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  1. Article ; Online: Panuveitis and optic neuropathy following SARS-COV-2 in the absence of multisystem inflammatory syndrome in a child.

    Land, Preston / Shah, Veeral / Lovell, Daniel J / Miraldi Utz, Virginia

    American journal of ophthalmology case reports

    2023  Volume 32, Page(s) 101876

    Abstract: Purpose: To describe the presentation of a healthy 8-year-old female referred to a pediatric ophthalmology clinic with blurred vision and concern for bilateral uveitis.: Observations: The patient was diagnosed with COVID-19 two weeks prior to the ... ...

    Abstract Purpose: To describe the presentation of a healthy 8-year-old female referred to a pediatric ophthalmology clinic with blurred vision and concern for bilateral uveitis.
    Observations: The patient was diagnosed with COVID-19 two weeks prior to the onset of ocular symptoms. An examination revealed bilateral pan-uveitis and patient underwent an extensive work-up for an underlying cause that was unremarkable. Two years following the initial presentation, she has not had any evidence of recurrence.
    Conclusions and importance: This case highlights the potential for COVID-19 to be temporally associated with ocular inflammation and underscores the importance of recognizing and investigating such manifestations in pediatric patients. The mechanism by which COVID-19 may lead to an immune response that affects the eyes is not fully understood, but it is believed to be related to an overactive immune response triggered by the virus. Further studies are needed to better understand the potential relationship between COVID-19 and ocular manifestations in pediatric patients.
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2023.101876
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  2. Article ; Online: Herbarium specimens reveal century-long trait shifts in poison ivy due to anthropogenic CO

    Ng, Molly / McCormick, Alyssa / Utz, Ryan M / Heberling, J Mason

    American journal of botany

    2023  Volume 110, Issue 9, Page(s) e16225

    Abstract: ... leaf carbon isotope discrimination (Δ: Results: Stomatal density significantly decreased (P < 0.05 ... in poison ivy and the ecologically similar liana P. quinquefolia over the past century, but did not change ...

    Abstract Premise: Previous experimental studies have shown that poison ivy (Toxicodendron radicans; Anacardicaceae) responds to elevated CO
    Methods: We measured stomatal density, leaf area, leaf N, leaf C:N, leaf carbon isotope discrimination (Δ
    Results: Stomatal density significantly decreased (P < 0.05) in poison ivy and the ecologically similar liana P. quinquefolia over the past century, but did not change in the related trees T. vernix and R. typhina. None of these species showed significant trends in changes in leaf N or C:N. Surprisingly, in poison ivy, but not the other species, Δ
    Conclusions: In contrast to the results of short-term experimental studies, iWUE decreased in poison ivy over the last century. Trait responses to pCO
    MeSH term(s) Toxicodendron ; Carbon Dioxide ; Trees ; Water
    Chemical Substances Carbon Dioxide (142M471B3J) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2935-x
    ISSN 1537-2197 ; 0002-9122
    ISSN (online) 1537-2197
    ISSN 0002-9122
    DOI 10.1002/ajb2.16225
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  3. Article: [No title information]

    Utz, Sandra / Klose, Petra / Langhorst, Jost

    Zeitschrift für Phytotherapie

    2023  Volume 44, Issue 06, Page(s) 250–256

    Abstract: Harnwegsinfektionen gehören zu den häufigsten bakteriellen Infektionen beim Menschen, wobei die unkomplizierte Zystitis die häufigste Form ist. Studien haben gezeigt, dass die ... ...

    Abstract Harnwegsinfektionen gehören zu den häufigsten bakteriellen Infektionen beim Menschen, wobei die unkomplizierte Zystitis die häufigste Form ist. Studien haben gezeigt, dass die Durchspülungstherapie mit Wasser und pflanzlichen Durchspülungsmitteln wie Birkenblätter, Brennnesselkraut, Hauhechelwurzel, Katzenbart, Schachtelhalmkraut, Bärentraubenblätter, Goldrutenkraut, Spargelwurzelstock, Cranberries und Wacholderbeeren effektiv zur Reduktion von rezidivierenden Harnwegsinfektionen beitragen kann. Die steigende Antibiotika-Resistenz hat dazu geführt, dass Phytopharmaka als mögliche Alternative betrachtet werden. Pflanzen enthalten sekundäre Inhaltsstoffe mit antibakterieller Wirkung, die auf verschiedenen Ebenen auf mikrobielle Erreger einwirken können. Phytopharmaka können als Antiinfektiva mit einer breiten Wirkung und als Adjuvantien zur Verbesserung der antibiotischen Therapie eingesetzt werden. Bei interstitieller Zystitis (IC), einer nichtinfektiösen chronischen Erkrankung der Harnblase, sind die Ursachen vielfältig und die Behandlung ist häufig komplex. Eine mögliche Verbindung zur Histaminintoleranz wird diskutiert, da viele histaminhaltige Nahrungsmittel Symptome der IC auslösen können. Die Phytotherapie, insbesondere mit Kräutern wie Rosmarin, Tausendgüldenkraut, Liebstöckel, Hauhechelwurzel, Orthosiphonblätter und Goldrutenkraut, die histaminreduzierende oder -stabilisierende Eigenschaften haben, könnte eine vielversprechende Option sein. Es gibt jedoch noch keine formellen Studien zur Phytotherapie bei IC. Zusammenfassend lässt sich sagen, dass die Phytotherapie bei Harnwegsinfektionen, einschließlich IC, vielversprechende Ansätze bietet. Weitere klinische Studien sind jedoch erforderlich, um die Wirksamkeit und Akzeptanz in der medizinischen Praxis zu bestätigen und möglicherweise in zukünftige Leitlinien aufzunehmen.
    Keywords interstitielle Zystitis ; akute Zystitis, rezidivierende Zystitis, Phytotherapie ; Phytopharmaka ; pflanzliche Arzneimittel ; interstitial cystitis ; acute cystitis, recurrent cystitis, phytotherapy ; phytopharmaceuticals ; herbal medicine
    Language German
    Publishing date 2023-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2201963-7
    ISSN 1438-9584 ; 0722-348X
    ISSN (online) 1438-9584
    ISSN 0722-348X
    DOI 10.1055/a-2197-7524
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  4. Article ; Online: Reconceptualization of the Erlangen Score for the Assessment of Dementia Risk: The ERlangen Score.

    Utz, Janine / Olm, Pauline / Jablonowski, Johannes / Siegmann, Eva-Maria / Spitzer, Philipp / Lewczuk, Piotr / Kornhuber, Johannes / Maler, Juan Manuel / Oberstein, Timo Jan

    Journal of Alzheimer's disease : JAD

    2023  Volume 96, Issue 1, Page(s) 265–275

    Abstract: Background: The established Erlangen Score (ES) for the interpretation of cerebrospinal fluid (CSF) biomarkers in the diagnostics of Alzheimer's disease (AD) uses markers of amyloidopathy and tauopathy, equally weighted to form an easy-interpretable ... ...

    Abstract Background: The established Erlangen Score (ES) for the interpretation of cerebrospinal fluid (CSF) biomarkers in the diagnostics of Alzheimer's disease (AD) uses markers of amyloidopathy and tauopathy, equally weighted to form an easy-interpretable ordinal scale. However, these biomarkers are not equally predictive for AD.
    Objective: The higher weighting of the Aβ42/Aβ40 ratio, as a reconceptualized ERlangen Score (ERS), was tested for advantages in diagnostic performance.
    Methods: Non-demented subjects (N = 154) with a mean follow up of 5 years were assigned to a group ranging from 0 to 4 in ES or ERS. Psychometric trajectories and dementia risk were assessed.
    Results: The distribution of subjects between ES and ERS among the groups differed considerably, as grouping allocated 32 subjects to ES group 2, but only 2 to ERS group 2. The discriminative accuracy between the ES (AUC 73.2%, 95% CI [64.2, 82.2]) and ERS (AUC 72.0%, 95% CI [63.1, 81.0]) for dementia risk showed no significant difference. Without consideration of the Aβ42/Aβ40 ratio in ES grouping, the optimal cut-off of the ES shifted to ≥2.
    Conclusions: The ERS showed advantages over the ES in test interpretation with comparable overall test performance, as fewer cases were allocated to the intermediate risk group. The established cut-off of ≥2 can be maintained for the ERS, whereas it must be adjusted for the ES when determining the Aβ42/Aβ40 ratio.
    MeSH term(s) Humans ; Amyloid beta-Peptides/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid ; Peptide Fragments/cerebrospinal fluid ; Alzheimer Disease/diagnosis ; Alzheimer Disease/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Peptide Fragments ; Biomarkers
    Language English
    Publishing date 2023-09-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230524
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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  5. Article: E-Learning Is Not Inferior to On-Site Teaching in a Psychiatric Examination Course.

    Rauch, Christoph / Utz, Janine / Rauch, Miriam / Kornhuber, Johannes / Spitzer, Philipp

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 624005

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.624005
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  6. Article ; Online: Childhood maltreatment and adulthood victimization: An evidence-based model.

    Fereidooni, Fatemeh / Daniels, Judith K / D Krause-Utz, Anne / Hagenaars, Muriel A / Smeets, Tom / Heins, Jenna / Dorahy, Martin J / Emmerik, Arnold A P van / de Jong, Peter J / Hoekstra, Steven / Warrens, Matthijs J / Lommen, Miriam J J

    Journal of psychiatric research

    2023  Volume 167, Page(s) 46–62

    Abstract: There is ample evidence showing that childhood maltreatment increases two to three fold the risk of victimization in adulthood. Various risk factors, including posttraumatic stress disorder (PTSD) symptoms, dissociation, self-blame, and alcohol abuse are ...

    Abstract There is ample evidence showing that childhood maltreatment increases two to three fold the risk of victimization in adulthood. Various risk factors, including posttraumatic stress disorder (PTSD) symptoms, dissociation, self-blame, and alcohol abuse are related to revictimization. Although previous research examined associations between risk factors for revictimization, the evidence is limited and the proposed models mostly include a handful of risk factors. Therefore, it is critical to investigate a more comprehensive model explaining the link between childhood maltreatment and adulthood (re)victimization. Accordingly, this study tested a data-driven theoretical path model consisting of 33 variables (and their associations) that could potentially enhance understanding of factors explaining revictimization. Cross-sectional data derived from a multi-wave study were used for this investigation. Participants (N = 2156, age
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2023.10.007
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  7. Article ; Online: Can Janus kinase inhibition improve ocular graft versus host disease?

    Sajjan, Seema / Tibbs, Ellis / Utz, Megan / Rapoport, Aaron P / Yared, Jean / Dahiya, Saurabh / Cao, Xuefang / Hardy, Nancy / Sunshine, Sarah B

    The ocular surface

    2023  Volume 28, Page(s) 27–29

    MeSH term(s) Humans ; Janus Kinases ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation
    Chemical Substances Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2208578-6
    ISSN 1937-5913 ; 1542-0124
    ISSN (online) 1937-5913
    ISSN 1542-0124
    DOI 10.1016/j.jtos.2023.01.001
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  8. Article ; Conference proceedings: Einfluss der Low-Dose 18F-FDG-PET/MRT auf das individuelle Therapiemanagement und Darstellung von Therapieeffekten bei Kindern und Jugendlichen mit zystischer Fibrose

    Schwarz, R / Frank Schäfer, J / Utz, P / Graepler-Mainka, U / Dittmann, H / Gatidis, S / Esser, M

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2023  Volume 195, Issue S 02

    Event/congress 60. GPR Jahrestagung, Wien, 2023-09-14
    Language German
    Publishing date 2023-09-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0043-1771426
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  9. Article ; Online: Cytokine signatures differentiate systemic sclerosis patients at high versus low risk for pulmonary arterial hypertension.

    Kolstad, Kathleen D / Khatri, Avani / Donato, Michele / Chang, Sarah E / Li, Shufeng / Steen, Virginia D / Utz, Paul J / Khatri, Purvesh / Chung, Lorinda

    Arthritis research & therapy

    2022  Volume 24, Issue 1, Page(s) 39

    Abstract: ... result. A multiple hypotheses corrected p value <0.05 was considered significant.: Results ...

    Abstract Background: Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. We sought to identify serum cytokine signatures that risk stratify SSc patients for this potentially fatal complication.
    Methods: Subjects at high risk for PAH and with incident PAH based on right heart catheterization (RHC) were enrolled in the multi-center prospective registry, Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS). Low-risk SSc patients were enrolled at Stanford and had normal pulmonary function test and echocardiogram parameters. Serum was available from 71 high-risk patients, 81 incident PAH patients, 10 low-risk patients, and 20 healthy controls (HC). Custom 14- and 65-plex arrays were used for cytokine analysis. Cytokine expression was compared between patient groups by principal component analysis and Tukey's test result. A multiple hypotheses corrected p value <0.05 was considered significant.
    Results: Exploratory analysis using principal components showed unique clustering for each patient group. There was a significant difference in cytokine expression in at least one group comparison for every cytokine. Overall, there was very little difference in cytokine expression comparing high-risk and PAH patient groups; however, these groups had substantially different cytokine profiles compared to low-risk patients and HC.
    Conclusion: These data suggest that cytokine profiles can distinguish SSc patients who are at high-risk for or have PAH from SSc patients who may be at lower risk for PAH and HC. However, high-risk and PAH patients had very similar cytokine profiles, suggesting that these patients are on a disease continuum.
    MeSH term(s) Cytokines ; Familial Primary Pulmonary Hypertension/complications ; Humans ; Hypertension, Pulmonary/etiology ; Pulmonary Arterial Hypertension ; Scleroderma, Systemic
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-022-02734-9
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  10. Conference proceedings: Mehr Motivation und weniger Stress durch Selbstbestimmung – konstruktive Kritik bleibt wichtig

    Triebner, Nina / Utz, Janine / Rauch, Christoph / Kersten, Gian-Marco / Kornhuber, Johannes / Spitzer, Philipp

    2023  , Page(s) P–06–12

    Event/congress Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA); Osnabrück; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-09-11
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23gma252
    Database German Medical Science

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