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  1. Article ; Online: "The change was as big as night and day"

    Watts, Gavin W / López, Eric J / Davis, Mariya T

    Journal of intellectual disabilities : JOID

    2023  Volume 28, Issue 2, Page(s) 295–314

    Abstract: Since the inception of the Higher Education Opportunity Act in 2008, there has been an increase in the number of post-secondary education institutions in the United States that have established inclusive postsecondary programs for individuals with ... ...

    Abstract Since the inception of the Higher Education Opportunity Act in 2008, there has been an increase in the number of post-secondary education institutions in the United States that have established inclusive postsecondary programs for individuals with intellectual disabilities to attend college and achieve higher levels of employment. Previous studies have investigated the development and outcomes of these programs, however, less has been explored related to professors' experiences and perceptions regarding this unique student population, particularly within Hispanic Serving Institutions (HSI). The current study focused on professors teaching inclusive courses within a new Comprehensive Transition and Postsecondary Program at a HSI and aimed to identify their perceptions and experiences related to instructing students with intellectual disabilities. Six professors participated in pre- and post-semester in-depth interviews. Findings from applied thematic analysis included: (a) barriers to success; (b) academic supports and strategies; (c) successful outcomes and (d) considerations for future, related programming.
    MeSH term(s) Humans ; Intellectual Disability/rehabilitation ; Adult ; Faculty ; Male ; Education of Intellectually Disabled ; Hispanic or Latino ; Qualitative Research ; Universities ; Female ; United States ; Students/psychology
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071898-6
    ISSN 1744-6309 ; 1469-0047 ; 1744-6295
    ISSN (online) 1744-6309
    ISSN 1469-0047 ; 1744-6295
    DOI 10.1177/17446295221148791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Replies to commentaries on beyond playing 20 questions with nature.

    Almaatouq, Abdullah / Griffiths, Thomas L / Suchow, Jordan W / Whiting, Mark E / Evans, James / Watts, Duncan J

    The Behavioral and brain sciences

    2024  Volume 47, Page(s) e65

    Abstract: Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of ... ...

    Abstract Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used.
    MeSH term(s) Dissent and Disputes
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X23002789
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1470: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus.

    Bellinge, Jamie W / Chan, Dick C / Pang, Jing / Francis, Roslyn J / Page, Michael M / Watts, Gerald F / Schultz, Carl J

    European journal of clinical investigation

    2024  Volume 54, Issue 5, Page(s) e14167

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aorta, Thoracic/diagnostic imaging ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Lipoprotein(a) ; Calcinosis/diagnostic imaging ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/complications ; Diabetes Mellitus ; Vascular Calcification/diagnostic imaging
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoprotein(a)
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Letter
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14167
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
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  4. Article ; Online: Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.

    Yen, Yu-Chen / Li, Yong / Chen, Chun-Liang / Klose, Thomas / Watts, Val J / Dessauer, Carmen W / Tesmer, John J G

    Nature structural & molecular biology

    2024  

    Abstract: The nine different membrane-anchored adenylyl cyclase isoforms (AC1-9) in mammals are stimulated by the heterotrimeric G protein, ... ...

    Abstract The nine different membrane-anchored adenylyl cyclase isoforms (AC1-9) in mammals are stimulated by the heterotrimeric G protein, Gα
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-024-01263-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4101: Show issues Location:
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    Zs.MG 56: Show issues

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  5. Article ; Online: Hypertension

    Trask, Aaron J / Bello, Natalie A / Carnevale, Daniela / Arnold, Amy C / Watts, Stephanie W

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 3, Page(s) 493–496

    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.122.20663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Computational screen for sex-specific drug effects in a cardiac fibroblast signaling network model.

    Watts, Kelsey M / Nichols, Wesley / Richardson, William J

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17068

    Abstract: Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the progression of heart failure, and there are currently no drugs approved ... ...

    Abstract Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the progression of heart failure, and there are currently no drugs approved specifically to target matrix accumulation in the heart. Computational signaling network models (SNMs) can be used to facilitate discovery of novel drug targets. However, the vast majority of SNMs are not sex-specific and/or are developed and validated using data skewed towards male in vitro and in vivo samples. Biological sex is an important consideration in cardiovascular health and drug development. In this study, we integrate a cardiac fibroblast SNM with estrogen signaling pathways to create sex-specific SNMs. The sex-specific SNMs demonstrated high validation accuracy compared to in vitro experimental studies in the literature while also elucidating how estrogen signaling can modulate the effect of fibrotic cytokines via multi-pathway interactions. Further, perturbation analysis and drug screening uncovered several drug compounds predicted to generate divergent fibrotic responses in male vs. female conditions, which warrant further study in the pursuit of sex-specific treatment recommendations for cardiac fibrosis. Future model development and validation will require more generation of sex-specific data to further enhance modeling capabilities for clinically relevant sex-specific predictions of cardiac fibrosis and treatment.
    MeSH term(s) Humans ; Female ; Male ; Heart ; Fibroblasts/metabolism ; Cardiomyopathies/pathology ; Fibrosis ; Estrogens/metabolism
    Chemical Substances Estrogens
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44440-9
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  7. Article: Computational Screen for Sex-Specific Drug Effects in a Cardiac Fibroblast Network Model.

    Watts, Kelsey M / Nichols, Wesley / Richardson, William J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the uncontrolled accumulation of extracellular matrix proteins which can exacerbate the progression of heart failure, and there are currently no drugs approved ... ...

    Abstract Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the uncontrolled accumulation of extracellular matrix proteins which can exacerbate the progression of heart failure, and there are currently no drugs approved specifically to target matrix accumulation in the heart. Computational signaling network models (SNMs) can be used to facilitate discovery of novel drug targets. However, the vast majority of SNMs are not sex-specific and/or are developed and validated using data skewed towards male in vitro and in vivo samples. Biological sex is an important consideration in cardiovascular health and drug development. In this study, we integrate a previously constructed cardiac fibroblast SNM with estrogen signaling pathways to create sex-specific SNMs. The sex-specific SNMs maintained previously high validation when compared to
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.11.536523
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  8. Article: Banker Plant Bonuses? The Benefits and Risks of Including Brassicas in Field Margins to Promote Conservation Biocontrol of Specialist Pests in Oilseed Rape.

    Skellern, Matthew P / Clark, Suzanne J / Ferguson, Andrew W / Watts, Nigel P / Cook, Samantha M

    Insects

    2023  Volume 14, Issue 4

    Abstract: European agri-environment schemes include the use of flower-rich field margins to promote on-farm biodiversity, but species mixtures rarely include Brassicaceae. As pests of oilseed rape (OSR; ...

    Abstract European agri-environment schemes include the use of flower-rich field margins to promote on-farm biodiversity, but species mixtures rarely include Brassicaceae. As pests of oilseed rape (OSR;
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14040349
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  9. Article ; Online: The Engaged Learners Program: Effects on Student Engagement During Small Group Reading Instruction.

    Roberts, Garrett J / Lindström, Esther R / Watts, Gavin W / Coté, Brooke / Ghosh, Ekta

    Behavior modification

    2023  Volume 48, Issue 2, Page(s) 150–181

    Abstract: In this study we tested the usability, feasibility, social validity, and effectiveness ... ...

    Abstract In this study we tested the usability, feasibility, social validity, and effectiveness of
    MeSH term(s) Humans ; Reading ; Students ; Cognition ; Mentoring
    Language English
    Publishing date 2023-12-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 432229-0
    ISSN 1552-4167 ; 0145-4455
    ISSN (online) 1552-4167
    ISSN 0145-4455
    DOI 10.1177/01454455231213980
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2195: Show issues Location:
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  10. Article ; Online: Controlling, Confounding, and Construct Clarity: Responding to Criticisms of "Revisiting the Marshmallow Test" by Doebel, Michaelson, and Munakata (2020) and Falk, Kosse, and Pinger (2020).

    Watts, Tyler W / Duncan, Greg J

    Psychological science

    2019  Volume 31, Issue 1, Page(s) 105–108

    MeSH term(s) Delay Discounting ; Humans ; Reinforcement, Psychology
    Language English
    Publishing date 2019-12-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2022256-7
    ISSN 1467-9280 ; 0956-7976
    ISSN (online) 1467-9280
    ISSN 0956-7976
    DOI 10.1177/0956797619893606
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