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  1. Article ; Online: Abiotic Changes Driving Microphytoplankton Functional Diversity in Admiralty Bay, King George Island (Antarctica)

    Domênica Teixeira de Lima / Gleyci Aparecida Oliveira Moser / Fernanda Reinhardt Piedras / Leticia Cotrim da Cunha / Denise Rivera Tenenbaum / Márcio Murilo Barboza Tenório / Marcos Vinícius Pereira Borges de Campos / Thais de Oliveira Cornejo / José Juan Barrera-Alba

    Frontiers in Marine Science, Vol

    2019  Volume 6

    Abstract: Environmental gradients can provide habitat-specific scenarios for community functional diversity (FD) that determine the composition of populations on both spatial and temporal scales. The western shelf of the Antarctic Peninsula has experiencing ... ...

    Abstract Environmental gradients can provide habitat-specific scenarios for community functional diversity (FD) that determine the composition of populations on both spatial and temporal scales. The western shelf of the Antarctic Peninsula has experiencing increasing air temperatures while the climate is transitioning to a warm-humid sub-Antarctic-type of climate. As a consequence, abiotic changes are leading to alterations in the trophic web. Microphytoplankton FD was analyzed across environmental gradients of sea surface temperature, salinity, meltwater percentage and nutrient availability in Admiralty Bay, South Shetland Islands, Western Antarctic Peninsula. Samples were collected during the austral summer from 2009 to 2011 and from 2013 to 2015, at Admiralty Bay for which FD indices were calculated based on species traits. The amount of meltwater (MW) present in Admiralty Bay groups microphytoplankton into communities according to physiological and ecological tolerances, thus leading to a greater FD. When meltwater dominated the bay (>2.25% MW scenarios iii - 2013-14 and iv - 2014-15), diatoms and dinoflagellates were codominant. An increase in the dinoflagellate fraction of microplankton, notably with auxotrophic and mixotrophic nutrition mode, can be considered a trigger for changes in the structure of the Antarctic food web. Our results suggest using Admiralty Bay as a model for studies on changes in microphytoplankton community composition and FD.
    Keywords functional diversity ; microphytoplankton ; Antarctic ; abiotic variation ; meltwater ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 910
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Double Jeopardy: Precapillary Pulmonary Hypertension Increases the Risk of Hospitalization and Death from COVID-19.

    Alba, George A

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 5, Page(s) 526–528

    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Hypertension, Pulmonary/physiopathology ; Prospective Studies ; Pulmonary Wedge Pressure
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202205-0884ED
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  3. Article ; Online: Response.

    Okin, Daniel / Alba, George A / Bebell, Lisa M / Lai, Peggy S

    Chest

    2023  Volume 163, Issue 6, Page(s) e291

    Language English
    Publishing date 2023-06-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.02.043
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  4. Article ; Online: Response.

    Okin, Daniel / Huang, Ching-Ying / Alba, George A / Thompson, B Taylor / Bebell, Lisa M / Lai, Peggy S

    Chest

    2024  Volume 163, Issue 6, Page(s) e287–e288

    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.02.029
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  5. Article ; Online: Case 31-2018: A Man with a Self-Inflicted Gunshot Wound.

    Alba, George A / Dudzinski, David M

    The New England journal of medicine

    2018  Volume 380, Issue 4, Page(s) 400–401

    MeSH term(s) Humans ; Male ; Wounds, Gunshot
    Language English
    Publishing date 2018-11-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1815048
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  6. Article ; Online: Dynamic Contrast-enhanced MRI Demonstrates Pulmonary Microvascular Abnormalities Months After SARS-CoV-2 Infection.

    Zhou, Iris Y / Mascia, Molly / Alba, George A / Magaletta, Michael / Ginns, Leo C / Caravan, Peter / Montesi, Sydney B

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 12, Page(s) 1636–1639

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202210-1884LE
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  7. Article ; Online: Case 15-2022: A 57-Year-Old Man with Persistent Cough and Pulmonary Opacities.

    Knipe, Rachel S / Alba, George A / Harvey Barnes, Jeanna M / Hariri, Lida P

    The New England journal of medicine

    2022  Volume 386, Issue 20, Page(s) 1933–1944

    MeSH term(s) Cough/etiology ; Humans ; Lung Diseases/complications ; Lung Diseases/diagnostic imaging ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2201234
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  8. Article: Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction.

    Alba, George A / Zhou, Iris Y / Mascia, Molly / Magaletta, Michael / Alladina, Jehan W / Giacona, Francesca L / Ginns, Leo C / Caravan, Peter / Maron, Bradley A / Montesi, Sydney B

    Pulmonary circulation

    2024  Volume 14, Issue 1, Page(s) e12356

    Abstract: Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This ... ...

    Abstract Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12356
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  9. Article ; Online: Care-engaged individuals with polysubstance use in Northeastern US are undertreated for methamphetamine use disorder: a retrospective cohort study.

    Yen Li, Mimi / Alba, George A / Mitton, Julian / Bearnot, Benjamin

    Addiction science & clinical practice

    2021  Volume 16, Issue 1, Page(s) 57

    Abstract: Background: Stimulant use has increased across the US, with concomitant opioid and methamphetamine use doubling between 2011 and 2017. Shifting patterns of polysubstance use have led to rising psychostimulant-involved deaths. While it is known that ... ...

    Abstract Background: Stimulant use has increased across the US, with concomitant opioid and methamphetamine use doubling between 2011 and 2017. Shifting patterns of polysubstance use have led to rising psychostimulant-involved deaths. While it is known that individuals who use methamphetamine require greater access to treatment, there is still little known about methamphetamine use and treatment among individuals who are already engaged in outpatient substance use treatment.
    Objectives: To characterize care-engaged individuals who use methamphetamine to guide harm reduction and treatment strategies.
    Methods: Retrospective cohort study of individuals at a large academic medical center in Massachusetts with ≥ 2 positive methamphetamine oral fluid toxicology tests between August 2019 and January 2020. We performed descriptive analysis of sociodemographic, medical, and drug use characteristics and a comparative analysis of injection methamphetamine use versus other routes of use.
    Results: Included were 71 individuals [56 male (80%), 66 non-Hispanic white (94%), median age 36 (IQR 30-42)]. Nearly all had opioid (94%) and stimulant use disorder (92%). Most had (93%) or were (83%) being treated with medications for opioid use disorder, but few received pharmacologic treatment for methamphetamine use disorder (24%). None received contingency management treatment. People who inject methamphetamine (68%) were more likely to have a history of overdose (91% vs. 70%; p = 0.02), have HCV (94% vs. 52%; p < 0.01), use fentanyl (93% vs. 65%; p = 0.02), and engage in sex work (19% vs. 0%; p = 0.03) compared to those who used via other routes. Both groups had prevalent homelessness (88% vs. 73%; p = 0.15), incarceration (81% vs. 64%; p = 0.11), depression (94% vs. 87%; p = 0.34), and bacteremia (27% vs. 22%; p = 0.63).
    Conclusions: Individuals in our study had high prevalence of polysubstance use, particularly concomitant methamphetamine and opioid use. Individuals who were well connected to substance use treatment for their opioid use were still likely to be undertreated for their methamphetamine use disorder and would benefit from greater access to contingency management treatment, harm reduction resources, and resources to address adverse social determinants of health.
    MeSH term(s) Adult ; Analgesics, Opioid/therapeutic use ; Central Nervous System Stimulants/adverse effects ; Cohort Studies ; Drug Overdose/drug therapy ; Humans ; Male ; Methamphetamine/adverse effects ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/epidemiology ; Retrospective Studies
    Chemical Substances Analgesics, Opioid ; Central Nervous System Stimulants ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2021-09-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2492632-2
    ISSN 1940-0640 ; 1940-0640
    ISSN (online) 1940-0640
    ISSN 1940-0640
    DOI 10.1186/s13722-021-00267-1
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  10. Article ; Online: Care-engaged individuals with polysubstance use in Northeastern US are undertreated for methamphetamine use disorder

    Mimi Yen Li / George A. Alba / Julian Mitton / Benjamin Bearnot

    Addiction Science & Clinical Practice, Vol 16, Iss 1, Pp 1-

    a retrospective cohort study

    2021  Volume 9

    Abstract: Abstract Background Stimulant use has increased across the US, with concomitant opioid and methamphetamine use doubling between 2011 and 2017. Shifting patterns of polysubstance use have led to rising psychostimulant-involved deaths. While it is known ... ...

    Abstract Abstract Background Stimulant use has increased across the US, with concomitant opioid and methamphetamine use doubling between 2011 and 2017. Shifting patterns of polysubstance use have led to rising psychostimulant-involved deaths. While it is known that individuals who use methamphetamine require greater access to treatment, there is still little known about methamphetamine use and treatment among individuals who are already engaged in outpatient substance use treatment. Objectives To characterize care-engaged individuals who use methamphetamine to guide harm reduction and treatment strategies. Methods Retrospective cohort study of individuals at a large academic medical center in Massachusetts with ≥ 2 positive methamphetamine oral fluid toxicology tests between August 2019 and January 2020. We performed descriptive analysis of sociodemographic, medical, and drug use characteristics and a comparative analysis of injection methamphetamine use versus other routes of use. Results Included were 71 individuals [56 male (80%), 66 non-Hispanic white (94%), median age 36 (IQR 30–42)]. Nearly all had opioid (94%) and stimulant use disorder (92%). Most had (93%) or were (83%) being treated with medications for opioid use disorder, but few received pharmacologic treatment for methamphetamine use disorder (24%). None received contingency management treatment. People who inject methamphetamine (68%) were more likely to have a history of overdose (91% vs. 70%; p = 0.02), have HCV (94% vs. 52%; p < 0.01), use fentanyl (93% vs. 65%; p = 0.02), and engage in sex work (19% vs. 0%; p = 0.03) compared to those who used via other routes. Both groups had prevalent homelessness (88% vs. 73%; p = 0.15), incarceration (81% vs. 64%; p = 0.11), depression (94% vs. 87%; p = 0.34), and bacteremia (27% vs. 22%; p = 0.63). Conclusions Individuals in our study had high prevalence of polysubstance use, particularly concomitant methamphetamine and opioid use. Individuals who were well connected to substance use treatment for their opioid ...
    Keywords Methamphetamine ; Opioid crisis ; Harm reduction ; Stimulants ; Drug overdose ; Medicine (General) ; R5-920 ; Social pathology. Social and public welfare. Criminology ; HV1-9960
    Subject code 360
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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