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  1. Article ; Online: Auf dem Weg zum virtuellen Mikroskop: Synchrotron-basierte dreidimensionale Bildgebung in der Pathologie.

    Ackermann, Maximilian

    Pathologie (Heidelberg, Germany)

    2022  Volume 43, Issue Suppl 1, Page(s) 15–20

    Title translation On the way to the virtual microscope: synchrotron-radiation-based three-dimensional imaging in pathology.
    MeSH term(s) Synchrotrons ; Imaging, Three-Dimensional/methods ; Microscopy/methods ; Biological Phenomena
    Language German
    Publishing date 2022-11-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-7196
    ISSN (online) 2731-7196
    DOI 10.1007/s00292-022-01161-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bifurcated Rhodaelectro-catalyzed C-H Activation for the Synthesis of Pyrroles and Lactones.

    Homölle, Simon L / Stangier, Maximilian / Reyes, Efraim / Ackermann, Lutz

    Precision chemistry

    2023  Volume 1, Issue 6, Page(s) 382–387

    Abstract: While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives, electrochemical C( ... ...

    Abstract While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives, electrochemical C(sp
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2771-9316
    ISSN (online) 2771-9316
    DOI 10.1021/prechem.3c00061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chemo- and Site-Selective Electro-Oxidative Alkane Fluorination by C(sp

    Stangier, Maximilian / Scheremetjew, Alexej / Ackermann, Lutz

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 60, Page(s) e202201654

    Abstract: Electrochemical fluorinations of C( ... ...

    Abstract Electrochemical fluorinations of C(sp
    Language English
    Publishing date 2022-08-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202201654
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  4. Article ; Online: Reply to Bush

    Ackermann, Maximilian / Mentzer, Steven J / Jonigk, Danny D

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 2, Page(s) 229–230

    MeSH term(s) Humans ; COVID-19 ; Microcirculation ; SARS-CoV-2 ; Bronchi
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202201-0122LE
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Microvascular placental alterations in maternal COVID-19.

    Ackermann, Maximilian / Jonigk, Danny D

    American journal of obstetrics and gynecology

    2021  Volume 226, Issue 1, Page(s) 135–136

    MeSH term(s) Adult ; COVID-19/pathology ; Female ; Humans ; Infant, Newborn ; Microvessels/pathology ; Placenta/blood supply ; Placenta/pathology ; Pregnancy ; Pregnancy Complications, Infectious/pathology ; SARS-CoV-2
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2021.06.098
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  6. Book ; Online ; Thesis: Entwicklung und Anwendung von MS-Bindungsassays für die Glycintransportersubtypen 1 (GlyT1) und 2 (GlyT2)

    Ackermann, Thomas Maximilian [Verfasser] / Wanner, Klaus T. [Akademischer Betreuer]

    2023  

    Author's details Thomas Maximilian Ackermann ; Betreuer: Klaus T. Wanner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  7. Article ; Online: Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19.

    Mentzer, Steven J / Ackermann, Maximilian / Jonigk, Danny

    Cold Spring Harbor perspectives in medicine

    2022  Volume 12, Issue 10

    Abstract: COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying ... ...

    Abstract COVID-19 has been associated with a range of illness severity-from minimal symptoms to life-threatening multisystem organ failure. The severe forms of COVID-19 appear to be associated with an angiocentric or vascular phase of the disease. In studying autopsy patients succumbing to COVID-19, we found alveolar capillary microthrombi were 9 times more common in COVID-19 than in comparable patients with influenza. Corrosion casting of the COVID-19 microcirculation has revealed microvascular distortion, enhanced bronchial circulation, and striking increases in intussusceptive angiogenesis. In patients with severe COVID-19, endothelial cells commonly demonstrate significant ultrastructural injury. High-resolution imaging suggests that microcirculation perturbations are linked to ischemic changes in microanatomic compartments of the lung (secondary lobules). NanoString profiling of these regions has confirmed a transcriptional signature compatible with microischemia. We conclude that irreversible tissue ischemia provides an explanation for the cystic and fibrotic changes associated with long-haul COVID-19 symptoms.
    MeSH term(s) COVID-19/complications ; COVID-19/pathology ; COVID-19/physiopathology ; Corrosion Casting ; Endothelial Cells/pathology ; Endothelial Cells/ultrastructure ; Humans ; Ischemia/complications ; Microcirculation ; Neovascularization, Pathologic/complications
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a041157
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  8. Article ; Online: Vascularization of the adult mouse lung grafted onto the chick chorioallantoic membrane.

    Chamoto, Kenji / Gibney, Barry C / Wagner, Willi L / Ackermann, Maximilian / Khalil, Hassan A / Mentzer, Steven J

    Microvascular research

    2023  Volume 151, Page(s) 104596

    Abstract: In the later stages of angiogenesis, the vascular sprout transitions into a functional vessel by fusing with a target vessel. Although this process appears to routinely occur in embryonic tissue, the biologic rules for sprout fusion and lumenization in ... ...

    Abstract In the later stages of angiogenesis, the vascular sprout transitions into a functional vessel by fusing with a target vessel. Although this process appears to routinely occur in embryonic tissue, the biologic rules for sprout fusion and lumenization in adult regenerating tissue are unknown. To investigate this process, we grafted portions of the regenerating post-pneumonectomy lung onto the chick chorioallantoic membrane (CAM). Grafts from all 4 lobes of the post-pneumonectomy right lung demonstrated peri-graft angiogenesis as reflected by fluorescent plasma markers; however, fluorescent microsphere perfusion primarily occurred in the lobe of the lung that is the dominant site of post-pneumonectomy angiogenesis-namely, the cardiac lobe. Vascularization of the cardiac lobe grafts was confirmed by active tissue growth (p < .05). Functional vascular connections between the cardiac lobe and the CAM vascular network were demonstrated by confocal fluorescence microscopy as well as corrosion casting and scanning electron microscopy (SEM). Bulk transcriptional profiling of the cardiac lobe demonstrated the enhanced expression of many genes relative to alveolar epithelial cell (CD11b
    MeSH term(s) Mice ; Animals ; Chorioallantoic Membrane/blood supply ; Neovascularization, Physiologic ; Chickens ; Neovascularization, Pathologic ; Lung
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2023.104596
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    Zs.A 746: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases.

    Lucas, Kurt / Fröhlich-Nowoisky, Janine / Oppitz, Nicole / Ackermann, Maximilian

    Frontiers in plant science

    2021  Volume 12, Page(s) 589783

    Language English
    Publishing date 2021-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.589783
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  10. Article ; Online: Facilitated Transport across Glycocalyceal Barriers in the Chick Chorioallantoic Membrane.

    Dayal, Anuhya / Pan, Jennifer M / Kwan, Stacey P / Ackermann, Maximilian / Khalil, Hassan A / Mentzer, Steven J

    Polymers

    2023  Volume 16, Issue 1

    Abstract: Targeted drug delivery to visceral organs offers the possibility of not only limiting the required dose, but also minimizing drug toxicity; however, there is no reliable method for delivering drugs to the surface of visceral organs. Here, we used six ... ...

    Abstract Targeted drug delivery to visceral organs offers the possibility of not only limiting the required dose, but also minimizing drug toxicity; however, there is no reliable method for delivering drugs to the surface of visceral organs. Here, we used six color tracers and the chick chorioallantoic membrane (CAM) model to investigate the use of the heteropolysaccharide pectin to facilitate tracer diffusion across the glycocalyceal charge barrier. The color tracers included brilliant blue, Congo red, crystal violet, indocyanine green, methylene blue, and methyl green. The direct application of the tracers to the CAM surface or embedding tracers into linear-chain nanocellulose fiber films resulted in no significant diffusion into the CAM. In contrast, when the tracers were actively loaded into branched-chain pectin films, there was significant detectable diffusion of the tracers into the CAM. The facilitated diffusion was observed in the three cationic tracers but was limited in the three anionic tracers. Diffusion appeared to be dependent on ionic charge, but independent of tracer size or molecular mass. We conclude that dye-loaded pectin films facilitated the diffusion of color tracers across the glycocalyceal charge barrier and may provide a therapeutic path for drug delivery to the surface of visceral organs.
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16010004
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