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  1. Book: Pulmonary pathology

    Duarte Achcar, Rosane / Groshong, Steve D. / Cool, Carlyne D.

    (Differential diagnosis in surgical pathology)

    2017  

    Author's details Rosane Duarte Achcar, Steve D. Groshong, Carlyne D. Cool
    Series title Differential diagnosis in surgical pathology
    Keywords Lung Diseases / diagnosis ; Lung Diseases / pathology ; Pulmonary Surgical Procedures / methods ; Diagnosis, Differential
    Language English
    Size xiii, 324 Seiten, Illustrationen
    Publisher Wolters Kluwer Health
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Accompanying material Zugang zu e-book über Code
    HBZ-ID HT019640068
    ISBN 978-1-4511-9527-9 ; 9781496360144 ; 1-4511-9527-3 ; 1496360141
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 480 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Pathology and Mineralogy of the Pneumoconioses.

    Hua, Jeremy T / Cool, Carlyne D / Green, Francis H Y

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 3, Page(s) 327–339

    Abstract: Pneumoconioses represent the spectrum of lung diseases caused by inhalation of respirable particulate matter small enough (typically <5-µm diameter) to reach the terminal airways and alveoli. Pneumoconioses primarily occur in occupational settings where ... ...

    Abstract Pneumoconioses represent the spectrum of lung diseases caused by inhalation of respirable particulate matter small enough (typically <5-µm diameter) to reach the terminal airways and alveoli. Pneumoconioses primarily occur in occupational settings where workers perform demanding and skilled manual labor including mining, construction, stone fabrication, farming, plumbing, electronics manufacturing, shipyards, and more. Most pneumoconioses develop after decades of exposure, though shorter latencies can occur from more intense particulate matter exposures. In this review, we summarize the industrial exposures, pathologic findings, and mineralogic features of various well-characterized pneumoconioses including silicosis, silicatosis, mixed-dust pneumoconiosis, coal workers' pneumoconiosis, asbestosis, chronic beryllium disease, aluminosis, hard metal pneumoconiosis, and some less severe pneumoconioses. We also review a general framework for the diagnostic work-up of pneumoconioses for pulmonologists including obtaining a detailed occupational and environmental exposure history. Many pneumoconioses are irreversible and develop due to excessive cumulative respirable dust inhalation. Accurate diagnosis permits interventions to minimize ongoing fibrogenic dust exposure. A consistent occupational exposure history coupled with typical chest imaging findings is usually sufficient to make a clinical diagnosis without the need for tissue sampling. Lung biopsy may be required when exposure history, imaging, and testing are inconsistent, there are unusual or new exposures, or there is a need to obtain tissue for another indication such as suspected malignancy. Close collaboration and information-sharing with the pathologist prior to biopsy is of great importance for diagnosis, as many occupational lung diseases are missed due to insufficient communication. The pathologist has a broad range of analytic techniques including bright-field microscopy, polarized light microscopy, and special histologic stains that may confirm the diagnosis. Advanced techniques for particle characterization such as scanning electron microscopy/energy dispersive spectroscopy may be available in some centers.
    MeSH term(s) Humans ; Air Pollutants ; Pneumoconiosis/diagnosis ; Pneumoconiosis/etiology ; Pneumoconiosis/pathology ; Silicosis/complications ; Silicosis/pathology ; Lung/pathology ; Dust ; Occupational Exposure/adverse effects
    Chemical Substances Air Pollutants ; Dust
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1764406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Use of a novel chinchilla skull base repair model to test a photo-initiated thiol-ene biopolymer.

    Terella, Adam M / Mariner, Peter / Cool, Carlyne D / Ramakrishnan, Vijay R

    International forum of allergy & rhinology

    2022  Volume 12, Issue 10, Page(s) 1317–1320

    MeSH term(s) Animals ; Biopolymers ; Cerebrospinal Fluid Leak/surgery ; Chinchilla ; Endoscopy ; Humans ; Postoperative Complications/surgery ; Reconstructive Surgical Procedures ; Retrospective Studies ; Skull Base/surgery ; Skull Base Neoplasms/surgery ; Sulfhydryl Compounds
    Chemical Substances Biopolymers ; Sulfhydryl Compounds
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  4. Article ; Online: Pulmonary Arteries and Microcirculation in COPD With Pulmonary Hypertension: Bystander or Culprit?

    Tuder, Rubin M / Cool, Carlyne D

    Chest

    2019  Volume 156, Issue 1, Page(s) 4–6

    MeSH term(s) Humans ; Hypertension, Pulmonary ; Lung ; Microcirculation ; Pulmonary Artery ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.04.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  5. Article ; Online: Lymphangioleiomyomatosis and Other Cystic Lung Diseases.

    Koslow, Matthew / Lynch, David A / Cool, Carlyne D / Groshong, Steve D / Downey, Gregory P

    Immunology and allergy clinics of North America

    2023  Volume 43, Issue 2, Page(s) 359–377

    Abstract: Cysts and cavities in the lung are commonly encountered on chest imaging. It is necessary to distinguish thin-walled lung cysts (≤2 mm) from cavities and characterize their distribution as focal or multifocal versus diffuse. Focal cavitary lesions are ... ...

    Abstract Cysts and cavities in the lung are commonly encountered on chest imaging. It is necessary to distinguish thin-walled lung cysts (≤2 mm) from cavities and characterize their distribution as focal or multifocal versus diffuse. Focal cavitary lesions are often caused by inflammatory, infectious, or neoplastic processes in contrast to diffuse cystic lung diseases. An algorithmic approach to diffuse cystic lung disease can help narrow the differential diagnosis, and additional testing such as skin biopsy, serum biomarkers, and genetic testing can be confirmatory. An accurate diagnosis is essential for the management and disease surveillance of extrapulmonary complications.
    MeSH term(s) Humans ; Lymphangioleiomyomatosis/diagnosis ; Lymphangioleiomyomatosis/etiology ; Lymphangioleiomyomatosis/therapy ; Histiocytosis, Langerhans-Cell/complications ; Histiocytosis, Langerhans-Cell/diagnosis ; Histiocytosis, Langerhans-Cell/pathology ; Birt-Hogg-Dube Syndrome/complications ; Birt-Hogg-Dube Syndrome/diagnosis ; Birt-Hogg-Dube Syndrome/pathology ; Tomography, X-Ray Computed/methods ; Lung Diseases/diagnosis ; Lung Diseases/etiology ; Lung/pathology ; Cysts/diagnosis ; Cysts/complications ; Cysts/pathology ; Diagnosis, Differential
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 710: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Pathology and Mineralogy of the Pneumoconioses

    Hua, Jeremy T. / Cool, Carlyne D. / Green, Francis H. Y.

    Seminars in Respiratory and Critical Care Medicine

    (Occupational Diseases)

    2023  Volume 44, Issue 03, Page(s) 327–339

    Abstract: Pneumoconioses represent the spectrum of lung diseases caused by inhalation of respirable particulate matter small enough (typically <5-µm diameter) to reach the terminal airways and alveoli. Pneumoconioses primarily occur in occupational settings where ... ...

    Series title Occupational Diseases
    Abstract Pneumoconioses represent the spectrum of lung diseases caused by inhalation of respirable particulate matter small enough (typically <5-µm diameter) to reach the terminal airways and alveoli. Pneumoconioses primarily occur in occupational settings where workers perform demanding and skilled manual labor including mining, construction, stone fabrication, farming, plumbing, electronics manufacturing, shipyards, and more. Most pneumoconioses develop after decades of exposure, though shorter latencies can occur from more intense particulate matter exposures. In this review, we summarize the industrial exposures, pathologic findings, and mineralogic features of various well-characterized pneumoconioses including silicosis, silicatosis, mixed-dust pneumoconiosis, coal workers' pneumoconiosis, asbestosis, chronic beryllium disease, aluminosis, hard metal pneumoconiosis, and some less severe pneumoconioses. We also review a general framework for the diagnostic work-up of pneumoconioses for pulmonologists including obtaining a detailed occupational and environmental exposure history. Many pneumoconioses are irreversible and develop due to excessive cumulative respirable dust inhalation. Accurate diagnosis permits interventions to minimize ongoing fibrogenic dust exposure. A consistent occupational exposure history coupled with typical chest imaging findings is usually sufficient to make a clinical diagnosis without the need for tissue sampling. Lung biopsy may be required when exposure history, imaging, and testing are inconsistent, there are unusual or new exposures, or there is a need to obtain tissue for another indication such as suspected malignancy. Close collaboration and information-sharing with the pathologist prior to biopsy is of great importance for diagnosis, as many occupational lung diseases are missed due to insufficient communication. The pathologist has a broad range of analytic techniques including bright-field microscopy, polarized light microscopy, and special histologic stains that may confirm the diagnosis. Advanced techniques for particle characterization such as scanning electron microscopy/energy dispersive spectroscopy may be available in some centers.
    Keywords occupational exposure ; silicosis ; coal workers' pneumoconiosis ; asbestosis ; berylliosis ; hard metal pneumoconiosis
    Language English
    Publishing date 2023-03-27
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0043-1764406
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Histopathological Correlation of Acute on Chronic Eosinophilic Pneumonitis Caused by Vaporized Cannabis Oil Inhalation.

    Lee, Michael H / Cool, Carlyne D / Maloney, James P

    Chest

    2020  Volume 159, Issue 3, Page(s) e137–e139

    Abstract: Whether eosinophilic pneumonitis represents a true manifestation of e-cigarette, or vaping, product use-associated lung injury remains uncertain, and this ambiguity stems from a lack of histopathological data. We present a previously healthy young woman ... ...

    Abstract Whether eosinophilic pneumonitis represents a true manifestation of e-cigarette, or vaping, product use-associated lung injury remains uncertain, and this ambiguity stems from a lack of histopathological data. We present a previously healthy young woman whose asthma-like symptoms and histopathologic finding of eosinophilic pneumonitis were caused by inhalation of vaporized cannabis hash oil concentrates. This report provides compelling evidence that eosinophilic pneumonitis can result from cannabis hash oil inhalation.
    MeSH term(s) Adult ; Asthma/diagnosis ; Biopsy/methods ; Cannabis/adverse effects ; Diagnosis, Differential ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Lung/pathology ; Lung Injury/etiology ; Lung Injury/pathology ; Marijuana Smoking/adverse effects ; Pulmonary Eosinophilia/chemically induced ; Pulmonary Eosinophilia/pathology ; Pulmonary Eosinophilia/physiopathology ; Symptom Assessment/methods ; Vaping/adverse effects
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.45: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  8. Article ; Online: Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis.

    Blumhagen, Rachel Z / Kurche, Jonathan S / Cool, Carlyne D / Walts, Avram D / Heinz, David / Fingerlin, Tasha E / Yang, Ivana V / Schwartz, David A

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 287

    Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) and dense fibrosis. Defining ... ...

    Abstract Background: Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) and dense fibrosis. Defining transcriptional differences between these pathologically heterogeneous regions of the IPF lung is critical to understanding the distribution and extent of fibrotic lung disease and identifying potential therapeutic targets. Application of a spatial transcriptomics platform would provide more detailed spatial resolution of transcriptional signals compared to previous single cell or bulk RNA-Seq studies.
    Methods: We performed spatial transcriptomics using GeoMx Nanostring Digital Spatial Profiling on formalin-fixed paraffin-embedded (FFPE) tissue from 32 IPF and 12 control subjects and identified 231 regions of interest (ROIs). We compared normal-appearing lung parenchyma and airways between IPF and controls with histologically normal lung tissue, as well as histologically distinct regions within IPF (normal-appearing lung parenchyma, transition zones containing fibroblastic foci, areas of dense fibrosis, and honeycomb epithelium metaplasia).
    Results: We identified 254 differentially expressed genes (DEGs) between IPF and controls in histologically normal-appearing regions of lung parenchyma; pathway analysis identified disease processes such as EIF2 signaling (important for cap-dependent mRNA translation), epithelial adherens junction signaling, HIF1α signaling, and integrin signaling. Within IPF, we identified 173 DEGs between transition and normal-appearing lung parenchyma and 198 DEGs between dense fibrosis and normal lung parenchyma; pathways dysregulated in both transition and dense fibrotic areas include EIF2 signaling pathway activation (upstream of endoplasmic reticulum (ER) stress proteins ATF4 and CHOP) and wound healing signaling pathway deactivation. Through cell deconvolution of transcriptome data and immunofluorescence staining, we confirmed loss of alveolar parenchymal signals (AGER, SFTPB, SFTPC), gain of secretory cell markers (SCGB3A2, MUC5B) as well as dysregulation of the upstream regulator ATF4, in histologically normal-appearing tissue in IPF.
    Conclusions: Our findings demonstrate that histologically normal-appearing regions from the IPF lung are transcriptionally distinct when compared to similar lung tissue from controls with histologically normal lung tissue, and that transition zones and areas of dense fibrosis within the IPF lung demonstrate activation of ER stress and deactivation of wound healing pathways.
    MeSH term(s) Humans ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Idiopathic Pulmonary Fibrosis/metabolism ; Lung/metabolism ; Transcriptome ; Fibrosis
    Chemical Substances Eukaryotic Initiation Factor-2
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02572-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Characterization of Immune Cells From the Lungs of Patients With Chronic Non-Tuberculous Mycobacteria or

    Schenkel, Alan R / Mitchell, John D / Cool, Carlyne D / Bai, Xiyuan / Groshong, Steve / Koelsch, Tilman / Verma, Deepshikha / Ordway, Diane / Chan, Edward D

    Immune network

    2022  Volume 22, Issue 3, Page(s) e27

    Abstract: Little is known of the lung cellular immunophenotypes in patients with non-tuberculous mycobacterial lung disease (NTM-LD). Flow-cytometric analyses for the major myeloid and lymphoid cell subsets were performed in less- and more-diseased areas of ... ...

    Abstract Little is known of the lung cellular immunophenotypes in patients with non-tuberculous mycobacterial lung disease (NTM-LD). Flow-cytometric analyses for the major myeloid and lymphoid cell subsets were performed in less- and more-diseased areas of surgically resected lungs from six patients with NTM-LD and two with
    Language English
    Publishing date 2022-04-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2022.22.e27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Histopathologic Analysis of Surgically Resected Lungs of Patients with Non-tuberculous Mycobacterial Lung Disease: a Retrospective and Hypothesis-generating Study.

    Choi, Sangbong / Potts, Kyle J / Althoff, Meghan D / Jimenez, Guillermo / Bai, Xiyuan / Calhoun, Kara M / Cool, Carlyne D / Chan, Edward D

    The Yale journal of biology and medicine

    2021  Volume 94, Issue 4, Page(s) 527–535

    Abstract: Non-tuberculous mycobacterial lung disease (NTM-LD) is most commonly due to species within ... ...

    Abstract Non-tuberculous mycobacterial lung disease (NTM-LD) is most commonly due to species within the
    MeSH term(s) Humans ; Lung/surgery ; Lung Diseases ; Mycobacterium Infections, Nontuberculous ; Mycobacterium avium Complex ; Retrospective Studies
    Language English
    Publishing date 2021-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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