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Article ; Online: RETRACTED ARTICLE: Coronary arteries and aortic valve calcifications in COVID-19.

Fogante, Marco / Cavagna, Enrico / Rinaldi, Giovanni

2022 Volume 29, Issue 3, Page(s) 623

Language	English
Publishing date	2022-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1425144-9
ISSN	1438-1435 ; 1070-3004
ISSN (online)	1438-1435
ISSN	1070-3004
DOI	10.1007/s10140-021-02011-3
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Article ; Online: REMOVED: Correlation between COVID-19 and cardiac calcification

Fogante, Marco / Cavagna, Enrico / Rinaldi, Giovanni

Journal of medical imaging and radiation sciences

2022

Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2426513-5
ISSN	1876-7982 ; 1939-8654
ISSN (online)	1876-7982
ISSN	1939-8654
DOI	10.1016/j.jmir.2022.01.002
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Article ; Online: Pulmonary Thromboembolism in COVID-19: Venous Thromboembolism or Arterial Thrombosis?

Cavagna, Enrico / Muratore, Francesco / Ferrari, Fabio

Radiology. Cardiothoracic imaging

2020 Volume 2, Issue 4, Page(s) e200289

Abstract: Purpose: To investigate CT pulmonary angiography findings of pulmonary thromboembolism (PTE) in coronavirus disease 2019 (COVID-19) and its association with clinical and radiologic conditions.: Materials and methods: This retrospective study includes ...

Abstract	Purpose: To investigate CT pulmonary angiography findings of pulmonary thromboembolism (PTE) in coronavirus disease 2019 (COVID-19) and its association with clinical and radiologic conditions. Materials and methods: This retrospective study includes 109 hospitalized patients with COVID-19 who underwent CT pulmonary angiography for suspected PTE from March 20 to May 3, 2020. Data were collected from our PACS. CT pulmonary angiography findings of PTE were evaluated. On the basis of the presence or absence of PTE, patients were divided into two groups, and their clinical and radiologic conditions were compared using the Mann-Whitney Results: The study population comprised 82 men and 19 women, with a mean age of 64.1 years ± 15.0 (95% confidence interval [CI]: 60.4, 67.6) years. CT pulmonary angiography was performed 19.8 days ± 6.1 (95% CI: 18.1, 20.2) after symptom onset and 10.5 days ± 3.8 (95% CI: 10.2, 12.9) after admission. Of 101 patients, 41 had PTE (40.6%). PTE was mostly bilateral or only right (37/41 [90.2%]), mainly involved segmental (37/41 [90.2%]) or subsegmental (25/41 [61.0%]) arteries and affected mainly the branches of the lower lobe (30/41 [73.2%]). Parenchymal segments supplied by segmental arteries with PTE showed a prevalent consolidation pattern (25/37 [67.6%]). Deep vein thrombosis was present only in five of 41 (12.2%) patients. Comparing groups with and without PTE, no significant difference was observed in age, sex, symptom onset, comorbidities, tumor history, use of respiratory supports, activated partial thromboplastin time, prothrombin time, and deep vein thrombosis. Conversely, differences were evaluated in CT lesion score (15.7 ± 1.4 [95% CI: 15.3, 16.1] vs 14.1 ± 1.1 [95% CI: 13.8, 14.4]; Conclusion: PTE in COVID-19 involves mainly the segmental and subsegmental arteries of segments affected by consolidations in patients with more severe lung disease. The authors hypothesize that the development of PTE in COVID-19 might be a pulmonary artery thrombosis because of severe lung inflammation and hypercoagulability rather than thromboembolism.© RSNA, 2020.
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Journal Article
ISSN	2638-6135
ISSN (online)	2638-6135
DOI	10.1148/ryct.2020200289
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Article: Respiratory failure due to concomitant interstitial lung disease and diaphragmatic involvement in a patient with anti-MDA5 dermatomyositis: a case report.

Grignaschi, Silvia / Mongodi, Silvia / Alfonsi, Enrico / Mojoli, Francesco / Vertui, Valentina / Zanframundo, Giovanni / Cavagna, Lorenzo

Clinical and experimental rheumatology

2022 Volume 40 Suppl 134, Issue 5, Page(s) 121–123

Abstract: Diaphragm myositis is a rare manifestation of idiopathic inflammatory myopathies, barely portrayed in literature despite its potential severity. We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history ... ...

Abstract	Diaphragm myositis is a rare manifestation of idiopathic inflammatory myopathies, barely portrayed in literature despite its potential severity. We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone. Chest high resolution computed tomography (HRCT) showed mild interstitial lung disease (ILD), whereas pulmonary function tests evidenced severe restrictive syndrome with high lung ultrasound score. Diaphragm ultrasound revealed a marked diaphragm dysmotility, confirmed by electromyography (EMG). The patient was treated with intravenous immunoglobulins and mofetil mycophenolate with progressive improvement of dyspnoea, lung volumes and ILD at CT scan. Ultrasound examination also revealed marked improvement of the diaphragmatic disfunction and a reduction of lung ultrasound score. The use of ultrasound may provide a valuable tool in the diagnosis of diaphragm myositis, which may play a major role in the respiratory impairment of these patients. A combined lung and diaphragm examination allowed bedside monitoring of the improvements in both lung aeration and diaphragm contractility.
MeSH term(s)	Autoantibodies ; Dermatomyositis/complications ; Dermatomyositis/drug therapy ; Diaphragm/diagnostic imaging ; Dyspnea ; Humans ; Interferon-Induced Helicase, IFIH1 ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/drug therapy ; Male ; Middle Aged ; Myositis/diagnosis ; Myositis/diagnostic imaging ; Respiratory Insufficiency/diagnostic imaging ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
Chemical Substances	Autoantibodies ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2022-02-10
Publishing country	Italy
Document type	Case Reports
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/0u7vdc
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Article ; Online: Pulmonary Thromboembolism in COVID-19: Venous Thromboembolism or Arterial Thrombosis?

Cavagna, Enrico / Muratore, Francesco / Ferrari, Fabio

Radiol Cardiothorac Imaging

Abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) in hospitalized patients is frequently complicated by pulmonary thromboembolism (PTE). PURPOSE: To investigate CT pulmonary angiography (CTPA) findings of PTE in COVID-19 and its association with clinical ... ...

Abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) in hospitalized patients is frequently complicated by pulmonary thromboembolism (PTE). PURPOSE: To investigate CT pulmonary angiography (CTPA) findings of PTE in COVID-19 and its association with clinical and radiological conditions. MATERIALS AND METHODS: This retrospective study includes 109 hospitalized patients with COVID-19 who underwent CTPA for suspected PTE from March 20 to May 3, 2020. Data were collected from our PACS. CTPA findings of PTE were evaluated. Based on the presence or absence of PTE, patients were divided in two groups and the clinical and radiological conditions were compared using Mann-Whitney U test and χ(2) test. RESULTS: Study population comprised 82M/19F, mean age 64.1±15.0 [95% confidence interval CI:60.4-67.6] years. CTPAs were performed 19.8±6.1 [95% CI:18.1-20.2] days after the symptom onset and 10.5±3.8 [95% CI:10.2-12.9] days after the admission. Patients with PTE were 41/101(40.6%). PTE was mostly bilateral or only right (37/41[90.2%]), mainly involved segmental (37/41[90.2%]) or subsegmental (25/41[61.0%]) arteries, and affected mainly the lower lobes branches (30/41[73.2%]). Parenchymal segments supplied by segmental arteries with PTE showed a prevalent consolidation pattern (25/37[67.6%]). Deep vein thrombosis (DVT) was present only in 5/41(12.2%). Comparing groups with and without PTE, no significant difference was observed in age, gender, onset symptoms, comorbidities, tumor history, use of respiratory supports, activated partial thromboplastin time, prothrombin time and DVT. Conversely, differences were evaluated in CT lesion score (15.7±1.4 [95% CI:15.3-16.1] vs 14.1±1.1 [95% CI:13.8-14.4], p=0.035); d-dimer (p<0.001); lactate dehydrogenase (LDH) (p<0.001), and C-reactive protein (CRP) (p=0.042). CONCLUSION: PTE in COVID-19 involves mainly the segmental and sub-segmental arteries of segments affected by consolidations in patients with more severe lung disease. We hypothesize that the development of PTE in COVID-19 might be a pulmonary artery thrombosis due to severe lung inflammation and hypercoagulability rather than thromboembolism.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1148/ryct.2020200289
Database	COVID19

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Article ; Online: Malnutrition Prevention after Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT): A Prospective Explorative Interventional Study with an Oral Polymeric Formulation Enriched with Transforming Growth Factor Beta 2 (TGF-β2).

Morello, Enrico / Arena, Francesco / Malagola, Michele / Farina, Mirko / Polverelli, Nicola / Cavagna, Elsa / Colnaghi, Federica / Donna, Lorenzo / Zollner, Tatiana / Accorsi Buttini, Eugenia / Andreoli, Marco / Ricci, Chiara / Leoni, Alessandro / Samarani, Emanuela / Bertulli, Alice / Leali, Daria / Bernardi, Simona / Russo, Domenico

Nutrients

2022 Volume 14, Issue 17

Abstract: Malnutrition is common after allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT), and interventions directed to correct nutritional status are warranted to improve transplant outcomes. In this prospective study, an oral polymeric formulation ... ...

Abstract	Malnutrition is common after allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT), and interventions directed to correct nutritional status are warranted to improve transplant outcomes. In this prospective study, an oral polymeric formulation enriched with TGF-β2 (TE-OPF) was explored to correct malnutrition according to Patient-Generated Subjective Global Assessment (PG-SGA). TE-OPF was proposed to 51 consecutive patients who received transplants at our institution for hematological malignancies, and sufficient dose intake was established per protocol as at least 50% of the prescribed dose of TE-OPF: group A received adequate nutritional support; group B, inadequate. The study met the primary outcomes in terms of safety (no adverse events reported during TE-OPF intake except for its disgusting taste) and malnutrition (PG-SGA C 28 days after transplant): severely malnourished patients (PG-SGA C) accounted for 13% in group A and 88.9% in group B (
MeSH term(s)	Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Malnutrition/etiology ; Prospective Studies ; Transforming Growth Factor beta2
Chemical Substances	Transforming Growth Factor beta2
Language	English
Publishing date	2022-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173589
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Article: Malnutrition Prevention after Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT): A Prospective Explorative Interventional Study with an Oral Polymeric Formulation Enriched with Transforming Growth Factor Beta 2 (TGF-β2)

Nutrients. 2022 Aug. 31, v. 14, no. 17

2022

Abstract	Malnutrition is common after allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT), and interventions directed to correct nutritional status are warranted to improve transplant outcomes. In this prospective study, an oral polymeric formulation enriched with TGF-β2 (TE-OPF) was explored to correct malnutrition according to Patient-Generated Subjective Global Assessment (PG-SGA). TE-OPF was proposed to 51 consecutive patients who received transplants at our institution for hematological malignancies, and sufficient dose intake was established per protocol as at least 50% of the prescribed dose of TE-OPF: group A received adequate nutritional support; group B, inadequate. The study met the primary outcomes in terms of safety (no adverse events reported during TE-OPF intake except for its disgusting taste) and malnutrition (PG-SGA C 28 days after transplant): severely malnourished patients (PG-SGA C) accounted for 13% in group A and 88.9% in group B (p = 0.000). At the end of the study, after a median follow-up of 416 days, the estimated median Overall Survival (OS) was 734 days for well or moderately nourished patients (PG-SGA A/B) in comparison to 424 for malnourished patients (p = 0.03). Inadequate TE-OPF intake was associated with an increase in acute gastrointestinal Graft Versus Host Disease (GVHD) cumulative incidence (38% vs. 0% p = 0.006). A higher incidence of pneumonia was reported in group B (p = 0.006). IGF-1 levels at 14 and 28 days after transplant were significantly higher in group A and were associated with a lower incidence of acute GVHD (aGVHD). Higher subsets of B, T, and NK cells were found in group A, and a higher number of CD16+ NK cells was associated with a lower incidence of acute GVHD (p = 0.005) and increased survival at the end of the study (p = 0.023). Artificial neural network analysis suggested that inadequate TE-OPF intake, pneumonia, and sepsis significantly affected malnutrition 28 days after alloHSCT and survival 365 days after alloHSCT (normalized importance 100%, 82%, and 68%, respectively). In this exploratory and preliminary study, the use of TE-OPF appeared to reduce the incidence of malnutrition after alloHSCT, but larger and controlled studies are required.
Keywords	cell transplantation ; clinical trials ; gastrointestinal system ; hematopoietic stem cells ; malnutrition ; neural networks ; nutritional status ; nutritional support ; pneumonia ; polymers ; prospective studies ; taste
Language	English
Dates of publication	2022-0831
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14173589
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence.

Bruschi, Maurizio / Angeletti, Andrea / Prunotto, Marco / Meroni, Pier Luigi / Ghiggeri, Gian Marco / Moroni, Gabriella / Sinico, Renato Alberto / Franceschini, Franco / Fredi, Micaela / Vaglio, Augusto / Cavalli, Andrea / Scapozza, Leonardo / Patel, Jigar J / Tan, John C / Lo, Ken C / Cavagna, Lorenzo / Petretto, Andrea / Pratesi, Federico / Migliorini, Paola /

Locatelli, Francesco / Pazzola, Giulia / Pesce, Giampaola / Giannese, Domenico / Manfredi, Angelo / Ramirez, Giuseppe A / Esposito, Pasquale / Murdaca, Giuseppe / Negrini, Simone / Bui, Federica / Trezzi, Barbara / Emmi, Giacomo / Cavazzana, Ilaria / Binda, Valentina / Fenaroli, Paride / Pisan, Isabella / Montecucco, Carlomaurizio / Santoro, Domenico / Scolari, Francesco / Mescia, Federica / Volpi, Stefano / Mosca, Marta / Tincani, Angela / Ravelli, Angelo / Murtas, Corrado / Candiano, Giovanni / Caridi, Gianluca / La Porta, Edoardo / Verrina, Enrico

Autoimmunity reviews

2024 Volume 23, Issue 5, Page(s) 103535

Abstract: Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the ... ...

Abstract	Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney. Moreover, the isotype of anti-dsDNA in SLE and LN has never received adequate interest until the recent observation that IgG2 are preponderant over IgG1, IgG3 and IgG4. Based on the above background, recent studies investigated the involvement of anti-dsDNA IgG2 and of other antibodies in LN. It was concluded that circulating anti-dsDNA IgG2 levels do not distinguish between LN versus non-renal SLE, and, in patients with LN, their levels do not change over time. Circulating levels of other antibodies such as anti-ENO1 and anti-H2 IgG2 were, instead, higher in LN vs non-renal SLE at the time of diagnosis and decreased following therapies. Finally, new classes of renal antibodies that potentially modify the anti-inflammatory response in the kidney are emerging as new co-actors in the pathogenetic scenario. They have been defined as 'second wave antibodies' for the link with detoxifying mechanisms limiting the oxidative stress in glomeruli that are classically stimulated in a second phase of inflammation. These findings have important clinical implications that may modify the laboratory approach to LN. Serum levels of anti-ENO1 and anti-H2 IgG2 should be measured in the follow up of patients for designing the length of therapies and identify those patients who respond to treatments. Anti-SOD2 could help to monitor and potentiate the anti-inflammatory response in the kidney.
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2024.103535
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Article: Computed tomography quantification of bone density adjacent to cemented pegged polyethylene glenoid components in shoulder arthroplasty.

Merolla, Giovanni / Amore, Barbara / Paladini, Paolo / Cavagna, Enrico / Porcellini, Giuseppe

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

2013 Volume 24, Issue 5, Page(s) 753–761

Abstract: Background: Cemented polyethylene devices are the prostheses implanted more frequently, but there is no agreement on the optimal glenoid component design. In this study, bone mineral density (BMD) adjacent to cemented all-polyethylene glenoid components ...

Abstract	Background: Cemented polyethylene devices are the prostheses implanted more frequently, but there is no agreement on the optimal glenoid component design. In this study, bone mineral density (BMD) adjacent to cemented all-polyethylene glenoid components was assessed to gain insights into the characteristics of glenoid bone as a potential risk factor implicated in the failure of shoulder arthroplasty. Patients and methods: Twenty-two subjects were examined at an average follow-up of 31 months using the Constant-Murley score (CS) and multi-detector computed tomography. BMD was measured in 5 regions of interest (ROIs) at the sites where radiolucent lines are usually detected. BMD differences among the ROIs were tested. The relationship between BMD and a number of variables (CS subscores, age, gender, follow-up duration) was explored. Results: There was a significant increase in CS scores (p<0.05). Significantly different BMD (p=0.0039) was found in the 5 ROIs, especially between ROIs 2 and 5 (p=0.016, Bonferroni's test) and between ROIs 3 and 5 (p=0.005, Bonferroni's test). BMD was lower in ROI 1 than ROI 3 and in ROI 2 than ROI 4, but the difference was not significant. Discussion: The heterogeneous BMD distribution may be related to: (1) an interindividual variability in glenoid BMD; (2) the fixation technique; or (3) the different bone response to eccentric loading of the prosthetic head on the glenoid component. Conclusions: BMD analysis may contribute to extent our knowledge on glenoid component loosening and encourage further techniques of glenoid fixation.
MeSH term(s)	Aged ; Analysis of Variance ; Arthroplasty, Replacement/instrumentation ; Arthroplasty, Replacement/methods ; Bone Cements/therapeutic use ; Bone Density/physiology ; Female ; Glenoid Cavity/diagnostic imaging ; Glenoid Cavity/physiology ; Humans ; Joint Prosthesis ; Male ; Multidetector Computed Tomography ; Observer Variation ; Polyethylene/therapeutic use ; Prosthesis Design ; Prosthesis Failure/etiology ; Risk Factors ; Shoulder Joint/diagnostic imaging
Chemical Substances	Bone Cements ; Polyethylene (9002-88-4)
Language	English
Publishing date	2013-11-26
Publishing country	France
Document type	Journal Article
ZDB-ID	1231084-0
ISSN	1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
ISSN (online)	1432-1068
ISSN	1633-8065 ; 0948-4817 ; 0940-3264
DOI	10.1007/s00590-013-1368-x
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Article ; Online: Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas.

De Vita, Alessandro / Vanni, Silvia / Fausti, Valentina / Cocchi, Claudia / Recine, Federica / Miserocchi, Giacomo / Liverani, Chiara / Spadazzi, Chiara / Bassi, Massimo / Gessaroli, Manlio / Campobassi, Angelo / De Luca, Giovanni / Pieri, Federica / Farnedi, Anna / Franchini, Eugenia / Ferrari, Anna / Domizio, Chiara / Cavagna, Enrico / Gurrieri, Lorena /

Bongiovanni, Alberto / Riva, Nada / Calpona, Sebastiano / Di Menna, Giandomenico / Debonis, Silvia Angela / Ibrahim, Toni / Mercatali, Laura

International journal of molecular sciences

2021 Volume 22, Issue 21

Abstract: Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical management of this disease are infrequently reported. In order to fill this ...

Abstract	Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical management of this disease are infrequently reported. In order to fill this gap, we investigated the molecular biology of an adult RMS case series. The expression of epithelial mesenchymal transition-related gene and chemoresistance-related gene panels were evaluated. Moreover, taking advantage of our STS translational model combining patient-derived primary culture and 3D-scaffold, the pharmacological profile of an adult head and neck sclerosing RMS was assessed. Furthermore, NGS, microsatellite instability, and in silico analyses were carried out. RT-PCR identified the upregulation of
MeSH term(s)	Adult ; Aged ; Biomarkers, Tumor/genetics ; Epithelial-Mesenchymal Transition/genetics ; Female ; Genomics/methods ; Humans ; Male ; Microsatellite Instability ; Mutation/genetics ; Rhabdomyosarcoma/genetics ; Sarcoma/genetics ; Soft Tissue Neoplasms/genetics ; Up-Regulation
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222111564
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