Article ; Online: Antimicrobial resistance pattern of anaerobic bacteria causing lower respiratory tract infections.
2023 Volume 23, Issue 1, Page(s) 301
Abstract: Background: Anaerobes are normal flora of the human body. However, they can cause serious infections in humans. Anaerobic bacteria are known to cause respiratory infections like pneumonia and acute exacerbation of chronic lower airway infections. These ... ...
| Abstract | Background: Anaerobes are normal flora of the human body. However, they can cause serious infections in humans. Anaerobic bacteria are known to cause respiratory infections like pneumonia and acute exacerbation of chronic lower airway infections. These are often missed due to the complexity of their isolation and identification. Hence, this study aimed to study anaerobes causing respiratory tract infections and determine their antibiotic susceptibility. Materials & methods: Clinical specimens such as bronchial aspirates and pleural aspirates collected from patients with respiratory diseases attending Vallabhbhai Patel Chest Institute were processed, the anaerobes isolated were identified, and their susceptibilities to various groups of antimicrobials were studied using standard microbiological methods. Results: Three hundred and fourteen patients were included in the study, 154 males and 160 females. Of these 314 patients, 148 (47%) yielded anaerobes in their clinical samples. Seventy patients had more than one type of anaerobic organism. Hence, 235 isolates were recovered belonging to as many as 17 genera. The MIC of seven antibiotics on 154 isolates was tested. The isolates belonged mostly to the genera Bacteroides, Prevotella, Veillonella, and Actinomyces. Variable resistance was observed to most classes of antibiotics by many genera. Conclusions: Metronidazole is commonly used against anaerobes, but the study showed that the isolates were 20-30% resistant to the antibiotic. Starting this as an empirical therapy might lead to treatment failure. |
|---|---|
| MeSH term(s) | Male ; Female ; Humans ; Anti-Bacterial Agents/pharmacology ; Bacteria, Anaerobic ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial ; Anti-Infective Agents ; Respiratory Tract Infections |
| Chemical Substances | Anti-Bacterial Agents ; Anti-Infective Agents |
| Language | English |
| Publishing date | 2023-10-23 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2041505-9 |
| ISSN | 1471-2180 ; 1471-2180 |
| ISSN (online) | 1471-2180 |
| ISSN | 1471-2180 |
| DOI | 10.1186/s12866-023-03059-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.