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  1. Article ; Online: Relationships Among Baseline Concussion Balance Test and Gaze Stability Test Scores in Division-I Collegiate Athletes.

    Quintana, Carolina P / Olson, Anne D / Heebner, Nicholas R / Hoch, Matthew C

    Journal of sport rehabilitation

    2024  , Page(s) 1–8

    Abstract: ... Concussion Balance Test errors (r = .20-.31, P = .001-.03).: Conclusions: The direction ...

    Abstract Context: Sports-related concussions are commonly occurring injuries as a result of sports and recreation that may cause alterations in brain functioning. It is important to be able to evaluate the impact of these injuries on function to manage the injury recovery and ensure recovery. Recent literature suggests the use of objective evaluation strategies in a multifaceted approach to evaluate and manage these injuries. It is important to understand the relationships between the assessments and how best to utilize each assessment. The purpose of this study was to investigate if relationships exist between measures of vestibular function at baseline in assessments that may be used following sports-related concussions. Additionally, a secondary purpose was to determine if self-reported symptoms were related to performance on the assessments. This study aimed to identify if these assessments measured independent functions of the vestibulo-ocular reflex or if some redundancy existed among the assessment strategies.
    Design: A cross-sectional study design was used in a cohort of collegiate athletes ages 18-24.
    Methods: Participants completed demographics questionnaires, the Post-Concussion Symptom Scale, Gaze Stabilization Test, and Concussion Balance Test. Spearman rho correlations were used to examine the relationships between the measures.
    Results: One hundred and thirty-five collegiate athletes (82 males and 53 females) were included, representative of 3 sports (cheerleading, soccer, and football) with a mean age of 19.77 (1.42) years old. There were weak to moderate, significant relationships between measures of Gaze Stabilization Test and Concussion Balance Test errors (r = .20-.31, P = .001-.03).
    Conclusions: The direction of these relationships indicated that greater Concussion Balance Test errors were associated with greater Gaze Stabilization Test performance. These relationships may be attributed to the difficulty created by the foam conditions and the integration of more complex sensory tasks required to maintain balance during the more difficult conditions.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106769-x
    ISSN 1543-3072 ; 1056-6716
    ISSN (online) 1543-3072
    ISSN 1056-6716
    DOI 10.1123/jsr.2023-0254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Detailed survey of an

    Ran, Ran / Muñoz Briones, Javier / Jena, Smrutiti / Anderson, Nicole L / Olson, Matthew R / Green, Leopold N / Brubaker, Douglas K

    iScience

    2024  Volume 27, Issue 4, Page(s) 109383

    Abstract: The co-culture of two adult human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as ... ...

    Abstract The co-culture of two adult human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as an
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: T

    Olson, Matthew R / Kaplan, Mark H

    The Journal of allergy and clinical immunology

    2018  Volume 143, Issue 3, Page(s) 935–936

    MeSH term(s) Humans ; Job Syndrome ; STAT1 Transcription Factor ; STAT3 Transcription Factor
    Chemical Substances STAT1 Transcription Factor ; STAT1 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.10.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A saliva urea test strip for use in feline and canine patients: a pilot study.

    Nickel, Matthew R / Sweet, Hillary M / Lee, Albert / Bohaychuk-Preuss, Kaylee / Varnhagen, Connie / Olson, Merle

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2022  Volume 34, Issue 3, Page(s) 496–503

    Abstract: ... correlation was found for saliva urea against serum urea in each species (dogs: r ...

    Abstract We evaluated a saliva urea test strip (Kidney-Chek; SN Biomedical), as a rapid, noninvasive method to screen for azotemia. The test is a semiquantitative method that assesses 7 levels of saliva urea concentration, and indirectly serum urea, from <3 to >17 mmol/L. Ninety-two dogs (14 azotemic) with serum urea of 1.3-37 mmol/L and 56 cats (16 azotemic) with serum urea of 4.1-89.3 mmol/L were enrolled. A positive correlation was found for saliva urea against serum urea in each species (dogs: r
    MeSH term(s) Animals ; Azotemia/veterinary ; Blood Urea Nitrogen ; Cat Diseases/diagnosis ; Cats ; Dog Diseases/diagnosis ; Dogs ; Female ; Male ; Pilot Projects ; Saliva/chemistry ; Urea/analysis
    Chemical Substances Urea (8W8T17847W)
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/10406387221086917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Granzyme-Producing CD4 T Cells in Cancer and Autoimmune Disease.

    Park, Sungtae / Anderson, Nicole L / Canaria, D Alejandro / Olson, Matthew R

    ImmunoHorizons

    2021  Volume 5, Issue 12, Page(s) 909–917

    Abstract: CD4 T cells play important roles in promoting protective immunity and autoimmune disease. A great deal of attention has been given to the differentiation and function of subsets of cytokine-producing CD4 T cells (i.e., Th1, Th2, and Th17 cells) in these ... ...

    Abstract CD4 T cells play important roles in promoting protective immunity and autoimmune disease. A great deal of attention has been given to the differentiation and function of subsets of cytokine-producing CD4 T cells (i.e., Th1, Th2, and Th17 cells) in these settings. However, others have also observed the accumulation of granzyme-producing CD4 T cells in tumors and in autoimmune patients that are distinct from their cytokine-producing counterparts. Despite the relatively large numbers of granzyme-producing cells in diseased tissues, their roles in driving disease have remained enigmatic. This review will focus on the phenotype(s) and roles of granzyme-producing CD4 T cells in cancer and autoimmunity. We will also examine how granzyme-producing cells interact with current therapeutics and speculate how they may be targeted during disease.
    MeSH term(s) Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmunity/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cytokines/immunology ; Granzymes/metabolism ; Humans ; Neoplasms/immunology ; Neoplasms/pathology ; Th1 Cells/immunology ; Th17 Cells/immunology ; Th2 Cells/immunology
    Chemical Substances Cytokines ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2100017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tox induces T cell IL-10 production in a BATF-dependent manner.

    Canaria, D Alejandro / Rodriguez, J Alejandra / Wang, Luopin / Yeo, Franklin J / Yan, Bingyu / Wang, Mengbo / Campbell, Charlotte / Kazemian, Majid / Olson, Matthew R

    Frontiers in immunology

    2023  Volume 14, Page(s) 1275423

    Abstract: Tox is a member of the high mobility group (HMG)-Box transcription factors and plays important roles in thymic T cell development. Outside of the thymus, however, Tox is also highly expressed by CD8 and CD4 T cells in various states of activation and in ... ...

    Abstract Tox is a member of the high mobility group (HMG)-Box transcription factors and plays important roles in thymic T cell development. Outside of the thymus, however, Tox is also highly expressed by CD8 and CD4 T cells in various states of activation and in settings of cancer and autoimmune disease. In CD4 T cells, Tox has been primarily studied in T follicular helper (TFH) cells where it, along with Tox2, promotes TFH differentiation by regulating key TFH-associated genes and suppressing CD4 cytotoxic T cell differentiation. However, the role of Tox in other T helper (Th) cell subtypes is less clear. Here, we show that Tox is expressed in several physiologically-activated Th subtypes and its ectopic expression enhances the
    MeSH term(s) Humans ; Basic-Leucine Zipper Transcription Factors/metabolism ; Interleukin-10/genetics ; Interleukin-10/metabolism ; T-Lymphocytes, Helper-Inducer ; Cell Differentiation ; Inflammation/metabolism
    Chemical Substances Basic-Leucine Zipper Transcription Factors ; Interleukin-10 (130068-27-8) ; BATF protein, human
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1275423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control

    Datta, Abhishek / Hernandez-Franco, Juan F / Park, Sungtae / Olson, Matthew R / HogenEsch, Harm / Thangamani, Shankar

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 6

    Abstract: ... ...

    Abstract Invasive
    Language English
    Publishing date 2022-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8060610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Technologist-Based Implementation of Total Metabolic Tumor Volume into Clinical Practice.

    Quinn, Erina / Olson, Claire / Jain, Manoj K / Sullivan, Jaiden / Thorpe, Matthew P / Johnson, Geoffrey B / Young, Jason R

    Journal of nuclear medicine technology

    2022  Volume 51, Issue 1, Page(s) 57–59

    Abstract: Metabolic tumor volume (MTV) is defined as the total metabolically active tumor volume seen ... ...

    Abstract Metabolic tumor volume (MTV) is defined as the total metabolically active tumor volume seen on
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Tumor Burden ; Positron-Emission Tomography ; Neoplasms ; Prognosis ; Retrospective Studies ; Radiopharmaceuticals
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189163-7
    ISSN 1535-5675 ; 0091-4916
    ISSN (online) 1535-5675
    ISSN 0091-4916
    DOI 10.2967/jnmt.122.264714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multiomic Profiling of Human Clonal Hematopoiesis Reveals Genotype and Cell-Specific Inflammatory Pathway Activation.

    Heimlich, Jonathan Brett / Bhat, Pawan / Parker, Alyssa / Jenkins, Matthew T / Vlasschaert, Caitlyn / Ulloa, Jessica / Van Amburg, Joseph / Potts, Chad R / Olson, Sydney / Silver, Alexander J / Ahmad, Ayesha / Sharber, Brian / Brown, Donovan / Hu, Ningning / van Galen, Peter / Savona, Michael R / Bick, Alexander G / Ferrell, Paul Brent

    Blood advances

    2024  

    Abstract: Clonal hematopoiesis (CH) is an age-associated phenomenon that increases risk for hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk through inflammation in the peripheral blood1. Here, we profile peripheral blood ... ...

    Abstract Clonal hematopoiesis (CH) is an age-associated phenomenon that increases risk for hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk through inflammation in the peripheral blood1. Here, we profile peripheral blood gene expression in 66,968 single cells from a cohort of 17 CH patients and 7 controls. Using a novel mitochondrial DNA barcoding approach, we were able to identify and separately compare mutant TET2 and DNMT3A cells to non-mutant counterparts. We discovered the vast majority of mutated cells were in the myeloid compartment. Additionally, patients harboring DNMT3A and TET2 CH mutations possessed a pro-inflammatory profile in CD14+ monocytes through previously unrecognized pathways such as galectin and macrophage Inhibitory Factor (MIF). We also found that T cells from CH patients, though mostly un-mutated, had decreased expression of GTPase of the immunity associated protein (GIMAP) genes, which are critical to T cell development, suggesting that CH impairs T cell function.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia.

    Connor, Matthew P / Prathapa, Neeharika / Frey, Noelle V / Gill, Saar I / Hexner, Elizabeth O / Bruno, Ximena Jordan / Lai, Catherine E / Loren, Alison W / Luger, Selina M / Matthews, Andrew H / McCurdy, Shannon R / Perl, Alexander E / Porter, David L / Zeringue, Arlene / Oved, Joseph H / Olson, Timothy S / Pratz, Keith W / Babushok, Daria V

    Haematologica

    2024  

    Abstract: Not available. ...

    Abstract Not available.
    Language English
    Publishing date 2024-04-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2024.285275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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