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  1. Book: Radiology Illustrated: Chest Radiology

    Lee, Kyung Soo / Jeong, Yeon Joo / Chung, Man Pyo / Han, Joungho

    Pattern Approach for Lung Imaging

    (Radiology Illustrated)

    2024  

    Author's details Kyung Soo Lee, MD PhD Department of Radiology, Samsung Medical Center Sungkyunkwan University School of Medicine Joungho Han, MD PhD Department of Pathology, Samsung Medical Center Sungkyunkwan University School of Medicine Man Pyo Chung, MD PhD Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Yeon Joo Jeong, MD PhD Department of Radiology, Pusan National University Hospital Pusan National University School of Medicine and Medical Research Institute
    Series title Radiology Illustrated
    Keywords Differential diagnosis ; Imaging-Pathology Correlation ; Lung Diseases ; Computed Tomography ; Differential Diagnosis ; Pattern Approach
    Language English
    Size 392 p.
    Edition 2
    Publisher Springer Nature Singapore
    Document type Book
    Note PDA Manuell_25
    Format 215 x 285 x 26
    ISBN 9789819966325 ; 9819966329
    Database PDA

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  2. Article: The application of a dual-lead locking screw could enhance the reduction and fixation stability of the proximal humerus fractures: a biomechanical evaluation.

    Lee, Eunju / Jeong, Hyeon Jang / Lee, Yeon Soo / Oh, Joo Han

    Frontiers in surgery

    2024  Volume 11, Page(s) 1333670

    Abstract: Introduction: Bicortical screw fixation, which penetrates and fixes the near and far cortex of bone, has been conventionally used to achieve compressive fixation for fracture using screws. Open reduction and internal fixation using the locking plate are ...

    Abstract Introduction: Bicortical screw fixation, which penetrates and fixes the near and far cortex of bone, has been conventionally used to achieve compressive fixation for fracture using screws. Open reduction and internal fixation using the locking plate are widely used for treating proximal humerus fractures. However, minimal contact between the bone and the locking plate can lead to an insufficient reduction. Theoretically, a dual-lead locking screw with different leads for the screw head and body could enhance the reduction and fixation stability of fragments in proximal humeral fractures without bicortical fixation, and achieve additional compression at the bone-plate-screw interface. This study assessed the insertion mechanics of the lead ratio of the dual-lead locking screw and its effect on the fixation stability of the proximal humerus fracture.
    Methods: A Multi-Fix® locking plating system composed of
    Results: The dual-lead locking screw elevated the compression between the locking plate and the bone. The elevation in the compression due to the dual-lead thread became weaker for the cancellous bone when the lead of the screw body was more than twice that of the screw head. The plate/humerus compression with strong bone quality withstood higher dual-lead-driven compression.
    Discussion: A dual-lead locking screw of
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1333670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Special Issue: Resistance to Targeted Therapies in Human Cancer.

    Lee, Tae-Won / Choi, Hee-Joo / Lee, Kyung-Min / Lee, Jeong-Yeon

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: Cancer is the second leading cause of death worldwide, accounting for approximately 10 million deaths in 2020 [ ... ]. ...

    Abstract Cancer is the second leading cause of death worldwide, accounting for approximately 10 million deaths in 2020 [...].
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020414
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  4. Article ; Online: Effect of Spray-Type Alginate Hydrogel Dressing on Burn Wounds.

    Choi, Jeong Yeon / Joo, Yong-Joon / Kang, Ri Jin / Jeon, Hee Kyung / Hong, Gyeong Sik

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 2

    Abstract: Immediate burn wound care is a critical factor influencing the outcomes of burn treatment. In this study, we developed a spray-type alginate hydrogel dressing that promotes wound healing, reduces pain, and increases the convenience of use in a burn ... ...

    Abstract Immediate burn wound care is a critical factor influencing the outcomes of burn treatment. In this study, we developed a spray-type alginate hydrogel dressing that promotes wound healing, reduces pain, and increases the convenience of use in a burn treatment emergency. We investigated the efficiency of newly developed spray-type alginate hydrogel dressing on the wound healing process. We investigated the efficacy of the alginate hydrogel dressing for wound healing in 30 Sprague Dawley rats. Four deep, round second-degree burn wounds (diameter, 1.5 cm) were created bilaterally on the dorsum of the rat's trunk; the rats were divided into four groups, in which different dressing materials were applied as follows: group A, gauze (control); group B, Mepilex™ (control); group C, 2.25% alginate hydrogel; and group D, 2.5% alginate hydrogel. The gross findings of each group were compared by tracing the remaining wound and performing visual and histological observations and biochemical analysis for proteins associated with wound healing at each time period. In burn wounds, groups C and D showed significantly higher contraction, epithelialization, and healing rates. Histologically, groups C and D showed an improved arrangement of collagen fibers and a thick epithelial layer 14 days after initial wound formation. Group C showed higher CD31, TGF-β, and fibronectin expression in Western blot analyses after day 14. This study suggests that the spray-type alginate hydrogel dressing is an effective material for initial burn wound care.
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10020152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Korean Imaging Cohort of COVID-19: Potential Role in Education and Research.

    Jeong, Yeon Joo / Kim, Yun-Hyeon

    Taehan Yongsang Uihakhoe chi

    2020  Volume 81, Issue 3, Page(s) 608–609

    Language English
    Publishing date 2020-05-29
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2288-2928
    ISSN (online) 2288-2928
    DOI 10.3348/jksr.2020.81.3.608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Statistical Analysis of the Role of Cavity Flexibility in Thermostability of Proteins.

    Hong, So Yeon / Yoon, Jihyun / An, Young Joo / Lee, Siseon / Cha, Haeng-Geun / Pandey, Ashutosh / Yoo, Young Je / Joo, Jeong Chan

    Polymers

    2024  Volume 16, Issue 2

    Abstract: Conventional statistical investigations have primarily focused on the comparison of the simple one-dimensional characteristics of protein cavities, such as number, surface area, and volume. These studies have failed to discern the crucial distinctions in ...

    Abstract Conventional statistical investigations have primarily focused on the comparison of the simple one-dimensional characteristics of protein cavities, such as number, surface area, and volume. These studies have failed to discern the crucial distinctions in cavity properties between thermophilic and mesophilic proteins that contribute to protein thermostability. In this study, the significance of cavity properties, i.e., flexibility and location, in protein thermostability was investigated by comparing structural differences between homologous thermophilic and mesophilic proteins. Three dimensions of protein structure were categorized into three regions (core, boundary, and surface) and a comparative analysis of cavity properties using this structural index was conducted. The statistical analysis revealed that cavity flexibility is closely related to protein thermostability. The core cavities of thermophilic proteins were less flexible than those of mesophilic proteins (averaged B' factor values, -0.6484 and -0.5111), which might be less deleterious to protein thermostability. Thermophilic proteins exhibited fewer cavities in the boundary and surface regions. Notably, cavities in mesophilic proteins, across all regions, exhibited greater flexibility than those in thermophilic proteins (>95% probability). The increased flexibility of cavities in the boundary and surface regions of mesophilic proteins, as opposed to thermophilic proteins, may compromise stability. Recent protein engineering investigations involving mesophilic xylanase and protease showed results consistent with the findings of this study, suggesting that the manipulation of flexible cavities in the surface region can enhance thermostability. Consequently, our findings suggest that a rational or computational approach to the design of flexible cavities in surface or boundary regions could serve as an effective strategy to enhance the thermostability of mesophilic proteins.
    Language English
    Publishing date 2024-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16020291
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  7. Article: Methicillin Resistance Increased the Risk of Treatment Failure in Native Joint Septic Arthritis Caused by

    Kim, Jungok / Park, So Yeon / Sohn, Kyung Mok / Kim, Bomi / Joo, Eun-Jeong

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: This study aimed to compare clinical characteristics and outcomes in patients with native joint septic arthritis (NJSA) due to methicillin- ... ...

    Abstract This study aimed to compare clinical characteristics and outcomes in patients with native joint septic arthritis (NJSA) due to methicillin-resistant
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12111628
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  8. Article ; Online: Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer.

    Lee, Kyeyoung / Jeong, Yeo Jin / Choo, Ki Seok / Nam, Su Bong / Kim, Hyun Yul / Jung, Youn Joo / Lee, Seung Ju / Joo, Ji Hyeon / Kim, Jin You / Kim, Jin Joo / Kim, Jee Yeon / Yun, Mi Sook / Nam, Kyung Jin

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091563
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article ; Online: Effectiveness of COVID-19 Vaccines Over Time Against Clinical and Radiologic Outcomes Related to Severe SARS-CoV-2 Infection.

    Lee, Jong Eun / Jin, Kwang Nam / Hong, Hyunsook / Jeong, Yeon Joo / Yoon, Soon Ho

    Radiology

    2024  Volume 310, Issue 1, Page(s) e231928

    Abstract: Background The impact of waning vaccine effectiveness on the severity of COVID-19-related findings discovered with radiologic examinations remains underexplored. Purpose To evaluate the effectiveness of vaccines over time against severe clinical and ... ...

    Abstract Background The impact of waning vaccine effectiveness on the severity of COVID-19-related findings discovered with radiologic examinations remains underexplored. Purpose To evaluate the effectiveness of vaccines over time against severe clinical and radiologic outcomes related to SARS-CoV-2 infections. Materials and Methods This multicenter retrospective study included patients in the Korean Imaging Cohort of COVID-19 database who were hospitalized for COVID-19 between June 2021 and December 2022. Patients who had received at least one dose of a SARS-CoV-2 vaccine were categorized based on the time elapsed between diagnosis and their last vaccination. Adjusted multivariable logistic regression analysis was used to estimate vaccine effectiveness against a composite of severe clinical outcomes (invasive ventilation, extracorporeal membrane oxygenation, or in-hospital death) and severe radiologic pneumonia (≥25% of lung involvement), and odds ratios (ORs) were compared between patients vaccinated within 90 days of diagnosis and those vaccinated more than 90 days before diagnosis. Results Of 4196 patients with COVID-19 (mean age, 66 years ± 17 [SD]; 2132 [51%] women, 2064 [49%] men), the ratio of severe pneumonia since their most recent vaccination was as follows: 90 days or less, 18% (277 of 1527); between 91 and 120 days, 22% (172 of 783); between 121 and 180 days, 27% (274 of 1032); between 181 and 240 days, 32% (159 of 496); and more than 240 days, 31% (110 of 358). Patients vaccinated more than 240 days before diagnosis showed increased odds of severe clinical outcomes compared with patients vaccinated within 90 days (OR = 1.94 [95% CI: 1.16, 3.24];
    MeSH term(s) Aged ; Female ; Humans ; Male ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Hospital Mortality ; Retrospective Studies ; SARS-CoV-2 ; Middle Aged ; Aged, 80 and over
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.231928
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  10. Article ; Online: Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation.

    Joo, Seyeon / Lee, See Young / Lee, Su Yeon / Hwang, Yeseong / Kim, Minki / Jeong, Jae Woong / Jang, Sung Ill / Fang, Sungsoon

    BMB reports

    2024  

    Abstract: We conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents ...

    Abstract We conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PCR, and transcriptome analysis, enabling us to examine alterations in factors related to fibrosis and inflammation at both the protein and RNA levels. Overall, our findings revealed a dose-dependent decrease in fibrosisrelated signaling with higher TA concentrations. The 15 mg of steroid treatment (1X) exhibited anti-fibrosis and anti-inflammatory effects after 4 weeks, whereas the 30 mg of steroid treatment (2X) rapidly reduced fibrosis and inflammation within 2 weeks in BBS. Transcriptomic analysis results consistently demonstrated significant downregulation of fibrosis- and inflammation- related pathways and genes in steroid-treated fibroblasts. Use of corticosteroids, specifically TA, together with FCSEMS was effective for the treatment of BBS, ameliorating fibrosis and inflammation. Our molecular biological analysis supports the potential development of steroid-eluted FCSEMS as a therapeutic option for BBS in humans resulting from various surgical procedures.
    Language English
    Publishing date 2024-03-25
    Publishing country Korea (South)
    Document type News
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
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