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  1. Article: Treatment of immunothrombosis dysregulation: high-dose corticosteroids is not the good option.

    Helms, Julie / Poissy, Julien / Dequin, Pierre-François / Timsit, Jean-François

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 58

    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01158-1
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  2. Article ; Online: What applications for plasma endocan measurement in intensive care? A clarification.

    Dubar, Victoria / Chenevier-Gobeaux, Camille / Poissy, Julien / Gaudet, Alexandre

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 397

    MeSH term(s) Humans ; Sepsis ; Biomarkers ; Critical Care
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04686-1
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    Zs.A 5517: Show issues Location:
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  3. Article ; Online: The Changing Landscape of Invasive Fungal Infections in ICUs: A Need for Risk Stratification to Better Target Antifungal Drugs and the Threat of Resistance.

    Poissy, Julien / Rouzé, Anahita / Cornu, Marjorie / Nseir, Saad / Sendid, Boualem

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 9

    Abstract: The landscape of invasive candidiasis and invasive aspergillosis has changed dramatically in intensive care units over the past two decades. Today, we are faced with new risk factors such as the emergence of resistance, but are also equipped with new ... ...

    Abstract The landscape of invasive candidiasis and invasive aspergillosis has changed dramatically in intensive care units over the past two decades. Today, we are faced with new risk factors such as the emergence of resistance, but are also equipped with new therapeutic strategies and diagnostic tools which are changing epidemiological data and diagnostic algorithms. Some common points need to be addressed: (i) the best way to use microbiological tools and to integrate their results in decisional algorithms; (ii) the need to find the optimum balance between under-diagnosis and overtreatment; (iii) and the need to decipher pathophysiology. In this short review, we will try to illustrate these points.
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8090946
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  4. Article ; Online: Effects of intermittent hemodialysis on plasmatic levels of endocan.

    Hureau, Maxence / Poissy, Julien / Mathieu, Daniel / Dubucquoi, Sylvain / Gaudet, Alexandre

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 412

    MeSH term(s) Humans ; Neoplasm Proteins/blood ; Proteoglycans/blood ; Renal Dialysis ; Treatment Outcome
    Chemical Substances ESM1 protein, human ; Neoplasm Proteins ; Proteoglycans
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03829-6
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  5. Article ; Online: Risk factors for difficult ventilatory weaning in intensive care patients with cervical cellulitis.

    Degouy, Guillaume / Nicot, Romain / Poissy, Julien / Mathieu, Daniel / Parmentier-Decrucq, Erika

    Journal of stomatology, oral and maxillofacial surgery

    2022  Volume 123, Issue 5, Page(s) e396–e401

    Abstract: Purpose: Cervical cellulitis is an infrequent but serious infection. The management of the upper airways is difficult, at the actual time of intubation but also regarding the necessity of maintaining mechanical ventilation. The objective of this study ... ...

    Abstract Purpose: Cervical cellulitis is an infrequent but serious infection. The management of the upper airways is difficult, at the actual time of intubation but also regarding the necessity of maintaining mechanical ventilation. The objective of this study is to identify risk factors on admission to the intensive care unit for difficult ventilatory weaning in patients with cervical cellulitis.
    Methods: Between January 2013 and December 2018, this retrospective observational study was performed in an intensive care unit with 10 beds in a university hospital recognized as a reference center for the management of cellulitis. All intensive care patients receiving mechanical ventilation after surgery for cervical cellulitis were eligible. Difficult ventilatory weaning was defined as mechanical ventilation lasting more than 7 days or failure of extubation as established by the WIND 2017 study.
    Results: We included 120 patients with severe cervical cellulitis. The median age was 43 years. Eighteen patients (16%) presented mediastinal extension. The risk factor for difficult ventilatory weaning (n = 49) in multivariate analysis was a high level of procalcitonin on admission (OR at 1.14[1.005-1.29]; p<0.042) and the protective factor was surgery in an expert center (OR at 0.11[0.026-0.47]; p<0.003). Eight patients required a tracheotomy in our study: 3 patients during surgery and at a later time for the other 5 of our 8 patients.
    Conclusion: No intensive care studies have investigated ventilatory weaning risk factors in patients with cervical cellulitis. Yet simple criteria seem to predict this risk. It is now necessary to confirm them by a multicenter prospective study.
    MeSH term(s) Adult ; Cellulitis/epidemiology ; Cellulitis/surgery ; Humans ; Procalcitonin ; Prospective Studies ; Risk Factors ; Ventilator Weaning
    Chemical Substances Procalcitonin
    Language English
    Publishing date 2022-02-25
    Publishing country France
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2916276-2
    ISSN 2468-7855 ; 2468-8509
    ISSN (online) 2468-7855
    ISSN 2468-8509
    DOI 10.1016/j.jormas.2022.02.014
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  6. Article ; Online: Altered microRNA expression in severe COVID-19: Potential prognostic and pathophysiological role.

    Garnier, Nathalie / Pollet, Kato / Fourcot, Marie / Caplan, Morgan / Marot, Guillemette / Goutay, Julien / Labreuche, Julien / Soncin, Fabrice / Boukherroub, Rabah / Hober, Didier / Szunerits, Sabine / Poissy, Julien / Engelmann, Ilka

    Clinical and translational medicine

    2022  Volume 12, Issue 6, Page(s) e899

    MeSH term(s) COVID-19/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Prognosis
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.899
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  7. Article: Κey Role of Early Source Control in Candidemic Patients With Sepsis or Septic Shock.

    Papadimitriou-Olivgeris, Matthaios / Battistolo, Julien / Poissy, Julien / Coste, Alix / Bochud, Pierre-Yves / Calandra, Thierry / Senn, Laurence / Lamoth, Frédéric

    Open forum infectious diseases

    2022  Volume 9, Issue 8, Page(s) ofac383

    Abstract: Background: Despite advances in diagnostic and therapeutic approaches, candidemia remains associated with high mortality rates. This study aimed at identifying predictors of mortality among patients with candidemia, with a focus on early interventions ... ...

    Abstract Background: Despite advances in diagnostic and therapeutic approaches, candidemia remains associated with high mortality rates. This study aimed at identifying predictors of mortality among patients with candidemia, with a focus on early interventions that can improve prognosis.
    Methods: This was a single-center retrospective study including all adult patients with at least 1 positive blood culture for
    Results: A total of 222 episodes of candidemia were included. Most candidemias were of unknown origin (36%) or vascular catheter related (29%). Septic shock developed in 29% episodes. Overall, 14-day mortality rate was 23%. In univariate analyses, septic shock was associated with higher 14-day mortality, whereas catheter-related candidemia and early (<72 hours) interventions, such as appropriate antifungal therapy, source control, and infectious diseases consultation, were associated with improved survival. In a Cox multivariate regression model, septic shock (odds ratio [OR], 3.62 [95% confidence interval {CI}, 2.05-6.38]) was associated with higher mortality. While the impact of early antifungal therapy did not reach statistical significance, early (<72 hours) infectious diseases consultation (OR, 0.46 [95% CI, .23-.91]) and early source control (OR, 0.15 [95% CI, .08-.31]) were associated with better survival. Subanalyses showed that the benefits of early source control, specifically catheter removal, were significant among patients with sepsis or septic shock, but not among those without sepsis. These associations remained significant after exclusion of patients who died prematurely or were in palliative care.
    Conclusions: Early source control, in particular catheter removal, was a key determinant of outcome among candidemic patients with sepsis or septic shock.
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac383
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  8. Article: Rationale and evidence for the use of new beta-lactam/beta-lactamase inhibitor combinations and cefiderocol in critically ill patients.

    Barbier, François / Hraiech, Sami / Kernéis, Solen / Veluppillai, Nathanaël / Pajot, Olivier / Poissy, Julien / Roux, Damien / Zahar, Jean-Ralph

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 65

    Abstract: Background: Healthcare-associated infections involving Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered outcomes and poses daily therapeutic challenges in most of intensive ... ...

    Abstract Background: Healthcare-associated infections involving Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered outcomes and poses daily therapeutic challenges in most of intensive care units worldwide. Over the recent years, four innovative β-lactam/β-lactamase inhibitor (BL/BLI) combinations (ceftolozane-tazobactam, ceftazidime-avibactam, imipenem-relebactam and meropenem-vaborbactam) and a new siderophore cephalosporin (cefiderocol) have been approved for the treatment of certain DTR-GNB infections. The literature addressing their microbiological spectrum, pharmacokinetics, clinical efficacy and safety was exhaustively audited by our group to support the recent guidelines of the French Intensive Care Society on their utilization in critically ill patients. This narrative review summarizes the available evidence and unanswered questions on these issues.
    Methods: A systematic search for English-language publications in PUBMED and the Cochrane Library database from inception to November 15, 2022.
    Results: These drugs have demonstrated relevant clinical success rates and a reduced renal risk in most of severe infections for whom polymyxin- and/or aminoglycoside-based regimen were historically used as last-resort strategies-namely, ceftazidime-avibactam for infections due to Klebsiella pneumoniae carbapenemase (KPC)- or OXA-48-like-producing Enterobacterales, meropenem-vaborbactam for KPC-producing Enterobacterales, ceftazidime-avibactam/aztreonam combination or cefiderocol for metallo-β-lactamase (MBL)-producing Enterobacterales, and ceftolozane-tazobactam, ceftazidime-avibactam and imipenem-relebactam for non-MBL-producing DTR Pseudomonas aeruginosa. However, limited clinical evidence exists in critically ill patients. Extended-infusion scheme (except for imipenem-relebactam) may be indicated for DTR-GNB with high minimal inhibitory concentrations and/or in case of augmented renal clearance. The potential benefit of combining these agents with other antimicrobials remains under-investigated, notably for the most severe presentations. Other important knowledge gaps include pharmacokinetic information in particular situations (e.g., pneumonia, other deep-seated infections, and renal replacement therapy), the hazard of treatment-emergent resistance and possible preventive measures, the safety of high-dose regimen, the potential usefulness of rapid molecular diagnostic tools to rationalize their empirical utilization, and optimal treatment durations. Comparative clinical, ecological, and medico-economic data are needed for infections in whom two or more of these agents exhibit in vitro activity against the causative pathogen.
    Conclusions: New BL/BLI combinations and cefiderocol represent long-awaited options for improving the management of DTR-GNB infections. Several research axes must be explored to better define the positioning and appropriate administration scheme of these drugs in critically ill patients.
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01153-6
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  9. Article: Effects of high oxygen tension on healthy volunteer microcirculation.

    Cousin, Nicolas / Goutay, Julien / Girardie, Patrick / Favory, Raphaël / Drumez, Elodie / Mathieu, Daniel / Poissy, Julien / Parmentier, Erika / Duburcq, Thibault

    Diving and hyperbaric medicine

    2022  Volume 52, Issue 4

    Abstract: Introduction: Previous studies have highlighted hyperoxia-induced microcirculation modifications, but few have focused on hyperbaric oxygen (HBO) effects. Our primary objective was to explore hyperbaric hyperoxia effects on the microcirculation of ... ...

    Abstract Introduction: Previous studies have highlighted hyperoxia-induced microcirculation modifications, but few have focused on hyperbaric oxygen (HBO) effects. Our primary objective was to explore hyperbaric hyperoxia effects on the microcirculation of healthy volunteers and investigate whether these modifications are adaptative or not.
    Methods: This single centre, open-label study included 15 healthy volunteers. Measurements were performed under five conditions: T0) baseline value (normobaric normoxia); T1) hyperbaric normoxia; T2) hyperbaric hyperoxia; T3) normobaric hyperoxia; T4) return to normobaric normoxia. Microcirculatory data were gathered via laser Doppler, near-infrared spectroscopy and transcutaneous oximetry (PtcO₂). Vascular-occlusion tests were performed at each step. We used transthoracic echocardiography and standard monitoring for haemodynamic investigation.
    Results: Maximal alterations were observed under hyperbaric hyperoxia which led, in comparison with baseline, to arterial hypertension (mean arterial pressure 105 (SD 12) mmHg vs 95 (11), P < 0.001) and bradycardia (55 (7) beats·min⁻¹ vs 66 (8), P < 0.001) while cardiac output remained unchanged. Hyperbaric hyperoxia also led to microcirculatory vasoconstriction (rest flow 63 (74) vs 143 (73) perfusion units, P < 0.05) in response to increased PtcO₂ (104.0 (45.9) kPa vs 6.3 (2.4), P < 0.0001); and a decrease in laser Doppler parameters indicating vascular reserve (peak flow 125 (89) vs 233 (79) perfusion units, P < 0.05). Microvascular reactivity was preserved in every condition.
    Conclusions: Hyperoxia significantly modifies healthy volunteer microcirculation especially during HBO exposure. The rise in PtcO₂ promotes an adaptative vasoconstrictive response to protect cellular integrity. Microvascular reactivity remains unaltered and vascular reserve is mobilised in proportion to the extent of the ischaemic stimulus.
    MeSH term(s) Humans ; Microcirculation/physiology ; Hyperoxia ; Healthy Volunteers ; Oxygen ; Hemodynamics/physiology ; Hyperbaric Oxygenation/methods
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-12-16
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2237920-4
    ISSN 1833-3516
    ISSN 1833-3516
    DOI 10.28920/dhm52.4.260-270
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    Zs.A 4375: Show issues Location:
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  10. Article ; Online: Time for Targeted Therapies in Acute Respiratory Distress Syndrome? Understanding Every Single Piece of the Puzzle.

    Gaudet, Alexandre / Poissy, Julien / Mathieu, Daniel

    Critical care medicine

    2018  Volume 46, Issue 5, Page(s) 834–835

    MeSH term(s) Humans ; Lung Injury ; Paraquat ; Pulmonary Edema ; Respiratory Distress Syndrome, Adult
    Chemical Substances Paraquat (PLG39H7695)
    Language English
    Publishing date 2018-04-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000002987
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