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  1. Article ; Online: In Reply.

    Flaifel, Abdallah / Melamed, Jonathan / Deng, Fang-Ming

    Archives of pathology & laboratory medicine

    2021  Volume 145, Issue 7, Page(s) 781b–782

    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2021-0090-LE
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  2. Article ; Online: Significance of the Percentage of Gleason Pattern 4 at Prostate Biopsy in Predicting Adverse Pathology on Radical Prostatectomy: Application in Active Surveillance.

    Ordner, Jeffrey / Flaifel, Abdallah / Serrano, Antonio / Graziano, Rebecca / Melamed, Jonathan / Deng, Fang-Ming

    American journal of clinical pathology

    2023  Volume 160, Issue 1, Page(s) 35–40

    Abstract: Objectives: To determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among ...

    Abstract Objectives: To determine the prognostic significance of the maximum allowable percentage of Gleason pattern 4 (GP4) at prostate biopsy compared with adverse pathology observed at radical prostatectomy (RP) to expand active surveillance eligibility among a cohort with intermediate risk of prostate cancer.
    Methods: A retrospective study of patients with grade group (GG) 1 or 2 prostate cancer on prostate biopsy with subsequent RP was performed at our institution. A Fisher exact test was used to understand the relationship among GP4 subgroups (0%, ≤5%, 6%-10%, and 11%-49%) assigned at biopsy and adverse pathologic findings at RP. Additional analyses comparing the GP4 ≤5% cohort's prebiopsy prostate-specific antigen (PSA) level and GP4 length with adverse pathology at RP were also performed.
    Results: No statistically significant difference in adverse pathology at RP was observed between the active surveillance-eligible control (GP4 0%) and the GP4 ≤5% subgroup. In total, 68.9% of the GP4 ≤5% cohort showed favorable pathologic outcomes. A separate analysis of the GP4 ≤5% subgroup revealed that neither prebiopsy serum PSA levels nor GP4 length showed statistical correlation with adverse pathology at RP.
    Conclusions: Active surveillance may be a reasonable option for management of patients in the GP4 ≤5% group until long-term follow-up data become available.
    MeSH term(s) Male ; Humans ; Prostate/surgery ; Prostate/pathology ; Prostate-Specific Antigen ; Retrospective Studies ; Watchful Waiting ; Biopsy ; Prostatectomy ; Prostatic Neoplasms/pathology ; Neoplasm Grading
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77) ; GP 4 (81746-15-8)
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqad005
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  3. Article: Characteristics of Breast Cancer Metastasizing to Bone in a Mediterranean Population.

    Bannoura, Sami / Nahouli, Hasan / Noubani, Aya / Flaifel, Abdallah / Khalifeh, Ibrahim

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11679

    Abstract: Aim: This study examines clinicopathological, molecular, and radiological characteristics of breast cancer metastasizing to the bone in a Mediterranean population.: Methods: Cases of breast cancer with metastasis to bone were retrieved from the ... ...

    Abstract Aim: This study examines clinicopathological, molecular, and radiological characteristics of breast cancer metastasizing to the bone in a Mediterranean population.
    Methods: Cases of breast cancer with metastasis to bone were retrieved from the pathology department archives. Descriptive statistics and bivariate inferential statistics of retrieved clinical (demographic, focality, laterality, axillary lymph node status, and metastasis-free interval), radiological (skeletal site of bone metastasis, type of bone lesion), and microscopic (grade, subtype of breast cancer, lymphovascular status, perineural status, lymph node involvement, nodal extracapsular extension, molecular subtype) data were conducted.
    Results: Out of 123 cases analyzed, 93.5% were ductal, 90% had axillary lymph node metastasis, 60.5% were luminal A, 59.6% were osteolytic, and 54.4% had grade III. Discordance in the status of ER, PR, and HER2 between the primary breast tumor and the corresponding bone metastases was noted, with the highest rate of change reported for PR (35.7%). Significance was detected at the level of difference between the subtype of breast cancer with regards to the radiologic features where the ductal subtype was found to be mostly osteolytic while the lobular subtype was mostly either osteoblastic or mixed (p-value=0.05). The metastasis-free interval was significantly associated with the number of metastatic bone lesions (P=0.001).
    Conclusion: The significant association between metastasis-free interval and the number of metastatic bone lesions suggests that a higher interval allows more time for tumors to manifest multiple lesions. The high rate of discordance in the status of PR, ER, and HER2 was congruent with the literature highlighting the need to further investigate underlying mechanisms.
    Language English
    Publishing date 2020-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11679
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  4. Article ; Online: Investigating the spectrum of dermatologic manifestations in COVID-19 infection in severely ill patients: A series of four cases.

    Occidental, Michael / Flaifel, Abdallah / Lin, Lawrence H / Guzzetta, Melissa / Thomas, Kristen / Jour, George

    Journal of cutaneous pathology

    2020  Volume 48, Issue 1, Page(s) 110–115

    Abstract: COVID-19, an infectious disease caused by the novel coronavirus, was initially identified in Wuhan, China, in December 2019. By March 2020, it was declared a pandemic by the World Health Organization. Although most findings have been reported in the ... ...

    Abstract COVID-19, an infectious disease caused by the novel coronavirus, was initially identified in Wuhan, China, in December 2019. By March 2020, it was declared a pandemic by the World Health Organization. Although most findings have been reported in the lungs, primarily due to catastrophic respiratory decline, other organs, including the skin, are affected. Recent reports have been published describing the clinical spectrum of COVID-19-related lesions. In addition, recent case series have described a subset of these lesions having underlying thrombotic microangiopathy with increased complement activation characterized by increased C4d deposition within the blood vessel walls. Herein, we describe a series of COVID-19-related cutaneous manifestations found at autopsy examination and their underlying histopathologic findings. Although the clinical manifestations seen in these lesions vary widely, the underlying etiology of thrombotic microangiopathy remains consistent and reproducible.
    MeSH term(s) COVID-19/complications ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Skin Diseases, Viral/pathology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.13867
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  5. Article ; Online: Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers.

    Signoretti, Sabina / Flaifel, Abdallah / Chen, Ying-Bei / Reuter, Victor E

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2018  , Page(s) JCO2018792259

    Abstract: Renal cell carcinoma (RCC) is not a single entity but includes various tumor subtypes that have been identified on the basis of either characteristic pathologic features or distinctive molecular changes. Clear cell RCC is the most common type of RCC and ... ...

    Abstract Renal cell carcinoma (RCC) is not a single entity but includes various tumor subtypes that have been identified on the basis of either characteristic pathologic features or distinctive molecular changes. Clear cell RCC is the most common type of RCC and is characterized by dysregulation of the von Hippel Lindau/hypoxia-inducible factor pathway. Non-clear cell RCC represents a more heterogeneous group of tumors with diverse histopathologic and molecular features. In the past two decades, the improved understanding of the molecular landscape of RCC has led to the development of more effective therapies for metastatic RCC, which include both targeted agents and immune checkpoint inhibitors. Because only subsets of patients with metastatic RCC respond to a given treatment, predictive biomarkers are needed to guide treatment selection and sequence. In this review, we describe the key histologic features and molecular alterations of RCC subtypes and discuss emerging tissue-based biomarkers of response to currently available therapies for metastatic disease.
    Language English
    Publishing date 2018-10-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2018.79.2259
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  6. Article ; Online: Association of SARS-CoV-2 placental histopathology findings with maternal-fetal comorbidities and severity of COVID-19 hypoxia.

    Meyer, Jessica A / Roman, Ashley S / Limaye, Meghana / Grossman, Tracy B / Flaifel, Abdallah / Vaz, Michelle J / Thomas, Kristen M / Penfield, Christina A

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2021  Volume 35, Issue 25, Page(s) 8412–8418

    Abstract: Objective: SARS-CoV-2 is known to impact multiple organ systems, with growing data to suggest the potential for placental infection and resultant pathology. Understanding how maternal COVID-19 disease can affect placental histopathology has been limited ...

    Abstract Objective: SARS-CoV-2 is known to impact multiple organ systems, with growing data to suggest the potential for placental infection and resultant pathology. Understanding how maternal COVID-19 disease can affect placental histopathology has been limited by small study cohorts with mild disease, review by multiple pathologists, and potential confounding by maternal-fetal comorbidities that can also influence placental findings. This study aims to identify pathologic placental findings associated with COVID-19 disease and severity, as well as to distinguish them from changes related to coexisting maternal-fetal comorbidities.
    Methods: This is an observational study of 61 pregnant women with confirmed SARS-CoV-2 infection who delivered and had a placental histological evaluation at NYU Langone Health between March 19, 2020 and June 30, 2020. Primary outcomes were the prevalence of placental histopathologic features and their association with maternal-fetal comorbidities and severity of COVID-19 related hypoxia. Analysis was performed using Fisher's exact test and
    Results: Sixty-one placentas were included in the study cohort, 71% from pregnancies complicated by at least one maternal-fetal comorbidity. Twenty-five percent of placentas were small for gestational age and 77% exhibited at least one feature of maternal vascular malperfusion. None of the histopathologic features in the examined placentas were associated with the presence of any specific maternal-fetal comorbidity. Thirteen percent of the cohort required maternal respiratory support for COVID-19 related hypoxia. Villous trophoblast necrosis was associated with maternal supplemental oxygen requirement (67
    Conclusion: In pregnancies complicated by COVID-19 disease, there was a high prevalence of placental histopathologic changes identified, particularly features of maternal vascular malperfusion, which could not be attributed solely to the presence of maternal-fetal comorbidities. The significantly increased prevalence of villous trophoblast necrosis in women needing respiratory support suggests a connection to the severity of COVID-19 illness.
    MeSH term(s) Female ; Pregnancy ; Humans ; SARS-CoV-2 ; COVID-19/complications ; Placenta/pathology ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/pathology ; Comorbidity ; Hypoxia/epidemiology ; Necrosis/epidemiology ; Necrosis/pathology
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2021.1977791
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    Zs.A 3510: Show issues Location:
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  7. Article ; Online: Testicular Changes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

    Flaifel, Abdallah / Guzzetta, Melissa / Occidental, Michael / Najari, Bobby B / Melamed, Jonathan / Thomas, Kristen M / Deng, Fang-Ming

    Archives of pathology & laboratory medicine

    2020  Volume 145, Issue 1, Page(s) 8–9

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/pathology ; Cadaver ; Epididymis/pathology ; Epididymis/virology ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Testis/pathology ; Testis/virology ; Young Adult
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Letter
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2020-0487-LE
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  8. Article ; Online: Pulmonary Pathology of End-Stage COVID-19 Disease in Explanted Lungs and Outcomes After Lung Transplantation.

    Flaifel, Abdallah / Kwok, Benjamin / Ko, Jane / Chang, Stephanie / Smith, Deane / Zhou, Fang / Chiriboga, Luis A / Zeck, Briana / Theise, Neil / Rudym, Darya / Lesko, Melissa / Angel, Luis / Moreira, Andre / Narula, Navneet

    American journal of clinical pathology

    2022  Volume 157, Issue 6, Page(s) 908–926

    Abstract: Objectives: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may develop end-stage lung disease requiring lung transplantation. We report the clinical course, pulmonary pathology with radiographic correlation, and ... ...

    Abstract Objectives: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may develop end-stage lung disease requiring lung transplantation. We report the clinical course, pulmonary pathology with radiographic correlation, and outcomes after lung transplantation in three patients who developed chronic respiratory failure due to postacute sequelae of SARS-CoV-2 infection.
    Methods: A retrospective histologic evaluation of explanted lungs due to coronavirus disease 2019 was performed.
    Results: None of the patients had known prior pulmonary disease. The major pathologic findings in the lung explants were proliferative and fibrotic phases of diffuse alveolar damage, interstitial capillary neoangiogenesis, and mononuclear inflammation, specifically macrophages, with varying numbers of T and B lymphocytes. The fibrosis varied from early collagen deposition to more pronounced interstitial collagen deposition; however, pulmonary remodeling with honeycomb change was not present. Other findings included peribronchiolar metaplasia, microvascular thrombosis, recanalized thrombi in muscular arteries, and pleural adhesions. No patients had either recurrence of SARS-CoV-2 infection or allograft rejection following transplant at this time.
    Conclusions: The major pathologic findings in the lung explants of patients with SARS-CoV-2 infection suggest ongoing fibrosis, prominent macrophage infiltration, neoangiogenesis, and microvascular thrombosis. Characterization of pathologic findings could help develop novel management strategies.
    MeSH term(s) COVID-19/complications ; Fibrosis ; Humans ; Lung/pathology ; Lung Transplantation/adverse effects ; Retrospective Studies ; SARS-CoV-2 ; Thrombosis/pathology
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqab208
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  9. Article ; Online: Investigating the spectrum of dermatologic manifestations in COVID ‐19 infection in severely ill patients

    Occidental, Michael / Flaifel, Abdallah / Lin, Lawrence H. / Guzzetta, Melissa / Thomas, Kristen / Jour, George

    Journal of Cutaneous Pathology ; ISSN 0303-6987 1600-0560

    A series of four cases

    2020  

    Keywords Pathology and Forensic Medicine ; Histology ; Dermatology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/cup.13867
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Patterns of pathologically confirmed metastasis to bone in Near East population.

    Flaifel, Abdallah / Tabaja, Farah / Bannoura, Sami / Loya, Asif / Mushtaq, Sajid / Khalifeh, Ibrahim

    Cancer epidemiology

    2018  Volume 54, Page(s) 7–11

    Abstract: Background: Metastatic tumors to bone constitute the majority of bone malignancies. The site of metastasis to bone and the prognosis depend chiefly on the primary tumor. Despite all the advances in diagnostic techniques, identifying the primary tumor ... ...

    Abstract Background: Metastatic tumors to bone constitute the majority of bone malignancies. The site of metastasis to bone and the prognosis depend chiefly on the primary tumor. Despite all the advances in diagnostic techniques, identifying the primary tumor has not improved significantly.
    Methods: A total of 576 cases (Lebanon; n = 306, Pakistan; n = 270) presenting with microscopic evidence of metastasis to bone were reviewed between 1996 and 2016. Clinical and radiologic data were recorded.
    Results: Out of 20 types of primary tumors, unknown primary (38.2%), followed by breast (23.8%), lung (10.4%) and thyroid (4.9%) tumors were the most commonly presenting with bone metastasis. The primary source of the tumor showed significant correlation with the site of metastasis, time lag to metastasis and radiologic presentation (p < 0.001). Interestingly, a significant variation was noted between the 2 observed populations.
    Conclusion: The patterns of pathologically confirmed metastasis to skeletal sites in Near East population showed a special distribution, and variation was even observed between the 2 studied centers. Understanding the biologic variations of the primary tumors in our population may further explain the variation in patterns of metastasis.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms/epidemiology ; Bone Neoplasms/pathology ; Bone Neoplasms/secondary ; Female ; Humans ; Lebanon ; Male ; Middle Aged ; Middle East ; Neoplasm Metastasis ; Pakistan ; Prognosis ; Young Adult
    Language English
    Publishing date 2018-03-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2018.03.002
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