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Article ; Online: Sudden Vision Loss.

Nair, Archana A / Pugh, Meredith E / Cherney, Edward F

2024

Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2024.0212
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Article ; Online: Reply to Mang

Gannon, Whitney D / Stokes, John W / Francois, Sean A / Patel, Yatrik J / Pugh, Meredith E / Benson, Clayne / Rice, Todd W / Bacchetta, Matthew / Semler, Matthew W / Casey, Jonathan D

American journal of respiratory and critical care medicine

2022 Volume 206, Issue 11, Page(s) 1433

Language	English
Publishing date	2022-07-26
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202207-1415LE
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Article ; Online: Association between Availability of Extracorporeal Membrane Oxygenation and Mortality in Patients with COVID-19 Eligible for Extracorporeal Membrane Oxygenation: A Natural Experiment.

Gannon, Whitney D / Stokes, John W / Francois, Sean A / Patel, Yatrik J / Pugh, Meredith E / Benson, Clayne / Rice, Todd W / Bacchetta, Matthew / Semler, Matthew W / Casey, Jonathan D

American journal of respiratory and critical care medicine

2022 Volume 205, Issue 11, Page(s) 1354–1357

MeSH term(s)	COVID-19 ; Extracorporeal Membrane Oxygenation ; Humans ; Respiratory Distress Syndrome ; SARS-CoV-2
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202110-2399LE
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Article ; Online: Index case for the fungal meningitis outbreak, United States.

Pettit, April C / Pugh, Meredith E

The New England journal of medicine

2013 Volume 368, Issue 10, Page(s) 970

MeSH term(s)	Aspergillosis/diagnosis ; Aspergillus fumigatus/isolation & purification ; Brain/pathology ; Cerebrospinal Fluid/parasitology ; Drug Contamination ; Humans ; Male ; Meningitis, Fungal/diagnosis
Language	English
Publishing date	2013-03-07
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc1300630
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Article ; Online: Update on chronic thromboembolic pulmonary hypertension.

Robbins, Ivan M / Pugh, Meredith E / Hemnes, Anna R

Trends in cardiovascular medicine

2017 Volume 27, Issue 1, Page(s) 29–37

Abstract: Chronic, unresolved thromboemboli are an important cause of pulmonary hypertension (PH) with specific treatment strategies differing from other types of PH. Chronic thromboembolic pulmonary hypertension (CTEPH) is classified as group 4 PH by the World ... ...

Abstract	Chronic, unresolved thromboemboli are an important cause of pulmonary hypertension (PH) with specific treatment strategies differing from other types of PH. Chronic thromboembolic pulmonary hypertension (CTEPH) is classified as group 4 PH by the World Health Organization. It is a rare, but underdiagnosed, complication of acute pulmonary embolism that does not resolve and results in occlusion of large pulmonary arteries with a fibro-thrombotic material. The etiology of CTEPH remains uncertain, and it is unknown why certain patients with acute pulmonary embolism develop this disorder. The evaluation for CTEPH is an important part of the evaluation for PH in general, and it is crucial not to overlook this diagnosis, as it is the only form of PH that is potentially curable. Patients diagnosed with CTEPH should be referred to an expert center for consideration of pulmonary endarterectomy, and surgical removal of the chronic thromboembolic material. Not all patients with CTEPH are surgical candidates, however, and there are emerging treatments-medical therapy and balloon pulmonary angioplasty-that have shown benefit in this patient population. Without treatment, CTEPH can lead to progressive pulmonary vascular obstruction, right heart failure, and death. Thus, it is important for clinicians to recognize this subtype of PH. In this review, we provide an overview of current understanding of the pathogenesis of CTEPH and highlight recommendations and recent advances in the evaluation and treatment of CTEPH.
MeSH term(s)	Angioplasty, Balloon/adverse effects ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Arterial Pressure/drug effects ; Blood Coagulation/drug effects ; Chronic Disease ; Endarterectomy/adverse effects ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/therapy ; Predictive Value of Tests ; Pulmonary Artery/drug effects ; Pulmonary Artery/physiopathology ; Pulmonary Artery/surgery ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/physiopathology ; Pulmonary Embolism/therapy ; Risk Factors ; Treatment Outcome
Chemical Substances	Anticoagulants ; Antihypertensive Agents
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1097434-9
ISSN	1873-2615 ; 1050-1738
ISSN (online)	1873-2615
ISSN	1050-1738
DOI	10.1016/j.tcm.2016.05.010
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Article ; Online: Extracorporeal Membrane Oxygenation Selection by Multidisciplinary Consensus: The ECMO Council.

Gannon, Whitney D / Trindade, Anil J / Stokes, John W / Casey, Jonathan D / Benson, Clayne / Patel, Yatrik J / Pugh, Meredith E / Semler, Matthew W / Bacchetta, Matthew / Rice, Todd W

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2022 Volume 69, Issue 2, Page(s) 167–173

Abstract: Coronavirus disease 2019 (COVID-19) has increased the demand for extracorporeal membrane oxygenation (ECMO) and introduced distinct challenges to patient selection for ECMO. Standardized processes for patient selection amidst resource limitations are ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has increased the demand for extracorporeal membrane oxygenation (ECMO) and introduced distinct challenges to patient selection for ECMO. Standardized processes for patient selection amidst resource limitations are lacking, and data on ECMO consults are underreported. We retrospectively reviewed consecutive adult ECMO consults for acute respiratory failure received at a single academic medical center from April 1, 2020, to February 28, 2021, and evaluated the implementation of a multidisciplinary selection committee (ECMO Council) and standardized framework for patient selection for ECMO. During the 334-day period, there were 202 total ECMO consults; 174 (86.1%) included a diagnosis of COVID-19. Among all consults, 157 (77.7%) were declined and 41 (20.3%) resulted in the initiation of ECMO. Frequent reasons for decline included the presence of multiple relative contraindications (n = 33), age greater than 60 years (n = 32), and resource limitations (n = 27). The ECMO Council deliberated on every case in which an absolute contraindication was not present (n = 96) via an electronic teleconference platform. Utilizing multidisciplinary consensus together with a standardized process for patient selection in ECMO is feasible during a pandemic and may be reliably exercised over time. Whether such an approach is feasible at other centers remains unknown.
MeSH term(s)	Adult ; Humans ; Middle Aged ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation/methods ; Retrospective Studies ; Patient Selection ; Respiratory Distress Syndrome/therapy
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000001757
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Article ; Online: Outcomes in elderly intensive care unit patients, pulmonary hypertension in sickle cell disease, and total liquid ventilation for therapeutic hypothermia after cardiac arrest in rabbits.

Brummel, Nathan E / Pugh, Meredith E / Fessel, Joshua P

American journal of respiratory and critical care medicine

2012 Volume 185, Issue 4, Page(s) 453–454

Language	English
Publishing date	2012-02-16
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201109-1608RR
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Article ; Online: Parenteral Prostanoid Use at a Tertiary Referral Center: A Retrospective Cohort Study.

Hay, Bryan R / Pugh, Meredith E / Robbins, Ivan M / Hemnes, Anna R

Chest

2016 Volume 149, Issue 3, Page(s) 660–666

Abstract: Background: Evidence-based guidelines recommend the use of parenteral prostaglandin (PP) therapy in patients with advanced pulmonary arterial hypertension (PAH). Despite this, many patients with PAH die without PP therapy. We sought to examine the ... ...

Abstract	Background: Evidence-based guidelines recommend the use of parenteral prostaglandin (PP) therapy in patients with advanced pulmonary arterial hypertension (PAH). Despite this, many patients with PAH die without PP therapy. We sought to examine the frequency of PP use at a large referral center and characterize patients with PAH who died without receiving PP. Methods: We conducted a single-center retrospective cohort analysis of consecutive patients with PAH between 2008 and 2012. Clinical data and cause of death were compared between patients with PAH treated with PP (PAH-PP) and those who were not but were not documented as poor PP candidates (PAH-nonPP). Results: Of the 101 patients who received a diagnosis of PAH and died, 61 received PP therapy. Of the 40 patients not treated with PP, 10 did not have documented evaluations for PP therapy (PAH-nonPP) whereas 30 were not considered candidates or refused PP therapy. Compared with PAH-PP, PAH-nonPP had a longer 6-min walk distance, had a longer duration between time of diagnosis and date of worse functional class visit, were less likely to be diagnosed as functional class IV, and had significantly lower right atrial pressure. None of the PAH-nonPP died of progressive PAH. Conclusions: We found that most patients who die with PAH are evaluated for PP therapy at a large referral center and the small minority of PAH-nonPP tended to have less severe disease and die of non-PAH-related causes. Our data suggest that at large pulmonary hypertension (PH) centers, the vast majority of patients who are appropriate candidates receive PP therapy.
MeSH term(s)	Adult ; Cause of Death ; Cohort Studies ; Comorbidity ; Connective Tissue Diseases/complications ; Death, Sudden ; Endothelin Receptor Antagonists/therapeutic use ; Familial Primary Pulmonary Hypertension/drug therapy ; Familial Primary Pulmonary Hypertension/mortality ; Female ; Guideline Adherence/statistics & numerical data ; HIV Infections/complications ; Heart Defects, Congenital/complications ; Heart Failure/mortality ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/mortality ; Infusions, Parenteral ; Male ; Middle Aged ; Patient Selection ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Practice Guidelines as Topic ; Prostaglandins/therapeutic use ; Quality Improvement ; Retrospective Studies ; Severity of Illness Index ; Tertiary Care Centers
Chemical Substances	Endothelin Receptor Antagonists ; Phosphodiesterase 5 Inhibitors ; Prostaglandins
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.15-1051
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Article ; Online: Pulmonary hypertension in women.

Pugh, Meredith E / Hemnes, Anna R

Expert review of cardiovascular therapy

2010 Volume 8, Issue 11, Page(s) 1549–1558

Abstract: Female predominance in pulmonary arterial hypertension (PAH) has been known for several decades and recent interest in the effects of sex hormones on the development of disease has substantially increased our understanding of this epidemiologic ... ...

Abstract	Female predominance in pulmonary arterial hypertension (PAH) has been known for several decades and recent interest in the effects of sex hormones on the development of disease has substantially increased our understanding of this epidemiologic observation. Basic science data suggest a beneficial effect of estrogens in the pulmonary vasculature both acutely and chronically, which seems to contradict the known predilection in women. Recent human and rodent data have suggested that altered levels of estrogen, differential signaling and altered metabolism of estrogens in PAH may underlie the gender difference in this disease. Studies of the effects of sex hormones on the right ventricle in animal and human disease will further aid in understanding gender differences in PAH. This article focuses on the effects of sex hormones on the pulmonary vasculature and right ventricle on both a basic science and translational level.
MeSH term(s)	Animals ; Calcium Channel Blockers/therapeutic use ; Endothelin Receptor Antagonists ; Estrogens/physiology ; Female ; Gonadal Steroid Hormones/physiology ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/physiopathology ; Phosphodiesterase Inhibitors/therapeutic use ; Prostaglandins I/therapeutic use ; Pulmonary Artery/physiopathology ; Sex Factors ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Remodeling
Chemical Substances	Calcium Channel Blockers ; Endothelin Receptor Antagonists ; Estrogens ; Gonadal Steroid Hormones ; Phosphodiesterase Inhibitors ; Prostaglandins I
Language	English
Publishing date	2010-10-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1586/erc.10.137
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Article ; Online: Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease.

Pugh, Meredith E / Hemnes, Anna R

Women's health (London, England)

2010 Volume 6, Issue 2, Page(s) 285–296

Abstract: Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature, ultimately resulting in right heart failure and death. This disease is strongly predominant in females, although little is known regarding how sex influences ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature, ultimately resulting in right heart failure and death. This disease is strongly predominant in females, although little is known regarding how sex influences disease development. Recent developments highlighting the importance of estrogen metabolites in both animal models and human disease have substantially increased our understanding of PAH in women. This review will focus on general knowledge of PAH, translational and basic science data regarding sex hormones in the pulmonary vasculature and on clinical issues that are particular to women with PAH. Future directions for study include the influence of sex hormones on right ventricular responses, improving the understanding of the influence of estrogen exposure in human disease and the study of dehydroepiandrosterone in basic science and human disease.
MeSH term(s)	Animals ; Dehydroepiandrosterone/metabolism ; Disease Models, Animal ; Estrogens/metabolism ; Female ; Gonadal Steroid Hormones/metabolism ; Humans ; Hypertension, Pulmonary/classification ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Inflammation ; Muscle, Smooth, Vascular/physiopathology ; Pulmonary Artery/physiopathology ; Sex Factors ; Ventricular Dysfunction, Right ; Ventricular Remodeling
Chemical Substances	Estrogens ; Gonadal Steroid Hormones ; Dehydroepiandrosterone (459AG36T1B)
Language	English
Publishing date	2010-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2274503-8
ISSN	1745-5065 ; 1745-5057
ISSN (online)	1745-5065
ISSN	1745-5057
DOI	10.2217/whe.09.88
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