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Article ; Online: Hypersensitivity Pneumonitis: Challenges of a Complex Disease.

Calaras, Diana / David, Aliona / Vasarmidi, Eirini / Antoniou, Katerina / Corlateanu, Alexandru

2024 Volume 2024, Page(s) 4919951

Abstract: Hypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of ... ...

Abstract	Hypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of inciting antigens causing hypersensitivity pneumonitis have been found to cover a wide range of occupations. As working practices have changed over time, especially in industrialized countries, new names for occupational HP have emerged. This review emphasizes the main diagnostic issues arising from the high variability of clinical presentation and the broad spectrum of causal antigens. Furthermore, it provides an overview of current methods to unveil possible causes of hypersensitivity pneumonitis, highlights HP's current diagnostic and treatment challenges and the remaining areas of uncertainty, and presents prevention strategies.
MeSH term(s)	Humans ; Lung ; Alveolitis, Extrinsic Allergic/diagnosis ; Alveolitis, Extrinsic Allergic/etiology ; Alveolitis, Extrinsic Allergic/drug therapy ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/therapy ; Antigens/therapeutic use ; Occupational Exposure/adverse effects
Chemical Substances	Antigens
Language	English
Publishing date	2024-01-18
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	1213103-9
ISSN	1916-7245 ; 1198-2241
ISSN (online)	1916-7245
ISSN	1198-2241
DOI	10.1155/2024/4919951
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Article ; Online: Whatever 'smells' like COVID-19 is not always COVID-19.

Vasarmidi, Eirini / Hindre, Raphael / Uzunhan, Yurdagül / Borie, Raphael / Crestani, Bruno

Rheumatology advances in practice

2022 Volume 6, Issue 2, Page(s) rkac063

Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Case Reports
ISSN	2514-1775
ISSN (online)	2514-1775
DOI	10.1093/rap/rkac063
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Article ; Online: Interstitial lung disease following coronavirus disease 2019.

Vasarmidi, Eirini / Ghanem, Mada / Crestani, Bruno

Current opinion in pulmonary medicine

2022 Volume 28, Issue 5, Page(s) 399–406

Abstract: Purpose of review: The aim of this review was to summarize the recent data concerning interstitial lung disease after COVID-19, a field where knowledge is evolving very quickly.: Recent findings: It has been found that a proportion of patients ... ...

Abstract	Purpose of review: The aim of this review was to summarize the recent data concerning interstitial lung disease after COVID-19, a field where knowledge is evolving very quickly. Recent findings: It has been found that a proportion of patients displayed fibrotic-like pattern on chest computed tomography shortly after COVID-19 pneumonia. Those lesions can potentially represent precursors of fibrosis, although most of them will resolve until 1 year postinfection. There was a wide range of the prevalence of post-COVID-19 interstitial lung disease detected in the literature, which can be attributed to the heterogeneous definition of lung abnormalities and the discrepancy of study design. The severity of acute COVID-19 disease has been linked to increased risk of residual imaging and functional abnormalities, while reduced DLco was the most common functional abnormality in long-term survivors. Studies indicated that pathophysiology of post-COVID interstitial lung disease shares common mechanisms with idiopathic pulmonary fibrosis. Regarding therapeutic strategies of post-COVID-19 interstitial lung disease, the role of immunosuppressive and antifibrotic treatment is currently under investigation. Summary: We still need to learn about the natural history of COVID-19 disease, allowing for a better targeting of therapeutic interventions through a multidisciplinary approach.
MeSH term(s)	COVID-19/complications ; Humans ; Idiopathic Pulmonary Fibrosis ; Lung ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/etiology ; Respiratory Function Tests
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1285505-4
ISSN	1531-6971 ; 1070-5287 ; 1078-1641
ISSN (online)	1531-6971
ISSN	1070-5287 ; 1078-1641
DOI	10.1097/MCP.0000000000000900
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Article: Reversibility of the Enlargement of the Pulmonary Artery in COVID-19 Pneumonia as a Marker of Remission of the Disease.

Matthaiou, Andreas M / Bizymi, Nikoleta / Pagonidis, Konstantinos / Manousaki, Eirini / Fragkoulakis, Michail / Lambiri, Irini / Mitrouska, Ioanna / Vasarmidi, Eirini / Tzanakis, Nikolaos / Antoniou, Katerina M

Journal of personalized medicine

2024 Volume 14, Issue 2

Abstract: Coronavirus disease 2019 (COVID-19) pneumonia is associated with extensive pulmonary microangiopathy and the enlargement of the pulmonary artery (PA), while its progression after the remission of the disease has not been investigated yet. The aim was to ... ...

Abstract	Coronavirus disease 2019 (COVID-19) pneumonia is associated with extensive pulmonary microangiopathy and the enlargement of the pulmonary artery (PA), while its progression after the remission of the disease has not been investigated yet. The aim was to assess the diametral increase in the PA in COVID-19 pneumonia, as revealed on chest computed tomography (CT), and further investigate its progression. This was a retrospective cohort study of patients with COVID-19 pneumonia, without prior history of pulmonary hypertension, who underwent CT pulmonary angiography before, during, and after the infection. Pulmonary embolism was excluded in all cases. The main PA diameter (MPAD) was assessed in consecutive chest imaging. Statistical analysis was performed with the non-parametric Wilcoxon and Kruskal-Wallis tests, while correlations were performed with the non-parametric Spearman test. A mean ± SD MPAD of 3.1 ± 0.3 cm in COVID-19 pneumonia was significantly decreased to 2.8 ± 0.3 cm in the post-infectious state after 2-18 months in 31 patients (
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14020161
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Article: Pulmonary fibrosis in the aftermath of the COVID-19 era (Review).

Vasarmidi, Eirini / Tsitoura, Eliza / Spandidos, Demetrios A / Tzanakis, Nikolaos / Antoniou, Katerina M

Experimental and therapeutic medicine

2020 Volume 20, Issue 3, Page(s) 2557–2560

Abstract: The year 2020 is characterized by the COVID-19 pandemic that has resulted in more than half a million deaths in recent months. The high mortality is associated with acute severe respiratory failure that results in ICU admission and intubation. While ... ...

Abstract	The year 2020 is characterized by the COVID-19 pandemic that has resulted in more than half a million deaths in recent months. The high mortality is associated with acute severe respiratory failure that results in ICU admission and intubation. While facing this fatal disease, research and clinical observations need to be carried out in order to evaluate the long-term effects of the COVID-19 acute respiratory distress syndrome (ARDS). Potent clinical and laboratory biomarkers should be studied to be able to predict the subgroup of patients that are going to deteriorate or develop lung fibrosis. The opportunity of personalized medicine is a good way to consider for these patients.
Keywords	covid19
Language	English
Publishing date	2020-07-09
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2020.8980
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Article ; Online: Assessing feasibility of targeted primary care referrals for patients with clinical suspicion of interstitial lung disease using lung ultrasound: a prospective case finding study. The potential benefits of LUS utilization.

Symvoulakis, Emmanouil / Vasarmidi, Eirini / Linardakis, Manolis / Tsiavos, Alexandros / Mantadaki, Aikaterini / Pitsidianakis, Georgios / Karelis, Andreas / Petraki, Chrysi / Nioti, Kadiani / Mastronikolis, Stelios / Tzanakis, Nikolaos / Eraclion Crete, Antoniou K

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

2023 Volume 40, Issue 2, Page(s) e2023022

Abstract: Background: In Primary Health Care (PHC) many interstitial lung disease (ILD) cases may remain at diagnostic delay, due to their challenging presentation and the limited experience of general practitioners (GPs) in recognizing their early symptoms.: ... ...

Abstract	Background: In Primary Health Care (PHC) many interstitial lung disease (ILD) cases may remain at diagnostic delay, due to their challenging presentation and the limited experience of general practitioners (GPs) in recognizing their early symptoms. Objective: We have designed a feasibility study to investigate early ILD case-finding competency between PHC and tertiary care. Methods: A cross-sectional prospective case-finding study was launched at two private health care centers of Heraklion, Crete, Greece, during nine months (2021-2022). After clinical assessment by GP, PHC attenders, who agreed to participate in the study, were referred to the Respiratory Medicine Department, University Hospital of Heraklion, Crete, underwent Lung Ultrasound (LUS) and those with an overall suspicion for ILDs underwent high resolution computed tomography (HRCT) scan. Descriptive statistics and chi-square tests were used. Multiple Poisson regression analysis was performed to explain positive LUS and HRCT decision with selected variables. Results: One hundred and nine patients out of 183 were finally included (54.1% females; mean age 61, SD: 8.3 years). Thirty-five (32.1%) were current smokers. Overall, two out of ten cases were assessed to need HRCT due to a moderate or high suspicion (19.3%; 95%CI 12.7, 27.4). However, in those who had dyspnea in relation to counterparts, a significantly higher percentage of patients with LUS findings (57.9% vs. 34.0%, p=0.013) was found, as in those who had crackles (100.0% vs. 44.2%, p= 0.005). Detected possible ILD provisional labelling cases were 6, and most importantly, 5 of those cases were considered highly suspicious for further evaluation based on LUS findings. Conclusions: This is a feasibility study exploring potentials by combining data of medical history, basic auscultation skills, as crackles detection, and inexpensive and radiation-free imaging technique, such as LUS. Cases of ILD labeling may be hidden within PHC, sometimes, much before any clinical manifestation.
Language	English
Publishing date	2023-06-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1339192-6
ISSN	2532-179X ; 1124-0490
ISSN (online)	2532-179X
ISSN	1124-0490
DOI	10.36141/svdld.v40i2.14017
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Article ; Online: Interstitial lung abnormalities: ignotum per ignotius.

Antoniou, Katerina M / Tzilas, Vasilios / Vasarmidi, Eirini / Symvoulakis, Emmanouil K / Tzouvelekis, Argyris / Bouros, Demosthenes

The Lancet. Respiratory medicine

2019 Volume 7, Issue 5, Page(s) 376–378

MeSH term(s)	Galectin 3/therapeutic use ; Humans ; Lung/diagnostic imaging ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/drug therapy ; Tomography, X-Ray Computed/methods
Chemical Substances	Galectin 3
Language	English
Publishing date	2019-03-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2686754-0
ISSN	2213-2619 ; 2213-2600
ISSN (online)	2213-2619
ISSN	2213-2600
DOI	10.1016/S2213-2600(19)30052-9
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Article ; Online: Precision medicine in idiopathic pulmonary fibrosis therapy: From translational research to patient-centered care.

Antoniou, Katerina M / Tsitoura, Eliza / Vasarmidi, Eirini / Symvoulakis, Emmanouil K / Aidinis, Vassilis / Tzilas, Vassilis / Tzouvelekis, Argyris / Bouros, Demosthenes

Current opinion in pharmacology

2021 Volume 57, Page(s) 71–80

Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic chronic lung disease affecting predominantly older adults, with a history of smoking. The current model of disease natural course is that recurrent injury of the alveolar ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic chronic lung disease affecting predominantly older adults, with a history of smoking. The current model of disease natural course is that recurrent injury of the alveolar epithelium in the context of advanced aging/cellular senescence is followed by defective re-epithelialization and scar tissue formation. Currently, two drugs, nintedanib and pirfenidone, that modify disease progression have been approved worldwide for the treatment of IPF. However, despite treatment, patients with IPF are not cured, and eventually, disease advances in most treated patients. Enhancing biogenomic and metabolic research output, its translation into clinical precision and optimal service delivery through patient-centeredness are key elements to support effective IPF care. In this review, we summarize therapeutic options currently investigated for IPF based on the major pathogenetic pathways and molecular targets that drive pulmonary fibrosis.
MeSH term(s)	Aged ; Fibrosis ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Patient-Centered Care ; Precision Medicine ; Translational Medical Research
Language	English
Publishing date	2021-02-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2020.12.007
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Article ; Online: Herpes simplex virus type-1 infection affects the expression of extracellular matrix components in human nucleus pulposus cells.

Alpantaki, Kalliopi / Zafiropoulos, Alexandros / Tseliou, Melpomeni / Vasarmidi, Eirini / Sourvinos, George

Virus research

2018 Volume 259, Page(s) 10–17

Abstract: Intervertebral disc (IVD) degeneration has a complex multifactorial origin and it is tightly associated with changes in the secretion of proteoglycans and collagen of the Nucleus Pulposus (NP) extracellular matrix. Chronic infection by Herpes virus has ... ...

Abstract	Intervertebral disc (IVD) degeneration has a complex multifactorial origin and it is tightly associated with changes in the secretion of proteoglycans and collagen of the Nucleus Pulposus (NP) extracellular matrix. Chronic infection by Herpes virus has been previously associated with disc degeneration after detection of Herpes Simplex Virus type-1 (HSV-1) and CMV DNA in human excised disc samples. The aim of the present study was to assess the effect of HSV-1 infection on proteoglycan synthesis employing human Nucleus Pulposus (HNPCs) cells as a model of intervertebral disc degeneration. During lytic HSV-1 infection, a significant reduction of Decorin expression was observed 8 h post infection (h.p.i) which furthered deteriorated at 24 h.p.i. Biglycan was also reduced but only 24 h.p.i. Collagen type II, although demonstrated a downward trend, it was not statistically significant, whereas both Versican and Aggrecan showed a substantial decrease at 24 h.p.i. Hyaluronan production was not significantly affected. In a non-productive HSV-1 infection, a substantial reduction of Decorin, Biglycan, Versican and Aggrecan expression was found, similarly to our findings from the lytic infection. Furthermore, collagen type II expression was completely abolished. HAS1 expression was not affected, whereas HAS 2 and 3 were found to be significantly reduced. These results indicate that HSV-1 infection of human NP cells yields a complex effect on host extracellular cell function. The viral-induced changes in proteoglycan and collagen type II concentration may affect cell-matrix interactions and lead to a dysfunctional intervertebral disc which may trigger or promote the degeneration process.
MeSH term(s)	Animals ; Biomarkers ; Cell Line ; Extracellular Matrix/metabolism ; Gene Expression ; Herpes Simplex/genetics ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Herpesvirus 1, Human ; Humans ; Intervertebral Disc/cytology ; Intervertebral Disc/metabolism ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/etiology ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/pathology ; Magnetic Resonance Imaging/methods ; Microscopy, Fluorescence ; Nucleus Pulposus/cytology ; Nucleus Pulposus/metabolism ; Proteoglycans/metabolism
Chemical Substances	Biomarkers ; Proteoglycans
Language	English
Publishing date	2018-10-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2018.10.010
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Article ; Online: FGF19 Is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits Lung Fibrosis in Mice.

Justet, Aurélien / Ghanem, Mada / Boghanim, Tiara / Hachem, Mouna / Vasarmidi, Eirini / Jaillet, Madeleine / Vadel, Aurélie / Joannes, Audrey / Mordant, Pierre / Bonniaud, Philippe / Kolb, Martin / Ling, Lei / Cazes, Aurélie / Mal, Hervé / Mailleux, Arnaud / Crestani, Bruno

American journal of respiratory cell and molecular biology

2022 Volume 67, Issue 2, Page(s) 173–187

Abstract: Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited therapeutic possibilities. FGF19 (fibroblast growth factor 19), an endocrine FGF, was recently shown to decrease liver fibrosis. To ask whether FGF19 had antifibrotic ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited therapeutic possibilities. FGF19 (fibroblast growth factor 19), an endocrine FGF, was recently shown to decrease liver fibrosis. To ask whether FGF19 had antifibrotic properties in the lung and decipher its effects on common features associated with lung fibrogenesis, we assessed, by ELISA, FGF19 concentrations in plasma and BAL fluids obtained from control subjects and patients with IPF.
MeSH term(s)	Animals ; Bleomycin/pharmacology ; Collagen/metabolism ; Fibroblast Growth Factors/metabolism ; Fibroblast Growth Factors/pharmacology ; Fibroblast Growth Factors/therapeutic use ; Fibroblasts/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Lung/metabolism ; Mice ; Myofibroblasts/metabolism ; Transforming Growth Factor beta/metabolism
Chemical Substances	FGF19 protein, human ; Transforming Growth Factor beta ; Bleomycin (11056-06-7) ; Fibroblast Growth Factors (62031-54-3) ; Collagen (9007-34-5)
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2021-0246OC
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