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  1. Article ; Online: The spectrum of pulmonary amyloidosis.

    Riehani, Anas / Soubani, Ayman O

    Respiratory medicine

    2023  Volume 218, Page(s) 107407

    Abstract: Amyloidosis is a disease caused by misfolded proteins that deposit in the extracellular matrix as fibrils, resulting in the dysfunction of the involved organ. The lung is a common target of Amyloidosis, but pulmonary amyloidosis is uncommonly diagnosed ... ...

    Abstract Amyloidosis is a disease caused by misfolded proteins that deposit in the extracellular matrix as fibrils, resulting in the dysfunction of the involved organ. The lung is a common target of Amyloidosis, but pulmonary amyloidosis is uncommonly diagnosed since it is rarely symptomatic. Diagnosis of pulmonary amyloidosis is usually made in the setting of systemic amyloidosis, however in cases of localized pulmonary disease, surgical or transbronchial tissue biopsy might be indicated. Pulmonary amyloidosis can be present in a variety of discrete entities. Diffuse Alveolar septal amyloidosis is the most common type and is usually associated with systemic AL amyloidosis. Depending on the degree of the interstitial involvement, it may affect alveolar gas exchange and cause respiratory symptoms. Localized pulmonary Amyloidosis can present as Nodular, Cystic or Tracheobronchial Amyloidosis which may cause symptoms of airway obstruction and large airway stenosis. Pleural effusions, mediastinal lymphadenopathy and pulmonary hypertension has also been reported. Treatment of all types of pulmonary amyloidosis depends on the type of precursor protein, organ involvement and distribution of the disease. Most of the cases are asymptomatic and require only close monitoring. Diffuse alveolar septal amyloidosis treatment follows the treatment of underlying systemic amyloidosis. Tracheobronchial amyloidosis is usually treated with bronchoscopic interventions including debulking and stenting or with external beam radiation. Long-term prognosis of pulmonary amyloidosis usually depends on the type of lung involvement and other organ function.
    MeSH term(s) Humans ; Lung Diseases/complications ; Lung Diseases/therapy ; Lung ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Prognosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107407
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  2. Article: Incidence and inhospital outcomes of coronavirus disease 2019-associated pulmonary aspergillosis in the United States.

    Sharma, Aditya / Sharma, Aditi / Soubani, Ayman O

    Annals of thoracic medicine

    2024  Volume 19, Issue 1, Page(s) 87–95

    Abstract: Objective: The aim of this study was to estimate the predictors, associations, and outcomes of COVID-19-associated pulmonary disease (CAPA) in the United States.: Study design and methods: This retrospective cohort study was performed by using the ... ...

    Abstract Objective: The aim of this study was to estimate the predictors, associations, and outcomes of COVID-19-associated pulmonary disease (CAPA) in the United States.
    Study design and methods: This retrospective cohort study was performed by using the National Inpatient Sample Database 2020 to identify coronavirus disease 2019 (COVID-19) and CAPA hospitalizations. Baseline variables and outcomes were compared between COVID-19 hospitalizations without aspergillosis and those with aspergillosis. These variables were then used to perform an adjusted analysis for obtaining predictors and factors associated with CAPA and its inhospital mortality.
    Results: Of the 1,020,880 hospitalizations identified with the principal diagnosis of COVID-19, CAPA was identified in 1510 (0.1%) hospitalizations. The CAPA cohort consisted of a higher proportion of males (58%) as well as racial and ethnic minorities (Hispanics, Blacks, and others [including Asian or Pacific islanders, native Americans]). Inhospital mortality was significantly higher (47.35% vs. 10.87%,
    Conclusion: While CAPA is an infrequent complication during hospitalizations for COVID-19, it significantly increases all-cause mortality, prolongs hospital stays, and leads to higher hospital expenses compared to COVID-19 cases without aspergillosis.
    Language English
    Publishing date 2024-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2241287-6
    ISSN 1998-3557 ; 1817-1737
    ISSN (online) 1998-3557
    ISSN 1817-1737
    DOI 10.4103/atm.atm_190_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Septic Shock Short-Term Outcomes in Patients With Psychiatric Disorders: Analysis From the National Inpatient Sample Database.

    Soubani, Ayman O / Sharma, Aditi / Soubani, Omar / Mishra, Tushar

    Journal of the Academy of Consultation-Liaison Psychiatry

    2023  Volume 64, Issue 5, Page(s) 436–443

    Abstract: Background: Major psychiatric disorders are associated with lower life expectancy primarily due to comorbid illnesses and suboptimal access to health care. Large-scale contemporary data in the United States on in-hospital mortality of patients with ... ...

    Abstract Background: Major psychiatric disorders are associated with lower life expectancy primarily due to comorbid illnesses and suboptimal access to health care. Large-scale contemporary data in the United States on in-hospital mortality of patients with major psychiatric disorder and sepsis are lacking.
    Objective: To describe the short-term outcomes of hospitalized patients with major psychiatric disorders and septic shock.
    Methods: We performed a retrospective cohort study using the National Inpatient Sample database from 2016 to 2019 to identify septic shock hospitalizations in patients with versus without major psychiatric disorder (defined as schizophrenia and affective disorders). Baseline variables and in-hospital mortality trends were compared between the 2 groups.
    Results: Out of 1,653,255 hospitalizations with septic shock identified between 2016 and 2019, 16.2% had a diagnosis of major psychiatric disorder as defined above. After adjusting for various patient-level and hospital-level demographics and coexisting clinical conditions in a multivariable logistic regression, the odds of in-hospital mortality in patients with any major psychiatric disorder were 0.71 times that of those without a diagnosis of psychiatric illness (95% confidence interval [CI], 0.69-0.73; P < 0.001). Similarly, when the disorders were divided into 2 categories for subanalysis, those with schizophrenia had 38% lower odds of dying compared to those without schizophrenia (adjusted odds ratio, 0.62; 95% CI, 0.58-0.66; P < 0.001). Those with affective disorders had 25% lower odds of in-hospital mortality than those without a diagnosis of an affective disorder (adjusted odds ratio, 0.75; 95% CI, 0.73-0.77; P < 0.001). The adjusted mean length of stay for those diagnosed with major psychiatric disorder was 0.38 days longer than those without significant psychiatric illness (95% CI, 0.28-0.49; P < 0.001). On the other hand, the mean hospitalization charges were $10,516 less for patients with a major psychiatric disorder compared to those without (95% CI, -$11,830 to -$9,201; P < 0.001).
    Conclusions: Hospitalized patients with major psychiatric disorder and septic shock had lower risk of short-term mortality. Further studies are needed to examine the reasons behind this lower in-hospital mortality risk.
    MeSH term(s) Humans ; United States/epidemiology ; Shock, Septic/epidemiology ; Shock, Septic/therapy ; Retrospective Studies ; Inpatients ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Logistic Models ; Hospital Mortality
    Language English
    Publishing date 2023-03-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2960
    ISSN (online) 2667-2960
    DOI 10.1016/j.jaclp.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epidemiology of COVID 19-Associated Mucormycosis in the United States.

    Sharma, Aditya / Sharma, Aditi / Soubani, Ayman O

    Chest

    2023  Volume 165, Issue 2, Page(s) 307–312

    MeSH term(s) United States/epidemiology ; Humans ; Mucormycosis/epidemiology ; COVID-19/epidemiology
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tocilizumab and Corticosteroids Increase Risk of COVID-19-Associated Pulmonary Aspergillosis Development Among Critically Ill Patients.

    Awad, Mohammed T / Niwinski, Rajmund Michal / Beran, Azizullah / Tidwell, Chad / Soubani, Ayman O

    American journal of therapeutics

    2023  Volume 30, Issue 3, Page(s) e268–e274

    MeSH term(s) Humans ; Critical Illness/therapy ; COVID-19/complications ; COVID-19 Drug Treatment ; Adrenal Cortex Hormones/adverse effects ; Pulmonary Aspergillosis/drug therapy
    Chemical Substances tocilizumab (I031V2H011) ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Letter
    ZDB-ID 1280786-2
    ISSN 1536-3686 ; 1075-2765
    ISSN (online) 1536-3686
    ISSN 1075-2765
    DOI 10.1097/MJT.0000000000001617
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  6. Article ; Online: Major pulmonary complications following Hematopoietic stem cell transplantation: What the pulmonologist needs to know.

    Shiari, Aryan / Nassar, Mo'ath / Soubani, Ayman O

    Respiratory medicine

    2021  Volume 185, Page(s) 106493

    Abstract: Hematopoietic stem cell transplantation (HSCT) is used for treatment of a myriad of both malignant and non-malignant disorders. However, despite many advances over the years which have resulted in improved patient mortality, this subset of patients ... ...

    Abstract Hematopoietic stem cell transplantation (HSCT) is used for treatment of a myriad of both malignant and non-malignant disorders. However, despite many advances over the years which have resulted in improved patient mortality, this subset of patients remains at risk for a variety of post-transplant complications. Pulmonary complications of HSCT are categorized into infectious and non-infectious and occur in up to one-third of patients undergoing HSCT. Infectious etiologies include bacterial, viral and fungal infections, each of which can have significant mortality if not identified and treated early in the course of infection. Advances in the diagnosis and management of infectious complications highlight the importance of non-infectious pulmonary complications related to chemoradiation toxicities, immunosuppressive drugs toxicities, and graft-versus-host disease. This report aims to serve as a guide and clinical update of pulmonary complications following HSCT for the general pulmonologist who may be involved in the care of these patients.
    MeSH term(s) Clinical Competence ; Female ; Health Knowledge, Attitudes, Practice ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Infection Control ; Infections/diagnosis ; Infections/etiology ; Infections/therapy ; Male ; Patient Care ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Postoperative Complications/therapy ; Pulmonologists ; Risk
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2021.106493
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  7. Article ; Online: Invasive Pulmonary Aspergillosis in Hospitalized Hematopoietic Stem Cell Transplantation Recipients: Outcomes Based on the United States National Readmission Database.

    Khalil, Amir / Singh, Paramveer / Mir, Tanveer / Uddin, Mohammed / Soubani, Ayman O

    Hematology/oncology and stem cell therapy

    2023  Volume 17, Issue 1, Page(s) 43–50

    Abstract: Background and objective: Hematopoietic stem cell transplant (HSCT) is a well-established treatment for hematologic malignancies and certain autoimmune and congenital conditions. HSCT is associated with immunocompromise and increased risk of infections. ...

    Abstract Background and objective: Hematopoietic stem cell transplant (HSCT) is a well-established treatment for hematologic malignancies and certain autoimmune and congenital conditions. HSCT is associated with immunocompromise and increased risk of infections. This study assessed whether invasive pulmonary aspergillosis (IPA) affects in-hospital mortality and 30-day readmission among HSCT patients. A secondary objective was to examine potential differences in complications between HSCT with and without IPA.
    Materials and methods: A retrospective study of a nationally representative cohort of hospital admissions was conducted, with data collected from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project Nationwide Readmissions Database between 2013 and 2019. The International Classification of Diseases, 10th revision (ICD-10), and 9th revision (ICD-9) diagnostic codes were used to identify patients with IPA and HSCT. All adult patients ≥18 years were included in the study.
    Results: There were 90,451 hospitalizations for HSCT from 2013 to 2019; 89,331 (98.8%) had HSCT without IPA, while 1092 (1.2%) hospitalizations had HSCT with IPA. The in-hospital mortality for HSCT-IPA was higher compared to HSCT without IPA (18.3% vs. 4.2%; p < 0.001). HSCT-IPA had a significantly higher 30-day readmission rate (36.2%) than that of HSCT without IPA (24.0%). HSCT-IPA also had a higher mean cost of admission ($303,437) than that of HSCT without IPA ($57,587).The HSCT-IPA group had higher multi-organ complications, including respiratory failure (51.3% vs. 13.5%, p < 0.001), sepsis (38.2% vs. 18.5%, p < 0.001), septic shock (16.1% vs. 5.1%, p < 0.001), need for mechanical ventilation (21.1% vs. 5.1% p < 0.001), non-invasive positive pressure ventilation (4.9% vs. 2.5%, p < 0.001), and intensive-care unit admission (21.8% vs. 6.1% p < 0.001).
    Conclusion: IPA is a rare but severe complication associated with HSCT, with higher in-hospital mortality, complications due to multi-organ failure, readmission rates, and cost of hospitalization when compared to HSCT without IPA.
    MeSH term(s) Adult ; Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hospitalization ; Invasive Pulmonary Aspergillosis/epidemiology ; Invasive Pulmonary Aspergillosis/therapy ; Invasive Pulmonary Aspergillosis/etiology ; Patient Readmission ; Retrospective Studies ; United States/epidemiology ; Adolescent
    Language English
    Publishing date 2023-07-20
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2651893-4
    ISSN 2589-0646 ; 1658-3876
    ISSN (online) 2589-0646
    ISSN 1658-3876
    DOI 10.56875/2589-0646.1109
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  8. Article: Endophthalmitis as the initial manifestation of invasive fusariosis in an allogeneic stem cell transplant patient: A case report.

    Kao, Andrew S / Cramer-Bour, Cassondra / Kupsky, William / Soubani, Ayman O

    Medical mycology case reports

    2023  Volume 40, Page(s) 5–7

    Abstract: ... ...

    Abstract Fusarium
    Language English
    Publishing date 2023-02-19
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2670415-8
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2023.02.004
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  9. Article ; Online: Critical Care Prognosis and Outcomes in Patients with Cancer.

    Soubani, Ayman O

    Clinics in chest medicine

    2017  Volume 38, Issue 2, Page(s) 333–353

    Abstract: Advances in cancer treatment and patient survival are associated with increasing number of these patients requiring intensive care. Over the last 2 decades, there has been a steady improvement in the outcomes of critically ill patients with cancer. This ... ...

    Abstract Advances in cancer treatment and patient survival are associated with increasing number of these patients requiring intensive care. Over the last 2 decades, there has been a steady improvement in the outcomes of critically ill patients with cancer. This review provides data on the use of the intensive care unit (ICU) and short and long-term outcomes of critically ill patients with cancer, the ICU system practices that influence patients outcomes, and the role of the different clinical variables in predicting the prognosis of these patients.
    MeSH term(s) Aged ; Critical Care/methods ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/mortality ; Neoplasms/therapy ; Prognosis ; Treatment Outcome
    Language English
    Publishing date 2017-03-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2016.12.011
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  10. Article ; Online: Sepsis Hospitalizations With Versus Without Cancer: Epidemiology, Outcomes, and Trends in Nationwide Analysis From 2008 to 2017.

    Sharma, Aditi / Nguyen, Paul / Taha, Muhanad / Soubani, Ayman O

    American journal of clinical oncology

    2021  Volume 44, Issue 10, Page(s) 505–511

    Abstract: Background: Sepsis and cancer continue to be one of the leading causes of death in the United States. Concomitantly, hospitalizations for sepsis with underlying cancer over the years have shown a decrease in mortality. However, large-scale contemporary ... ...

    Abstract Background: Sepsis and cancer continue to be one of the leading causes of death in the United States. Concomitantly, hospitalizations for sepsis with underlying cancer over the years have shown a decrease in mortality. However, large-scale contemporary data on mortality trends in sepsis hospitalizations with underlying malignancy are lacking.
    Research question: Are there any identifiable trends in patients hospitalized for sepsis with underlying malignancy versus without malignancy?
    Study design and methods: We performed a retrospective cohort study using the National Inpatient Sample database from 2008 to 2017 to identify sepsis hospitalizations with versus without cancer. Baseline variables and mortality trends were compared between the 2 groups.
    Results: Of the 19,160,734 sepsis hospitalizations identified between 2008 and 2017, 3,913,813 (20.4%) were associated with cancer and 15,246,921 (79.6%) did not have underlying malignancy. Compared with 2008 to 2009, the multivariable-adjusted odds ratio (aOR) of death was lower in 2016 to 2017 for both cancer (aOR: 0.55, 95% confidence interval [CI]: 0.53-0.57) and noncancer-associated (aOR: 0.55, 95% CI: 0.53-0.57) sepsis hospitalizations. The nonsignificant interaction term (P=0.2239) revealed that the rate of decline in mortality did not differ between the 2 groups. Stratification of the mortality in sepsis hospitalizations by various age groups revealed that the odds of death associated with cancer were highest in the younger population (18 to 44 y) with an aOR: 3.40, 95% CI: 3.24-3.57. The aOR: showed a declining trend with increasing age until cancer-associated admissions had slightly lower odds of mortality than the noncancer group at age 85 years old and older (aOR: 0.93, 95% CI: 0.91-0.95).
    Conclusion: In the 10-year study period, mortality in cancer and noncancer-associated sepsis hospitalizations has shown a declining trend. Furthermore, differences in mortality between the 2 groups decreased with increasing age.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Hospital Mortality/trends ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neoplasms/complications ; Neoplasms/epidemiology ; Retrospective Studies ; Sepsis/complications ; Sepsis/epidemiology ; Time Factors ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 604536-4
    ISSN 1537-453X ; 0277-3732
    ISSN (online) 1537-453X
    ISSN 0277-3732
    DOI 10.1097/COC.0000000000000859
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