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  1. Article ; Online: Quarter-Century PET/Computed Tomography Transformation of Oncology: Hepatobiliary and Pancreatic Cancer.

    Kandathil, Asha / Subramaniam, Rathan

    PET clinics

    2024  Volume 19, Issue 2, Page(s) 163–175

    Abstract: 18F] Fluorodeoxyglucose ( ...

    Abstract [18F] Fluorodeoxyglucose (
    MeSH term(s) Male ; Humans ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Tomography, X-Ray Computed ; Pancreatic Neoplasms/diagnostic imaging
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium Radioisotopes
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2023.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PET/Computed Tomography: Laryngeal and Hypopharyngeal Cancers.

    Kandathil, Asha / Subramaniam, Rathan M

    PET clinics

    2022  Volume 17, Issue 2, Page(s) 235–248

    Abstract: Treatment of laryngeal and hypopharyngeal tumors with surgery, radiation therapy, and chemotherapy is aimed at improving survival and preserving function. PET with fluorodeoxyglucose F 18 ( ...

    Abstract Treatment of laryngeal and hypopharyngeal tumors with surgery, radiation therapy, and chemotherapy is aimed at improving survival and preserving function. PET with fluorodeoxyglucose F 18 (
    MeSH term(s) Cross-Sectional Studies ; Fluorodeoxyglucose F18 ; Head and Neck Neoplasms ; Humans ; Hypopharyngeal Neoplasms/diagnostic imaging ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Staging ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-03-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2021.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gastroenteropancreatic Neuroendocrine Tumor Diagnosis: DOTATATE PET/CT.

    Kandathil, Asha / Subramaniam, Rathan M

    PET clinics

    2022  Volume 18, Issue 2, Page(s) 189–200

    Abstract: Gastroenteropancreatic neuroendocrine tumors(NETs), which arise from the small intestine, rectum, colon, appendix, or pancreas, have variable malignant potential with clinical behavior determined by proliferative activity according to the Ki-67 index and ...

    Abstract Gastroenteropancreatic neuroendocrine tumors(NETs), which arise from the small intestine, rectum, colon, appendix, or pancreas, have variable malignant potential with clinical behavior determined by proliferative activity according to the Ki-67 index and tumor differentiation. Somatostatin receptor (SSTR) expression by NETs allows SSTR imaging using 68Ga-DOTATATE PET/computed tomography (CT) and treatment with octreotide or SSTR-targeted peptide receptor radionuclide therapy (PRRT). 68Ga-DOTATATE PET/CT is indicated for localization of the primary tumor in select cases, staging patients with known NET, and selecting patients for PRRT. NCCN guidelines consider imaging with 68Ga-DOTATATE PET/CT appropriate for staging and receptor status assessment.
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography ; Neuroendocrine Tumors ; Tomography, X-Ray Computed/methods ; Organometallic Compounds
    Chemical Substances copper dotatate CU-64 ; gallium Ga 68 dotatate (9L17Y0H71P) ; Organometallic Compounds
    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2022.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma.

    Kandathil, Asha / Subramaniam, Rathan M

    Seminars in nuclear medicine

    2022  Volume 52, Issue 6, Page(s) 650–661

    Abstract: Lung cancer is the leading cause of cancer-related mortality in the United States. Accurate staging at initial diagnosis determines appropriate treatment and is the most important predictor of survival. Since 2018, the 8th edition of the TNM staging ... ...

    Abstract Lung cancer is the leading cause of cancer-related mortality in the United States. Accurate staging at initial diagnosis determines appropriate treatment and is the most important predictor of survival. Since 2018, the 8th edition of the TNM staging system has been used to stage lung cancer based on local tumor extent (T), nodal involvement (N), and metastases (M). 18 F fluorodeoxyglucose (FDG) PET/CT, which combines functional and anatomic imaging, is the standard of care and an integral part of clinical staging of patients with lung cancer. Malignant pleural mesothelioma (MPM), the most common primary malignant pleural tumor affecting the pleura is staged with 8th edition of TNM staging for MPM. 18 F FDG PET/CT is indicated in select patients who are surgical candidates to identify locally advanced tumor, nodal metastases, or extrathoracic metastases, which may preclude surgery.
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Mesothelioma, Malignant/diagnostic imaging ; Positron Emission Tomography Computed Tomography/methods ; Tomography, X-Ray Computed ; Mesothelioma/diagnostic imaging ; Positron-Emission Tomography/methods ; Lung Neoplasms/diagnostic imaging ; Neoplasm Staging ; Radiopharmaceuticals
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2022.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Augmentation of Radioiodine Uptake by Pulmonary Metastasis of Papillary Thyroid Carcinoma Treated with Dabrafenib and Trametinib.

    Malja, Elona / Kandathil, Asha / Peng, Fangyu

    Nuclear medicine and molecular imaging

    2023  Volume 58, Issue 2, Page(s) 92–94

    Abstract: Redifferentiation therapy with Dabrafenib (a BRAF inhibitor) and Trametinib (a MEK inhibitor) restores radioiodine avidity of radioiodine-refractory papillary thyroid carcinoma (PTC). A 50-year-old man was diagnosed with radioiodine-refractory PTC ... ...

    Abstract Redifferentiation therapy with Dabrafenib (a BRAF inhibitor) and Trametinib (a MEK inhibitor) restores radioiodine avidity of radioiodine-refractory papillary thyroid carcinoma (PTC). A 50-year-old man was diagnosed with radioiodine-refractory PTC pulmonary metastasis post prior total thyroidectomy and radioiodine ablation. The patient was treated with Dabrafenib and Trametinib, followed by second radioiodine ablation with I-131 sodium iodine. Diffuse increased radioiodine uptake by pulmonary metastasis was visualized on post ablation whole body scan. Response to second radioiodine ablation was demonstrated by decrease in size of pulmonary nodules seen on chest CT, along with decrease of thyroglobulin level.
    Language English
    Publishing date 2023-09-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2541855-5
    ISSN 1869-3482 ; 1869-3474
    ISSN (online) 1869-3482
    ISSN 1869-3474
    DOI 10.1007/s13139-023-00824-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: FDG PET/CT findings and post-treatment changes of COVID-19 pneumonia in a patient with lymphoma: A case report.

    Matsui, Joy / Kandathil, Asha / Peng, Fangyu

    Molecular and clinical oncology

    2021  Volume 16, Issue 3, Page(s) 56

    Abstract: A 29-year-old male with a history of Hodgkin's lymphoma presented for evaluation of response to chemotherapy with positron emission tomography/computed tomography using fluorine-18-fluoro-2-deoxy-d-glucose ( ...

    Abstract A 29-year-old male with a history of Hodgkin's lymphoma presented for evaluation of response to chemotherapy with positron emission tomography/computed tomography using fluorine-18-fluoro-2-deoxy-d-glucose (
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Case Reports
    ZDB-ID 2796865-0
    ISSN 2049-9469 ; 2049-9450
    ISSN (online) 2049-9469
    ISSN 2049-9450
    DOI 10.3892/mco.2021.2489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fibrin-Associated Large B-Cell Lymphoma (FA-LBCL) Involving Solid Organs as Necrotic Cystic Lesions-A Rare Entity with Potential Diagnostic Pitfalls: A Two-Case Series and Review of the Literature.

    Jia, Liwei / Xing, Changhong / Kandathil, Asha / Rosado, Flavia / Chen, Weina / Ramakrishnan Geethakumari, Praveen

    International journal of surgical pathology

    2023  Volume 32, Issue 3, Page(s) 543–550

    Abstract: Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare subtype of Epstein-Barr virus (EBV)-associated lymphoma, recognized as an independent entity per the 5th edition of the WHO classification of hematolymphoid neoplasms. It is usually associated ... ...

    Abstract Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare subtype of Epstein-Barr virus (EBV)-associated lymphoma, recognized as an independent entity per the 5th edition of the WHO classification of hematolymphoid neoplasms. It is usually associated with longstanding chronic inflammation and arises within fibrinous material in confined anatomic spaces. We report the clinicopathologic manifestations of two patients of FA-LBCL involving the adrenal gland and kidney. Both tumors were diagnosed after presenting as cystic masses on imaging studies. These lymphomas were non-invasive, with microscopic aggregates of large B-lymphoma cells along/within cystic wall and admixed with fibrinous material and without prominent inflammation. By immunohistochemistry and in-situ hybridization, lymphoma cells were positive for CD45, PAX5, CD79a, MUM1, BCL2, PD-L1, and EBV/EBER (Epstein-Barr virus encoded small RNA) with a high proliferation index. Both patients remain in remission after management with complete surgical resection and additional chemo-immunotherapy in one patient. Considering its rarity, scant tumor cells, and varied clinical presentations, FA-LBCL may pose diagnostic challenges, especially when presenting as extensively necrotic cystic lesions, needing multidisciplinary collaboration in formulating management.
    MeSH term(s) Humans ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Herpesvirus 4, Human/genetics ; Fibrin ; Lymphoma, Large B-Cell, Diffuse/pathology ; Inflammation
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231185078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pulmonary vascular anatomy & anatomical variants.

    Kandathil, Asha / Chamarthy, Murthy

    Cardiovascular diagnosis and therapy

    2018  Volume 8, Issue 3, Page(s) 201–207

    Abstract: The vessels supplying the lungs include the pulmonary arteries, pulmonary veins, and bronchial arteries. The segmental and sub segmental pulmonary arteries parallel the bronchi and are named according to the bronchopulmonary segments they supply. There ... ...

    Abstract The vessels supplying the lungs include the pulmonary arteries, pulmonary veins, and bronchial arteries. The segmental and sub segmental pulmonary arteries parallel the bronchi and are named according to the bronchopulmonary segments they supply. There are however considerable anatomic variations, particularly in the upper lobes with variations in number or presence of accessory arteries from adjacent segments. The subsegmental pulmonary vein branches, run within interlobular septa and do not parallel the segmental or sub segmental pulmonary artery branches and bronchi. They converge to form right and left superior and inferior pulmonary veins which drain into the left atrium. Knowledge of normal and variant anatomy on cross-sectional and angiographic images is essential for accurate diagnosis of vascular pathology and aids planning of interventional procedures.
    Language English
    Publishing date 2018-02-06
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Review
    ZDB-ID 2685043-6
    ISSN 2223-3660 ; 2223-3652
    ISSN (online) 2223-3660
    ISSN 2223-3652
    DOI 10.21037/cdt.2018.01.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: PET/Computed Tomography and Precision Medicine: Musculoskeletal Sarcoma.

    Kandathil, Asha / Subramaniam, Rathan M

    PET clinics

    2017  Volume 12, Issue 4, Page(s) 475–488

    Abstract: Skeletal and soft tissue sarcomas need early and accurate diagnosis, staging, and treatment for optimal outcome. ...

    Abstract Skeletal and soft tissue sarcomas need early and accurate diagnosis, staging, and treatment for optimal outcome.
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2017.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 18F-fluciclovine PET/CT detection of biochemical recurrent prostate cancer in patients with PSA levels <2.00 ng/mL.

    Garza, Daniel / Kandathil, Asha / Xi, Yin / Subramaniam, Rathan M

    Nuclear medicine communications

    2021  Volume 42, Issue 8, Page(s) 907–913

    Abstract: Objective: To establish the detection rate of prostate cancer recurrence following definitive therapy by 18F-fluciclovine PET/computed tomography (CT) in patients with biochemical recurrence (BCR) and prostate-specific antigen (PSA) levels less than 2 ... ...

    Abstract Objective: To establish the detection rate of prostate cancer recurrence following definitive therapy by 18F-fluciclovine PET/computed tomography (CT) in patients with biochemical recurrence (BCR) and prostate-specific antigen (PSA) levels less than 2.00 ng/mL.
    Methods: In this retrospective study, 78 patients with a PSA level of less than 2.00 ng/mL were selected from the 211 patients who underwent at least one 18F-fluciclovine PET/CT scan at our institution for the detection of biochemical recurrent prostate cancer between April 2017 and December 2018. Inherent differences in the characteristics of patients with and without a positive scan were investigated for possible associations using multivariable analysis.
    Results: One or more positive sites of recurrence were identified in 44 out of 78 patients (56.4%). Patients with a Gleason score between 8 and 10 were more likely to have a positive scan compared to patients with Gleason scores of 6-7 [adjusted odds ratio: 3.53, 95% confidence interval (1.13-10.99), P = 0.03]. No other significant association was found between PSA, T classification, and detection rate.
    Conclusion: 18F-fluciclovine PET/CT demonstrated a detection rate of 56.4% among patients with a PSA below 2.0 ng/mL. The results of this study support the use of 18F-fluciclovine PET/CT for the detection of recurrent prostate cancer at lower PSA levels, even at PSA levels less than 0.5 ng/mL.
    MeSH term(s) Humans ; Male ; Middle Aged ; Neoplasm Grading ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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