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Article ; Online: Distribution characteristics of perioperative deep vein thrombosis (DVT) and risk factors of postoperative DVT exacerbation in patients with thoracolumbar fractures caused by high-energy injuries.

Lv, Bing / Wang, Haiying / Zhang, Zipeng / Li, Weifeng

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2024

Abstract: Objective: To investigate the distribution characteristics of perioperative deep venous thrombosis (DVT) in patients with thoracolumbar fractures caused by high-energy injuries and analyze the risk factors of postoperative DVT exacerbation.: Methods: ...

Abstract	Objective: To investigate the distribution characteristics of perioperative deep venous thrombosis (DVT) in patients with thoracolumbar fractures caused by high-energy injuries and analyze the risk factors of postoperative DVT exacerbation. Methods: From October 2016 to July 2021, a total of 550 patients with thoracolumbar fractures due to high-energy injuries in our hospital were retrospectively analyzed. Both lower limbs were examined by ultrasound before and after operation. Depending on whether the postoperative DVT was exacerbating, the group was divided into a DVT exacerbation group and a non-DVT exacerbation group. Clinical data were used to study the characteristics of perioperative DVT. Logistic regression analysis and receiver operating characteristic (ROC) curve were used to explore the risk factors of postoperative DVT exacerbation. Results: DVT was found in 97 patients before operation, including 78 cases of distal thrombus, 6 cases of proximal thrombus, and 13 cases of mixed thrombus. Postoperative DVT increased to 116, including 87 distal thrombus, 10 proximal thrombus, and 19 mixed thrombus. The intermuscular vein was the most easily involved vein. Compared with lumbar fractures, thoracic fractures were more likely to have postoperative proximal thrombus (P=0.014). There were 48 cases of thrombus exacerbation after operation. Logistic regression analysis revealed that age, lower extremity muscle strength, time from injury to operation, and blood loss were risk factors for postoperative DVT exacerbation. Conclusions: The intermuscular vein is the most easily involved vein. The anatomical distribution of DVT at different fracture sites is different, and patients with thoracic fractures are more likely to have proximal DVT after operation. Age, lower extremity muscle strength, time from injury to operation, and blood loss were risk factors for postoperative DVT exacerbation.
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-024-02468-0
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Article ; Online: Unveiling the underappreciated: The bonding features of C-H⋯S-S interactions observed from rotational spectroscopy.

Lv, Wenqi / Xu, Yugao / Yang, Tingting / Wang, Liuting / Huang, Jinxi / Huang, Haiying / Feng, Gang

The Journal of chemical physics

2024 Volume 160, Issue 13

Abstract: The C-H⋯S-S interactions are fundamentally important to understand the stability of biomacromolecules and their binding with small molecules, but they are still underappreciated. Herein, we characterized the C-H⋯S-S interactions in model molecular ... ...

Abstract	The C-H⋯S-S interactions are fundamentally important to understand the stability of biomacromolecules and their binding with small molecules, but they are still underappreciated. Herein, we characterized the C-H⋯S-S interactions in model molecular complexes. The rotational spectra of the complexes of diethyl disulfide with CH2CH2 and CH2CHF were measured and analyzed. All the detected structures are mainly stabilized by a C-H⋯S-S hydrogen bond, providing stabilization energies of 2.3-7.2 kJ mol-1. Incidental C-H⋯π or C-H⋯F interactions enhance the stabilization of the complexes. London dispersion, which accounts for 54%-68% of the total attractions, is the main driving force of stabilization. The provided bonding features of C-H⋯S-S are crucial for understanding the stabilizing role of this type of interaction in diverse processes such as supramolecular recognition, protein stability, and enzyme activity.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0200788
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Article: The impact of obstructive sleep apnea on nonalcoholic fatty liver disease.

Tang, Haiying / Lv, Furong / Zhang, Peng / Liu, Jia / Mao, Jingwei

Frontiers in endocrinology

2023 Volume 14, Page(s) 1254459

Abstract: Obstructive sleep apnea (OSA) is characterized by episodic sleep state-dependent collapse of the upper airway, with consequent hypoxia, hypercapnia, and arousal from sleep. OSA contributes to multisystem damage; in severe cases, sudden cardiac death ... ...

Abstract	Obstructive sleep apnea (OSA) is characterized by episodic sleep state-dependent collapse of the upper airway, with consequent hypoxia, hypercapnia, and arousal from sleep. OSA contributes to multisystem damage; in severe cases, sudden cardiac death might occur. In addition to causing respiratory, cardiovascular and endocrine metabolic diseases, OSA is also closely associated with nonalcoholic fatty liver disease (NAFLD). As the prevalence of OSA and NAFLD increases rapidly, they significantly exert adverse effects on the health of human beings. The authors retrieved relevant documents on OSA and NAFLD from PubMed and Medline. This narrative review elaborates on the current knowledge of OSA and NAFLD, demonstrates the impact of OSA on NAFLD, and clarifies the underlying mechanisms of OSA in the progression of NAFLD. Although there is a lack of sufficient high-quality clinical studies to prove the causal or concomitant relationship between OSA and NAFLD, existing evidence has confirmed the effect of OSA on NAFLD. Elucidating the underlying mechanisms through which OSA impacts NAFLD would hold considerable importance in terms of both prevention and the identification of potential therapeutic targets for NAFLD.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Hypoxia ; Sleep Apnea, Obstructive ; Sleep ; Polysomnography/adverse effects
Language	English
Publishing date	2023-10-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1254459
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Article ; Online: α-tocopherol pretreatment alleviates cerebral ischemia-reperfusion injury in rats.

Lv, Shitao / Yang, Haiyan / Jing, Pengcheng / Song, Haiying

CNS neuroscience & therapeutics

2022 Volume 28, Issue 6, Page(s) 964–970

Abstract: α-tocopherol showed antioxidant, anti-inflammatory and anti-apoptotic abilities in rat brain tissue, thus alleviating cerebral ischemia-reperfusion injury-induced nerve damage. ...

Abstract	α-tocopherol showed antioxidant, anti-inflammatory and anti-apoptotic abilities in rat brain tissue, thus alleviating cerebral ischemia-reperfusion injury-induced nerve damage.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Apoptosis ; Brain Ischemia/drug therapy ; Oxidative Stress ; Rats ; Reperfusion Injury/drug therapy ; alpha-Tocopherol/pharmacology ; alpha-Tocopherol/therapeutic use
Chemical Substances	Antioxidants ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2022-03-18
Publishing country	England
Document type	Letter
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.13814
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Zs.A 4537: Show issues

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Article ; Online: Evaluation of Supramolecular Gel Properties and Its Application in Drilling Fluid Plugging

Xiaoyong Du / Shaobo Feng / Haiying Lu / Yingrui Bai / Zhiqiang Lv

Processes, Vol 11, Iss 2749, p

2023 Volume 2749

Abstract: Supramolecular gels are physically cross-linked hydrogels formed by non-covalent interactions. The synthesis, structure optimization, property regulation, and application expansion of supramolecular gels has gradually become the research hotspot in the ... ...

Abstract	Supramolecular gels are physically cross-linked hydrogels formed by non-covalent interactions. The synthesis, structure optimization, property regulation, and application expansion of supramolecular gels has gradually become the research hotspot in the field of gel materials. According to the non-covalent interactions such as hydrophobic association and hydrogen bonding, the supramolecular gel prepared in this study has excellent rheological properties and adaptive filling and plugging properties, and can be used in the field of drilling fluid plugging. In this paper, the microstructure, rheological properties, temperature resistance, and plugging properties of supramolecular gels were studied and characterized in detail. The experimental findings demonstrated that when the strain was less than 10%, the supramolecular gel displayed an excellent linear viscoelastic region. The increase in strain weakens the rheological properties of supramolecular gel and reduces the elastic modulus of supramolecular gel to a certain extent. The supramolecular gel still had a neat three-dimensional reticular structure after curing at high temperatures, and the network of each layer was closely connected. Its extensibility and tensile properties were good, and it had excellent temperature resistance and mechanical strength. The supramolecular gel had excellent tensile and compressive properties and good deformation recovery properties. When the elongation of the supramolecular gel reached 300%, the tensile stress was 2.33 MPa. When the compression ratio of supramolecular gel was 91.2%, the compressive stress could reach 4.78 MPa. The supramolecular gel could show an excellent plugging effect on complex loss layers with different fracture pore sizes, the plugging success rate could reach more than 90%, and the plugging layer could withstand 6.3 MPa external pressure. The smart plugging fluid prepared with supramolecular gel material could quickly form a fine barrier layer on the rock surface of the reservoir. It could effectively ...
Keywords	supramolecular gel ; non-covalent effect ; rheological mechanical properties ; plugging performance ; drilling fluid plugging ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The relationship between posttraumatic growth, self-efficacy, and social support in burn patients: A cross-sectional study.

Li, Na / Cheng, Haiying / Lv, Liming

Burns : journal of the International Society for Burn Injuries

2022 Volume 48, Issue 7, Page(s) 1626–1631

Abstract: Aims: To explore the effects of self-efficacy and social support on posttraumatic growth among burn patients.: Methods: This study adopted a cross-sectional design and used convenience sampling method to recruit moderate and severe burn patients. The ...

Abstract	Aims: To explore the effects of self-efficacy and social support on posttraumatic growth among burn patients. Methods: This study adopted a cross-sectional design and used convenience sampling method to recruit moderate and severe burn patients. The study was conducted from January to July, 2018 in a tertiary hospital in Linyi, China. Self-administered questionnaires were used to collect data on posttraumatic growth, social support, and self-efficacy. Path analysis conducted using SPSS AMOS 21.0 software was used to explore the relationship between the above three variables. Results: The mean scores for posttraumatic growth, social support, and self-efficacy were 58.11 ± 9.60, 43.48 ± 6.81, and 24.97 ± 5.71, respectively. Self-efficacy and social support were directly and positively related to posttraumatic growth among burn patients. Social support was also indirectly and positively associated with posttraumatic growth. Self-efficacy partially mediated the relationship between social support and posttraumatic growth. Conclusions: Self-efficacy was an important mediator for burn patients' social support and posttraumatic growth. Therefore, self-efficacy and social support should be considered when designing and implementing of interventions for posttraumatic growth among burn patients.
MeSH term(s)	Humans ; Self Efficacy ; Posttraumatic Growth, Psychological ; Cross-Sectional Studies ; Burns ; Social Support ; Surveys and Questionnaires ; Adaptation, Psychological
Language	English
Publishing date	2022-08-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2022.08.009
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Zs.A 1250: Show issues

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Article ; Online: The influences of social support and emotion regulation strategies on posttraumatic growth of burn survivors: A cross-sectional study in Linyi, China.

Li, Na / Cheng, Haiying / Li, Shaojie / Lv, Liming

Nursing & health sciences

2022 Volume 25, Issue 1, Page(s) 89–97

Abstract: This cross-sectional study aimed to test the influences of social support and emotion regulation strategies (cognitive reappraisal and expression suppression) on burn survivors' posttraumatic growth. A convenience sampling method was adopted to recruit ... ...

Abstract	This cross-sectional study aimed to test the influences of social support and emotion regulation strategies (cognitive reappraisal and expression suppression) on burn survivors' posttraumatic growth. A convenience sampling method was adopted to recruit 130 burn survivors from the department of burns and plastic surgery of a public hospital in Linyi, China. Data were collected using self-reported questionnaires on social support, emotion regulation strategies, and posttraumatic growth. Structural equation modeling was performed to explore the associations among social support, emotion regulation strategies, and posttraumatic growth in burn survivors. The results showed that social support positively affected cognitive reappraisal and negatively affected expression suppression. Furthermore, it positively affected posttraumatic growth. Moreover, social support indirectly influenced posttraumatic growth through cognitive reappraisal, which implies that cognitive reappraisal played a partial mediating effect in the relationship between social support and posttraumatic growth. These findings provide new insights into the predictors of posttraumatic growth. Cognitive reappraisal and social support should be taken into account to improve burn survivors' posttraumatic growth.
MeSH term(s)	Humans ; Posttraumatic Growth, Psychological ; Cross-Sectional Studies ; Emotional Regulation ; Social Support ; Survivors/psychology ; Burns/complications
Language	English
Publishing date	2022-11-28
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2213282-X
ISSN	1442-2018 ; 1441-0745
ISSN (online)	1442-2018
ISSN	1441-0745
DOI	10.1111/nhs.12993
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Article ; Online: Ovarian sensitivity index can be used as a more sensitive indicator than follicular output rate to predict IVF/ICSI outcomes in patients of normal expected ovarian response stimulated with GnRH antagonist protocol.

Hu, Fen / Wang, Xiaocheng / Ren, Haiying / Lv, Yasu / Li, Huanhuan / Liu, Shan / Zhou, Wenhui

Human fertility (Cambridge, England)

2023 Volume 26, Issue 5, Page(s) 1264–1270

Abstract: This retrospective study was performed to investigate the predictive power of the Ovarian Sensitivity Index (OSI) for IVF/ICSI outcomes in infertile patients who were of normal expected ovarian response. A total of 912 infertile patients who underwent ... ...

Abstract	This retrospective study was performed to investigate the predictive power of the Ovarian Sensitivity Index (OSI) for IVF/ICSI outcomes in infertile patients who were of normal expected ovarian response. A total of 912 infertile patients who underwent GnRH antagonist protocol between January 2017 to August 2019 at the Medical Center for Human Reproduction, Beijing Chao-Yang Hospital were included. All patients completed the full oocyte retrieval cycle and either had a live birth or had no embryos left. OSI was significantly lower in patients with a live birth (196.0 ± 120.4 in the live birth group vs 276.4 ± 235.7 in the non-live birth group,
MeSH term(s)	Pregnancy ; Female ; Humans ; Fertilization in Vitro/methods ; Sperm Injections, Intracytoplasmic/methods ; Pregnancy Rate ; Ovulation Induction/methods ; Retrospective Studies ; Birth Rate ; Live Birth ; Infertility ; Gonadotropin-Releasing Hormone
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2023-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2086960-5
ISSN	1742-8149 ; 1464-7273
ISSN (online)	1742-8149
ISSN	1464-7273
DOI	10.1080/14647273.2023.2164869
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Zs.A 5775: Show issues

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Article ; Online: The Impact of D-Dimer on Postoperative Deep Vein Thrombosis in Patients with Thoracolumbar Fracture Caused by High-Energy Injuries.

Wang, Haiying / Lv, Bing / Li, Weifeng / Wang, Shunyi

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2022 Volume 28, Page(s) 10760296211070009

Abstract: Objective: To investigate the dynamic variation of D-dimer and to evaluate the efficacy and accuracy of D-dimer level in patients with thoracolumbar fractures caused by high-energy injuries.: Methods: A total of 121 patients with thoracolumbar ... ...

Abstract	Objective: To investigate the dynamic variation of D-dimer and to evaluate the efficacy and accuracy of D-dimer level in patients with thoracolumbar fractures caused by high-energy injuries. Methods: A total of 121 patients with thoracolumbar fractures caused by high-energy injuries were retrospectively identified and included in this study. There were 83 males and 38 females, with an average age of 48.6 ± 11.2 years. All patients were treated with either screw fixation surgery or decompression fixation surgery. The D-dimer levels were measured 1 day before surgery and on the first, third, and fifth days after surgery. The dynamic variation of D-dimer and the effects of risk factors on D-dimer levels were analysed. A receiver operating characteristic (ROC) curve analysis was performed and the appropriate D-dimer cut-off level was determined for deep vein thrombosis (DVT) screening. Results: Due to a trough on the third day, D-dimer levels grew in an unsustainable manner following surgery (P < 0.001). Patients with the operation time >120 min (P = 0.009) and those with an American Spinal Injury Association (ASIA) score A-C (P < 0.001) had higher D-dimer levels. The area under the curve of D-dimer was the greatest on the third day. Applying stratified cut-off values did not change the sensitivity, specificity and negative predictive value in the group with an operation time >120 min, and ASIA score A-C group. Conclusions: D-dimer levels elevated with fluctuation in patients with thoracolumbar fractures caused by high-energy injuries after surgery. Both operation time and ASIA score had an impact on D-dimer levels. Regarding DVT diagnoses, the diagnostic value of D-dimer was highest on the third day postoperatively, and stratified cut-off values by these two factors did not show better diagnostic efficacy compared with a collective one.
MeSH term(s)	Biomarkers/blood ; Bone Screws/adverse effects ; Decompression, Surgical/adverse effects ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Follow-Up Studies ; Fracture Fixation, Internal/adverse effects ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/injuries ; Male ; Middle Aged ; Postoperative Complications/blood ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Predictive Value of Tests ; Protein Multimerization ; ROC Curve ; Retrospective Studies ; Spinal Fractures/blood ; Spinal Fractures/diagnosis ; Spinal Fractures/surgery ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/injuries ; Trauma Severity Indices ; Ultrasonography, Doppler, Duplex/methods ; Venous Thrombosis/blood ; Venous Thrombosis/diagnosis ; Venous Thrombosis/etiology
Chemical Substances	Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/10760296211070009
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Zs.A 4370: Show issues

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Article ; Online: Glycyrrhizic Acid-Based Carbonized Dots Boost Antiviral Activity against Influenza A Virus via Multisite Inhibition Mechanisms.

Li, Chengfei / Han, Pengfei / Mao, Haiying / Lv, Changjie / Huang, Kun / Jin, Meilin

ACS applied materials & interfaces

2023 Volume 15, Issue 8, Page(s) 10441–10451

Abstract: Influenza A virus (IVA) has been continuously causing pandemics in several animal hosts and has become a worldwide public health threat. Currently, antiviral drugs have become associated with a lot of side effects and limited activity against emerging ... ...

Abstract	Influenza A virus (IVA) has been continuously causing pandemics in several animal hosts and has become a worldwide public health threat. Currently, antiviral drugs have become associated with a lot of side effects and limited activity against emerging drug-resistant influenza viruses. Therefore, the development of novel antiviral drugs is of great importance. In this study, we synthesized a kind of carbon dots (CDs) with high dispersibility from glycyrrhizic acid (GA) using a simple dry heating method. Compared with glycyrrhizic acid alone, GA-CDs exhibit superior solubility and significantly improve the antiviral property against IVA. Investigation of the mechanism revealed that GA-CDs act against IVA mainly by inhibiting viral internalization, replication of the viral genome, neuraminidase activity, and host inflammatory responses. More importantly, in a mouse model, GA-CDs can significantly alleviate the clinical symptoms and decrease mortality and lung viral titers. In vitro and in vivo experiments demonstrate that GA-CDs possess extraordinary therapeutic effects; therefore, we propose that GA-CDs may be a promising alternative therapy for IVA infection.
MeSH term(s)	Animals ; Mice ; Antiviral Agents/pharmacology ; Influenza A virus ; Glycyrrhizic Acid/therapeutic use ; Orthomyxoviridae Infections/drug therapy ; Virus Replication
Chemical Substances	Antiviral Agents ; Glycyrrhizic Acid (6FO62043WK)
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c21319
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