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Article: Correlation between Histopathological Prognostic Tumor Characteristics and [

Boers, Jorianne / Eisses, Bertha / Zwager, Mieke C / van Geel, Jasper J L / Bensch, Frederike / de Vries, Erik F J / Hospers, Geke A P / Glaudemans, Andor W J M / Brouwers, Adrienne H / den Dekker, Martijn A M / Elias, Sjoerd G / Kuip, Evelien J M / van Herpen, Carla M L / Jager, Agnes / van der Veldt, Astrid A M / Oprea-Lager, Daniela E / de Vries, Elisabeth G E / van der Vegt, Bert / Menke-van der Houven van Oordt, Willemien C /

Schröder, Carolina P

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: Background: In metastatic breast cancer (MBC), [: Patients and methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [: Results: Of 200 patients, 188 had evaluable ... ...

Abstract	Background: In metastatic breast cancer (MBC), [ Patients and methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [ Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [ Conclusions: [
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14040416
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Article: Molecular imaging predicts lack of T-DM1 response in advanced HER2-positive breast cancer (final results of ZEPHIR trial).

NPJ breast cancer

2024 Volume 10, Issue 1, Page(s) 4

Abstract: Efficacy of the human epidermal growth factor receptor (HER)2-targeting trastuzumab emtansine (T-DM1) in breast cancer (BC) relies on HER2 status determined by immunohistochemistry or fluorescence in-situ hybridization. Heterogeneity in HER2 expression, ... ...

Abstract	Efficacy of the human epidermal growth factor receptor (HER)2-targeting trastuzumab emtansine (T-DM1) in breast cancer (BC) relies on HER2 status determined by immunohistochemistry or fluorescence in-situ hybridization. Heterogeneity in HER2 expression, however, generates interest in "whole-body" assessment of HER2 status using molecular imaging. We evaluated the role of HER2-targeted molecular imaging in detecting HER2-positive BC lesions and patients unlikely to respond to T-DM1. Patients underwent zirconium-89 (
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2374-4677
ISSN	2374-4677
DOI	10.1038/s41523-023-00610-6
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Article: Explainable artificial intelligence (XAI) in radiology and nuclear medicine: a literature review.

de Vries, Bart M / Zwezerijnen, Gerben J C / Burchell, George L / van Velden, Floris H P / Menke-van der Houven van Oordt, Catharina Willemien / Boellaard, Ronald

Frontiers in medicine

2023 Volume 10, Page(s) 1180773

Abstract: Rational: Deep learning (DL) has demonstrated a remarkable performance in diagnostic imaging for various diseases and modalities and therefore has a high potential to be used as a clinical tool. However, current practice shows low deployment of these ... ...

Abstract	Rational: Deep learning (DL) has demonstrated a remarkable performance in diagnostic imaging for various diseases and modalities and therefore has a high potential to be used as a clinical tool. However, current practice shows low deployment of these algorithms in clinical practice, because DL algorithms lack transparency and trust due to their underlying black-box mechanism. For successful employment, explainable artificial intelligence (XAI) could be introduced to close the gap between the medical professionals and the DL algorithms. In this literature review, XAI methods available for magnetic resonance (MR), computed tomography (CT), and positron emission tomography (PET) imaging are discussed and future suggestions are made. Methods: PubMed, Embase.com and Clarivate Analytics/Web of Science Core Collection were screened. Articles were considered eligible for inclusion if XAI was used (and well described) to describe the behavior of a DL model used in MR, CT and PET imaging. Results: A total of 75 articles were included of which 54 and 17 articles described Conclusion: There is currently no clear consensus on how XAI should be deployed in order to close the gap between medical professionals and DL algorithms for clinical implementation. We advocate for systematic technical and clinical quality assessment of XAI methods. Also, to ensure end-to-end unbiased and safe integration of XAI in clinical workflow, (anatomical) data minimization and quality control methods should be included.
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1180773
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Article: 3D Convolutional Neural Network-Based Denoising of Low-Count Whole-Body

de Vries, Bart M / Golla, Sandeep S V / Zwezerijnen, Gerben J C / Hoekstra, Otto S / Jauw, Yvonne W S / Huisman, Marc C / van Dongen, Guus A M S / Menke-van der Houven van Oordt, Willemien C / Zijlstra-Baalbergen, Josée J M / Mesotten, Liesbet / Boellaard, Ronald / Yaqub, Maqsood

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: Acquisition time and injected activity ... ...

Abstract	Acquisition time and injected activity of
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12030596
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Article ; Online: Correction to

van Dijk, Luuk C.M. / de Vries, Michiel E. / Lommen, Willemien J.M. / Struik, Paul C.

Potato Research

Transplanting hybrid potato seedlings at increased densities enhances tuber yield and shifts tuber-size distributions

2022 Volume 65, Issue 2

Abstract: The original version of the article was unfortunately published online without approval of that latest version by the authors of the article. Corrections for the too early published version are listed below (locations are indicated by Heading, paragraph, ...

Abstract	The original version of the article was unfortunately published online without approval of that latest version by the authors of the article. Corrections for the too early published version are listed below (locations are indicated by Heading, paragraph, sentence): Introduction, 3rd paragraph, 1st sentence: incorrect hyphenation of “gen-otype”, should be changed to “geno-type” Table 1: the descriptive header cell, “Date of:” should cover both "Planting" and "Harvest" a headline below Field Locations, Experimental Design and Cultural Practices, 2nd paragraph, 4th sentence: Inconsistent use of Figure vs Fig.: “(Figure S3)” should be changed to “(Fig. S3)” Fig. 1: In the caption “(T-Σ, T-base = 0°Cd)” should be changed to “(T-Σ in °Cd, T-base = 0 °C)” Observations, Measurements and Calculations, 2nd paragraph, last two lines: in the previous version these last two lines were shifted to previous page. Also in the final version these two lines should be shifter to the previous page Fig. 2: The white lines between the figure caption and the main text is too large, 30% more compared to previous version. These white lines should be reduced.
Keywords	Life Science
Subject code	005
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	407680-1
ISSN	1871-4528 ; 0014-3065
ISSN (online)	1871-4528
ISSN	0014-3065
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Noise sensitivity of

Somasundaram, Ananthi / García, David Vállez / Pfaehler, Elisabeth / Jauw, Yvonne W S / Zijlstra, Josée M / van Dongen, Guus A M S / Menke-van der Houven van Oordt, Willemien C / Huisman, Marc C / de Vries, Elisabeth G E / Boellaard, Ronald

EJNMMI physics

2022 Volume 9, Issue 1, Page(s) 16

Abstract: Purpose: Low photon count in : Methods: Count-split : Results: For S50p, a total of 92% and 90% features were classified as having good or excellent ICC and SDM respectively, while for S25p, these decreased to 81% and 31%. In total, 148 features ( ... ...

Abstract	Purpose: Low photon count in Methods: Count-split Results: For S50p, a total of 92% and 90% features were classified as having good or excellent ICC and SDM respectively, while for S25p, these decreased to 81% and 31%. In total, 148 features (31%) showed robustness to noise with good or moderate ICC and SDM in both S50p and S25p. The number of features classified into the four ICC and SDM categories between S50p and S25p was significantly different statistically. Conclusion: Several radiomic features derived from low SNR
Language	English
Publishing date	2022-03-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-022-00444-4
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Article: Pain in Optic Perineuritis: Author Response.

Coppens, Stefan / Petzold, Axel / de Vries-Knoppert, Willemien A E J

Neuro-ophthalmology (Aeolus Press)

2015 Volume 39, Issue 2, Page(s) 101–102

Language	English
Publishing date	2015-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	604820-1
ISSN	1744-506X ; 0165-8107
ISSN (online)	1744-506X
ISSN	0165-8107
DOI	10.3109/01658107.2015.1004589
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Zs.A 1784: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article: Transplanting Hybrid Potato Seedlings at Increased Densities Enhances Tuber Yield and Shifts Tuber-Size Distributions [Erratum: June 2022, v.65(2); p.333]

van Dijk, Luuk C. M. / de Vries, Michiel E. / Lommen, Willemien J. M. / Struik, Paul C.

Potato research. 2022 June, v. 65, no. 2

2022

Abstract: To contribute to the development of a novel cropping system for potato grown from greenhouse-derived seedlings from hybrid true potato seeds, planting density trials were carried out under normal Dutch agronomic conditions. For two consecutive years, 5- ... ...

Abstract	To contribute to the development of a novel cropping system for potato grown from greenhouse-derived seedlings from hybrid true potato seeds, planting density trials were carried out under normal Dutch agronomic conditions. For two consecutive years, 5-week-old seedlings of two experimental genotypes were transplanted into farmers’ potato production fields at two contrasting locations: a flat-bed system on sandy soil and a traditional ridge system on clay soil. Planting densities were 6.25, 12.5, 25, 50, 100 and 200 plants/m² in the flat-bed system, and 3.125, 4.688, 6.25, 12.5, 25 and 50 plants/m² in the ridge system. In general, increasing planting density of hybrid seedlings per area decreased tuber fresh weight per plant and reduced the number of tubers per plant. On a per hectare basis, an increased planting density resulted in increased total tuber yield and number of tubers up to very high densities, but finally both parameters levelled off. Highest total tuber yields harvested were 107 and 45 Mg/ha for the flat-bed and ridge system, respectively. On flat-beds, the optimal planting density for total yield was 50 plants/m². On ridges, planting density interacted with year and genotype, resulting in an optimum planting density of 25 plants/m² to reach the maximum total yield. Obtained yields in the commercial size classes Baby Baker (20 < size class ≤ 35 mm) and Seed Tubers (28 < size class ≤ 50 mm) were in general very high on the flat-beds, with a maximum Seed Tuber yield of 64 Mg/ha at 50 plants/m². The current study showed that transplanted hybrid seedlings are feasible alternatives for seed-tuber-grown systems for certain potato outlets.
Keywords	clay soils ; genotype ; potatoes ; research ; sandy soils ; seed tubers
Language	English
Dates of publication	2022-06
Size	p. 307-331.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	407680-1
ISSN	1871-4528 ; 0014-3065
ISSN (online)	1871-4528
ISSN	0014-3065
DOI	10.1007/s11540-021-09522-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Clinical Validity of 16α-[

van Geel, Jasper J L / Boers, Jorianne / Elias, Sjoerd G / Glaudemans, Andor W J M / de Vries, Erik F J / Hospers, Geke A P / van Kruchten, Michel / Kuip, Evelien J M / Jager, Agnes / Menke-van der Houven van Oordt, Willemien C / van der Vegt, Bert / de Vries, Elisabeth G E / Schröder, Carolina P

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 31, Page(s) 3642–3652

Abstract: Purpose: Determining the estrogen receptor (ER) status is essential in metastatic breast cancer (MBC) management. Whole-body ER imaging with 16α-[: Methods: In a prospective multicenter trial, 200 patients with newly diagnosed MBC underwent extensive ...

Abstract	Purpose: Determining the estrogen receptor (ER) status is essential in metastatic breast cancer (MBC) management. Whole-body ER imaging with 16α-[ Methods: In a prospective multicenter trial, 200 patients with newly diagnosed MBC underwent extensive workup including molecular imaging. For this subanalysis, ER expression in the biopsied metastasis was related to qualitative whole-body [ Results: Whole-body [ Conclusion: In this largest prospective series so far, we established the clinical validity of [
MeSH term(s)	Humans ; Female ; Estradiol ; Breast Neoplasms/pathology ; Receptors, Estrogen/metabolism ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Multicenter Studies as Topic
Chemical Substances	Estradiol (4TI98Z838E) ; Receptors, Estrogen
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.00400
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Patterns of retrograde axonal degeneration in the visual system.

de Vries-Knoppert, Willemien A / Baaijen, Johannes C / Petzold, Axel

Brain : a journal of neurology

2019 Volume 142, Issue 9, Page(s) 2775–2786

Abstract: Conclusive evidence for existence of acquired retrograde axonal degeneration that is truly trans-synaptic (RTD) has not yet been provided for the human visual system. Convincing data rely on experimental data of lesions to the posterior visual pathways. ... ...

Abstract	Conclusive evidence for existence of acquired retrograde axonal degeneration that is truly trans-synaptic (RTD) has not yet been provided for the human visual system. Convincing data rely on experimental data of lesions to the posterior visual pathways. This study aimed to overcome the limitations of previous human studies, namely pathology to the anterior visual pathways and neurodegenerative co-morbidity. In this prospective, longitudinal cohort retinal optical coherence tomography scans were acquired before and after elective partial temporal lobe resection in 25 patients for intractable epilepsy. Newly developed region of interest-specific, retinotopic areas substantially improved on conventional reported early treatment diabetic retinopathy study (ETDRS) grid-based optical coherence tomography data. Significant inner retinal layer atrophy separated patients with normal visual fields from those who developed a visual field defect. Acquired RTD affected the retinal nerve fibre layer, ganglion cell and inner plexiform layer and stopped at the level of the inner nuclear layer. There were significant correlations between the resected brain tissue volume and the ganglion cell layer region of interest (R = -0.78, P < 0.0001) and ganglion cell inner plexiform layer region of interest (R = -0.65, P = 0.0007). In one patient, damage to the anterior visual pathway resulted in occurrence of microcystic macular oedema as recognized from experimental data. In the remaining 24 patients with true RTD, atrophy rates in the first 3 months were strongly correlated with time from surgery for the ganglion cell layer region of interest (R = -0.74, P < 0.0001) and the ganglion cell inner plexiform layer region of interest (R = -0.51, P < 0.0001). The different time course of atrophy rates observed relate to brain tissue volume resection and suggest that three distinct patterns of retrograde axonal degeneration exist: (i) direct retrograde axonal degeneration; (ii) rapid and self-terminating RTD; and (iii) prolonged RTD representing a 'penumbra', which slowly succumbs to molecularly governed spatial cellular stoichiometric relationships. We speculate that the latter could be a promising target for neuroprotection.
MeSH term(s)	Adult ; Axons/chemistry ; Axons/pathology ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Retinal Ganglion Cells/chemistry ; Retinal Ganglion Cells/pathology ; Retrograde Degeneration/diagnostic imaging ; Retrograde Degeneration/prevention & control ; Tomography, Optical Coherence/methods ; Visual Fields/physiology ; Visual Pathways/chemistry ; Visual Pathways/diagnostic imaging ; Young Adult
Language	English
Publishing date	2019-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awz221
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