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  1. Article ; Online: Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy.

    Belen-Apak, F Burcu / Sarıalioğlu, F

    Journal of thrombosis and thrombolysis

    2020  Volume 50, Issue 2, Page(s) 278–280

    MeSH term(s) Anticoagulants ; Betacoronavirus ; Blood Coagulation/drug effects ; COVID-19 ; Coronavirus Infections ; Humans ; Lung Diseases/drug therapy ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thrombolytic Therapy ; Thrombosis/drug therapy
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02129-0
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    Zs.A 4352: Show issues Location:
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  2. Article ; Online: Promising Drug Fondaparinux for the Treatment of COVID-19: an In Silico Analysis of Low Molecular Weight Heparin, Direct Oral Anticoagulant, and Antiplatelet Drug Interactions with Host Protease Furin.

    Ertan-Bolelli, Tugba / Bolelli, Kayhan / Elçi, Sıtkı Doga / Belen-Apak, F Burcu

    Cardiovascular drugs and therapy

    2022  

    Abstract: Purpose: As of July 2022, the COVID-19 pandemic has affected over 555 million worldwide confirmed cases and caused more than 6.3 million deaths. The studies showed that the D-dimer levels were increased in non-survivors compared to survivors and heparin ...

    Abstract Purpose: As of July 2022, the COVID-19 pandemic has affected over 555 million worldwide confirmed cases and caused more than 6.3 million deaths. The studies showed that the D-dimer levels were increased in non-survivors compared to survivors and heparin treatment has begun to be administered to the patients in severe clinics. As we knew that the entrance of SARS-CoV-2 to the host cell needs to be facilitated by host proteases; we published our hypothesis that heparin as a serine protease inhibitor may block the interaction between spike protein receptor-binding domain and host proteases. In our study, we aimed to investigate the interactions between not only heparins but also other antiplatelet and anticoagulant drugs including fondaparinux.
    Methods: In this study, docking studies were carried out to evaluate the interactions between low molecular weight heparins (LMWHs) (enoxaparin, dalteparin, tinzaparin), direct oral anticoagulant, and antiplatelet drugs with host proteases. Molecular docking studies were performed by using Schrödinger molecular modeling software. 3D structures of the ligands were obtained from the 2D structures by assigning the OPLS-2005 force field using the Maestro 12.7. The 3D crystal structure of the furin complexed with an inhibitor, 2,5-dideoksistreptamin derivative, was extracted from the Protein Data Bank (PDB ID: 5MIM). Docking studies were carried out using the Grid-based Ligand Docking with Energetics module of the Schrödinger Software.
    Results: The docking studies revealed that fondaparinux was the most relevant molecule to interact with furin with a docking score of - 12.74. It showed better interaction than the natural ligand of furin with an increased score compared to the docking score of - 8.155 of the natural ligand. AnaGA*IsA structure representing LMWH structure has shown a docking score of - 11.562 which was also better than the score of the natural ligand of furin.
    Conclusion: Our findings have shown that LMWHs and fondaparinux can be used for their possible antiviral effects in COVID-19 patients. Our results have shown that in accordance with heparin and LMWH, fondaparinux can also be a candidate for "drug repurposing" in COVID-19 therapy, not only because of their anticoagulant but also possible antiviral effects.
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-022-07406-z
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  3. Article: Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy

    Belen-Apak, F Burcu / Sarialioglu, F

    J Thromb Thrombolysis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #175842
    Database COVID19

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  4. Article ; Online: Pulmonary intravascular coagulation in COVID-19

    Belen-Apak, F. Burcu / Sarıalioğlu, F.

    Journal of Thrombosis and Thrombolysis

    possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy

    2020  Volume 50, Issue 2, Page(s) 278–280

    Keywords Hematology ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1230645-9
    ISSN 0929-5305
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02129-0
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    Zs.A 4352: Show issues Location:
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  5. Article ; Online: Persistent Hyperinsulinemic Hypoglycemia with Pancreatic Teratoma in Infancy: A Case Report.

    Cemeroglu, Ayse Pinar / Sarialioglu, Faik / Belen-Apak, Fatma Burcu / Terzi, Yunus Kasim

    The American journal of case reports

    2020  Volume 21, Page(s) e925273

    Abstract: BACKGROUND Pediatric intraabdominal pancreatic teratomas have been rarely reported. This is the first case of severe hyperinsulinemic hypoglycemia in a 6-month-old infant secondary to an intraabdominal teratoma. The hypoglycemia resolved after surgical ... ...

    Abstract BACKGROUND Pediatric intraabdominal pancreatic teratomas have been rarely reported. This is the first case of severe hyperinsulinemic hypoglycemia in a 6-month-old infant secondary to an intraabdominal teratoma. The hypoglycemia resolved after surgical removal. CASE REPORT A 6-month-old infant was seen in a pediatric emergency department with complaints of lethargy and abnormal eye movements. She was diagnosed with hyperinsulinemic hypoglycemia and started on diazoxide. A CT and MRI of the abdomen revealed a 165×77×72 mm cyst with a 51×45×30 mm solid structure connecting to the wall of the cyst by a stalk, raising suspicion of a fetus in fetu. The mass had no connection to her pancreas. Following total excision of the intraabdominal mass, her hypoglycemia resolved. Histopathological examination showed immature fetal pancreatic tissue consistent with a mature teratoma. Whole exon sequencing of the infant's peripheral blood showed a negative mutation of ABCC8 and presence of heterozygous variations of HNF1ß and IRS1 genes. CONCLUSIONS This is the first case report of an infant with severe hyperinsulinemic hypoglycemia secondary to a pancreatic teratoma. The heterozygous variations of HNF1ß and IRS1 genes likely played a role in the embryogenesis, causing a pancreatic teratoma and hyperinsulinemic hypoglycemia.
    MeSH term(s) Congenital Hyperinsulinism/etiology ; Female ; Genetic Variation ; Hepatocyte Nuclear Factor 1-beta/genetics ; Heterozygote ; Humans ; Infant ; Insulin Receptor Substrate Proteins/genetics ; Magnetic Resonance Imaging ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Teratoma/diagnostic imaging ; Teratoma/pathology ; Tomography, X-Ray Computed
    Chemical Substances HNF1B protein, human ; IRS1 protein, human ; Insulin Receptor Substrate Proteins ; Hepatocyte Nuclear Factor 1-beta (138674-15-4)
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.925273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Can Hepatitis A Vaccine Provide Protection Against COVID-19?

    Sarialioglu, Faik / Belen Apak, Fatma Burcu / Haberal, Mehmet

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2020  Volume 18, Issue 2, Page(s) 141–143

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; China ; Coronavirus Infections ; Hepatitis A Vaccines ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Hepatitis A Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-04-11
    Publishing country Turkey
    Document type Journal Article ; Review ; Comment
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2020.0109
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    Zs.A 6632: Show issues Location:
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  8. Article ; Online: COVID-19 Patogenezinde Pulmoner İntravasküler Koagülasyon ve Tedavi Önerileri ; Pulmonary Intravascular Coagulation Pathogenesis in COVID-19 and Treatment Recommendations

    SARIALİOĞLU, Faik / BELEN APAK, Fatma Burcu

    Volume: 3, Issue: S1 106-110 ; 2651-4060 ; Sağlık Bilimlerinde İleri Araştırmalar Dergisi

    2020  

    Abstract: Tüm dünyayı ve ülkemizi etkisi altına alan COVID-19 hastalığının patogenezinde koagülasyon sisteminin aktive olmasının önemli rolü olduğu, dissemine intravasküler koagülasyonun (DİK) laboratuvar bulgularından D-dimer değeri yüksek olan olgulara erken ... ...

    Abstract Tüm dünyayı ve ülkemizi etkisi altına alan COVID-19 hastalığının patogenezinde koagülasyon sisteminin aktive olmasının önemli rolü olduğu, dissemine intravasküler koagülasyonun (DİK) laboratuvar bulgularından D-dimer değeri yüksek olan olgulara erken dönemde düşük molekül ağırlıklı heparin (DMAH) başlanması durumunda mortalitenin azaldığı bilinmektedir. COVID-19 enfeksiyonundaki ana mekanizmalardan birinin sepsis ilişkili DİK’ten farklı organa özgü ‘Pulmoner İntravasküler Koagülasyon-PİK’ olduğunu düşünmekteyiz. Patogenetik mekanizmaları açıkladığımız derlememizde PİK erken dönemlerinde profilaktik dozda DMAH, D-dimer artışı devam etmesi durumunda tedavi dozunda DMAH, respiratuar yetmezlik gelişmesi durumunda kanama riski göz önünde bulundurularak doku plazminojen aktivatörü (tPA) ve defibrotid tedavilerinin kullanımı konusunda tedavi önerileri yer almaktadır. Bu tedavilerin COVID-19 enfeksiyonunun hangi aşamalarında kullanılmasının uygun olacağının netleştirilmesi için klinik araştırmalara gerek duyulmaktadır.

    It has been recently shown that the activation of the coagulation system takes an important part in the pathogenesis of COVID-19. It has come into insight that the mortality rate is lower in patients who were administered low molecular weight heparin (LMWH) during the course of COVID-19 when compared with those who were treated without LMWH. However, we observe that the coagulopathy accompanying COVID-19 seems to be different from sepsis associated disseminated intravascular coagulation (DIC), therefore we think that organ specific coagulopathy should be better named ‘Pulmonary Intravascular CoagulationPIC’. Here we provide possible pathogenetic mechanisms underlying COVID-19 including PIC and give treatment recommendations as administration of prophylactic LMWH at patients with increased D-dimer levels at early phase, escalation to treatment dose of LMWH in case of increasing D-dimers and usage of tPA or defibrotide with evaluation of bleeding risk in patients with respiratory insufficiency. However, in what point of COVID-19 disease shall those anticoagulant/antitrombotic-thrombolytic agents used must be evaluated with further studies.
    Keywords COVID-19,pulmoner intravasküler koagülasyon (PİK),düşük molekül ağırlıklı heparin (DMAH),doku plazminojen aktivatörü (tPA),defibrotid ; COVID-19,pulmonary intravascular coagulation (PİC),low molecular weight heparin,tissue plasminogen activator (tPA),defibrotide ; covid19
    Language Turkish
    Publishing date 2020-05-15T00:00:00Z
    Publisher İstanbul Üniversitesi
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Castleman Disease: A Multicenter Case Series from Turkey

    Gündüz, Eren / Kırkızlar, Hakkı Onur / Ümit, Elif Gülsüm / Karaman Gülsaran, Sedanur / Özkocaman, Vildan / Özkalemkaş, Fahir / Candar, Ömer / Elverdi, Tugrul / Küçükyurt, Selin / Paydaş, Semra / Çeneli, Özcan / Karakuş, Sema / Maral, Senem / Ekinci, Ömer / İpek, Yıldız / Kis, Cem / Güven, Zeynep Tuğba / Akdeniz, Aydan / Celkan, Tiraje /
    Eroğlu Küçükdiler, Ayşe Hilal / Akgün Çağlıyan, Gülsüm / Özçelik Şengöz, Ceyda / Karataş, Ayşe / Bulduk, Tuba / Özcan, Alper / Belen Apak, Fatma Burcu / Canbolat, Aylin / Kartal, İbrahim / Ören, Hale / Töret, Ersin / Özdemir, Gül Nihal / Bakanay Öztürk, Şule Mine

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2022  Volume 39, Issue 2, Page(s) 130–135

    Abstract: Objective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or ... ...

    Abstract Objective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved. The aim of this multicenter study was to evaluate all cases of CD identified to date in Turkey to set up a national registry to improve the early recognition, treatment, and follow-up of CD.
    Materials and methods: Both adult (n=130) and pediatric (n=10) patients with lymph node or involved field biopsy results reported as CD were included in the study. Patients’ demographic information, clinical and laboratory characteristics, imaging study results, treatment strategies, and clinical outcomes were evaluated retrospectively.
    Results: A total of 140 patients (69 male and 71 female) with a diagnosis of UCD (n=73) or MCD (n=67) were included. The mean age was 39 years in the UCD group and 47 years in the MCD group. Female patients were more common in the UCD group. The most common histological subtype was hyaline vascular for both UCD and MCD patients. Asymptomatic patients were more common in the UCD group. Anemia, elevations of acute phase reactants, and hypoalbuminemia were more common in the MCD group. The most commonly used treatment strategies for UCD were surgical excision, rituximab, and radiotherapy, respectively. All UCD patients were alive at a median of 19.5 months of follow-up. The most commonly used treatment strategies for MCD were methyl prednisolone, R-CHOP, R-CVP, and rituximab. Thirteen MCD patients had died at a median of 34 months of follow-up.
    Conclusion: This study is important in presenting the patient characteristics and treatment strategies for CD from Turkey, with the potential of increasing awareness about CD. Treatment data may help in making decisions, particularly in countries that do not have access to siltuximab. However, larger prospective studies are needed to make definitive conclusions.
    MeSH term(s) Adult ; Castleman Disease/diagnosis ; Castleman Disease/therapy ; Child ; Female ; Humans ; Lymph Nodes/pathology ; Male ; Retrospective Studies ; Rituximab/therapeutic use ; Turkey/epidemiology
    Chemical Substances Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-02-18
    Publishing country Turkey
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2022.2021.0670
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    Zs.A 6534: Show issues Location:
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  10. Article ; Online: Results of multicenter registry for patients with inherited factor VII deficiency in Turkey.

    Akdeniz, Aydan / Ünüvar, Ayşegül / Ar, Muhlis Cem / Pekpak, Esra / Akyay, Arzu / Mehtap, Özgür / Karadağ, Fatma Keklik / Acıpayam, Can / Doğan, Ali / Ekinci, Ömer / Köker, Sultan Aydın / Albayrak, Canan / Demirci, Ufuk / Güney, Tekin / Kurt, Meltem / Karaman, Serap / Kimyon, Özge Şahin / Albayrak, Sinan / Öncül, Yurday /
    Ünal, Serkan / Şahin, Fahri / Tuna, Rumeysa / Zulfikar, Bulent / Apak, Burcu Belen / Ümit, Elif Gülsüm / Demir, Ahmet Muzaffer

    Scandinavian journal of clinical and laboratory investigation

    2021  Volume 82, Issue 1, Page(s) 28–36

    Abstract: Introduction: Inherited factor VII (FVII) deficiency (FVIID) is the most common of inherited rare bleeding disorders. Other determinants of clinical severity apart from FVII level (FVIIL) include genetic and environmental factors. We aimed to identify ... ...

    Abstract Introduction: Inherited factor VII (FVII) deficiency (FVIID) is the most common of inherited rare bleeding disorders. Other determinants of clinical severity apart from FVII level (FVIIL) include genetic and environmental factors. We aimed to identify the cut-off FVIILs for general and severe bleedings in patients with FVIID by using an online national registry system including clinical, laboratory, and demographic characteristics of patients.
    Methods: Demographic, clinical, and laboratory data of patients with FVIID extracted from the national database, constituted by the Turkish Society of Hematology, were examined. Bleeding phenotypes, general characteristics, and laboratory features were assessed in terms of FVIILs. Bleeding rates and prophylaxis during special procedures/interventions were also recorded.
    Results: Data from 197 patients showed that 46.2% of patients had FVIIL< 10%. Most bleeds were of mucosal origin (67.7%), and severe bleeds tended to occur in younger patients (median age: 15 (IQR:6-29)). Cut-off FVIILs for all and severe bleeds were 16.5% and 7.5%, respectively. The major reason for long-term prophylaxis was observed as central nervous system bleeding (80%).
    Conclusion: Our data are consistent with most of the published literature in terms of cut-off FVIIL for bleeding, as well as reasons for prophylaxis, showing both an increased severity of bleeding and younger age at diagnosis with decreasing FVIIL. However, in order to offer a classification similar to that in Hemophilia A or B, data of a larger cohort with information about environmental and genetic factors are required.
    MeSH term(s) Blood Coagulation Disorders, Inherited ; Factor VII/therapeutic use ; Factor VII Deficiency/diagnosis ; Factor VII Deficiency/drug therapy ; Factor VII Deficiency/genetics ; Hemorrhage/prevention & control ; Humans ; Registries ; Turkey/epidemiology
    Chemical Substances Factor VII (9001-25-6)
    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 3150-1
    ISSN 1502-7686 ; 0036-5513
    ISSN (online) 1502-7686
    ISSN 0036-5513
    DOI 10.1080/00365513.2021.2013524
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