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  1. Book: Pulmonary arterial hypertension related to congenital heart disease

    Beghetti, Maurice

    2006  

    Author's details Chief ed. Maurice Beghetti. Co-ed. Robyn J. Barst
    Keywords Hypertension, Pulmonary / epidemiology ; Hypertension, Pulmonary / therapy ; Heart Defects, Congenital / complications ; Heart Defects, Congenital / therapy ; Herzkrankheit ; Angeborene Krankheit ; Pulmonale Hypertonie
    Subject Herzerkrankung ; Herzkrankheiten ; Lungenhochdruck ; Pulmonale hypertension ; Pulmonal-arterielle Hypertonie ; PAH ; Congenitale Krankheit ; Kongenitale Krankheit ; Konnatale Krankheit ; Angeborene Krankheiten
    Language English
    Size XI, 228 S.: Ill.
    Publisher Elsevier, Urban & Fischer
    Publishing place München u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014843352
    ISBN 978-3-437-24110-9 ; 3-437-24110-9 ; 978-0-7020-2897-7 ; 0-7020-2897-5
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Echocardiographic Evaluation of Pulmonary Pressures and Right Ventricular Function after Pediatric Cardiac Surgery: A Simple Approach for the Intensivist.

    Beghetti, Maurice

    Frontiers in pediatrics

    2017  Volume 5, Page(s) 184

    Abstract: Pulmonary hypertension (PH) is diagnosed using cardiac catheterization and is defined as an elevation of mean pulmonary artery pressure (PAP) greater than 25 mmHg. Although invasive hemodynamics remains the gold standard and is mandatory for disease ... ...

    Abstract Pulmonary hypertension (PH) is diagnosed using cardiac catheterization and is defined as an elevation of mean pulmonary artery pressure (PAP) greater than 25 mmHg. Although invasive hemodynamics remains the gold standard and is mandatory for disease confirmation, transthoracic echocardiography (TTE) is an extremely useful non-invasive and widely available tool that allows for screening and follow-up, in particular, in the acute setting. TTE may be a valuable alternative, allowing for direct measurement and/or indirect assessment of PAP. Because of the complex geometric shape and pattern of contraction of the right ventricle (RV), as well as the inherent complexity of cardiac repair, no single view or measurement can provide definite information on RV function and PAP and/or pulmonary vascular resistance. In addition, specific training and expertise may be necessary to obtain the views and measurements required. Some simple measurements may be of help when rapid evaluation is mandatory and potentially life saving: the assessment of tricuspid and/or pulmonary valve regurgitant jet and the use of the Bernoulli equation allow for measurement of PAP. Measurements such as the analysis of the pulmonary Doppler wave flow, the septal curvature, or the eccentricity index, assessing ventricular interdependence, are useful for indirect assessment. A four-chamber view of the RV gives information on its size, hypertrophy, function (fractional area change), and tricuspid annular plane systolic excursion as an evaluation of the longitudinal function. Based on these simple measurements, TTE can provide detection of PH, measurement or estimation of PAP, and assessment of cardiac function. TTE is also of importance in follow up of PH as well as providing an assessment of therapeutic strategies in the postoperative setting of cardiac surgery. However, PAP may be misleading as it is dependent on cardiac output and requires accurate measurements. In the presence of residual lesions, analyses of some Doppler measurements may be misleading and not reflect real PAP. Should the TTE evaluation reveal non-conclusive, invasive hemodynamics remains the gold standard.
    Language English
    Publishing date 2017-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2017.00184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Risques des préparations magistrales en pédiatrie.

    Rosen, Charlotte / Jacqmart, Caroline / Charlier, Corinne / Beghetti, Maurice / Seghaye, Marie-Christine

    Revue medicale de Liege

    2024  Volume 79, Issue 2, Page(s) 104–109

    Abstract: Vasoreactive pulmonary arterial hypertension (PAH) in children is a form of idiopathic PAH that responds to vasoreactive testing with nitric oxide (NO) by a significant decrease of pulmonary vascular resistances and pressure. Oral calcium channel ... ...

    Title translation Risks of magistral preparations in pediatrics.
    Abstract Vasoreactive pulmonary arterial hypertension (PAH) in children is a form of idiopathic PAH that responds to vasoreactive testing with nitric oxide (NO) by a significant decrease of pulmonary vascular resistances and pressure. Oral calcium channel antagonists (CCA) that allow pulmonary arterial vasodilation are the treatment of choice. The therapeutic effect is strongly depending on adequate drug intake. In growing children, drug dose must be adapted to weight. In case of unavailability of low-dose pharmaceutical preparations, officinal formulations become mandatory. Officinal formulations may be related to a multitude of errors at different steps including prescription, transcription, preparation and administration. This may have life-threatening consequences for the child.To illustrate this, we report a case of a compounding error with underdosage of CCA, leading to acute cardiovascular failure in an adolescent with vasoreactive PAH.
    MeSH term(s) Adolescent ; Humans ; Calcium Channel Blockers/adverse effects ; Calcium Channel Blockers/therapeutic use ; Hypertension, Pulmonary/drug therapy ; Nitric Oxide/therapeutic use
    Chemical Substances Calcium Channel Blockers ; Nitric Oxide (31C4KY9ESH)
    Language French
    Publishing date 2024-02-15
    Publishing country Belgium
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pulmonary vascular disease as a complication of pediatric congenital heart diseases.

    Wacker, Julie / Joye, Raphael / Genecand, Leon / Lador, Frederic / Beghetti, Maurice

    Translational pediatrics

    2023  Volume 12, Issue 5, Page(s) 1041–1052

    Abstract: Congenital and acquired heart diseases can cause pulmonary hypertension (PH) in children, either by increasing pulmonary blood flow (PBF), left atrial pressure (LAp), and/or pulmonary vascular resistance (PVR). Pathophysiological process of pulmonary ... ...

    Abstract Congenital and acquired heart diseases can cause pulmonary hypertension (PH) in children, either by increasing pulmonary blood flow (PBF), left atrial pressure (LAp), and/or pulmonary vascular resistance (PVR). Pathophysiological process of pulmonary vascular disease (PVD) in different types of congenital heart diseases (CHDs) are reviewed hereafter. As with other types of PH, a rigorous diagnostic evaluation is mandatory to characterize the etiology of the PH, rule out other or additional causes of PH, and establish a risk profile. Cardiac catheterization remains the gold standard exam for PH diagnosis. Treatment of pulmonary arterial hypertension (PAH) associated with CHD (PAH-CHD) can then be started according to the recent guidelines recommendations, although most of the evidence is extrapolated from studies on other causes of PAH. PH in pediatric heart disease is often multifactorial, and sometimes unclassifiable, making the management of these patients complicated. The operability of patients with a prevalent left-to-right shunt and increase of PVR, the management of children with PH associated with left-sided heart disease, the challenges of pulmonary vascular disorders in children with univentricular heart physiology and the role of vasodilator therapy in failing Fontan patients are some of the hot topics discussed in this review.
    Language English
    Publishing date 2023-05-24
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-64
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Atrial Septal Defect, Pulmonary Arterial Hypertension, and Diastolic Left Heart Failure: When 3 Players Come into the Game.

    Rutz, Tobias / Aubert, John-David / Beghetti, Maurice / Eeckhout, Eric / Muller, Olivier / Bouchardy, Judith / Yerly, Patrick

    Circulation. Heart failure

    2024  , Page(s) e010545

    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.123.010545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of CO

    Cousin, Vladimir L / Joye, Raphael / Wacker, Julie / Beghetti, Maurice / Polito, Angelo

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 5

    Abstract: Shock is a life-threatening condition, and its timely recognition is essential for adequate management. Pediatric patients with congenital heart disease admitted to a cardiac intensive care unit (CICU) after surgical corrections are particularly at risk ... ...

    Abstract Shock is a life-threatening condition, and its timely recognition is essential for adequate management. Pediatric patients with congenital heart disease admitted to a cardiac intensive care unit (CICU) after surgical corrections are particularly at risk of low cardiac output syndrome (LCOS) and shock. Blood lactate levels and venous oxygen saturation (ScVO
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10050208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Letter to the Editor, regarding Li L, Zhu X, Chen X, Gao J, Ding C, et al. Advances in targeted therapy for pulmonary arterial hypertension in children. Eur J Pediatr. 2022 Dec 17.

    Beghetti, Maurice / Ivy, Dunbar / Scott, Nicola / Machlitt-Northen, Sandra / Lukas, Mary Ann

    European journal of pediatrics

    2023  Volume 182, Issue 5, Page(s) 2453–2454

    MeSH term(s) Humans ; Child ; Pulmonary Arterial Hypertension
    Language English
    Publishing date 2023-02-27
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-04877-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Goal-oriented therapy in paediatric pulmonary arterial hypertension: are we ready?

    Beghetti, Maurice

    The European respiratory journal

    2014  Volume 44, Issue 6, Page(s) 1404–1407

    MeSH term(s) Endothelin Receptor Antagonists/therapeutic use ; Female ; Humans ; Hypertension, Pulmonary/therapy ; Lung Transplantation ; Male ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Prostaglandins I/therapeutic use
    Chemical Substances Endothelin Receptor Antagonists ; Phosphodiesterase 5 Inhibitors ; Prostaglandins I
    Language English
    Publishing date 2014-12
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00164014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Early Diagnosis in Pulmonary Arterial Hypertension: The Search for the Holy Grail.

    Berger, Rolf M F / Beghetti, Maurice

    American journal of respiratory and critical care medicine

    2019  Volume 199, Issue 11, Page(s) 1306–1307

    MeSH term(s) Child ; Early Diagnosis ; Electrocardiography ; Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201812-2314ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Triple switch' aortic and pulmonary root inversion and modified Senning procedure for anatomically complex left transposition of the great arteries with inlet ventricular septal defect and pulmonary stenosis.

    Nalecz, Tomasz / Bédert, Ludmila / Jolou, Jalal / Wacker, Julie / Beghetti, Maurice / Prêtre, René / Sologashvili, Tornike

    Multimedia manual of cardiothoracic surgery : MMCTS

    2023  Volume 2023

    Abstract: Left transposition of the great arteries with inlet ventricular septal defect and pulmonary stenosis is a relatively uncommon cardiac malformation. Two surgical treatments are available: double switch or physiological correction. The choice of surgical ... ...

    Abstract Left transposition of the great arteries with inlet ventricular septal defect and pulmonary stenosis is a relatively uncommon cardiac malformation. Two surgical treatments are available: double switch or physiological correction. The choice of surgical technique depends on the results of a discussion between the family and the surgeon. Choosing the appropriate technique is challenging because all options present various complications and benefits. We present a 'triple switch' aortic and pulmonary root inversion and modified Senning procedure for an anatomically complex left transposition of the great arteries with an inlet ventricular septal defect and pulmonary stenosis.
    MeSH term(s) Humans ; Infant ; Arterial Switch Operation/methods ; Transposition of Great Vessels/surgery ; Bays ; Aorta/surgery ; Pulmonary Valve Stenosis/surgery ; Heart Septal Defects, Ventricular/surgery
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Video-Audio Media
    ZDB-ID 2280156-X
    ISSN 1813-9175 ; 1813-9175
    ISSN (online) 1813-9175
    ISSN 1813-9175
    DOI 10.1510/mmcts.2023.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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