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Book ; Online: Les principes métaphysiques

Declos, Alexandre / Guillon, Jean-Baptiste

2020

Abstract: ... Les connaît-on de manière immédiate ou a priori, ou sont-ils plutôt épistémiquement dérivés ...

Abstract	La métaphysique s'entend depuis toujours comme la science des « premiers principes ». Mais comment comprendre ces termes ? Existe-t-il vraiment des principes proprement métaphysiques ? Faut-il y voir des vérités générales ou fondamentales, qui concerneraient l'ensemble de la réalité ? Portent-ils, au contraire, sur certaines régions spécifiques de l'être ? Ont-il trait à des rapports nécessaires entre les choses ? Faut-il les concevoir comme des « fondements » ? Interrogent-ils tant l'actuel que le possible ? Les connaît-on de manière immédiate ou a priori, ou sont-ils plutôt épistémiquement dérivés ? Comment différencier les principes qui conditionnent la connaissance métaphysique de ceux qui concernent plus directement la structure ou l'ameublement de la réalité ? En quoi les principes métaphysiques se rapportent-ils à ceux de la science ou du sens commun ? Comment se distinguent-ils des principes logiques, épistémologiques ou théologiques ? Autant de questions, trop rarement étudiées pour elles-mêmes, auxquelles les contributions ici réunies voudraient apporter des éléments de réponse. De manière transversale ou via des études de cas plus spécifiques, cet ouvrage tâchera de déterminer quels sont, dans la tradition comme dans la philosophie contemporaine, les candidats sérieux au titre de « principe métaphysique »
Keywords	Philosophy (General)
Size	1 electronic resource ( pages)
Publisher	Collège de France
Document type	Book ; Online
Note	French ; Open Access
HBZ-ID	HT020676805
ISBN	9782722605350 ; 272260535X
DOI	10.4000/books.cdf.7845
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality.

Sauvage, Ambre / Laurent, Emeline / Gaborit, Christophe / Guillon, Antoine / Grammatico-Guillon, Leslie

Infection

2024

Abstract: Background: Herpes simplex encephalitis (HSE) is a disease with unfavorable vital and functional prognoses. There are no recent epidemiological data on HSE at a national level using real-life databases, especially in France. This study aimed to report ... ...

Abstract	Background: Herpes simplex encephalitis (HSE) is a disease with unfavorable vital and functional prognoses. There are no recent epidemiological data on HSE at a national level using real-life databases, especially in France. This study aimed to report the incidence, the clinical characteristics and outcomes of the patients with HSE. Methods: We conducted a comprehensive retrospective cohort study on all patients hospitalized for HSE in France between 2015 and 2022 using national hospital discharge databases. Incidence, socio-demographic and clinical characteristics (including comorbidities, seizure, stays' features, intensive care supports) were described. The short- (first stay) and long-term (6-month) outcomes were reported, in terms of mortality and rehospitalizations. Results: 1425 HSE patients were included (median age 67 [54-77] years old, M/F sex ratio 1.07), giving a mean yearly hospital incidence of 2.3 [2.1-2.5] per 1,000,000 inhabitants. 51.2% of the patients were admitted in ICU (n = 730), of whom 59.0% were mechanically ventilated. The overall mortality during the first stay was 14.3% (n = 204), up to 17.9% for ICU patients. Within 6 months, among the survivors, 10.1% had at least one rehospitalization related to HSE. At 6 months, 16.5% of all patients had died (n = 235), 20.8% for ICU patients. Conclusion: In France, the incidence of hospitalizations for HSE was 2.3 per 1,000,000 inhabitants with more than half of the patients admitted in ICU and a 6-month in-hospital mortality about 16.5%. This real-life update on the characteristics and severe outcomes of the disease raises awareness among care practitioners, of the serious nature of the disease, and thus can lead to higher vigilance.
Language	English
Publishing date	2024-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-024-02272-3
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Article ; Online: Enhancing mathematics learning through finger-counting: A study investigating tactile strategies in 2 visually impaired cases.

Marlair, Cathy / Guillon, Aude / Vynckier, Menik / Crollen, Virginie

Applied neuropsychology. Child

2024 , Page(s) 1–13

Abstract: Finger-counting plays a crucial role in grounding and establishing mathematics, one of the most abstract domains of human cognition. While the combination of visual and proprioceptive information enables the coordination of finger movements, it was ... ...

Abstract	Finger-counting plays a crucial role in grounding and establishing mathematics, one of the most abstract domains of human cognition. While the combination of visual and proprioceptive information enables the coordination of finger movements, it was recently suggested that the emergence of finger-counting primarily relies on visual cues. In this study, we aimed to directly test this assumption by examining whether explicit finger-counting training (through tactile stimulation) may assist visually impaired children in overcoming their difficulties in learning mathematics. Two visually impaired participants (2 boys of 8.5 and 7.5 years) were therefore trained to use their fingers to calculate. Their pre- and post-training performance were compared to two control groups of sighted children who underwent either the same finger counting training (8 boys, 10 girls, Mage = 5.9 years; 10 kindergarteners and eight 1st graders) or another control vocabulary training (10 boys, 8 girls, Mage = 5.9 years; 11 kindergarteners and seven 1st graders). Results demonstrated that sighted children's arithmetic performance improved much more after the finger training than after the vocabulary training. Importantly, the positive impact of the finger training was also observed in both visually impaired participants (for addition and subtraction in one child; only for addition in the other child). These results are discussed in relation to the sensory compensation hypothesis and emphasize the importance of early and appropriate instruction of finger-based representations in both sighted and visually impaired children.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673759-0
ISSN	2162-2973 ; 2162-2965
ISSN (online)	2162-2973
ISSN	2162-2965
DOI	10.1080/21622965.2024.2333832
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Article ; Online: Pneumomediastinum in critically ill adult with COVID-19.

Collercandy, N / Guillon, A

Medicina intensiva

2022 Volume 46, Issue 11, Page(s) 663

MeSH term(s)	Humans ; COVID-19/complications ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Critical Illness ; SARS-CoV-2 ; Risk Factors
Language	English
Publishing date	2022-09-12
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2020.06.016
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Article ; Online: The use of uncemented stems in femoral neck fractures in elderly patients: A comparative study of 671 cases.

Gounot, Alexandre / Charlot, Anahita / Guillon, Pascal / Schaefer, Augustin / Moslemi, Aymane / Boutroux, Pierre / Sautet, Alain

Orthopaedics & traumatology, surgery & research : OTSR

2024 , Page(s) 103878

Abstract: Introduction: The use of cemented stems in elderly patients is associated with the risk of intraoperative embolic complications. Uncemented stems eliminate this risk, but their use is controversial because of the risk of mechanical complications, with ... ...

Abstract	Introduction: The use of cemented stems in elderly patients is associated with the risk of intraoperative embolic complications. Uncemented stems eliminate this risk, but their use is controversial because of the risk of mechanical complications, with estimated subsidence between 3.6 and 30% and periprosthetic fractures between 2.1 and 11% at 6 weeks. A retrospective multicenter comparative study was conducted using a propensity score analysis to evaluate mechanical performances of uncemented stems in femoral neck fractures in elderly patients to (1) compare the risk of mechanical complications and (2) assess the use of metaphyseal-anchored stems for this indication. Hypothesis: There is no difference in the risk of mechanical complications, intraoperatively or postoperatively, between these stems. Materials and methods: We conducted a multicenter retrospective comparative study including 358 uncemented and 313 cemented stems. The mean age was 84.5 years [83.9-85.1]. The inclusion criteria were patients 70 years and older and a follow-up of at least 6 weeks. The primary endpoint was a composite endpoint comprised of stem subsidence≥2mm or periprosthetic fracture (up to 3 months postoperatively). The secondary endpoints were infection, stem subsidence≥2mm, and operative time. These endpoints were analyzed using a propensity score to control confounding factors. A secondary analysis used the same endpoints to compare metaphyseal-anchored (short stems) versus Corail-like stems. Results: After adjusting for the propensity score, we found 11.17% mechanical complications in the uncemented group (n=40, 5.59% subsidence, and 5.59% fractures) versus 13.42% for the cemented group (n=42, 7.99% subsidence, and 5.43% fractures). There was no statistically significant difference between the 2 values (Odds Ratio [OR]=0.64 [95% Confidence Interval [CI]: 0.14-2.85] [p=0.7]). The mortality rate due to cement embolism was 1%. There was no difference in the rate of subsidence (OR=0.55 [95% CI: 0.02-12.5] [p=0.7]), periprosthetic fracture (OR=0.65 [95% CI: 0.13-3.12] [p=0.7]) or infection (OR=0.71 [95% CI: 0.32-1.55] [p=0.4]). However, the operative times were longer in the cemented group (p=0.03 for hemiarthroplasties [mean additional time 16minutes] and p=0.02 for total hip arthroplasties [mean additional time 22minutes]). No difference was observed between the metaphyseal-anchored (short stems) and Corail-like stems regarding operative time, rate of infection, and rate of stem subsidence or periprosthetic fractures. Discussion: This is one of the first studies to highlight cemented stem subsidence when used for femoral neck fractures in elderly patients. Using uncemented stems in this indication is still warranted, especially since they do not bring about more mechanical complications in the first few months. Metaphyseal-anchored short stems seem to give the same results as "standard" stems. However, these findings need to be assessed in the longer term. Level of evidence: III; retrospective comparative study.
Language	English
Publishing date	2024-04-04
Publishing country	France
Document type	Journal Article
ISSN	1877-0568
ISSN (online)	1877-0568
DOI	10.1016/j.otsr.2024.103878
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Article ; Online: Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS.

Guillon, Antoine / Jouan, Youenn / Kassa-Sombo, Arthur / Paget, Christophe / Dequin, Pierre-François

Critical care (London, England)

2024 Volume 28, Issue 1, Page(s) 101

MeSH term(s)	Humans ; COVID-19/complications ; Interleukin-6 ; Hydrocortisone/therapeutic use ; Lung ; Respiratory Distress Syndrome/drug therapy
Chemical Substances	Interleukin-6 ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Letter
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-024-04887-2
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Zs.A 5517: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: 2-year survival among elderly hospitalised for acute respiratory infection

Guillon, Antoine / Mizgerd, Joseph P / Grammatico-Guillon, Leslie

European respiratory review : an official journal of the European Respiratory Society

2020 Volume 29, Issue 158

MeSH term(s)	Aged ; Hip Fractures/diagnosis ; Hip Fractures/therapy ; Humans ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-12-02
Publishing country	England
Document type	Letter
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0156-2020
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Article ; Online: Metformin and lamotrigine sorption on a digestate amended soil in presence of trace metal contamination.

Baldasso, Veronica / Sayen, Stéphanie / Gomes, Carlos A R / Frunzo, Luigi / Almeida, C Marisa R / Guillon, Emmanuel

Journal of hazardous materials

2024 Volume 466, Page(s) 133635

Abstract: The antidiabetic drug metformin and antiepileptic drug lamotrigine are contaminants of emerging concern that have been detected in biowaste-derived amendments and in the environment, and their fate must be carefully studied. This work aimed to evaluate ... ...

Abstract	The antidiabetic drug metformin and antiepileptic drug lamotrigine are contaminants of emerging concern that have been detected in biowaste-derived amendments and in the environment, and their fate must be carefully studied. This work aimed to evaluate their sorption behaviour on soil upon digestate application. Experiments were conducted on soil and digestate-amended soil as a function of time to study kinetic processes, and at equilibrium also regarding the influence of trace metals (Pb, Ni, Cr, Co, Cu, Zn) at ratio pharmaceutical/metal 1/1, 1/10, and 1/100. Pharmaceutical desorption experiments were also conducted to assess their potential mobility to groundwater. Results revealed that digestate amendment increased metformin and lamotrigine adsorbed amounts by 210% and 240%, respectively, increasing organic matter content. Metformin adsorption kinetics were best described by Langmuir model and those of lamotrigine by Elovich and intraparticle diffusion models. Trace metals did not significantly affect the adsorption of metformin in amended soil while significantly decreased that of lamotrigine by 12-39%, with exception for Cu
MeSH term(s)	Soil ; Metals, Heavy/analysis ; Lamotrigine ; Anticonvulsants ; Metformin ; Soil Pollutants/analysis ; Trace Elements ; Adsorption ; Pharmaceutical Preparations
Chemical Substances	Soil ; Metals, Heavy ; Lamotrigine (U3H27498KS) ; Anticonvulsants ; Metformin (9100L32L2N) ; Soil Pollutants ; Trace Elements ; Pharmaceutical Preparations
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133635
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Article ; Online: Multifocal contact lens success predictability.

Lazon de la Jara, Percy / Sulley, Anna / Pepe, Pasquale / Walsh, Karen / Guillon, Michel

Contact lens & anterior eye : the journal of the British Contact Lens Association

2024 Volume 47, Issue 2, Page(s) 102105

Abstract: Purpose: The current multi-study analysis combined data from three studies to quantify the relationship between the initial reaction to soft multifocal contact lens (MFCL) design types at dispensing and evaluate the predictability of overall vision ... ...

Abstract	Purpose: The current multi-study analysis combined data from three studies to quantify the relationship between the initial reaction to soft multifocal contact lens (MFCL) design types at dispensing and evaluate the predictability of overall vision satisfaction (OVS) and intention to purchase (ITP) after 1 week of wear. Method: Three prospective studies tested MFCLs over 1-week of wear following the same protocol, using a range of potentially predictive ratings at dispensing, and both OVS and ITP at 1-week as an indicator acceptance level. In each study, two of MyDay® multifocal, clariti® 1 day multifocal, Biofinity® multifocal (worn as a daily disposable lens) or 1 DAY ACUVUE® MOIST MULTIFOCAL were dispensed for 1-week of daily wear. OVS was recorded on a 100-point VAS and ITP on a 5-point LIKERT scale. Fourteen possible predictors were entered in the statistical model, and predictability was assessed using Chi-square Automatic Interaction Detector (CHAID) statistical test. Results: A total of 210 participants (152 female & 58 male; 53.9 ± 6.5 years, range 41-71 years), representing 420 MFCL fits, equally distributed between emergent n = 65, established n = 70 and advanced n = 75 presbyopes, completed the studies. OVS on dispensing was the predictor of both OVS (p < 0.001) and ITP (p < 0.001) at 1-week. For OVS predictability, 70.8 % with OVS at dispensing > 91 points reported good OVS at 1-week and 73.4 % with OVS on dispensing ≤ 80 points reported poor OVS at 1-week. For ITP predictability, 74.6 % with OVS at dispensing > 94 points reported a positive ITP at 1-week and 65.9 % with OVS on dispensing ≤ 63 points reported negative ITP at 1-week. Conclusion: Overall vision satisfaction at the time of dispensing MFCLs is a powerful indicator of both OVS and ITP after 1-week of wear. Initial patient subjective assessments provide a clinically useful indicator of the likeliness of success.
MeSH term(s)	Humans ; Male ; Female ; Visual Acuity ; Prospective Studies ; Vision, Ocular ; Contact Lenses, Hydrophilic ; Presbyopia
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2004847-6
ISSN	1476-5411 ; 1367-0484
ISSN (online)	1476-5411
ISSN	1367-0484
DOI	10.1016/j.clae.2023.102105
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Article ; Online: Novel insights into the host cell glycan binding profile of human metapneumovirus.

Van Den Bergh, Annelies / Bailly, Benjamin / Guillon, Patrice / von Itzstein, Mark / Dirr, Larissa

Journal of virology

2024 , Page(s) e0164123

Abstract: Numerous viruses have been found to exploit glycoconjugates expressed on human cells as their initial attachment factor for viral entry and infection. The virus-cell glycointeractome, when characterized, may serve as a template for antiviral drug design. ...

Abstract	Numerous viruses have been found to exploit glycoconjugates expressed on human cells as their initial attachment factor for viral entry and infection. The virus-cell glycointeractome, when characterized, may serve as a template for antiviral drug design. Heparan sulfate proteoglycans extensively decorate the human cell surface and were previously described as a primary receptor for human metapneumovirus (HMPV). After respiratory syncytial virus, HMPV is the second most prevalent respiratory pathogen causing respiratory tract infection in young children. To date, there is neither vaccine nor drug available to prevent or treat HMPV infection. Using a multidisciplinary approach, we report for the first time the glycointeractome of the HMPV fusion (F) protein, a viral surface glycoprotein that is essential for target-cell recognition, attachment, and entry. Our glycan microarray and surface plasmon resonance results suggest that Galβ1-3/4GlcNAc moieties that may be sialylated or fucosylated are readily recognized by HMPV F. The bound motifs are highly similar to the
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01641-23
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