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  1. Article ; Online: A mutation 'hot spot' in the Schmallenberg virus M segment.

    Fischer, Melina / Hoffmann, Bernd / Goller, Katja V / Höper, Dirk / Wernike, Kerstin / Beer, Martin

    The Journal of general virology

    2013  Volume 94, Issue Pt 6, Page(s) 1161–1167

    Abstract: ... of the Simbu serogroup have been performed, and detailed data on the S and M segments, relevant for virus-host ... cell interaction, have been missing. In this study, we investigated the S- and M-segment sequences obtained from 24 ... a mutation 'hot spot') within the glycoprotein Gc encoded by the M segment. ...

    Abstract In the autumn of 2011, Schmallenberg virus (SBV), a novel orthobunyavirus of the Simbu serogroup, was identified by metagenomic analysis in Germany. SBV has since been detected in ruminants all over Europe, and investigations on phylogenetic relationships, clinical signs and epidemiology have been conducted. However, until now, only comparative sequence analysis of SBV genome segments with other species of the Simbu serogroup have been performed, and detailed data on the S and M segments, relevant for virus-host-cell interaction, have been missing. In this study, we investigated the S- and M-segment sequences obtained from 24 SBV-positive field samples from sheep, cattle and a goat collected from all over Germany. The results obtained indicated that the overall genome variability of SBV is neither regionally nor host species dependent. Nevertheless, we characterized for the first time a region of high sequence variability (a mutation 'hot spot') within the glycoprotein Gc encoded by the M segment.
    MeSH term(s) Animals ; Base Sequence ; Bunyaviridae Infections/veterinary ; Bunyaviridae Infections/virology ; Cattle ; Cattle Diseases/virology ; Europe ; Goat Diseases/virology ; Goats ; Molecular Sequence Data ; Mutation ; Orthobunyavirus/chemistry ; Orthobunyavirus/classification ; Orthobunyavirus/genetics ; Orthobunyavirus/metabolism ; Phylogeny ; Sheep ; Sheep Diseases/virology ; Viral Matrix Proteins/chemistry ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/metabolism
    Chemical Substances Viral Matrix Proteins
    Language English
    Publishing date 2013-01-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/vir.0.049908-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A mutation ‘hot spot’ in the Schmallenberg virus M segment

    Fischer, Melina / Hoffmann, Bernd / Goller, Katja Verena / Höper, Dirk / Wernike, Kerstin / Beer, Martin

    2013  

    Abstract: ... of the Simbu serogroup have been performed, and detailed data on the S and M segments, relevant for virus–host ... cell interaction, have been missing. In this study, we investigated the S- and M-segment sequences obtained from 24 ... a mutation ‘hot spot’) within the glycoprotein Gc encoded by the M segment. The GenBank/EMBL/DDBJ accession ...

    Abstract In the autumn of 2011, Schmallenberg virus (SBV), a novel orthobunyavirus of the Simbu serogroup, was identified by metagenomic analysis in Germany. SBV has since been detected in ruminants all over Europe, and investigations on phylogenetic relationships, clinical signs and epidemiology have been conducted. However, until now, only comparative sequence analysis of SBV genome segments with other species of the Simbu serogroup have been performed, and detailed data on the S and M segments, relevant for virus–host-cell interaction, have been missing. In this study, we investigated the S- and M-segment sequences obtained from 24 SBV-positive field samples from sheep, cattle and a goat collected from all over Germany. The results obtained indicated that the overall genome variability of SBV is neither regionally nor host species dependent. Nevertheless, we characterized for the first time a region of high sequence variability (a mutation ‘hot spot’) within the glycoprotein Gc encoded by the M segment. The GenBank/EMBL/DDBJ accession numbers for the S- and M-segment sequences of the Schmallenberg virus field samples determined in this study are KC108842–KC108887.
    Keywords Schmallenberg virus; Orthobunyavirus; sequence variability; M-segment; glycoprotein C
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A mutation ‘hot spot’ in the Schmallenberg virus M segment

    Fischer, Melina / Hoffmann, Bernd / Goller, Katja Verena / Höper, Dirk / Wernike, Kerstin / Beer, Martin

    2013  

    Abstract: ... of the Simbu serogroup have been performed, and detailed data on the S and M segments, relevant for virus–host ... cell interaction, have been missing. In this study, we investigated the S- and M-segment sequences obtained from 24 ... a mutation ‘hot spot’) within the glycoprotein Gc encoded by the M segment. The GenBank/EMBL/DDBJ accession ...

    Abstract In the autumn of 2011, Schmallenberg virus (SBV), a novel orthobunyavirus of the Simbu serogroup, was identified by metagenomic analysis in Germany. SBV has since been detected in ruminants all over Europe, and investigations on phylogenetic relationships, clinical signs and epidemiology have been conducted. However, until now, only comparative sequence analysis of SBV genome segments with other species of the Simbu serogroup have been performed, and detailed data on the S and M segments, relevant for virus–host-cell interaction, have been missing. In this study, we investigated the S- and M-segment sequences obtained from 24 SBV-positive field samples from sheep, cattle and a goat collected from all over Germany. The results obtained indicated that the overall genome variability of SBV is neither regionally nor host species dependent. Nevertheless, we characterized for the first time a region of high sequence variability (a mutation ‘hot spot’) within the glycoprotein Gc encoded by the M segment. The GenBank/EMBL/DDBJ accession numbers for the S- and M-segment sequences of the Schmallenberg virus field samples determined in this study are KC108842–KC108887.
    Keywords Text ; ddc:570 ; Schmallenberg virus -- Orthobunyavirus -- sequence variability -- M-segment -- glycoprotein C
    Language English
    Publishing date 2013-06-01
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Audio / Video ; Online: A "Hot spot of mutation" in the Schmallenberg Virus M-Segment

    Fischer, Melina / Hoffmann, Bernd / Goller, Katja / Höper, Dirk / Wernike, Kerstin / Beer, Martin

    2013  

    Language English
    Publishing date 2013-06-05
    Publishing country de
    Document type Book ; Audio / Video ; Online
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  5. Book ; Audio / Video ; Online: A "Hot spot of mutation" in the Schmallenberg Virus M-Segment

    Fischer, Melina / Hoffmann, Bernd / Goller, Katja / Höper, Dirk / Wernike, Kerstin / Beer, Martin

    2013  

    Keywords Text
    Language English
    Publishing date 2013-06-05
    Publishing country de
    Document type Book ; Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Thesis: Ursachen und Implikationen der prolongierten maschinellen Ventilation nach Doppellungentransplantation

    Jäger, Diana / Höper, Marius

    eine retrospektive, monozentrische Untersuchung

    2021  

    Institution Medizinische Hochschule Hannover
    Klinik für Pneumologie
    Author's details vorgelegt von Diana Jäger ; aus der Klinik für Pneumologie der Medizinischen Hochschule Hannover ; Betreuer der Arbeit Prof. Dr. med. Marius Hoeper
    Language German
    Size 50 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    HBZ-ID HT021695688
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2023 E 93 order for loan Magazin

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  7. Article ; Online: Surrogate endpoints in pulmonary arterial hypertension trials.

    Hoeper, Marius M

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 10, Page(s) 852–853

    MeSH term(s) Humans ; Pulmonary Arterial Hypertension ; Familial Primary Pulmonary Hypertension ; Hypertension, Pulmonary/drug therapy ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00190-X
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    Zs.A 7041: Show issues Location:
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  8. Article ; Online: Extracorporeal Life Support in Pulmonary Hypertension: Practical Aspects.

    Hoeper, Marius M

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 6, Page(s) 771–776

    Abstract: Extracorporeal life support (ECLS), in particular veno-arterial extracorporeal membrane oxygenation, has emerged as a potentially life-saving treatment modality in patients presenting with pulmonary hypertension and right heart failure refractory to ... ...

    Abstract Extracorporeal life support (ECLS), in particular veno-arterial extracorporeal membrane oxygenation, has emerged as a potentially life-saving treatment modality in patients presenting with pulmonary hypertension and right heart failure refractory to conventional treatment. Used mainly as a bridge to lung transplantation, ECLS is also being used occasionally as a bridge to recovery in patients with treatable causes of right heart failure. This review article describes indications, contraindications, techniques, and outcomes of the use of ECLS in patients with PH, focusing on practical aspects in the management of such patients.
    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation/methods ; Hypertension, Pulmonary/therapy ; Hypertension, Pulmonary/etiology ; Heart Failure/therapy ; Contraindications ; Treatment Outcome
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1772752
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  9. Article: Extracorporeal Life Support in Pulmonary Hypertension: Practical Aspects

    Hoeper, Marius M.

    Seminars in Respiratory and Critical Care Medicine

    (Pulmonary Hypertension)

    2023  Volume 44, Issue 06, Page(s) 771–776

    Abstract: Extracorporeal life support (ECLS), in particular veno-arterial extracorporeal membrane oxygenation, has emerged as a potentially life-saving treatment modality in patients presenting with pulmonary hypertension and right heart failure refractory to ... ...

    Series title Pulmonary Hypertension
    Abstract Extracorporeal life support (ECLS), in particular veno-arterial extracorporeal membrane oxygenation, has emerged as a potentially life-saving treatment modality in patients presenting with pulmonary hypertension and right heart failure refractory to conventional treatment. Used mainly as a bridge to lung transplantation, ECLS is also being used occasionally as a bridge to recovery in patients with treatable causes of right heart failure. This review article describes indications, contraindications, techniques, and outcomes of the use of ECLS in patients with PH, focusing on practical aspects in the management of such patients.
    Keywords pulmonary hypertension ; right heart failure ; extracorporeal life support ; extracorporeal membrane oxygenation ; lung transplantation
    Language English
    Publishing date 2023-09-14
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1772752
    Database Thieme publisher's database

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  10. Article ; Online: Exercise Pulmonary Hypertension Is Back.

    Hoeper, Marius M

    Journal of the American College of Cardiology

    2020  Volume 75, Issue 1, Page(s) 27–28

    MeSH term(s) Dyspnea ; Exercise ; Humans ; Hypertension, Pulmonary
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.11.010
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