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Article ; Online: Beware of Invisible Chest Wall Veins.

Salguero, Bertin D / Shujaat, Adil

American journal of respiratory and critical care medicine

2019 Volume 201, Issue 5, Page(s) 606

MeSH term(s)	Aged, 80 and over ; Brachiocephalic Veins/diagnostic imaging ; Constriction, Pathologic ; Hemorrhage/etiology ; Humans ; Male ; Pharyngeal Neoplasms/radiotherapy ; Radiotherapy ; Thoracentesis/adverse effects ; Thoracic Surgery, Video-Assisted ; Thoracic Wall/blood supply ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-09-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201812-2358IM
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Article ; Online: Phosphorus and Serendipita indica synergism augments arsenic stress tolerance in rice by regulating secondary metabolism related enzymatic activity and root metabolic patterns.

Sehar, Shafaque / Adil, Muhammad Faheem / Ma, Zhengxin / Karim, Muhammad Fazal / Faizan, Mohammad / Zaidi, Syed Shujaat Ali / Siddiqui, Manzer H / Alamri, Saud / Zhou, Fanrui / Shamsi, Imran Haider

Ecotoxicology and environmental safety

2023 Volume 256, Page(s) 114866

Abstract: The multifarious problems created by arsenic (As), for collective environment and human health, serve a cogent case for searching integrative agricultural approaches to attain food security. Rice (Oryza sativa L.) acts as a sponge for heavy metal(loid)s ... ...

Abstract	The multifarious problems created by arsenic (As), for collective environment and human health, serve a cogent case for searching integrative agricultural approaches to attain food security. Rice (Oryza sativa L.) acts as a sponge for heavy metal(loid)s accretion, specifically As, due to anaerobic flooded growth conditions facilitating its uptake. Acclaimed for their positive impact on plant growth, development and phosphorus (P) nutrition, 'mycorrhizas' are able to promote stress tolerance. Albeit, the metabolic alterations underlying Serendipita indica (S. indica; S.i) symbiosis-mediated amelioration of As stress along with nutritional management of P are still understudied. By using biochemical, RT-qPCR and LC-MS/MS based untargeted metabolomics approach, rice roots of ZZY-1 and GD-6 colonized by S. indica, which were later treated with As (10 µM) and P (50 µM), were compared with non-colonized roots under the same treatments with a set of control plants. The responses of secondary metabolism related enzymes, especially polyphenol oxidase (PPO) activities in the foliage of ZZY-1 and GD-6 were enhanced 8.5 and 12-fold, respectively, compared to their respective control counterparts. The current study identified 360 cationic and 287 anionic metabolites in rice roots, and the commonly enriched pathway annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was biosynthesis of phenylalanine, tyrosine and tryptophan, which validated the results of biochemical and gene expression analyses associated with secondary metabolic enzymes. Particularly under As+S.i+P comparison, both genotypes exhibited an upregulation of key detoxification and defense related metabolites, including fumaric acid, L-malic acid, choline, 3,4-dihydroxybenzoic acid, to name a few. The results of this study provided the novel insights into the promising role of exogenous P and S. indica in alleviating As stress.
MeSH term(s)	Humans ; Arsenic/toxicity ; Chromatography, Liquid ; Oryza/metabolism ; Oryza/microbiology ; Phosphorus/analysis ; Plant Roots/metabolism ; Secondary Metabolism ; Tandem Mass Spectrometry ; Soil Pollutants/toxicity
Chemical Substances	Arsenic (N712M78A8G) ; Phosphorus (27YLU75U4W) ; Soil Pollutants
Language	English
Publishing date	2023-04-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.114866
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Article ; Online: Phosphorus and Serendipita indica synergism augments arsenic stress tolerance in rice by regulating secondary metabolism related enzymatic activity and root metabolic patterns

Shafaque Sehar / Muhammad Faheem Adil / Zhengxin Ma / Muhammad Fazal Karim / Mohammad Faizan / Syed Shujaat Ali Zaidi / Manzer H. Siddiqui / Saud Alamri / Fanrui Zhou / Imran Haider Shamsi

Ecotoxicology and Environmental Safety, Vol 256, Iss , Pp 114866- (2023)

2023

Abstract	The multifarious problems created by arsenic (As), for collective environment and human health, serve a cogent case for searching integrative agricultural approaches to attain food security. Rice (Oryza sativa L.) acts as a sponge for heavy metal(loid)s accretion, specifically As, due to anaerobic flooded growth conditions facilitating its uptake. Acclaimed for their positive impact on plant growth, development and phosphorus (P) nutrition, ‘mycorrhizas’ are able to promote stress tolerance. Albeit, the metabolic alterations underlying Serendipita indica (S. indica; S.i) symbiosis-mediated amelioration of As stress along with nutritional management of P are still understudied. By using biochemical, RT-qPCR and LC-MS/MS based untargeted metabolomics approach, rice roots of ZZY-1 and GD-6 colonized by S. indica, which were later treated with As (10 µM) and P (50 µM), were compared with non-colonized roots under the same treatments with a set of control plants. The responses of secondary metabolism related enzymes, especially polyphenol oxidase (PPO) activities in the foliage of ZZY-1 and GD-6 were enhanced 8.5 and 12-fold, respectively, compared to their respective control counterparts. The current study identified 360 cationic and 287 anionic metabolites in rice roots, and the commonly enriched pathway annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was biosynthesis of phenylalanine, tyrosine and tryptophan, which validated the results of biochemical and gene expression analyses associated with secondary metabolic enzymes. Particularly under As+S.i+P comparison, both genotypes exhibited an upregulation of key detoxification and defense related metabolites, including fumaric acid, L-malic acid, choline, 3,4-dihydroxybenzoic acid, to name a few. The results of this study provided the novel insights into the promising role of exogenous P and S. indica in alleviating As stress.
Keywords	Endomycorrhizae ; Metal stress ; Oryza sativa L ; Phosphorus ; RT-qPCR ; Metabolomics ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	580
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Optimization of preload in severe sepsis and septic shock.

Shujaat, Adil / Bajwa, Abubakr A

Critical care research and practice

2012 Volume 2012, Page(s) 761051

Abstract: In sepsis both under- and overresuscitation are associated with increased morbidity and mortality. Moreover, sepsis can be complicated by myocardial dysfunction, and only half of the critically ill patients exhibit preload responsiveness. It is of ... ...

Abstract	In sepsis both under- and overresuscitation are associated with increased morbidity and mortality. Moreover, sepsis can be complicated by myocardial dysfunction, and only half of the critically ill patients exhibit preload responsiveness. It is of paramount importance to accurately, safely, and rapidly determine and optimize preload during resuscitation. Traditional methods of determining preload based on measurement of pressure in a heart chamber or volume of a heart chamber ("static" parameters) are inaccurate and should be abandoned in favor of determining preload responsiveness by using one of the "dynamic parameters" based on respiratory variation in the venous or arterial circulation or based on change in stroke volume in response to an endogenous or exogenous volume challenge. The recent development and validation of a number of noninvasive technologies now allow us to optimize preload in an accurate, safe, rapid and, cost-effective manner.
Language	English
Publishing date	2012-08-07
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2573849-5
ISSN	2090-1313 ; 2090-1305
ISSN (online)	2090-1313
ISSN	2090-1305
DOI	10.1155/2012/761051
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Article ; Online: Reducing length of stay with the direct oral anti-coagulants in low and intermediate risk pulmonary embolism: a single center experience.

Filopei, Jason / Bondarsky, Eric E / Ehrlich, Madeline / Islam, Marjan / Bajpayee, Gargi / Pang, Daniel / Shujaat, Adil / Rowland, John / Steiger, David J

Journal of thrombosis and thrombolysis

2020 Volume 50, Issue 2, Page(s) 399–407

Abstract: Direct oral anti-coagulants (DOACs) reduce hospital length-of-stay (LOS) in patients with acute pulmonary embolism (PE) in clinical trials. There is a paucity of literature describing real world utility of DOACs, particularly in intermediate-risk ... ...

Abstract	Direct oral anti-coagulants (DOACs) reduce hospital length-of-stay (LOS) in patients with acute pulmonary embolism (PE) in clinical trials. There is a paucity of literature describing real world utility of DOACs, particularly in intermediate-risk patients. To evaluate if the utilization of DOACs vs. non-DOACs in acute PE patients, reduces LOS without a difference in safety in patients defined as low and intermediate-risk of mortality by the European Society of Cardiology. This was a retrospective cohort study of prospectively collected data from a single center registry of consecutive adult outpatients diagnosed with acute PE who survived to hospital discharge. Primary outcome was median hospital LOS. Secondary outcomes were 30-day readmission, survival, and incidence of major and minor bleeding. There were 307 outpatients admitted with acute PE 88 (28.7%) low-risk, 213 (69.4%) intermediate-risk, and 6 (2.0%) high-risk. Two hundred and twenty-six (73.6%) received a DOAC. There was a statistically significant shorter median LOS in all patients treated with a DOAC (2.9 days, IQR 1.8-4.7) vs non-DOAC (4.9 days, IQR 3-8.9) (Generalized Linear Model p < 0.001). There was a shorter median LOS between intermediate-risk patients treated with a DOAC (3.6 days, IQR 2-5.8) vs non-DOAC (5, IQR 3-9). There was no difference in 30-day readmission, survival, or bleeding complications in both cohorts. There was a reduction in LOS in low and intermediate risk patients treated with a DOAC without a difference in 30-day safety and efficacy. Treating acute PE patients with DOACs including intermediate-risk patients, compared to conventional anticoagulation, may facilitate early discharge, and potentially reduce hospital costs.
MeSH term(s)	Adult ; Aged ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/therapeutic use ; Female ; Hemorrhage/chemically induced ; Humans ; Length of Stay ; Male ; Middle Aged ; Patient Discharge ; Patient Readmission ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/mortality ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Chemical Substances	Factor Xa Inhibitors
Language	English
Publishing date	2020-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02045-3
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Zs.A 4352: Show issues

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Article: An unusual case of cirrhosis.

Alkaddour, Ahmad / Vega, Kenneth J / Shujaat, Adil

Case reports in gastrointestinal medicine

2014 Volume 2014, Page(s) 670176

Abstract: 49-year-old white female with remote h/o sarcoidosis was referred to GI when her liver was noted to be nodular. Physical examination revealed normal vital signs and no icterus, spider nevi, clubbing, ascites, hepatosplenomegaly, or ankle edema. LFTs, ... ...

Abstract	49-year-old white female with remote h/o sarcoidosis was referred to GI when her liver was noted to be nodular. Physical examination revealed normal vital signs and no icterus, spider nevi, clubbing, ascites, hepatosplenomegaly, or ankle edema. LFTs, hepatitis serologies, ANA, AMA, ASMA, Ferritin, Ceruloplasmin, and α 1-AT, level were unremarkable. Liver biopsy showed cirrhosis. She developed worsening of baseline SOB and was hospitalized. She was eventually diagnosed with constrictive pericarditis. A diagnosis of cardiac cirrhosis was made.
Language	English
Publishing date	2014-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627636-7
ISSN	2090-6536 ; 2090-6528
ISSN (online)	2090-6536
ISSN	2090-6528
DOI	10.1155/2014/670176
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Article ; Online: Inflammatory pseudotumor of the pleura.

Girdhar, Ankur / Singh, Amita / Bajwa, Abubakr / Shujaat, Adil

Journal of bronchology & interventional pulmonology

2014 Volume 21, Issue 2, Page(s) 154–157

Abstract: Inflammatory pseudotumors are rare solid, non-neoplastic masses that can mimic pulmonary malignancy. It occurs most commonly in children and young adults and is usually found incidentally. There are many reports of the existence of this tumor in various ... ...

Abstract	Inflammatory pseudotumors are rare solid, non-neoplastic masses that can mimic pulmonary malignancy. It occurs most commonly in children and young adults and is usually found incidentally. There are many reports of the existence of this tumor in various organs in the human body. The occurrence of this tumor exclusively in the pleura has not been described before. We present a case of inflammatory pseudotumor of the pleura and its successful management.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Biopsy ; Child ; Drainage ; Exudates and Transudates/cytology ; Female ; Granuloma, Plasma Cell/diagnostic imaging ; Granuloma, Plasma Cell/pathology ; Granuloma, Plasma Cell/surgery ; Humans ; Inflammation/metabolism ; Pleural Diseases/diagnostic imaging ; Pleural Diseases/pathology ; Pleural Diseases/surgery ; Recurrence ; Thoracic Surgery, Video-Assisted/methods ; Thoracoscopy ; Tomography, X-Ray Computed
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000070
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Zs.A 4027: Show issues

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Article ; Online: Optimization of Preload in Severe Sepsis and Septic Shock

Adil Shujaat / Abubakr A. Bajwa

Critical Care Research and Practice, Vol

2012 Volume 2012

Abstract	In sepsis both under- and overresuscitation are associated with increased morbidity and mortality. Moreover, sepsis can be complicated by myocardial dysfunction, and only half of the critically ill patients exhibit preload responsiveness. It is of paramount importance to accurately, safely, and rapidly determine and optimize preload during resuscitation. Traditional methods of determining preload based on measurement of pressure in a heart chamber or volume of a heart chamber (“static” parameters) are inaccurate and should be abandoned in favor of determining preload responsiveness by using one of the “dynamic parameters” based on respiratory variation in the venous or arterial circulation or based on change in stroke volume in response to an endogenous or exogenous volume challenge. The recent development and validation of a number of noninvasive technologies now allow us to optimize preload in an accurate, safe, rapid and, cost-effective manner.
Keywords	Internal medicine ; RC31-1245 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article: How an Opportunistic Infection Can Mess with Your Brain and Take Your Breath Away: A Rare Case of Simultaneous Lung and Brain Abscess due to Streptococcus anginosus.

Al-Saffar, Farah / Torres-Miranda, Daisy / Ibrahim, Saif / Shujaat, Adil

Case reports in infectious diseases

2015 Volume 2015, Page(s) 462459

Abstract: Streptococcus anginosus (S. anginosus) is considered a friendly bug and is a one of many different bacteria that constitute the normal flora of the oral cavity. Nevertheless, it has been infrequently associated with more invasive infections, like lung ... ...

Abstract	Streptococcus anginosus (S. anginosus) is considered a friendly bug and is a one of many different bacteria that constitute the normal flora of the oral cavity. Nevertheless, it has been infrequently associated with more invasive infections, like lung abscess. It is extremely rare to have multisystemic involvement with S. anginosus group. We present a unique case of pulmonary and brain abscess due to S. anginosus in an immunocompetent patient.
Language	English
Publishing date	2015-04-01
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2627642-2
ISSN	2090-6633 ; 2090-6625
ISSN (online)	2090-6633
ISSN	2090-6625
DOI	10.1155/2015/462459
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Article: A Large Pleural Effusion following Abdominal Aortic Surgery.

Ramsaran, Vinoo K / Seeram, Vandana K / Cury, James / Shujaat, Adil

Case reports in pulmonology

2015 Volume 2015, Page(s) 254010

Abstract: Chylous ascites and coexistent chylothorax is a rare but important complication following retroperitoneal abdominal surgery. We report a 70-year-old male who developed gradual abdominal distension, chest tightness, and dyspnea five months after having an ...

Abstract	Chylous ascites and coexistent chylothorax is a rare but important complication following retroperitoneal abdominal surgery. We report a 70-year-old male who developed gradual abdominal distension, chest tightness, and dyspnea five months after having an uncomplicated aortobifemoral bypass performed. Physical examination was consistent with a large right sided effusion and ascites which were confirmed by computed tomography. Thoracentesis yielded an opaque milky fluid with analysis consistent with a chylothorax with a paracentesis revealing fluid that was similar in both appearance and biochemistry. The patient failed initial conservative management so a chest tube was placed followed by chemical pleurodesis. We review the literature of the pathophysiology and treatment approach to such a pleural effusion.
Language	English
Publishing date	2015-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2666707-1
ISSN	2090-6854 ; 2090-6846
ISSN (online)	2090-6854
ISSN	2090-6846
DOI	10.1155/2015/254010
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