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Article ; Online: L’heure tourne ou le réseau s’affole (au choix).

Sfeir, C / Bigot, W / Mouthon, L / Dunogue, B / Hadjadj, J / Lega, J-C

2023 Volume 44, Issue 11, Page(s) 623–625

Title translation	Asthenia and weakness in a 75-year-old man.
MeSH term(s)	Male ; Humans ; Aged ; Animals ; Frailty ; Ixodes
Language	French
Publishing date	2023-06-23
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2023.06.003
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Article ; Online: Physiopathologie de l’artérite à cellules géantes : de l’inflammation au remodelage vasculaire.

Régent, Alexis / Ly, Kim Heang / Mouthon, Luc

Presse medicale (Paris, France : 1983)

2019 Volume 48, Issue 9, Page(s) 919–930

Abstract: Giant cell arteritis (GCA) is a large-vessel vasculitis involving the aorta and its main branches, especially supra aortic branches. Although much progress has been made, the pathophysiology remains incompletely understood. An initial trigger, suspected ... ...

Title translation	Physiopathology of giant cell arteritis: From inflammation to vascular remodeling.
Abstract	Giant cell arteritis (GCA) is a large-vessel vasculitis involving the aorta and its main branches, especially supra aortic branches. Although much progress has been made, the pathophysiology remains incompletely understood. An initial trigger, suspected of infectious origin, lead to the maturation and recruitment of dendritic cells (DC). The lack of migration of these DC allows the local recruitment of T-lymphocytes (LT). These LT- CD4
MeSH term(s)	Animals ; B-Lymphocytes/physiology ; CD4-Positive T-Lymphocytes/physiology ; Cell Movement ; Cell Proliferation ; Dendritic Cells/physiology ; Disease Models, Animal ; Genetic Predisposition to Disease ; Giant Cell Arteritis/drug therapy ; Giant Cell Arteritis/etiology ; Giant Cell Arteritis/pathology ; Giant Cell Arteritis/physiopathology ; Humans ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Interleukin-33/metabolism ; Interleukin-6/physiology ; Interleukins/biosynthesis ; Lymphocyte Activation/physiology ; Macrophages/metabolism ; Matrix Metalloproteinases/metabolism ; Muscle, Smooth, Vascular/pathology ; Neovascularization, Pathologic/physiopathology ; T-Lymphocytes, Regulatory/physiology ; Th17 Cells/physiology ; Vascular Remodeling/physiology
Chemical Substances	IL33 protein, human ; Interleukin-17 ; Interleukin-33 ; Interleukin-6 ; Interleukins ; Interferon-gamma (82115-62-6) ; Matrix Metalloproteinases (EC 3.4.24.-) ; interleukin-21 (MKM3CA6LT1)
Language	French
Publishing date	2019-09-19
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2019.07.031
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Anti-IL-5 dans l’asthme sévère associé à une granulomatose éosinophilique avec polyangéite. Étude en vie réelle.

Akdime, F / Habib, S / Regard, L / Terrier, B / Cohen, P / Mouthon, L / Guillevin, L / Burgel, P R / Honore, I / Puéchal, X / Roche, N

Revue des maladies respiratoires

2023 Volume 40, Issue 9-10, Page(s) 732–742

Abstract: Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of necrotizing vasculitis affecting small vessels and typically characterized by severe glucocorticoid (GC)-dependent eosinophilic asthma. While mepolizumab, which is indicated ...

Title translation	Anti-IL-5 in severe asthma associated with eosinophilic granulomatosis with polyangiitis. Real-life study.
Abstract	Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of necrotizing vasculitis affecting small vessels and typically characterized by severe glucocorticoid (GC)-dependent eosinophilic asthma. While mepolizumab, which is indicated at a dose of 100mg/4weeks in severe eosinophilic asthma, has been shown to be an effective treatment for EGPA-related asthma at a dose of 300mg/4weeks, it was only recently approved at this dose. Methods: This retrospective, single-center, observational study was conducted to investigate over a 5-year period (2014-2019) the effect of mepolizumab 100mg/4weeks at 12months in patients with EGPA and glucocorticoid-dependant severe asthma. Response to treatment was defined as reduction in daily dose of oral corticosteroids to at most 5mg/day or reduction in annual exacerbation by at least 50%. Results: Thirty patients were included, of whom twenty-three were treated (two were not fully evaluable). Among the 21 evaluable treated patients, 13 (62%) had responded at 12months. At baseline, non-responders had lower FEV1 levels and lower blood eosinophil levels than responders. Conclusions: Mepolizumab at a "severe asthma" dose (100mg/4weeks) is effective in treatment of GC-dependent severe asthma in most patients with EGPA.
MeSH term(s)	Humans ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/drug therapy ; Churg-Strauss Syndrome/complications ; Churg-Strauss Syndrome/diagnosis ; Churg-Strauss Syndrome/drug therapy ; Glucocorticoids/therapeutic use ; Retrospective Studies ; Asthma/complications ; Asthma/diagnosis ; Asthma/drug therapy
Chemical Substances	Glucocorticoids
Language	French
Publishing date	2023-11-01
Publishing country	France
Document type	Observational Study ; English Abstract ; Journal Article
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2023.10.003
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Zs.A 1945: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: État des lieux de l’enseignement théorique et pratique de 3

Samson, M / Terrier, B / Mangin, O / Mouthon, L

La Revue de medecine interne

2017 Volume 38, Issue 5, Page(s) 300–306

Abstract: Objective: To make an inventory of training of Internal Medicine in France.: Method: This study was conducted between May and September 2015 with coordinators (interviews of 45minutes) of local Internal Medicine training and fellows (online ... ...

Title translation	Inventory of training of internal medicine in France: Results of a national survey.
Abstract	Objective: To make an inventory of training of Internal Medicine in France. Method: This study was conducted between May and September 2015 with coordinators (interviews of 45minutes) of local Internal Medicine training and fellows (online questionnaire). Results: All coordinators (n=28) responded to the interviews. Local training of Internal Medicine exists in 86% of regions (3.1±3.1hours/month) and an interregional training in all interregions (34.7±13.9hours/year). When excluding Île-de-France, no correlation between the number of teachers and the amount of lessons was noted (P=0.61). Of the 550 fellows in Internal Medicine in 2014-2015, 223 (41%) responded to the online questionnaire. Mean level was 5.5±2.7 semesters. The rate of satisfaction (1=very dissatisfied and 5=very satisfied) was 3.0±1.0 and 3.8±0.8 for regional and interregional teaching, respectively (P<0.0001). Regional teaching satisfaction was correlated with the perceived expanse of diseases covered into the program (P<0.0001). In addition, 89% of fellows wish to evaluate themselves online, 66% wish to have a practical evaluation at the bedside and 70% in simulation centers. Finally, 91% of fellows support the establishment of a national program for the training of Internal Medicine. Conclusion: This survey states for the first time an inventory of training of Internal Medicine dedicated to fellows in France. This report highlights that fellows wish to have a national program, be further evaluated and have access to more interactive approach of teaching.
MeSH term(s)	Biomedical Research/economics ; Biomedical Research/education ; Biomedical Research/manpower ; Biomedical Research/standards ; Education, Medical, Graduate/economics ; Education, Medical, Graduate/standards ; Education, Medical, Graduate/statistics & numerical data ; Fellowships and Scholarships/statistics & numerical data ; Female ; France/epidemiology ; Humans ; Internal Medicine/education ; Internal Medicine/manpower ; Internal Medicine/standards ; Internal Medicine/statistics & numerical data ; Internship and Residency/economics ; Internship and Residency/standards ; Internship and Residency/statistics & numerical data ; Male ; Personal Satisfaction ; Students, Medical/psychology ; Students, Medical/statistics & numerical data ; Surveys and Questionnaires
Language	French
Publishing date	2017-05
Publishing country	France
Document type	Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2016.10.385
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Article ; Online: Autogreffe de cellules souches périphériques dans la sclérodermie systémique : un progrès important, mais il faut tempérer notre enthousiasme !

Mouthon, L

La Revue de medecine interne

2024 Volume 45, Issue 2, Page(s) 100–103

Abstract: Three prospective randomized studies have demonstrated the efficacy of autologous hematopoietic stem cell (HSC) transplantation in systemic sclerosis (SSc) on survival. These results encourage us to offer this therapy to patients who have a rapidly ... ...

Title translation	Autologous peripheral stem cell transplantation in systemic sclerosis: An important step forward, but we must temper our enthusiasm!
Abstract	Three prospective randomized studies have demonstrated the efficacy of autologous hematopoietic stem cell (HSC) transplantation in systemic sclerosis (SSc) on survival. These results encourage us to offer this therapy to patients who have a rapidly progressive disease and who have early symptoms but no advanced visceral involvement. HSC autograft can thus be discussed in patients with diffuse cutaneous SSc with a duration of the disease since the first visceral manifestations (cutaneous, cardiac, digestive, pulmonary, or renal) excluding Raynaud's phenomenon of less than 5 years. However, the indications for HSC autograft in SSc validated at European level and in the national diagnostic and care protocol (PNDS) are broader and some of these indications are debatable, in particular in patients with worsening diffuse interstitial lung disease. These indications are discussed in a reasoned way, taking into account the level of evidence and the toxicity of the HSC autograft.
MeSH term(s)	Humans ; Peripheral Blood Stem Cell Transplantation ; Prospective Studies ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Transplantation, Autologous
Language	French
Publishing date	2024-01-18
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2024.01.001
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Article ; Online: Autogreffe de cellules souches périphériques dans la sclérodermie systémique : un progrès important, mais il faut tempérer notre enthousiasme !

Mouthon, L

La Revue de medecine interne

2023

Title translation	Autologous peripheral stem cell transplantation in systemic sclerosis: An important step forward, but we must temper our enthusiasm!
Abstract	Three prospective randomized studies have demonstrated the efficacy of autologous hematopoietic stem cell (HSC) transplantation in systemic sclerosis (SSc) on survival. These results encourage us to offer this therapy to patients who have a rapidly progressive disease and who have early symptoms but no advanced visceral involvement. HSC autograft can thus be discussed in patients with diffuse cutaneous SSc with a duration of the disease since the first visceral manifestations (cutaneous, cardiac, digestive, pulmonary, or renal) excluding Raynaud's phenomenon of less than 5 years. However, the indications for HSC autograft in SSc validated at European level and in the national diagnostic and care protocol (PNDS) are broader and some of these indications are debatable, in particular in patients with worsening diffuse interstitial lung disease. These indications are discussed in a reasoned way, taking into account the level of evidence and the toxicity of the HSC autograft.
Language	French
Publishing date	2023-12-05
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2023.11.010
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Article ; Online: États généraux de la médecine interne : pour une meilleure connaissance et reconnaissance de notre spécialité.

Sève, P / Mouthon, L

La Revue de medecine interne

2023 Volume 44, Issue 12, Page(s) 629–631

Title translation	Estates general on internal medicine: For better knowledge and recognition of our specialty.
MeSH term(s)	Humans ; Internal Medicine ; Specialization
Language	French
Publishing date	2023-11-24
Publishing country	France
Document type	Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2023.11.008
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Article ; Online: Biothérapies ciblées : nouveautés dans la sclérodermie systémique !

Chaigne, B / Mouthon, L

La Revue de medecine interne

2023 Volume 45, Issue 2, Page(s) 109–113

Abstract: Systemic sclerosis (SSc) is a rare connective tissue disease characterized by inflammation, fibrosis, and autoimmunity. Despite few clinical trials when compared to other autoimmune diseases, SSc has benefited from renewed interest over the past ten ... ...

Title translation	Update on targeted biopharmaceuticals in systemic sclerosis!
Abstract	Systemic sclerosis (SSc) is a rare connective tissue disease characterized by inflammation, fibrosis, and autoimmunity. Despite few clinical trials when compared to other autoimmune diseases, SSc has benefited from renewed interest over the past ten years and a large number of clinical trials have been performed or are underway. We present here the results of the trials published in the last 5 years in ScS according to the chosen endpoint criteria and describe the trials in progress or expected in the years to come.
MeSH term(s)	Humans ; Biological Products/therapeutic use ; Scleroderma, Systemic/drug therapy ; Connective Tissue Diseases ; Raynaud Disease
Chemical Substances	Biological Products
Language	French
Publishing date	2023-11-18
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2023.11.002
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Article ; Online: Pulmonary arterial hypertension associated with connective tissue diseases (CTD-PAH): Recent and advanced data.

Thoreau, Benjamin / Mouthon, Luc

Autoimmunity reviews

2023 Volume 23, Issue 4, Page(s) 103506

Abstract: Pulmonary arterial hypertension (PAH), corresponding to group 1 of pulmonary hypertension classification, is a rare disease with a major prognostic impact on morbidity and mortality. PAH can be either primary in idiopathic and heritable forms or ... ...

Abstract	Pulmonary arterial hypertension (PAH), corresponding to group 1 of pulmonary hypertension classification, is a rare disease with a major prognostic impact on morbidity and mortality. PAH can be either primary in idiopathic and heritable forms or secondary to other conditions including connective tissue diseases (CTD-PAH). Within CTD-PAH, the leading cause of PAH is systemic sclerosis (SSc) in Western countries, whereas systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) are predominantly associated with PAH in Asia. Although many advances have been made during the last two decades regarding classification, definition early screening and risk stratification and therapeutic aspects with initial combination treatment, the specificities of CTD-PAH are not yet clear. In this manuscript, we review recent literature data regarding the updated definition and classification of PAH, pathogenesis, epidemiology, detection, prognosis and treatment of CTD-PAH.
Language	English
Publishing date	2023-12-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2023.103506
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Article ; Online: Authors reply: Clinical presentation, course, and prognosis of patients with mixed connective tissue disease.

Chevalier, Kevin / Chaigne, Benjamin / Mouthon, Luc

Journal of internal medicine

2024 Volume 295, Issue 4, Page(s) 576–578

MeSH term(s)	Humans ; Mixed Connective Tissue Disease/complications ; Mixed Connective Tissue Disease/diagnosis ; Prognosis ; Connective Tissue Diseases/complications ; Connective Tissue Diseases/diagnosis
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Letter
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13765
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