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  1. Article: Pulmonary aspergillosis: a clinical update.

    Zmeili, O S / Soubani, A O

    QJM : monthly journal of the Association of Physicians

    2007  Volume 100, Issue 6, Page(s) 317–334

    Abstract: Aspergillus spp may cause a variety of pulmonary diseases, depending on immune status and the presence of underlying lung disease. These manifestations range from invasive pulmonary aspergillosis in severely immunocompromised patients, to chronic ... ...

    Abstract Aspergillus spp may cause a variety of pulmonary diseases, depending on immune status and the presence of underlying lung disease. These manifestations range from invasive pulmonary aspergillosis in severely immunocompromised patients, to chronic necrotizing aspergillosis in patients with chronic lung disease and/or mildly compromised immune systems. Aspergilloma is mainly seen in patients with cavitary lung disease, while allergic bronchopulmonary aspergillosis is described in patients with hypersensitivity to Aspergillus antigens. Recent major advances in the diagnosis and management of pulmonary aspergillosis include the introduction of non-invasive tests, and the development of new antifungal agents, such as azoles and echinocandins, that significantly affect the management and outcome of patients with pulmonary aspergillosis. This review provides a clinical update on the epidemiology, risk factors, clinical presentation, diagnosis and management of the major syndromes associated with pulmonary aspergillosis.
    MeSH term(s) Antifungal Agents/therapeutic use ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Aspergillosis/epidemiology ; Humans ; Lung Diseases, Fungal/diagnosis ; Lung Diseases, Fungal/drug therapy ; Lung Diseases, Fungal/epidemiology ; Prevalence ; Risk Factors ; Treatment Outcome ; Triazoles/therapeutic use
    Chemical Substances Antifungal Agents ; Triazoles
    Language English
    Publishing date 2007-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 1460-2725 ; 0033-5622
    ISSN (online) 1460-2393
    ISSN 1460-2725 ; 0033-5622
    DOI 10.1093/qjmed/hcm035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
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  2. Article: Toxicity of a new antismoking mouthwash 881010 in rats and rabbits.

    Tamimi, S O / Zmeili, S M / Gharaibeh, M N / Shubair, M S / Salhab, A S

    Journal of toxicology and environmental health. Part A

    1998  Volume 53, Issue 1, Page(s) 47–60

    Abstract: ... toxicity of a new antismoking (A.S.) mouth wash (0.5% silver nitrate as the active ingredient). The LD50 ... doses of A.S. mouthwash by swabbing the oral cavity daily for 30 consecutive days. Body weight ...

    Abstract Male and female rats and rabbits were used in this study to investigate the acute and subchronic toxicity of a new antismoking (A.S.) mouth wash (0.5% silver nitrate as the active ingredient). The LD50 values for i.p. administration in male and female rats were 35.7 and 37.2 mg/kg body weight, respectively. The corresponding values in male and female rabbits were 113 and 128 mg/kg body weight, respectively. The oral LD50 values of the mouthwash in male and female rats were 428 and 433 mg/kg body weight, respectively. The corresponding values in male and female rabbits were 1261 and 1320 mg/kg body weight, respectively. Postmortem and histopathological examination revealed congestion, edema, hemorrhage, and mucosal necrosis with brown pigment deposition in the upper gastrointestinal and respiratory tracts for the orally treated animals and ascitis, peritoneal fat necrosis, and pigment deposition in i.p. administered animals. Subchronic toxicity involved administration of low (1.5 mg/kg), intermediate (15 mg/kg), and high (150 mg/kg) doses of A.S. mouthwash by swabbing the oral cavity daily for 30 consecutive days. Body weight, hematologic observations, and histopathological examination showed no significant differences between control and treated animals, except for dark coloration in teeth and increased platelet counts in treated rats.
    MeSH term(s) Administration, Oral ; Animals ; Blood Cell Count/drug effects ; Female ; Gastric Mucosa/drug effects ; Gastric Mucosa/pathology ; Injections, Intraperitoneal ; Kidney/drug effects ; Kidney/pathology ; Lethal Dose 50 ; Lung/drug effects ; Lung/pathology ; Male ; Mouth Mucosa/drug effects ; Mouth Mucosa/pathology ; Mouthwashes/toxicity ; Necrosis ; Organ Size/drug effects ; Peritoneum/drug effects ; Peritoneum/pathology ; Pigmentation/drug effects ; Rabbits ; Rats ; Rats, Inbred F344 ; Silver Nitrate/toxicity ; Smoking Prevention ; Stomach/drug effects ; Stomach/pathology ; Tongue/drug effects ; Tongue/pathology
    Chemical Substances Mouthwashes ; Silver Nitrate (95IT3W8JZE)
    Language English
    Publishing date 1998-01-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413345-3
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    DOI 10.1080/009841098159466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1268: Show issues Location:
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  3. Article: Pharmacokinetics and pharmacodynamics of two commercial oral nifedipine products.

    Shaheen, O / Zmeili, S / al-Qussuois, Y / Arafat, T / Mouti, H

    International journal of clinical pharmacology, therapy, and toxicology

    1991  Volume 29, Issue 9, Page(s) 337–341

    Abstract: Nifedipine, a calcium channel blocker, is widely used in the management of hypertension, angina and cardiac arrhythmias. In this study, the bioequivalence of two pharmaceutical formulations of nifedipine, Nifecard (10 mg capsules) manufactured by Dar Al- ... ...

    Abstract Nifedipine, a calcium channel blocker, is widely used in the management of hypertension, angina and cardiac arrhythmias. In this study, the bioequivalence of two pharmaceutical formulations of nifedipine, Nifecard (10 mg capsules) manufactured by Dar Al-Dawa Development and Investment Co, Ltd. and Adalat (10 mg capsules) manufactured by Bayer Pharmaceutical Company, was assessed in twelve healthy male subjects. Nifecard or Adalat was given orally on two occasions separated by one week wash-out interval. Blood samples for the determination of plasma nifedipine concentration were taken for 8 hours following drug administration. Blood pressure and pulse were also measured after each treatment. Plasma nifedipine concentrations were measured by a simple, sensitive and reproducible HPLC method. There were no significant differences in oral absorption, Cmax, tmax, t1/2 and AUC between Nifecard and Adalat. Also, Nifecard and Adalat produced similar hemodynamic profiles (blood pressure and pulse). In conclusion, our results demonstrate that both Adalat and Nifecard are bioequivalent and produced similar pharmacological effects.
    MeSH term(s) Administration, Oral ; Adult ; Capsules ; Chemistry, Pharmaceutical ; Hemodynamics/drug effects ; Humans ; Male ; Nifedipine/administration & dosage ; Nifedipine/blood ; Nifedipine/pharmacokinetics ; Nifedipine/pharmacology ; Therapeutic Equivalency
    Chemical Substances Capsules ; Nifedipine (I9ZF7L6G2L)
    Language English
    Publishing date 1991-09
    Publishing country Germany
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 124384-6
    ISSN 0174-4879 ; 0340-0026 ; 0300-9718 ; 0946-1965
    ISSN 0174-4879 ; 0340-0026 ; 0300-9718 ; 0946-1965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 467: Show issues Location:
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  4. Article: Alpha and luteinizing hormone beta subunit messenger ribonucleic acids during the rat estrous cycle.

    Zmeili, S M / Papavasiliou, S S / Thorner, M O / Evans, W S / Marshall, J C / Landefeld, T D

    Endocrinology

    1986  Volume 119, Issue 4, Page(s) 1867–1869

    Abstract: Alpha and LH beta subunit mRNAs were measured in pituitaries of 4-day cycling rats during the estrous cycle. A two-fold increase in alpha mRNA occurred between 0800-2000 h on diestrus, but alpha mRNA concentrations were stable during other days of the ... ...

    Abstract Alpha and LH beta subunit mRNAs were measured in pituitaries of 4-day cycling rats during the estrous cycle. A two-fold increase in alpha mRNA occurred between 0800-2000 h on diestrus, but alpha mRNA concentrations were stable during other days of the cycle. LH beta mRNA concentrations were low during estrus and metestrus (11-16 pg cDNA bound/100 micrograms pituitary DNA), but were elevated (27-30 pg) between 0800-2000 h on diestrus. A second increase in LH beta mRNA was observed on the afternoon of proestrus, prior to the onset of the LH surge with maximum values (45 pg) coincident with peak LH secretion. LH beta mRNA concentrations declined rapidly and had fallen to basal values by midnight on proestrus. These data show that alpha and LH beta mRNAs change in a similar manner during metestrus, diestrus and estrus, suggesting coordinate regulation of alpha and LH beta gene expression at these times. During the LH surge, however, LH beta mRNA alone is increased, suggesting that the LH beta gene can be differentially expressed at times when maximum LH secretion is occurring.
    MeSH term(s) Animals ; Diestrus/metabolism ; Estrus/metabolism ; Female ; Glycoprotein Hormones, alpha Subunit ; Luteinizing Hormone/genetics ; Metestrus/metabolism ; Peptide Fragments/genetics ; Pituitary Gland/metabolism ; Pituitary Hormones, Anterior/genetics ; Proestrus/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred Strains
    Chemical Substances Glycoprotein Hormones, alpha Subunit ; Peptide Fragments ; Pituitary Hormones, Anterior ; RNA, Messenger ; Luteinizing Hormone (9002-67-9)
    Language English
    Publishing date 1986-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endo-119-4-1867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.72: Show issues Location:
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