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  1. Book ; Online: Chapter Leonardo da Vinci e il lago di Serravalle

    Nieri, Ilaria / Pagliara, Stefano / PALERMO, MICHELE

    (Territori)

    2023  

    Series title Territori
    Keywords History ; Lake of San Lorenzo ; Lake of Vinci ; Serravalle lake ; Leonardo da Vinci Lake ; Leonardo da Vinci
    Language Italian
    Size 1 electronic resource (8 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note Italian
    HBZ-ID HT030375946
    ISBN 9788855185141 ; 8855185144
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: P-selectin blockade in COVID-19-related ARDS.

    Neri, Tommaso / Nieri, Dario / Celi, Alessandro

    American journal of physiology. Lung cellular and molecular physiology

    2020  Volume 318, Issue 6, Page(s) L1237–L1238

    MeSH term(s) A549 Cells ; Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Leukocyte Rolling ; Membrane Glycoproteins ; Mice, Knockout ; P-Selectin/antagonists & inhibitors ; P-Selectin/immunology ; Pandemics ; Pneumonia, Viral/complications ; Rats ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/immunology ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; Membrane Glycoproteins ; P-Selectin ; P-selectin ligand protein ; SELP protein, human ; crizanlizumab (L7451S9126)
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Letter
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00202.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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  3. Article ; Online: A novel prothrombotic role of proprotein convertase subtilisin kexin 9: the generation of procoagulant extracellular vesicles by human mononuclear cells.

    Scalise, Valentina / Lombardi, Stefania / Sanguinetti, Chiara / Nieri, Dario / Pedrinelli, Roberto / Celi, Alessandro / Neri, Tommaso

    Molecular biology reports

    2022  Volume 49, Issue 5, Page(s) 4129–4134

    Abstract: Background: Proprotein convertase subtilisin kexin 9 (PCSK9) is a serin protease synthesized mainly in the liver that binds the receptor of low-density lipoprotein and promotes its degradation in lysosomes. PCSK9 is considered a promising target for the ...

    Abstract Background: Proprotein convertase subtilisin kexin 9 (PCSK9) is a serin protease synthesized mainly in the liver that binds the receptor of low-density lipoprotein and promotes its degradation in lysosomes. PCSK9 is considered a promising target for the development of new therapies for the treatment of hypercholesterolemia and related cardiovascular diseases. Extracellular vesicles represent a heterogeneous population of vesicles, ranging in size between 0.05 and 1 μm involved in numerous pathophysiological processes, including blood coagulation. We investigated whether PCSK9 stimulation induces the release of procoagulant extracellular vesicles from human mononuclear cells (PBMCs) and THP-1 cells.
    Methods and results: PBMCs and THP-1 cells were stimulated whit PCSK9, the generation of EV was assessed by the prothrombinase assay and by cytofluorimetric analysis. EV-associated tissue factor activity was assessed by a one-stage clotting assay. PCSK9 induced an increase in extracellular generation by PBMCs and THP-1 cells as well as an increase in extracellular vesicle-associated tissue factor. Pre-treatment with inhibitors of the toll like receptor, TLR4 (C34), and of NF-κB signaling (BAY 11-7082), downregulated PCSK9-induced extracellular vesicle generation and of extracellular- bound tissue factor. Similar effect was obtained by an anti-PCSK9 human-monoclonal antibody.
    Conclusions: PCSK9-mediated generation of procoagulant EV could contribute to increase the prothrombotic status in patients with cardiovascular diseases.
    MeSH term(s) Cardiovascular Diseases ; Extracellular Vesicles/metabolism ; Humans ; Proprotein Convertase 9/metabolism ; Receptors, LDL ; Subtilisins ; Thromboplastin
    Chemical Substances Receptors, LDL ; Thromboplastin (9035-58-9) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-)
    Language English
    Publishing date 2022-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07433-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pulmonary embolism: yet another cause of hypoxaemic respiratory failure in COVID-19.

    Nieri, Dario / Lenzini, Giulia / Canari Venturi, Barbara / Celi, Alessandro

    ERJ open research

    2020  Volume 6, Issue 2

    Abstract: Pulmonary embolism represents an overlooked cause of worsening respiratory failure in COVID-19. A regular bedside evaluation for atypical features like pleuritic chest pain or pleural effusion could help identify suspected cases for appropriate ... ...

    Abstract Pulmonary embolism represents an overlooked cause of worsening respiratory failure in COVID-19. A regular bedside evaluation for atypical features like pleuritic chest pain or pleural effusion could help identify suspected cases for appropriate management.
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00220-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Changes in endothelial cell-derived extracellular vesicles after acute exercise in patients with COPD: a pilot study.

    Nieri, Dario / Neri, Tommaso / Santerini, Sabrina / Lombardi, Stefania / Celi, Alessandro

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2020  Volume 46, Issue 5, Page(s) e20200007

    MeSH term(s) Aged ; Endothelial Cells/metabolism ; Exercise/physiology ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/pathology ; Humans ; Pilot Projects ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Function Tests
    Language Portuguese
    Publishing date 2020-11-02
    Publishing country Brazil
    Document type Letter
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.36416/1806-3756/e20200007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Expression Analysis of Muscle-Specific miRNAs in Plasma-Derived Extracellular Vesicles from Patients with Chronic Obstructive Pulmonary Disease.

    Carpi, Sara / Polini, Beatrice / Nieri, Dario / Dubbini, Nevio / Celi, Alessandro / Nieri, Paola / Neri, Tommaso

    Diagnostics (Basel, Switzerland)

    2020  Volume 10, Issue 7

    Abstract: MicroRNAs (miRNAs) are a class of short non-coding RNAs involved in the regulation of gene expression and the control of several cellular processes at physiological and pathological levels. Furthermore, extracellular vesicles (EV), which are small ... ...

    Abstract MicroRNAs (miRNAs) are a class of short non-coding RNAs involved in the regulation of gene expression and the control of several cellular processes at physiological and pathological levels. Furthermore, extracellular vesicles (EV), which are small membrane-bound vesicles secreted by cells in the extracellular environment, contain functional miRNAs. The remarkable deregulation of many miRNAs has been demonstrated in respiratory diseases. Among them, miR-206, miR-133a-5p, and miR-133a-3p are striated muscle-specific miRNAs (myo-miRNA), related to skeletal muscle dysfunction, one of the commonest systemic manifestations in patients with chronic obstructive pulmonary disease (COPD). Nevertheless, their circulating expression in COPD patients is not demonstrated. For these reasons, we performed a pilot study to analyze the expression profiles of myo-miRNAs in plasma-derived EV from patients with COPD. We analyzed the expression profiles of selected myo-miRNAs in plasma-derived EV from COPD. Receiver operating characteristic analyses were carried out to evaluate whether selected plasma miRNAs were able to discriminate between different groups of COPD patients. We found EV-embedded myo-miRNAs in the bloodstream of COPD patients. Specifically, miR-206, miR-133a-5p and miR-133a-3p were significantly upregulated in group B patients. Receiver operating characteristic analyses of the combination of these selected miRNAs showed their high capacity to discriminate group B from other COPD patients. Our data provide evidence that myo-miRNA are present in EV in the plasma of COPD patients and their expression (miR-206, miR-133a-5p, and miR-133a-3p) can discriminate group B from group C patients. The future analysis of a larger number of patients should allow us to obtain more refined correlations.
    Language English
    Publishing date 2020-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10070502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enhanced prothrombotic and proinflammatory activity of circulating extracellular vesicles in acute exacerbations of chronic obstructive pulmonary disease.

    Nieri, Dario / Morani, Camilla / De Francesco, Miriam / Gaeta, Roberta / Niceforo, Mariapia / De Santis, Mariella / Giusti, Ilaria / Dolo, Vincenza / Daniele, Marta / Papi, Alberto / Celi, Alessandro / Neri, Tommaso

    Respiratory medicine

    2024  Volume 223, Page(s) 107563

    Abstract: Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with a high rate of cardiovascular events. Thromboinflammation (the interplay between coagulation and inflammation) is probably involved in these events. ... ...

    Abstract Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with a high rate of cardiovascular events. Thromboinflammation (the interplay between coagulation and inflammation) is probably involved in these events. Extracellular vesicles (EV) increase during AE-COPD, but their role in thromboinflammation in COPD is still unknown. We investigated EV-associated prothrombotic and proinflammatory activity in COPD.
    Methods: Patients with AE-COPD, stable COPD (sCOPD) and age- and sex-matched subjects (controls) were enrolled. AE-COPD patients were evaluated at hospital admission and 8 weeks after discharge (recovery; longitudinal arm). In a cross-sectional arm, AE-COPD were compared with sCOPD and controls. EV-mediated prothrombotic activity was tested by measuring the concentration of EV-associated phosphatidylserine, as assessed by a prothrombinase assay, and tissue factor, as assessed by a modified one-stage clotting assay (EV-PS and EV-TF, respectively). Synthesis of interleukin-8 (IL-8) and C-C motif chemokine ligand-2 (CCL-2) by cells of the human bronchial epithelial cell line 16HBE incubated with patients' EV was used to measure EV-mediated proinflammatory activity.
    Results: Twenty-five AE-COPD (median age [interquartile range] 74.0 [14.0] years), 31 sCOPD (75.0 [9.5] years) and 12 control (67.0 [3.5] years) subjects were enrolled. In the longitudinal arm, EV-PS, EV-TF, IL-8 and CCL-2 levels were all significantly higher at hospital admission than at recovery. Similarly, in the cross-sectional arm, EV-PS, EV-TF and cytokines synthesis were significantly higher in AE-COPD than in sCOPD and controls.
    Conclusions: EV exert prothrombotic and proinflammatory activities during AE-COPD and may therefore be effectors of thromboinflammation, thus contributing to the higher cardiovascular risk in AE-COPD.
    MeSH term(s) Humans ; Aged ; Inflammation/complications ; Interleukin-8 ; Thromboinflammation ; Cross-Sectional Studies ; Thrombosis/etiology ; Extracellular Vesicles ; Pulmonary Disease, Chronic Obstructive/complications
    Chemical Substances Interleukin-8
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2024.107563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.19: Show issues Location:
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  8. Article ; Online: Pulmonary embolism

    Dario Nieri / Giulia Lenzini / Barbara Canari Venturi / Alessandro Celi

    ERJ Open Research, Vol 6, Iss

    yet another cause of hypoxaemic respiratory failure in COVID-19

    2020  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: A novel prothrombotic role of proprotein convertase subtilisin kexin 9: the generation of procoagulant extracellular vesicles by human mononuclear cells

    Scalise, Valentina / Lombardi, Stefania / Sanguinetti, Chiara / Nieri, Dario / Pedrinelli, Roberto / Celi, Alessandro / Neri, Tommaso

    Molecular biology reports. 2022 May, v. 49, no. 5

    2022  

    Abstract: BACKGROUND: Proprotein convertase subtilisin kexin 9 (PCSK9) is a serin protease synthesized mainly in the liver that binds the receptor of low-density lipoprotein and promotes its degradation in lysosomes. PCSK9 is considered a promising target for the ... ...

    Abstract BACKGROUND: Proprotein convertase subtilisin kexin 9 (PCSK9) is a serin protease synthesized mainly in the liver that binds the receptor of low-density lipoprotein and promotes its degradation in lysosomes. PCSK9 is considered a promising target for the development of new therapies for the treatment of hypercholesterolemia and related cardiovascular diseases. Extracellular vesicles represent a heterogeneous population of vesicles, ranging in size between 0.05 and 1 μm involved in numerous pathophysiological processes, including blood coagulation. We investigated whether PCSK9 stimulation induces the release of procoagulant extracellular vesicles from human mononuclear cells (PBMCs) and THP-1 cells. METHODS AND RESULTS: PBMCs and THP-1 cells were stimulated whit PCSK9, the generation of EV was assessed by the prothrombinase assay and by cytofluorimetric analysis. EV-associated tissue factor activity was assessed by a one-stage clotting assay. PCSK9 induced an increase in extracellular generation by PBMCs and THP-1 cells as well as an increase in extracellular vesicle-associated tissue factor. Pre-treatment with inhibitors of the toll like receptor, TLR4 (C34), and of NF-κB signaling (BAY 11-7082), downregulated PCSK9-induced extracellular vesicle generation and of extracellular- bound tissue factor. Similar effect was obtained by an anti-PCSK9 human-monoclonal antibody. CONCLUSIONS: PCSK9-mediated generation of procoagulant EV could contribute to increase the prothrombotic status in patients with cardiovascular diseases.
    Keywords antibodies ; blood coagulation ; humans ; hypercholesterolemia ; liver ; low density lipoprotein ; lysosomes ; molecular biology ; subtilisin
    Language English
    Dates of publication 2022-05
    Size p. 4129-4134.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07433-x
    Database NAL-Catalogue (AGRICOLA)

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