Sahiwal (n = 965), and Tharparkar (n = 18) were studied. Heterozygous carrier animals were identified for bovine leukocyte adhesion deficiency (BLAD), Citrullinemia, complex vertebral malformation (CVM), Brachyspina, Holstein Haplotype 1 (HH1), Holstein Haplotype 3 (HH3),Holstein Haplotype 4 (HH4) and Jersey Haplotype 1 (JH1). Breed purity analysis confirmed inheritance of Bos taurus genes contributing to the presence of lethal mutant alleles like BLAD, Citrullinemia, HH1, and JH1 in apparently phenotypic Bos indicus animals. Screening and elimination of heterozygous carrier bulls/cows is essential to control fertility loss associated with lethal alleles.
    MeSH term(s) Pregnancy ; Female ; Cattle/genetics ; Animals ; Male ; Alleles ; Genetic Introgression ; Prevalence ; Citrullinemia/genetics ; Citrullinemia/veterinary ; Phenotype ; Cattle Diseases/epidemiology ; Cattle Diseases/genetics
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-023-03798-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2159: Show issues Location:
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  8. Article ; Online: Investigation of Microvesicle Uptake by Mouse Lung-marginated Monocytes

    Tan, Ying Ying / O'Dea, Kieran P / Patel, Brijesh V / Takata, Masao

    Bio-protocol

    2022  Volume 12, Issue 3, Page(s) e4307

    Abstract: Extracellular microvesicles (MVs) are released into the circulation in large numbers during acute systemic inflammation, yet little is known of their intravascular cell/tissue-specific interactions under these conditions. We recently described a dramatic ...

    Abstract Extracellular microvesicles (MVs) are released into the circulation in large numbers during acute systemic inflammation, yet little is known of their intravascular cell/tissue-specific interactions under these conditions. We recently described a dramatic increase in the uptake of intravenously injected MVs by monocytes marginated within the pulmonary vasculature, in a mouse model of low-dose lipopolysaccharide-induced systemic inflammation. To investigate the mechanisms of enhanced MV uptake by monocytes, we developed an in vitro model using in vivo derived monocytes. Although mouse blood is a convenient source, monocyte numbers are too low for in vitro experimentation. In contrast, differentiated bone marrow monocytes are abundant, but they are rapidly mobilized during systemic inflammation, and thus no longer available. Instead, we developed a protocol using marginated monocytes from the pulmonary vasculature as an anatomically relevant and abundant source. Mice are sacrificed by terminal anesthesia, the lungs inflated and perfused via the pulmonary artery. Perfusate cell populations are evaluated by flow cytometry, combined with in vitro generated fluorescently labelled MVs, and incubated in suspension for up to one hour. Washed cells are analyzed by flow cytometry to quantify MV uptake and confocal microscopy to localize MVs within cells (O'Dea et al., 2020). Using this perfusion-based method, substantial numbers of marginated pulmonary vascular monocytes are recovered, allowing multiple in vitro tests to be performed from a single mouse donor. As MV uptake profiles were comparable to those observed in vivo, this method is suitable for physiologically relevant high throughput mechanistic studies on mouse monocytes under in vitro conditions. Graphic abstract: Figure 1. Schematic of lung perfusate cell harvest and co-incubation with
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Himalayan Natural Fiber-Reinforced Epoxy Composites: Effect of Grewia optiva/Bauhinia Vahlii Fibers on Physico-mechanical and Dry Sliding Wear Behavior

    Kumar, Sandeep / Patel, V. K. / Mer, K. K. S. / Gangil, Brijesh / Singh, Tej / Fekete, Gusztáv

    Journal of natural fibers

    2021  Volume 18, Issue 1/3, Page(s) 192

    Language English
    Document type Article
    ZDB-ID 2182715-1
    ISSN 1544-0478
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 7564: Show issues

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  10. Article: Himalayan Natural Fiber-Reinforced Epoxy Composites: Effect of Grewia optiva/Bauhinia Vahlii Fibers on Physico-mechanical and Dry Sliding Wear Behavior

    Kumar, Sandeep / Patel, V. K. / Mer, K. K. S. / Gangil, Brijesh / Singh, Tej / Fekete, Gusztáv

    Journal of natural fibers

    2021  Volume 18, Issue 1/3, Page(s) 192

    Language English
    Document type Article
    ZDB-ID 2182715-1
    ISSN 1544-0478
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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