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Article ; Online: Flow-Mediated Factors in the Pathogenesis of Hypoplastic Left Heart Syndrome.

Rahman, Anum / Chaturvedi, Rajiv R / Sled, John G

Journal of cardiovascular development and disease

2022 Volume 9, Issue 5

Abstract: Hypoplastic left heart syndrome (HLHS) is a life-threatening congenital heart disease that is characterized by severe underdevelopment of left heart structures. Currently, there is no cure, and affected individuals require surgical palliation or cardiac ... ...

Abstract	Hypoplastic left heart syndrome (HLHS) is a life-threatening congenital heart disease that is characterized by severe underdevelopment of left heart structures. Currently, there is no cure, and affected individuals require surgical palliation or cardiac transplantation to survive. Despite these resource-intensive measures, only about half of individuals reach adulthood, often with significant comorbidities such as liver disease and neurodevelopmental disorders. A major barrier in developing effective treatments is that the etiology of HLHS is largely unknown. Here, we discuss how intracardiac blood flow disturbances are an important causal factor in the pathogenesis of impaired left heart growth. Specifically, we highlight results from a recently developed mouse model in which surgically reducing blood flow through the mitral valve after cardiogenesis led to the development of HLHS. In addition, we discuss the role of interventional procedures that are based on improving blood flow through the left heart, such as fetal aortic valvuloplasty. Lastly, using the surgically-induced mouse model, we suggest investigations that can be undertaken to identify the currently unknown biological pathways in left heart growth failure and their associated therapeutic targets.
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd9050154
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Article ; Online: Myocardial Extracellular Volume Fraction Varies With Hemodynamic Load and After Pulmonary Valve Replacement in TOF.

Ishikita, Ayako / Karur, Gauri R / Hanneman, Kate / Yuen, Darren A / Chaturvedi, Rajiv R / Friedberg, Mark K / Epelman, Slava / He, Xiaolin / Roche, S Lucy / Wald, Rachel M

JACC. Cardiovascular imaging

2024

Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Letter
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2024.02.013
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Zs.A 6846: Show issues

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Article ; Online: Transcatheter creation of a Potts shunt with the Occlutech Atrial Flow Regulator: Feasibility in a pig model.

Kang, Sok-Leng / Contreras, Juan / Chaturvedi, Rajiv R

International journal of cardiology

2020 Volume 327, Page(s) 63–65

Abstract: Background: Creation of a Potts shunt, a connection between the left pulmonary artery (LPA) and descending aorta (DAo), improves functional status and survival in drug-refractory suprasystemic pulmonary arterial hypertension. We investigated a new ... ...

Abstract	Background: Creation of a Potts shunt, a connection between the left pulmonary artery (LPA) and descending aorta (DAo), improves functional status and survival in drug-refractory suprasystemic pulmonary arterial hypertension. We investigated a new approach to transcatheter Potts shunt creation in pigs. Methods and results: In six pigs, a steerable SureFlex sheath was used to optimize the trajectory of perforation from the DAo into LPA using a 0.035″ radiofrequency wire. The combination of a larger perforation, stiffer radiofrequency wire and smooth dilator-to-sheath transition allowed sheath entry into the LPA without requiring an arterio-venous wire circuit. The Occlutech Atrial Flow Regulator (AFR), a double-disc device with a central fenestration, was deployed through this sheath with apposition of the distal disc to the posterior LPA wall and the proximal disc to the anterior DAo wall. The AFR is compliant and crumpling of the central fenestration was resolved by balloon dilation. It was feasible to implant a stent within the fenestration (n = 3). Aortography confirmed a left-to-right shunt through the AFR without contrast extravasation. Autopsy demonstrated anchoring of both discs against the vessel walls, patency of the fenestration and secure placement of the stent with no intra-thoracic bleeding. Conclusions: In an acute pig model, we have demonstrated the feasibility of creating a transcatheter Potts shunt with a simplified technique using a steerable sheath, a double-disc device with a central fenestration that acts as the shunt channel and optional stenting of the fenestration.
MeSH term(s)	Animals ; Aortography ; Familial Primary Pulmonary Hypertension ; Feasibility Studies ; Pulmonary Artery ; Stents ; Swine ; Treatment Outcome
Language	English
Publishing date	2020-11-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2020.11.008
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Zs.A 1673: Show issues

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Article ; Online: An Overview of Contemporary Outcomes in Fetal Cardiac Intervention: A Case for High-Volume Superspecialization?

Kang, Sok-Leng / Jaeggi, Edgar / Ryan, Greg / Chaturvedi, Rajiv R

Pediatric cardiology

2020 Volume 41, Issue 3, Page(s) 479–485

Abstract: Fetal cardiac interventions (FCI) offer the opportunity to rescue a fetus at risk of intrauterine death, or more ambitiously to alter disease progression. Most of these fetuses require multiple additional postnatal procedures, and it is difficult to ... ...

Abstract	Fetal cardiac interventions (FCI) offer the opportunity to rescue a fetus at risk of intrauterine death, or more ambitiously to alter disease progression. Most of these fetuses require multiple additional postnatal procedures, and it is difficult to disentangle the effect of the fetal procedure from that of the postnatal management sequence. The true clinical impact of FCI may only be discernible in large-volume institutions that can commit to a standardized postnatal approach and have sufficient case volume to overcome their FCI learning curve.
MeSH term(s)	Cardiology/standards ; Female ; Fetal Heart/diagnostic imaging ; Fetal Heart/surgery ; Fetoscopy/standards ; Humans ; Pregnancy ; Ultrasonography, Prenatal
Language	English
Publishing date	2020-03-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-020-02294-2
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Zs.A 1528: Show issues

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Article ; Online: Identification of functional traits responsible for environmental vulnerability of Cedrus deodara in temperate forests of Western Himalaya

Rajiv Pandey / Monika Rawat / Ashutosh Pathak / Divya Mehta / N. Bala / I.D. Bhatt / R.K. Chaturvedi

Ecological Indicators, Vol 157, Iss , Pp 111302- (2023)

2023

Abstract: Climate change is impacting forest tree species adversely and making the ecological system vulnerable. The present study attempts to assess the internal vulnerability of Cedrus deodara occurring in nine sub-types of temperate forests in Western Himalaya, ...

Abstract	Climate change is impacting forest tree species adversely and making the ecological system vulnerable. The present study attempts to assess the internal vulnerability of Cedrus deodara occurring in nine sub-types of temperate forests in Western Himalaya, India via a plant functional trait-based approach. Internal vulnerability was assessed based on sensitivity and adaptive capacity through proposing an index using IPCC framework. Sensitivity was determined based on various traits (indicators) of light harvesting, carbon assimilation, nutrient content, and water budget, whereas adaptability was defined based on light harvesting efficiency, water use efficiency, resource use efficiency, and nutrient limitation. Sensitivity was maximum in Dry Deodar Forest (0.51) and Low-Level Blue Pine Forest (0.51) and minimum in Western Mixed Coniferous Forest (o.38), however adaptability was maximum in Kharsu Oak Forest (0.65) and Moist Deodar Forest-II (0.65) with minimum adaptability for Ban Oak Forest (0.53). In Ban Oak Forest, Low-Level Blue Pine Forest and Moist Deodar Forest-II high stomatal conductance compensates the low chlorophyll achieving homeostasis state for photosynthesis. Negative minimum temperature (-6.95 to −2.04 °C) in winters followed by high monsoon rainfall (417.74 to 1256.13 mm) causes high sensitivity amongst the C. deodara population in Low Level Blue Pine Forest, Dry Deodar Forest and Moist Deodar Forest-II; and adaptability was majorly affected by water availability i.e., excessive monsoon rainfall in Ban Oak Forest (1962.45 mm) and least rainfall in Neoza Pine Forest (349.50 mm). Overall, the vulnerability was high in Low Level Blue Pine Forest (0.46), Ban Oak Forest (0.45) and Dry Deodar Forest (0.45). Present study identified key traits for species vulnerability therefore management intervention should orient towards those silvicultural operations which may reduce relative water use of the species and may also facilitate for improved photosynthesis i.e., through water provision and density ...
Keywords	Adaptation ; Fitness ; Species adaptability ; Species functionality ; Species strategies ; Ecology ; QH540-549.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Using the arterial cannula for cardiac catheterization in neonates and small infants supported by extracorporeal membrane oxygenation.

Kang, Sok-Leng / Lee, Kyong-Jin / Stanisic, Anamaria / Chaturvedi, Rajiv R

The Journal of thoracic and cardiovascular surgery

2019 Volume 159, Issue 1, Page(s) e79–e81

Language	English
Publishing date	2019-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2019.03.119
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Article: A simple and fast technique for radiofrequency-assisted perforation of the atrial septum in congenital heart disease.

Sandoval, Juan Pablo / Chaturvedi, Rajiv R

Annals of pediatric cardiology

2016 Volume 9, Issue 1, Page(s) 39–41

Abstract: Radiofrequency (RF) assisted perforation of the atrial septum was performed successfully in three infants using a 0.035" RF wire deployed through a Williams right posterior catheter. Balloon atrial septoplasty was performed over the 0.035" RF wire in two ...

Abstract	Radiofrequency (RF) assisted perforation of the atrial septum was performed successfully in three infants using a 0.035" RF wire deployed through a Williams right posterior catheter. Balloon atrial septoplasty was performed over the 0.035" RF wire in two of them, shortening the procedural time.
Language	English
Publishing date	2016-02-29
Publishing country	India
Document type	Case Reports
ZDB-ID	2430956-4
ISSN	0974-5149 ; 0974-2069
ISSN (online)	0974-5149
ISSN	0974-2069
DOI	10.4103/0974-2069.171405
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Article: Laparoscopic choledochal cyst excision and biliary reconstruction in patients with previous surgery/ intervention: Feasibility and outcome.

Ojha, Sunita / Bharadia, Lalit / Sharma, Ravi / Bansal, Rajiv Kumar / Chaturvedi, Anupam

Journal of minimal access surgery

2024 Volume 20, Issue 2, Page(s) 121–126

Abstract: Introduction: The aim of the study was to evaluate the feasibility and outcome of laparoscopic surgery in complicated choledochal cyst (CDC) with previous interventions (laparotomy or biliary drainage).: Patients and methods: Patients with CDC who ... ...

Abstract	Introduction: The aim of the study was to evaluate the feasibility and outcome of laparoscopic surgery in complicated choledochal cyst (CDC) with previous interventions (laparotomy or biliary drainage). Patients and methods: Patients with CDC who underwent surgery from July 2014 to July 2019 were evaluated. CDC without previous interventions (Group A) was compared with CDC that had previous interventions (Group B) to assess the feasibility and outcome of laparoscopic surgery. Results: In 5 years' period, 38 patients were operated for CDC. The mean age was similar in both groups (3.78 ± 2.27 in Group A and 4.08 ± 2.73 in Group B). Out of six CDC with previous intervention (Group B), five patients were previously managed at other institutions as follows: (1) Laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) stenting. (2) Laparotomy for biliary peritonitis and ERCP. (3) Percutaneous drainage of the large cyst. (4) Laparoscopic cholecystectomy. (5) ERCP stenting. (6) Percutaneous drainage for biliary ascites. All patients underwent laparoscopic CDC excision and hepatico-duodenostomy. The mean duration of surgery was 160.3 ± 17.22 in Group A and 169.2 ± 17.5 in Group B ( P = 0.258). None required intraoperative blood transfusion. None had a bile leak. Drain was removed at 4.47 ± 0.98 in Group A, while at 4.17 ± 0.75 days in Group B ( P = 0.481). There was statistically no significant difference in feed starting time or length of stay. In follow-up of 6 months-3 years, all patients are asymptomatic. Conclusions: Laparoscopy in complicated CDC with previous intervention is technically tedious but is feasible. The procedure is safe and delivers a good outcome.
Language	English
Publishing date	2024-01-09
Publishing country	India
Document type	Journal Article
ZDB-ID	2186884-0
ISSN	1998-3921 ; 0972-9941
ISSN (online)	1998-3921
ISSN	0972-9941
DOI	10.4103/jmas.jmas_269_22
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Article ; Online: Melody Mitral Valve Is a Promising Alternative to Mechanical Valve Replacement for Young Children.

Chetan, Devin / Szabo, Adrienn B / Fan, Chun-Po S / Morgan, Conall T / Villemain, Olivier / Chaturvedi, Rajiv R / Benson, Lee N / Honjo, Osami

The Annals of thoracic surgery

2022 Volume 115, Issue 3, Page(s) 778–783

Abstract: Purpose: The purpose of this study was to compare outcomes of Melody mitral valve to mechanical mitral valve replacement (MVR) for young children.: Description: Children who underwent Melody MVR from 2014 to 2020 were case-matched to mechanical MVR ... ...

Abstract	Purpose: The purpose of this study was to compare outcomes of Melody mitral valve to mechanical mitral valve replacement (MVR) for young children. Description: Children who underwent Melody MVR from 2014 to 2020 were case-matched to mechanical MVR patients. Transplant-free survival and cumulative incidence of reintervention were compared. A subanalysis was performed for infants aged < 1 year (9 Melody MVRs and their matches). Evaluation: Twelve children underwent Melody MVR. Two children (17%) salvaged from mechanical support died. Five of 10 survivors (50%) had subsequent MVR. At 1 and 3 years, transplant-free survival (Melody: 83%, 83%; mechanical: 83%, 67%; P = .180) and reintervention (Melody: 9%, 39%; mechanical: 0%, 18%; P = .18) were equivalent between groups. For children < 1 year of age, Melody MVR had a modest survival benefit (Melody: 89%, 89%; mechanical: 80%, 60%; P = .046), while rate of reintervention remained equivalent (Melody: 13%, 32%; mechanical: 0%, 22%; P = .32). Conclusions: For patients < 1 year old, Melody MVR offers a promising alternative and is a reasonable bridge to mechanical MVR, which can be performed safely at an older age. Further studies are necessary to corroborate these findings.
MeSH term(s)	Infant ; Humans ; Child ; Child, Preschool ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation ; Treatment Outcome ; Mitral Valve Insufficiency/surgery ; Mitral Valve Stenosis/surgery ; Heart Valve Prosthesis ; Retrospective Studies
Language	English
Publishing date	2022-12-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2022.11.019
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Article ; Online: A Model for the Integration of Genome Sequencing Into a Pediatric Cardiology Clinic.

Liston, Eriskay J / Kalbfleisch, Kelsey J / Stanley, Kaitlin J / Chaturvedi, Rajiv R / Cohn, Iris / Farncombe, Kirsten M / Hayeems, Robin Z / Schwartz, Marci L B / Somerville, Cherith B / Kim, Raymond H / Jobling, Rebekah K

The Canadian journal of cardiology

2022 Volume 38, Issue 9, Page(s) 1454–1457

MeSH term(s)	Ambulatory Care Facilities ; Cardiology ; Child ; Humans
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2022.04.015
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