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  1. Article ; Online: Analysis of Participant Stigma and Associated Costs of a Peer-Led Social Media HIV Intervention.

    Gill, Navkiranjit / Banta, Jim E / Gashugi, Leonard / Young, Sean D

    AIDS education and prevention : official publication of the International Society for AIDS Education

    2024  Volume 36, Issue 2, Page(s) 113–128

    Abstract: HIV-related stigma is a primary barrier to seeking HIV care. Online social media interventions utilizing peer-led approaches provide an opportunity to revolutionize HIV health behavior change. Secondary analysis of the UCLA HOPE Study (6 waves) was done ... ...

    Abstract HIV-related stigma is a primary barrier to seeking HIV care. Online social media interventions utilizing peer-led approaches provide an opportunity to revolutionize HIV health behavior change. Secondary analysis of the UCLA HOPE Study (6 waves) was done to examine the effectiveness of an online peer-led intervention in reducing HIV-related internalized stigma (IS), association between IS and sexual risk behaviors (SRB), and associated costs for changing the likelihood of HIV testing. Among 897 participants, an inverse relationship between IS (Discomfort with people with HIV, Stereotypes, Moral Judgment) and SRB (Number of Sexual Partners, Sexual Encounters) factors was identified over time (
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1075448-9
    ISSN 1943-2755 ; 0899-9546
    ISSN (online) 1943-2755
    ISSN 0899-9546
    DOI 10.1521/aeap.2024.36.2.113
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    Zs.A 3231: Show issues Location:
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  2. Article: Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine.

    Mehta, Sanjay / Gill, Sean E

    Journal of thoracic disease

    2019  Volume 11, Issue 1, Page(s) 21–28

    Language English
    Publishing date 2019-03-07
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.11.74
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors.

    Das, Nabangshu / Benko, Colette / Gill, Sean E / Dufour, Antoine

    Pharmaceuticals (Basel, Switzerland)

    2020  Volume 14, Issue 1

    Abstract: Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of ... ...

    Abstract Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat
    Language English
    Publishing date 2020-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Botryomycosis: a rare mimic of sarcoma as an initial presentation of acquired immunodeficiency syndrome.

    Boone, Sean L / Horvai, Andrew E / Zimel, Melissa N / Brown, Robert / Link, Thomas M / McGill, Kevin C

    Skeletal radiology

    2023  

    Abstract: Botryomycosis is a rare granulomatous response to chronic bacterial infection most frequently associated with Staphylococcus aureus. This disease, which predominantly affects immunocompromised patients, may present with cutaneous, visceral, or soft ... ...

    Abstract Botryomycosis is a rare granulomatous response to chronic bacterial infection most frequently associated with Staphylococcus aureus. This disease, which predominantly affects immunocompromised patients, may present with cutaneous, visceral, or soft tissue manifestations. Soft tissue involvement typically has an aggressive mass-like appearance on imaging which can be concerning for malignancy. In immunocompromised patients, botryomycosis can resemble fungal infection both clinically and histologically; therefore, definitive diagnosis requires tissue sampling along with histological and microbiological analysis. Presented here is a 25-year-old man with an enlarging intramuscular soft tissue mass of the right forearm as his first presentation of undiagnosed acquired immunodeficiency syndrome (AIDS). MR imaging showed a mildly T2 hyperintense and enhancing mass with infiltrative margins extending through tissue planes. Biopsy of the mass revealed Staphylococcus aureus-associated botryomycosis, which improved with nonsurgical treatment employing antibiotics. Unfortunately, the patient subsequently expired from other manifestations of his new AIDS diagnosis. This case describes the MR and PET-CT appearance of botryomycosis and also underscores that infection can mimic sarcoma, particularly in the setting of immunodeficiency.
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-023-04527-w
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    Zs.A 1304: Show issues Location:
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  5. Article ; Online: Imbalance of Pulmonary Microvascular Endothelial Cell-Expression of Metalloproteinases and Their Endogenous Inhibitors Promotes Septic Barrier Dysfunction.

    Jayawardena, Devika P / Masciantonio, Marcello G / Wang, Lefeng / Mehta, Sanjay / DeGurse, Natalie / Pape, Cynthia / Gill, Sean E

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Sepsis is a life-threatening disease characterized by excessive inflammation leading to organ dysfunction. During sepsis, pulmonary microvascular endothelial cells (PMVEC) lose barrier function associated with inter-PMVEC junction disruption. Matrix ... ...

    Abstract Sepsis is a life-threatening disease characterized by excessive inflammation leading to organ dysfunction. During sepsis, pulmonary microvascular endothelial cells (PMVEC) lose barrier function associated with inter-PMVEC junction disruption. Matrix metalloproteinases (MMP) and a disintegrin and metalloproteinases (ADAM), which are regulated by tissue inhibitors of metalloproteinases (TIMPs), can cleave cell-cell junctional proteins, suggesting a role in PMVEC barrier dysfunction. We hypothesize that septic PMVEC barrier dysfunction is due to a disruption in the balance between PMVEC-specific metalloproteinases and TIMPs leading to increased metalloproteinase activity. The effects of sepsis on TIMPs and metalloproteinases were assessed ex vivo in PMVEC from healthy (sham) and septic (cecal ligation and perforation) mice, as well as in vitro in isolated PMVEC stimulated with cytomix, lipopolysaccharide (LPS), and cytomix + LPS vs. PBS. PMVEC had high basal
    MeSH term(s) Animals ; Mice ; Cells, Cultured ; Endothelial Cells/metabolism ; Lipopolysaccharides/pharmacology ; Tissue Inhibitor of Metalloproteinases/genetics ; Tissue Inhibitor of Metalloproteinases/metabolism ; Metalloproteases/metabolism ; Sepsis/metabolism
    Chemical Substances Lipopolysaccharides ; Tissue Inhibitor of Metalloproteinases ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097875
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  6. Article ; Online: The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors

    Nabangshu Das / Colette Benko / Sean E. Gill / Antoine Dufour

    Pharmaceuticals, Vol 14, Iss 31, p

    2021  Volume 31

    Abstract: Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat ® , have failed in Phase III clinical trials. As an alternative ... ...

    Abstract Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat ® , have failed in Phase III clinical trials. As an alternative strategy, recent efforts have been focussed on the development of more selective inhibitors or targeting other domains than their active sites through specific small molecule inhibitors or monoclonal antibodies. Here, we present some examples that aim to better understand the mechanisms of conformational changes/allosteric control of MMPs functions. In addition to MMP inhibitors, we discuss unbiased global approaches, such as proteomics and N-terminomics, to identify new MMP substrates. We present some examples of new MMP substrates and their implications in regulating biological functions. By characterizing the roles and substrates of individual MMP, MMP inhibitors could be utilized more effectively in the optimal disease context or in diseases never tested before where MMP activity is elevated and contributing to disease progression.
    Keywords matrix metalloproteinases (MMPs) ; protease ; tissue inhibitors of metalloproteinases (TIMPs) ; exosite ; small molecule inhibitors ; monoclonal antibodies ; proteomics ; N-terminomics ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 540
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Correction to: Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.

    Carter, Alice R / Harrison, Sean / Gill, Dipender / Smith, George Davey / Taylor, Amy E / Howe, Laura D / Davies, Neil M

    International journal of epidemiology

    2022  Volume 51, Issue 5, Page(s) 1703

    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyac169
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    Zs.A 893: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank.

    Carter, Alice R / Harrison, Sean / Gill, Dipender / Davey Smith, George / Taylor, Amy E / Howe, Laura D / Davies, Neil M

    International journal of epidemiology

    2022  Volume 51, Issue 3, Page(s) 885–897

    Abstract: Background: Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease.: Methods: In up to 320 120 UK ... ...

    Abstract Background: Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of the aetiology of educational inequalities in cardiovascular disease.
    Methods: In up to 320 120 UK Biobank participants of White British ancestry (mean age = 57 years, female 54%), we created polygenic scores for nine cardiovascular risk factors or diseases: alcohol consumption, body mass index, low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes and stroke. We estimated whether educational attainment modified genetic susceptibility to these risk factors and diseases.
    Results: On the additive scale, higher educational attainment reduced genetic susceptibility to higher body mass index, smoking, atrial fibrillation and type 2 diabetes, but increased genetic susceptibility to higher LDL-C and higher systolic blood pressure. On the multiplicative scale, there was evidence that higher educational attainment increased genetic susceptibility to atrial fibrillation and coronary heart disease, but little evidence of effect modification was found for all other traits considered.
    Conclusions: Educational attainment modifies the genetic susceptibility to some cardiovascular risk factors and diseases. The direction of this effect was mixed across traits considered and differences in associations between the effect of the polygenic score across strata of educational attainment was uniformly small. Therefore, any effect modification by education of genetic susceptibility to cardiovascular risk factors or diseases is unlikely to substantially explain the development of inequalities in cardiovascular risk.
    MeSH term(s) Atrial Fibrillation/epidemiology ; Atrial Fibrillation/genetics ; Biological Specimen Banks ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Coronary Disease/epidemiology ; Coronary Disease/genetics ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/genetics ; Educational Status ; Female ; Genetic Predisposition to Disease ; Humans ; Middle Aged ; Risk Factors ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyac002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 893: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Quantification of adherens junction disruption and contiguous paracellular protein leak in human lung endothelial cells under septic conditions.

    Wang, Lefeng / Chung, Justin / Gill, Sean E / Mehta, Sanjay

    Microcirculation (New York, N.Y. : 1994)

    2019  Volume 26, Issue 3, Page(s) e12528

    Abstract: Objective: Sepsis is associated with dysfunction of MVEC resulting in organ edema and inflammation. VE-cadherin, a component of MVEC adherens junctions, may be disrupted in sepsis. However, the direct connection between individual MVEC VE-cadherin ... ...

    Abstract Objective: Sepsis is associated with dysfunction of MVEC resulting in organ edema and inflammation. VE-cadherin, a component of MVEC adherens junctions, may be disrupted in sepsis. However, the direct connection between individual MVEC VE-cadherin disruption and increased paracellular permeability is uncertain.
    Methods: Human pulmonary MVEC were cultured on a biotin matrix and treated with cytomix, as a model of sepsis, vs PBS. MVEC permeability was assessed by trans-MVEC monolayer leak of Oregon green 488-conjugated avidin, which bound subcellular biotin to localize sites of paracellular leak. Leak was correlated with individual cell-specific MVEC surface VE-cadherin continuity by fluorescence microscopy.
    Results: Cytomix treatment reduced total MVEC VE-cadherin density, disrupted surface VE-cadherin continuity, was associated with intercellular gap formation, and enhanced paracellular avidin leak. Cytomix-induced MVEC paracellular avidin leak was strongly correlated temporally and was highly contiguous with focal MVEC surface VE-cadherin disruption. Total cellular VE-cadherin density was less strongly correlated with MVEC paracellular avidin leak and individual cell-specific focal surface VE-cadherin discontinuity.
    Conclusions: These data support a mechanistic link between septic human lung MVEC VE-cadherin disruption and contiguous paracellular protein leak, and will permit more detailed assessment of individual cell-specific mechanisms of septic MVEC barrier dysfunction.
    MeSH term(s) Adherens Junctions/metabolism ; Adherens Junctions/pathology ; Antigens, CD/metabolism ; Cadherins/metabolism ; Capillary Permeability ; Cells, Cultured ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Lung/metabolism ; Lung/pathology ; Sepsis/metabolism ; Sepsis/pathology
    Chemical Substances Antigens, CD ; Cadherins ; cadherin 5
    Language English
    Publishing date 2019-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217758-1
    ISSN 1549-8719 ; 1073-9688
    ISSN (online) 1549-8719
    ISSN 1073-9688
    DOI 10.1111/micc.12528
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    Zs.A 4187: Show issues Location:
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  10. Article ; Online: A global perspective on collision and non-collision match characteristics in male rugby union: Comparisons by age and playing standard.

    Till, Kevin / Hendricks, Sharief / Scantlebury, Sean / Dalton-Barron, Nick / Gill, Nicholas / den Hollander, Steve / Kemp, Simon / Kilding, Andrew E / Lambert, Mike / Mackreth, Peter / O'Reilly, John / Owen, Cameron / Spencer, Kirsten / Stokes, Keith / Tee, Jason / Tucker, Ross / Vaz, Luis / Weaving, Dan / Jones, Ben

    European journal of sport science

    2023  Volume 23, Issue 7, Page(s) 1131–1145

    Abstract: ... categories (i.e. U12, U14, U16, U18, Senior) for both amateur and elite playing standards from Tier 1 rugby ... union nations (i.e. England, South Africa, New Zealand). Two-hundred and one male matches (5911 min ball ... in-play) were coded using computerised notational analysis, including 193,708 match characteristics (e.g ...

    Abstract This study quantified and compared the collision and non-collision match characteristics across age categories (i.e. U12, U14, U16, U18, Senior) for both amateur and elite playing standards from Tier 1 rugby union nations (i.e. England, South Africa, New Zealand). Two-hundred and one male matches (5911 min ball-in-play) were coded using computerised notational analysis, including 193,708 match characteristics (e.g. 83,688 collisions, 33,052 tackles, 13,299 rucks, 1006 mauls, 2681 scrums, 2923 lineouts, 44,879 passes, 5568 kicks). Generalised linear mixed models with
    MeSH term(s) Humans ; Male ; Football ; Rugby ; Athletes ; South Africa
    Language English
    Publishing date 2023-02-19
    Publishing country England
    Document type Journal Article
    ISSN 1536-7290
    ISSN (online) 1536-7290
    DOI 10.1080/17461391.2022.2160938
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