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Article ; Online: A Strategic Approach to Identification of Selective Inhibitors of Cancer Stem Cells.

Patel, Nirmita / Baranwal, Somesh / Patel, Bhaumik B

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2303, Page(s) 765–777

Abstract: Cancer stem-like cells (CSC) have been implicated in resistance to conventional chemotherapy as well as invasion and metastasis resulting in tumor relapse in majority of epithelial cancers including colorectal cancer. Hence, targeting CSC by small ... ...

Abstract	Cancer stem-like cells (CSC) have been implicated in resistance to conventional chemotherapy as well as invasion and metastasis resulting in tumor relapse in majority of epithelial cancers including colorectal cancer. Hence, targeting CSC by small molecules is likely to improve therapeutic outcomes. Glycosaminoglycans (GAGs) are long linear polysaccharide molecules with varying degrees of sulfation that allows specific GAG-protein interaction which plays a key role in regulating cancer hallmarks such as cellular growth, angiogenesis, and immune modulation. However, identifying selective CSC-targeting GAG mimetic has been marred by difficulties associated with isolating and enriching CSC in vitro. Herein, we discuss two distinct methods, spheroid growth and EMT-transformed cells, to enrich CSC and set up medium- and high-throughput screen to identify selective CSC-targeting agents.
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Humans ; Neoplasms ; Neoplastic Stem Cells
Language	English
Publishing date	2021-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1398-6_57
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laryngeal histoplasmosis: masquerading malignancy.

Gupta, Devendra Kumar / Tanwar, Deepika / Patel, Bhaumik / Singh, Vikram

BMJ case reports

2022 Volume 15, Issue 7

Abstract: ... amphotericin B and oral itraconazole with complete resolution of symptoms. ...

Abstract	Laryngeal histoplasmosis is a very rare cause of laryngitis which is encountered usually in the immunosuppressed states but can also occur in immunologically intact status. We report a rare case of laryngeal histoplasmosis in a man in his 60s, a chronic smoker who presented with a history of progressive hoarseness for 3 months. The glottic growth was biopsied. The rarity of diagnosis was aided by histopathological examination of the tissue, which revealed histoplasmosis. Management was done with intravenous liposomal amphotericin B and oral itraconazole with complete resolution of symptoms.
MeSH term(s)	Antifungal Agents/therapeutic use ; Histoplasmosis/diagnosis ; Histoplasmosis/drug therapy ; Humans ; Itraconazole/therapeutic use ; Larynx/pathology ; Male ; Neoplasms/drug therapy
Chemical Substances	Antifungal Agents ; Itraconazole (304NUG5GF4)
Language	English
Publishing date	2022-07-11
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-248738
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Article ; Online: Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells.

Kurakula, Mallesh / Naveen N, Raghavendra / Patel, Bhaumik / Manne, Ravi / Patel, Devang B

Gels (Basel, Switzerland)

2021 Volume 7, Issue 3

Abstract: 1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as "active moiety carriers" was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or ... ...

Abstract	(1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as "active moiety carriers" was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or controlled release activity. The nano-based neuroprotective strategy is explored as an imperative treatment for diabetic neuropathy (DN). Avanafil (AV), that selectively inhibits the degradation of cGMP-specific phosphodiesterase, thereby increasing the levels of cGMP, makes a decisive mediator for cytoprotection. (2) Methods: AVnanocomplex formulations were prepared by a modified anti-solvent precipitation method and the method was optimized by Box-Behnken design. An optimized formulation was characterized and evaluated for various in vitro parameters; (3) results:based on the desirability approach, the formulation containing 2.176 g of chitosan, 7.984 g of zein and 90%
Language	English
Publishing date	2021-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels7030096
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Article ; Online: Chitosan as Functional Biomaterial for Designing Delivery Systems in Cardiac Therapies.

Patel, Bhaumik / Manne, Ravi / Patel, Devang B / Gorityala, Shashank / Palaniappan, Arunkumar / Kurakula, Mallesh

Gels (Basel, Switzerland)

2021 Volume 7, Issue 4

Abstract: Cardiovascular diseases are a leading cause of mortality across the globe, and transplant surgeries are not always successful since it is not always possible to replace most of the damaged heart tissues, for example in myocardial infarction. Chitosan, a ... ...

Abstract	Cardiovascular diseases are a leading cause of mortality across the globe, and transplant surgeries are not always successful since it is not always possible to replace most of the damaged heart tissues, for example in myocardial infarction. Chitosan, a natural polysaccharide, is an important biomaterial for many biomedical and pharmaceutical industries. Based on the origin, degree of deacetylation, structure, and biological functions, chitosan has emerged for vital tissue engineering applications. Recent studies reported that chitosan coupled with innovative technologies helped to load or deliver drugs or stem cells to repair the damaged heart tissue not just in a myocardial infarction but even in other cardiac therapies. Herein, we outlined the latest advances in cardiac tissue engineering mediated by chitosan overcoming the barriers in cardiac diseases. We reviewed in vitro and in vivo data reported dealing with drug delivery systems, scaffolds, or carriers fabricated using chitosan for stem cell therapy essential in cardiac tissue engineering. This comprehensive review also summarizes the properties of chitosan as a biomaterial substrate having sufficient mechanical stability that can stimulate the native collagen fibril structure for differentiating pluripotent stem cells and mesenchymal stem cells into cardiomyocytes for cardiac tissue engineering.
Language	English
Publishing date	2021-12-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels7040253
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Article ; Online: Training Initiative for Psychiatry Post-graduate students (TIPPS)-a Unique Early Career Psychiatry Training Initiative in India and Its Response to the COVID-19 Pandemic.

Suhas, Satish / Chougule, Amitkumar / Innamuri, Raviteja / Nayok, Swarna Buddha / Sheth, Sweta / Nagendrappa, Sachin / Patel, Krishna G / Shetty, Sharanya B / Nagendra, Bhargavi / Bhaumik, Udayan / Pugalenthi, Sharnita / Uppal, Gaurav / Babu, Girish N / Rao, Naren P / Behere, Rishikesh V

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

2022 Volume 46, Issue 6, Page(s) 763–768

MeSH term(s)	Humans ; COVID-19 ; Pandemics ; Psychiatry/education ; Career Choice ; Students ; Students, Medical/psychology
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1045331-3
ISSN	1545-7230 ; 1042-9670
ISSN (online)	1545-7230
ISSN	1042-9670
DOI	10.1007/s40596-021-01570-4
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Article ; Online: Chitosan as Functional Biomaterial for Designing Delivery Systems in Cardiac Therapies

Bhaumik Patel / Ravi Manne / Devang B. Patel / Shashank Gorityala / Arunkumar Palaniappan / Mallesh Kurakula

Gels, Vol 7, Iss 253, p

2021 Volume 253

Abstract	Cardiovascular diseases are a leading cause of mortality across the globe, and transplant surgeries are not always successful since it is not always possible to replace most of the damaged heart tissues, for example in myocardial infarction. Chitosan, a natural polysaccharide, is an important biomaterial for many biomedical and pharmaceutical industries. Based on the origin, degree of deacetylation, structure, and biological functions, chitosan has emerged for vital tissue engineering applications. Recent studies reported that chitosan coupled with innovative technologies helped to load or deliver drugs or stem cells to repair the damaged heart tissue not just in a myocardial infarction but even in other cardiac therapies. Herein, we outlined the latest advances in cardiac tissue engineering mediated by chitosan overcoming the barriers in cardiac diseases. We reviewed in vitro and in vivo data reported dealing with drug delivery systems, scaffolds, or carriers fabricated using chitosan for stem cell therapy essential in cardiac tissue engineering. This comprehensive review also summarizes the properties of chitosan as a biomaterial substrate having sufficient mechanical stability that can stimulate the native collagen fibril structure for differentiating pluripotent stem cells and mesenchymal stem cells into cardiomyocytes for cardiac tissue engineering.
Keywords	chitosan ; drug delivery systems ; myocardial infarction ; cardiac therapies ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation, Optimization and Evaluation of Chitosan-Based Avanafil Nanocomplex Utilizing Antioxidants for Enhanced Neuroprotective Effect on PC12 Cells

Mallesh Kurakula / Raghavendra Naveen N. / Bhaumik Patel / Ravi Manne / Devang B. Patel

Gels, Vol 7, Iss 96, p

2021 Volume 96

Abstract: 1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as “active moiety carriers” was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or ... ...

Abstract	(1) Introduction: in recent decades, interdisciplinary research on the utilization of natural products as “active moiety carriers” was focused on due to their superior safety profile, biodegradability, biocompatibility and the ability for sustained or controlled release activity. The nano-based neuroprotective strategy is explored as an imperative treatment for diabetic neuropathy (DN). Avanafil (AV), that selectively inhibits the degradation of cGMP-specific phosphodiesterase, thereby increasing the levels of cGMP, makes a decisive mediator for cytoprotection. (2) Methods: AVnanocomplex formulations were prepared by a modified anti-solvent precipitation method and the method was optimized by Box–Behnken design. An optimized formulation was characterized and evaluated for various in vitro parameters; (3) results:based on the desirability approach, the formulation containing 2.176 g of chitosan, 7.984 g of zein and 90% v/v ethanol concentration can fulfill the prerequisites of optimum formulation (OB-AV-NC).OB-AV-NC was characterized and evaluated for various parameters. The neuroprotective mechanism of AV was evaluated by pretreatment of PC12 cells with plain AV, avanafil nanocomplex (NC) without antioxidants (AV-NC) and with antioxidants (α-Lipoic acid LP; Ellagic Acid EA), AV-LP-EA-Nanocomplex has also shown considerable attenuation in intracellular reactive oxygen species (ROS) and lipid peroxidation with a significant increase in the PC 12 viability under HG conditions in comparison to pure AV; (4) conclusion: the nanocomplex of AV prepared to utilize natural polymers and antioxidants aided for high solubility of AV and exhibited desired neuroprotective activity.This can be one of the promisingstrategy to translate the AV nanocomplex with safety and efficacy in treating DN.
Keywords	avanafil ; chitosan ; alpha lipoic acid ; ellagic acid ; optimization ; diabetic neuropathy ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
Subject code	540
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting

Morla, Shravan / Ravikumar, Ongolu / O'Hara, Connor / Boothello, Rio / Vera, Alberto / Abdelfadiel, Elsamani I / Fayyad, Rawan / Afosah, Daniel K / Sharon, Chetna / Fernandez, Leopoldo / Shah, Syed Ammer / Patel, Bhaumik B / Desai, Umesh R

Journal of medicinal chemistry

2023 Volume 66, Issue 2, Page(s) 1321–1338

Abstract: Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic sulfate groups. Devising an approach for oral delivery of such highly sulfated molecules would ... ...

Abstract	Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic sulfate groups. Devising an approach for oral delivery of such highly sulfated molecules would be very useful. This work presents the concept that conjugating cholesterol to synthetic sulfated GAG mimetics enables oral delivery. A focused library of sulfated GAG mimetics was synthesized and found to inhibit the growth of a colorectal cancer cell line under spheroid conditions with a wide range of potencies ( 0.8 to 46 μM). Specific analogues containing cholesterol, either alone or in combination with clinical utilized drugs, exhibited pronounced
MeSH term(s)	Glycosaminoglycans/pharmacology ; Glycosaminoglycans/metabolism ; Sulfates ; Neoplastic Stem Cells/metabolism ; Biomimetics
Chemical Substances	A73025 (268AW7000T) ; Glycosaminoglycans ; Sulfates
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c01511
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Article: Gum arabic nanoemulsion coating for shelf life extension of tomato (Solanum lycopersicum L.) fruit under ambient storage

Vahora, Khushbu A. / Patel, Bhaumik B. / Sutar, Roy F. / Mankad, Mounil C. / Patil, Ghanshyam B.

Indian journal of horticulture. 2022 Mar., v. 79, no. 1

2022

Abstract: In the present study efficacy of the gum arabic nanoemulsion coating for shelf life extension of tomato fruit was evaluated. Nanoemulsion coating was synthesised using gum arabic (0.5, 1.0, 1.5%), glycerol (0.5, 0.75, 1.0%) and sodium benzoate (1.0, 1.5, ...

Abstract	In the present study efficacy of the gum arabic nanoemulsion coating for shelf life extension of tomato fruit was evaluated. Nanoemulsion coating was synthesised using gum arabic (0.5, 1.0, 1.5%), glycerol (0.5, 0.75, 1.0%) and sodium benzoate (1.0, 1.5, 2.0%). Stability study of synthesised gum arabic nanoemulsions was carried out for 30 days under ambient storage by analysing their mean particle size, polydispersity index, count rate and zeta potential. Nanoemulsion contained 1% gum arabic, 0.5% glycerol and 1.5% sodium benzoate was found to be most stable and hence freshly harvested, breaker tomato fruits were coated by selected gum arabic nanoemulsion and gum arabic microemulsion with five different dipping times (1, 2, 3, 4, 5 min) followed by ambient storage. Tomato fruits coated with 4 min dipping in gum arabic nanoemulsion had maximum shelf life (24 days) with advantage of 15 days over the control whereas fruits coated with 4 min dipping in gum arabic microemulsion had shelf life of 15 days when stored under ambient condition. Furthermore, the gum arabic nanoemulsion coating retained quality attributes of fruits during extended storage. Hence, coating of gum arabic nanoemulsion can improve the quality and shelf life of fruits and vegetables significantly compared to gum arabic microemulsion.
Keywords	Solanum lycopersicum ; fruits ; glycerol ; gum arabic ; horticulture ; nanoemulsions ; particle size ; shelf life ; sodium benzoate ; tomatoes ; zeta potential
Language	English
Dates of publication	2022-03
Size	p. 99-108.
Publishing place	Indian Academy of Horticultural Sciences
Document type	Article
ISSN	0974-0112
DOI	10.5958/0974-0112.2022.00015.9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications.

Carpenter, Valerie J / Patel, Bhaumik B / Autorino, Riccardo / Smith, Steven C / Gewirtz, David A / Saleh, Tareq

Biochimica et biophysica acta. Reviews on cancer

2020 Volume 1874, Issue 2, Page(s) 188424

Abstract: The development of Castration-Resistant Prostate Cancer (CRPC) remains a major challenge in the treatment of this disease. While Androgen Deprivation Therapy (ADT) can result in tumor shrinkage, a primary response of Prostate Cancer (PCa) cells to ADT is ...

Abstract	The development of Castration-Resistant Prostate Cancer (CRPC) remains a major challenge in the treatment of this disease. While Androgen Deprivation Therapy (ADT) can result in tumor shrinkage, a primary response of Prostate Cancer (PCa) cells to ADT is a senescent growth arrest. As a response to cancer therapies, senescence has often been considered as a beneficial outcome due to its association with stable growth abrogation, as well as the potential for immune system activation via the Senescence-Associated Secretory Phenotype (SASP). However, there is increasing evidence that not only can senescent cells regain proliferative capacity, but that senescence contributes to deleterious effects of cancer chemotherapy, including disease recurrence. Notably, the preponderance of work investigating the consequences of therapy-induced senescence on tumor progression has been performed in non-PCa models. Here, we summarize the evidence that ADT promotes a senescent response in PCa and postulate mechanisms by which senescence may contribute to the development of castration-resistance. Primarily, we suggest that ADT-induced senescence may support CRPC development via escape from senescence, by cell autonomous-reprogramming, and by the formation of a pro-tumorigenic SASP. However, due to the scarcity of direct evidence from PCa models, the consequences of ADT-induced senescence outlined here remain speculative until the relationship between senescence and CRPC can be experimentally defined.
MeSH term(s)	Androgen Antagonists/adverse effects ; Cellular Reprogramming ; Cellular Senescence ; Disease Progression ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/chemically induced ; Prostatic Neoplasms, Castration-Resistant/pathology ; Treatment Outcome
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2020-09-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2020.188424
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