LIVIVO - Search results -

Search results

Result 1 - 10 of total 13283

Search options

Article: Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis

Xu, Rui / Zeng, Qinghe / Xia, Chenjie / Chen, Jiali / Wang, Pinger / Zhao, Shan / Yuan, Wenhua / Lou, Zhaohuan / Lin, Houfu / Xia, Hanting / Lv, Shuaijie / Xu, Taotao / Tong, Peijian / Gu, Mancang / Jin, Hongting

Frontiers in pharmacology

2021 Volume 12, Page(s) 711004

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.711004
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ

Li, Bin / Xie, Pei-Jun / Hao, Yan-Wei / Guo, Yu / Yu, Jun-Rong / Gong, Dao-Yin / Guo, Jing / Zeng, Jin-Hao / Zhang, Yi

Molecular medicine reports

2021 Volume 23, Issue 4

Abstract: Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported ...

Abstract	Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported to aid in the treatment of Alzheimer's disease (AD). The present study aimed to investigate the effects of YZS on tau protein aggregation, a hallmark of AD pathology, and its possible mechanisms. The results demonstrated that YZS improved learning and memory abilities, and decreased the severity of AD pathology in β‑amyloid (Aβ
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Animals ; Brain/drug effects ; Brain/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Humans ; Peptide Fragments/genetics ; Phosphorylation/drug effects ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/genetics ; Protein Aggregates/drug effects ; Rats ; Ubiquitin/genetics ; tau Proteins/genetics
Chemical Substances	Amyloid beta-Peptides ; Drugs, Chinese Herbal ; Peptide Fragments ; Protein Aggregates ; Ubiquitin ; amyloid beta-protein (1-40) ; tau Proteins ; yuan zhi ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2021-02-19
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2021.11918
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation.

Cheng, Tao-Fang / Zhao, Jing / Wu, Qiu-Lin / Zeng, Hua-Wu / Sun, Yu-Ting / Zhang, Yu-Hao / Mi, Rui / Qi, Xiao-Po / Zou, Jing-Tao / Liu, Ai-Jun / Jin, Hui-Zi / Zhang, Wei-Dong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2020 Volume 79, Page(s) 153330

Abstract: Background: Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula ...

Abstract	Background: Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula. It has been used for the treatment of ischemic stroke for many years in clinical. However, its pharmacological mechanism is unclear. Purpose: The aim of the current study was to understand the protective effects and underlying mechanisms of DZT on ischemic stroke. Methods: Fifteen representative chemical markers in DZT were determined by ultra-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). The protective effect of DZT against ischemic stroke was studied in a rat model of middle cerebral artery occlusion (MCAO), and the mechanism was further explored through a combination of network pharmacology and experimental verification. Results: Quantitative analysis showed that the contents of phenolic acids, furan sulfonic acids, tanshinones, flavonoids, saponins and phthalides in DZT were calculated as 7.47, 0.788, 0.627, 0.531 and 0.256 mg/g, respectively. Phenolic acids were the most abundant constituents. Orally administered DZT (1.701 g kg Conclusion: DZT protected against cerebral ischemic injury. The inhibition of TXA
MeSH term(s)	Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/pathology ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Infarction, Middle Cerebral Artery/drug therapy ; Ischemic Stroke/drug therapy ; Male ; Mice, Inbred ICR ; Platelet Activation/drug effects ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Pulmonary Embolism/drug therapy ; Rabbits ; Rats, Sprague-Dawley ; Tablets ; Thrombosis/chemically induced ; Thrombosis/drug therapy ; Thromboxane A2/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Platelet Aggregation Inhibitors ; Tablets ; Thromboxane A2 (57576-52-0)
Language	English
Publishing date	2020-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2020.153330
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Erratum: SHUO QI, ZHI-TONG LYU, JIAN WANG, YUN-MING MO, ZHAO-CHI ZENG, YANG-JIN ZENG, KE-YUAN DAI, YUAN-QIU LI, L. LEE GRISMER amp; YING-YONG WANG (2022) Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China. Zootaxa, 5072: 401438.

Qi, Shuo / Lyu, Zhi-Tong / Wang, Jian / Mo, Yun-Ming / Zeng, Zhao-Chi / Zeng, Yang-Jin / Dai, Ke-Yuan / Li, Yuan-Qiu / Grismer, L Lee / Wang, Ying-Yong

Zootaxa

2022 Volume 5115, Issue 4, Page(s) 600

Language	English
Publishing date	2022-03-16
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5115.4.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation

Cheng, Tao-Fang / Zhao, Jing / Wu, Qiu-Lin / Zeng, Hua-Wu / Sun, Yu-Ting / Zhang, Yu-Hao / Mi, Rui / Qi, Xiao-Po / Zou, Jing-Tao / Liu, Ai-Jun / Jin, Hui-Zi / Zhang, Wei-Dong

Phytomedicine. 2020 Dec., v. 79

2020

Abstract: Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula. It has been ...

Abstract	Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula. It has been used for the treatment of ischemic stroke for many years in clinical. However, its pharmacological mechanism is unclear.The aim of the current study was to understand the protective effects and underlying mechanisms of DZT on ischemic stroke.Fifteen representative chemical markers in DZT were determined by ultra-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). The protective effect of DZT against ischemic stroke was studied in a rat model of middle cerebral artery occlusion (MCAO), and the mechanism was further explored through a combination of network pharmacology and experimental verification.Quantitative analysis showed that the contents of phenolic acids, furan sulfonic acids, tanshinones, flavonoids, saponins and phthalides in DZT were calculated as 7.47, 0.788, 0.627, 0.531 and 0.256 mg/g, respectively. Phenolic acids were the most abundant constituents. Orally administered DZT (1.701 g kg⁻¹) significantly alleviated the infarct size and neurological scores in MCAO rats. The network analysis predicted that 53 absorbed active compounds in DZT-treated plasma targeted 189 proteins and 47 pathways. Ten pathways were associated with anti-platelet activity. In further experiments, DZT (0.4 and 0.8 mg mL⁻¹) markedly inhibited in vitro prostaglandin G/H synthase 1 (PTGS1) activity. DZT (0.4 and 0.8 mg mL⁻¹) significantly inhibited in vitro platelet aggregation in response to ADP or AA. DZT (113 and 226 mg kg⁻¹, p.o.) also produced a marked inhibition of ADP- or AA-induced ex vivo platelet aggregation with a short duration of action. DZT decreased the level of thromboxane A₂ (TXA₂) in MCAO rats. In the carrageenan-induced tail thrombosis model and ADP-induced acute pulmonary thromboembolism mice model, DZT (113 and 226 mg kg⁻¹, p.o.) prevented thrombus formation. Importantly, DZT (113 and 226 mg kg⁻¹, p.o.) exhibited a low bleeding liability.DZT protected against cerebral ischemic injury. The inhibition of TXA₂ level, platelet aggregation and thrombosis formation might involve in the protective mechanism.
Keywords	Oriental traditional medicine ; animal models ; flavonoids ; furans ; infarction ; mass spectrometry ; pharmacology ; phthalides ; platelet aggregation ; prostaglandins ; protective effect ; saponins ; stroke ; tail ; thrombosis ; ultra-performance liquid chromatography
Language	English
Dates of publication	2020-12
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-light
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2020.153330
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma.

Chen, Jiayi / Chen, Zhi / Ma, Li / Liang, Qiaowen / Jia, Wei / Pan, Zhenzhen / Zeng, Yuaner / Jiang, Bin

Biomedical chromatography : BMC

2014 Volume 28, Issue 10, Page(s) 1384–1392

Abstract: Zhi-Shao-San (ZSS), a traditional Chinese medicinal prescription, has been clinically used ...

Abstract	Zhi-Shao-San (ZSS), a traditional Chinese medicinal prescription, has been clinically used for the treatment of irritable bowel syndrome (IBS) for centuries. A comparative study was designed and conducted to compare the pharmacokinetic differences between paeoniflorin naringin, hesperidin and neohesperidin after oral administration of ZSS decoction to normal rats and IBS rats induced by acetic acid and restraint stress. Further, an efficient, sensitive and selective liquid chromatography/tandem mass spectrometry for the simultaneous determination of four analytes of ZSS decoction in rat plasma was developed and validated. The validated method was successfully applied to comparison of pharmacokinetic profiles of analytes in rat plasma. The results showed that the absorptions of naringin, hesperidin and neohesperidin in IBS group were all significantly higher than those in normal group and no obvious difference was seen for paeoniflorin between the two groups, which is helpful for improving clinical therapeutic efficacy and further pharmacological studies of ZSS.
MeSH term(s)	Animals ; Chromatography, Liquid/methods ; Drug Stability ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Flavanones/blood ; Flavanones/chemistry ; Flavanones/pharmacokinetics ; Glucosides/blood ; Glucosides/chemistry ; Glucosides/pharmacokinetics ; Irritable Bowel Syndrome/metabolism ; Linear Models ; Male ; Monoterpenes/blood ; Monoterpenes/chemistry ; Monoterpenes/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Flavanones ; Glucosides ; Monoterpenes ; peoniflorin (21AIQ4EV64)
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.3180
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Simultaneous determination of kaempferol, quercetin, mangiferin, gallic acid, p-hydroxybenzoic acid, and chlorpheniramine maleate in rat plasma after oral administration of Mang-Guo-Zhi-Ke Tablets by UHPLC-MS/MS and its application to pharmacokinetics.

Xu, Weijie / Deng, Jiagang / Qian, Yiyun / Hou, Xiao-Tao / Zhu, Zhenhua / Zhao, Ming / Shang, Erxin / Qian, Dawei / Zeng, Huiting / Pang, Hanqing / Duan, Jinao

Biomedical chromatography : BMC

2017

Abstract: Mang-Guo-Zhi-Ke Tablets (MGZKTS) is an effective Chinese patent medicine, contains mango ... of MGZKTS. This evidence will be useful for the clinical rational use of Mang-Guo-Zhi-Ke tablets. ...

Abstract	Mang-Guo-Zhi-Ke Tablets (MGZKTS) is an effective Chinese patent medicine, contains mango leaf extract as the main raw material, and the antihistamine drug, chlorpheniramine maleate, is included in the formulation. However, its pharmacokinetic effect is rarely reported. A highly sensitive, reliable and rapid high-throughput method using ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously determine kaempferol, quercetin, mangiferin, p-hydroxybenzoic acid, gallic acid and chlorpheniramine maleate in rat plasma after oral administration of MGZKTS. The method was successfully developed and fully validated to investigate the pharmacokinetics of MGZKTS. Chloramphenicol and clarithromycin were used as internal standards (IS). A practicable protein precipitation procedure with methanol was adopted for sample preparation. The samples were separated on an Acquity UHPLC Syncronis C18 column (100 mm×2.1 mm, 1.7 μm) using 0.1% formic acid-acetonitrile as the mobile phase. The flow rate was set at 0.4 mL/min. The obtained calibration curves were linear in the concentration range of approximately 1-1000 ng/mL for plasma (r>0.99). Method validation results met the criteria reported in the United States Food and Drug Administration guidelines. Quercetin, p-hydroxybenzoic acid and kaempferol were absorbed rapidly and reached the Cmax between 0.16 h and 0.25 h. This validated that the UHPLC-MS/MS method was successfully applied to study the pharmacokinetic parameters of the six compounds in rat plasma after oral administration of MGZKTS. This evidence will be useful for the clinical rational use of Mang-Guo-Zhi-Ke tablets.
Language	English
Publishing date	2017-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.4155
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book: Yuan fa xing gan ai fang she zhi liao lin chuang shi jian

Zeng, Zhaochong

Radiotherapy for primary liver cancer in clinical practice

2013

Title variant	Radiotherapy for primary liver cancer in clinical practice
Author's details	zhu bian Zeng Zhaochong
MeSH term(s)	Liver Neoplasms/radiotherapy
Language	Chinese
Size	13, 432 pages :, illustrations, portrait
Edition	Di 1 ban.
Document type	Book
ISBN	9787117176989 ; 7117176989
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement.

Zeng, Le / Wang, Meiling / Yuan, Yu / Guo, Bin / Zhou, Jing / Tan, Zhen / Ye, Meiling / Ding, Li / Chen, Bo

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2014 Volume 967, Page(s) 245–254

Abstract: Ying-zhi-huang injection (YZH-I) is an injectable multi-herbal prescription derived ...

Abstract	Ying-zhi-huang injection (YZH-I) is an injectable multi-herbal prescription derived from the ancient Chinese remedy "Yin-chen-hao-tang", which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, little information is available on the pharmacokinetic properties of this poly-herbal formulation. Herein, we reported a simple, rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantitative multiple reaction monitoring (MRM) of eight major ingredients of YZH-I (including baicalin, baicalein, wogonoside, geniposide, geniposidic acid, chlorogenic acid, neochlorogenic acid, and caffeic acid) in rat plasma. A fast single-tube multi-impurity precipitation extraction ("SMIPE") procedure was introduced for straightforward plasma preparation, based on one-pot deproteinization precipitation with acidified methanol extraction and in-situ multifunction impurity removal by a solid sorbent mixture (anh. magnesium sulfate plus octadecylsilane). Particularly, the addition of ascorbic acid in methanol (10 mg/mL) was found to exhibit a pronounced protective effect and significantly increase extraction effectiveness of the herbal phenolic components. Some pretreatment variables (protein precipitating solvent, acidifying agent and sorbent) were optimized with acceptable matrix effect (-18 to 7.7%), extraction recovery (65-88%) and process efficiency (62-91%) for the SMIPE-based LC-MRM multi-analyte quantitation using matrix-matched calibration (5-1000 ng/mL) without using internal standard. Mean accuracies were obtained in the range of 83-114% at three different fortification levels, with intra- and inter-day variations within 13%. This validated method was successfully applied to the simultaneous measurement and pharmacokinetic investigation of the chemical constituents in rats following an intravenous administration of YZH-I.
MeSH term(s)	Animals ; Chromatography, Liquid/methods ; Cinnamates/blood ; Cinnamates/pharmacokinetics ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Iridoids/blood ; Iridoids/pharmacokinetics ; Linear Models ; Male ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods
Chemical Substances	Cinnamates ; Drugs, Chinese Herbal ; Iridoids ; yin zhi huang
Language	English
Publishing date	2014-09-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2014.07.037
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 813: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: Sui tang chu tu mu zhi wen zi yan jiu ji zheng li

Zeng, Liang

2007

Author's details	Zeng liang zhu
Keywords	Chinese characters ; Epitaphs
Language	Chinese
Size	1, 302 p, facsims, 21 cm
Edition	Di 1 ban
Publisher	Qi lu shu she
Publishing place	Ji nan
Document type	Book
Note	Includes bibliographical references (p. 287-293) and index
ISBN	7533319001 ; 9787533319007
Database	Former special subject collection: coastal and deep sea fishing

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED