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  1. Book ; Online ; E-Book: Elastography of the musculoskeletal system

    Marsico, Salvatore / Solano, Albert

    2023  

    Author's details Salvatore Marsico, Albert Solano editors
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (x, 127 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030062325
    ISBN 978-3-031-31054-6 ; 9783031310539 ; 3-031-31054-3 ; 3031310535
    DOI 10.1007/978-3-031-31054-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Transfer learning identifies sequence determinants of cell-type specific regulatory element accessibility.

    Salvatore, Marco / Horlacher, Marc / Marsico, Annalisa / Winther, Ole / Andersson, Robin

    NAR genomics and bioinformatics

    2023  Volume 5, Issue 2, Page(s) lqad026

    Abstract: Dysfunction of regulatory elements through genetic variants is a central mechanism in the pathogenesis of disease. To better understand disease etiology, there is consequently a need to understand how DNA encodes regulatory activity. Deep learning ... ...

    Abstract Dysfunction of regulatory elements through genetic variants is a central mechanism in the pathogenesis of disease. To better understand disease etiology, there is consequently a need to understand how DNA encodes regulatory activity. Deep learning methods show great promise for modeling of biomolecular data from DNA sequence but are limited to large input data for training. Here, we develop ChromTransfer, a transfer learning method that uses a pre-trained, cell-type agnostic model of open chromatin regions as a basis for fine-tuning on regulatory sequences. We demonstrate superior performances with ChromTransfer for learning cell-type specific chromatin accessibility from sequence compared to models not informed by a pre-trained model. Importantly, ChromTransfer enables fine-tuning on small input data with minimal decrease in accuracy. We show that ChromTransfer uses sequence features matching binding site sequences of key transcription factors for prediction. Together, these results demonstrate ChromTransfer as a promising tool for learning the regulatory code.
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ISSN 2631-9268
    ISSN (online) 2631-9268
    DOI 10.1093/nargab/lqad026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bilateral intercostal, subscapular and teres major heterotopic ossifications in a 63-year-old male with COVID-19.

    Micolich Vergara, Alejandra / Marsico, Salvatore / Solano López, Alberto / Zuccarino, Flavio

    Oxford medical case reports

    2022  Volume 2022, Issue 3, Page(s) omac024

    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omac024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Spontaneous Pneumothorax in COVID-19 Patients.

    Marsico, Salvatore / Bellido, Luis Alexander Del Carpio / Zuccarino, Flavio

    Archivos de bronconeumologia

    2020  Volume 57, Page(s) 66

    Language English
    Publishing date 2020-08-28
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2020.07.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Re-expansion of vertebral compression fractures in patients with multiple myeloma with percutaneous vertebroplasty using spinejack implants: a preliminary and retrospective study.

    Pusceddu, Claudio / Faiella, Eliodoro / Derudas, Daniele / Ballicu, Nicola / Melis, Luca / Zedda, Stefano / Marsico, Salvatore

    Frontiers in surgery

    2023  Volume 10, Page(s) 1121981

    Abstract: Objective: To retrospectively evaluate the feasibility and effectiveness of vertebroplasty using Spinejack implantation for the treatment and stabilization of painful vertebral compression fractures, in patients diagnosed with Multiple Myeloma (MM), to ... ...

    Abstract Objective: To retrospectively evaluate the feasibility and effectiveness of vertebroplasty using Spinejack implantation for the treatment and stabilization of painful vertebral compression fractures, in patients diagnosed with Multiple Myeloma (MM), to allow both an effective pain reduction and a global structural spine stabilization.
    Materials and methods: From July 2017 and May 2022 thirty-nine patients diagnosed MM, with forty-nine vertebral compression fractures underwent percutaneous Vertebroplasty using Spinejack Implants. We analyzed the feasibility and complications of the procedure, the decrease in pain using visual analogue scale (VAS) and Functional Mobility Scale (FMS).
    Results: The technical success rate was 100%. No procedure-related major complications or death occurred. In the 6-month follow-up, the mean VAS score decreased from 5.4 ± 1.0 to 0.2 ± 0.5 with a mean reduction of 96.3%. FMS decreased from 2.3 ± 0.5 vs. 1.2 ± 0.4 with a mean reduction of -47.8%. There were no major complications related to incorrect positioning of the Expandable Titanium SpineJack Implants. In five patients, a cement leak was observed with no associated clinical manifestations. The average length of hospital stay was 6-8 Hours6.6 ± 1.2 h. No new bone fractures or local disease recurrence occurred during a median contrast-enhanced CT follow-up of 6 months.
    Conclusions: Our results suggest that vertebroplasty, using Spinejack implantation for the treatment and stabilization of painful vertebral compression fractures, secondary to Multiple Myeloma is a safe and effective procedure with long - term pain relief and restoration of vertebral height.
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1121981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bacterial Superinfection in COVID-19 Patients Diagnosed With Dual-Energy CT Pulmonary Angiography.

    Marsico, Salvatore / Toledo, Santiago Javier Carbullanca / Zuccarino, Flavio

    Open respiratory archives

    2020  Volume 2, Issue 4, Page(s) 295

    Language English
    Publishing date 2020-10-09
    Publishing country Spain
    Document type Journal Article
    ISSN 2659-6636
    ISSN (online) 2659-6636
    DOI 10.1016/j.opresp.2020.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Towards in silico CLIP-seq: predicting protein-RNA interaction via sequence-to-signal learning.

    Horlacher, Marc / Wagner, Nils / Moyon, Lambert / Kuret, Klara / Goedert, Nicolas / Salvatore, Marco / Ule, Jernej / Gagneur, Julien / Winther, Ole / Marsico, Annalisa

    Genome biology

    2023  Volume 24, Issue 1, Page(s) 180

    Abstract: We present RBPNet, a novel deep learning method, which predicts CLIP-seq crosslink count distribution from RNA sequence at single-nucleotide resolution. By training on up to a million regions, RBPNet achieves high generalization on eCLIP, iCLIP and ... ...

    Abstract We present RBPNet, a novel deep learning method, which predicts CLIP-seq crosslink count distribution from RNA sequence at single-nucleotide resolution. By training on up to a million regions, RBPNet achieves high generalization on eCLIP, iCLIP and miCLIP assays, outperforming state-of-the-art classifiers. RBPNet performs bias correction by modeling the raw signal as a mixture of the protein-specific and background signal. Through model interrogation via Integrated Gradients, RBPNet identifies predictive sub-sequences that correspond to known and novel binding motifs and enables variant-impact scoring via in silico mutagenesis. Together, RBPNet improves imputation of protein-RNA interactions, as well as mechanistic interpretation of predictions.
    MeSH term(s) Humans ; Alleles ; Base Sequence ; Bias ; Binding Sites ; Computer Simulation ; Consensus Sequence ; Datasets as Topic ; Deep Learning ; Internet ; Mutation ; Nucleotide Motifs ; Nucleotides/metabolism ; RNA/chemistry ; RNA/genetics ; RNA/metabolism ; RNA Splice Sites ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Viral/chemistry ; RNA, Viral/genetics ; RNA, Viral/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism
    Chemical Substances Nucleotides ; RNA (63231-63-0) ; RNA Splice Sites ; RNA, Messenger ; RNA, Viral ; RNA-Binding Proteins
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-023-03015-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Spontaneous Pneumomediastinum and Macklin Effect in COVID-19 Patients.

    Marsico, Salvatore / Del Carpio Bellido, Luis Alexander / Zuccarino, Flavio

    Archivos de bronconeumologia

    2020  Volume 57, Page(s) 67

    Language English
    Publishing date 2020-08-27
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2020.07.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2655: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Calcifying Aponeurotic Fibroma: A Multimodal Imaging Description of an Unusual Case Involving Soft Tissues Adjacent to the Clavicle.

    Sanmiguel, Javier / Diaz, Pablo Santiago / Marsico, Salvatore / Lloreta Trull, José / Solano López, Alberto

    Radiology case reports

    2022  Volume 17, Issue 5, Page(s) 1424–1430

    Abstract: Calcifying aponeurotic fibromas (CAFs) are rare benign tumors that typically develop in the soft tissue of the extremities. We report a case of 64-year-old woman with a CAF in the soft tissue surrounding her left clavicle. A plain radiograph showed an ... ...

    Abstract Calcifying aponeurotic fibromas (CAFs) are rare benign tumors that typically develop in the soft tissue of the extremities. We report a case of 64-year-old woman with a CAF in the soft tissue surrounding her left clavicle. A plain radiograph showed an asymmetrical increase in opacity of the left internal clavicular region. Computed tomography and magnetic resonance imaging confirmed the presence of a heterogeneous lesion of the periclavicular soft tissue, with peripheral calcifications, and remodeling of the adjacent clavicular bone. Following ultrasound-guided biopsy and surgical resection of the mass, the final histological diagnosis was made. To the best of our knowledge, this is the first case of a CAF described in the soft tissue adjacent to the clavicle. It is essential to use all the diagnostic methods available (X-ray, ultrasound, CT, MRI, and percutaneous biopsy) to obtain the final diagnosis of this rare disease.
    Language English
    Publishing date 2022-03-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Percutaneous Cryoablation under Conscious Sedation: A Safe, Effective and Painless Option for the Treatment of Pediatric Osteoid Osteoma.

    Pusceddu, Claudio / Vergantino, Elva / Santucci, Domiziana / Marsico, Salvatore / Cappucci, Matteo / Vaccarino, Federica / Beomonte Zobel, Bruno / Grasso, Rosario Francesco / Faiella, Eliodoro

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: Background: Percutaneous CT-guided cryoablation is an emerging technique for treating bone tumors. However, experience with using this procedure for osteoid osteomas in pediatric patients remains limited. Our study aims to assess its technical ... ...

    Abstract Background: Percutaneous CT-guided cryoablation is an emerging technique for treating bone tumors. However, experience with using this procedure for osteoid osteomas in pediatric patients remains limited. Our study aims to assess its technical feasibility, clinical efficacy, and safety in children treated under conscious anesthesia.
    Methods: We conducted a retrospective study of consecutive pediatric patients who underwent CT-guided percutaneous cryoablation for osteoid osteomas at our institution between September 2017 and March 2021. All patients received conscious anesthesia. Data on peri-procedural VAS scores, post-procedural VAS scores, imaging findings, and nonsteroidal anti-inflammatory drug (NSAID) usage rates were collected for each patient. Technical success was defined as proper cryoprobe placement at the nidus center, while clinical success referred to pain relief without NSAID use. Intra- and post-operative complications were also evaluated.
    Results: Nine patients underwent CT-guided percutaneous cryoablation for osteoid osteomas under conscious sedation, with a 100% overall success rate with low peri-procedural and median VAS scores (
    Conclusions: CT-guided percutaneous cryoablation of pediatric osteoid osteomas is an effective and safe minimally invasive procedure feasible under conscious anesthesia, holding promise as a valuable treatment option.
    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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