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Article ; Online: Untangling severe pulmonary hypertension in chronic obstructive pulmonary disease.

Barberà, Joan Albert / Peinado, Víctor Ivo / Blanco, Isabel

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2024

Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Editorial
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2024.03.015
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Article ; Online: Influence of sex hormones status and type of training on regional bone mineral density in exercising females.

Guisado-Cuadrado, Isabel / Alfaro-Magallanes, Víctor M / Romero-Parra, Nuria / Rael, Beatriz / Guadalupe-Grau, Amelia / Peinado, Ana B

European journal of sport science

2023 Volume 23, Issue 11, Page(s) 2139–2147

Abstract: The primary objective of this study was to examine the influence of hormonal ovarian profile and training characteristics on spine, pelvis, and total body bone mineral density (BMD) in a group of well-trained females. Forty-two eumenorrheic females, ... ...

Abstract	The primary objective of this study was to examine the influence of hormonal ovarian profile and training characteristics on spine, pelvis, and total body bone mineral density (BMD) in a group of well-trained females. Forty-two eumenorrheic females, twenty-eight monophasic oral contraceptive (OC) users and thirteen postmenopausal females participated in this study. Body composition was measured by total body dual-energy X-ray absorptiometry (DXA) to determine BMD of the areas of interest. Endurance-trained premenopausal females showed lower spine BMD compared to resistance-trained premenopausal females (1.03 ± 0.1 vs. 1.09 ± 0.09 g/cm
MeSH term(s)	Female ; Humans ; Bone Density ; Absorptiometry, Photon ; Spine ; Contraceptives, Oral/pharmacology ; Gonadal Steroid Hormones/pharmacology
Chemical Substances	Contraceptives, Oral ; Gonadal Steroid Hormones
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ISSN	1536-7290
ISSN (online)	1536-7290
DOI	10.1080/17461391.2023.2211947
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Article ; Online: Atrophy signaling pathways in respiratory and limb muscles of guinea pigs exposed to chronic cigarette smoke: role of soluble guanylate cyclase stimulation.

Peinado, Víctor Ivo / Guitart, Maria / Blanco, Isabel / Tura-Ceide, Olga / Paul, Tanja / Barberà, Joan Albert / Barreiro, Esther

American journal of physiology. Lung cellular and molecular physiology

2023 Volume 324, Issue 5, Page(s) L677–L693

Abstract: Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is characterized by a significant reduction in muscle strength and endurance. Preclinical studies show that stimulation of the soluble guanylate cyclase (sGC)-cGMP pathway ... ...

Abstract	Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is characterized by a significant reduction in muscle strength and endurance. Preclinical studies show that stimulation of the soluble guanylate cyclase (sGC)-cGMP pathway attenuates muscle mass loss and prevents cigarette smoke-induced oxidative stress, indicating that pharmacological activation of the guanylyl cyclase pathway in COPD may provide a beneficial therapeutic strategy that reaches beyond the lung. In this study, conducted in an animal model of COPD, we first set out to assess the effect of cigarette smoke (CS) on biomarkers of muscle fatigue, such as protein degradation and its transcriptional regulation, in two types of muscles with different energy demands, i.e., the diaphragm and the gastrocnemius muscle of the limbs. Second, we evaluated the administration of an sGC stimulator on these markers to study the potential efficacy of such treatment in the recovery of skeletal muscle function. Exposure to CS led to weight loss, which was associated in the gastrocnemius with increased levels of proteolytic markers of muscle atrophy (MURF-1, Atrogin-1, proteasome C8 subunit 20 s, and total protein ubiquitination), whereas the size of fast-twitch muscle fibers decreased significantly. Long-term treatment with the sGC stimulator BAY 41-2272 resulted in a significant reduction in gastrocnemius levels of the aforementioned proteolytic markers, concomitant with a weight recovery and increased cGMP levels. Remarkably, levels of some of the analyzed biomarkers differed between respiratory and limb muscles. In conclusion, targeting sGC might exert beneficial effects on muscle alterations in patients with COPD.
MeSH term(s)	Guinea Pigs ; Animals ; Soluble Guanylyl Cyclase/metabolism ; Cigarette Smoking ; Guanylate Cyclase/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Muscle, Skeletal/metabolism ; Signal Transduction ; Biomarkers/metabolism ; Atrophy/metabolism ; Atrophy/pathology
Chemical Substances	Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Guanylate Cyclase (EC 4.6.1.2) ; Biomarkers
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00258.2022
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Uc I Zs.89: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 2749: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)

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Article: Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension.

Blanco, Isabel / Marquina, Maribel / Tura-Ceide, Olga / Ferrer, Elisabet / Ramírez, Ana M / Lopez-Meseguer, Manuel / Callejo, Maria / Perez-Vizcaino, Francisco / Peinado, Victor Ivo / Barberà, Joan Albert

Frontiers in pharmacology

2023 Volume 14, Page(s) 1145994

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1145994
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Article ; Online: Updated Perspectives on Pulmonary Hypertension in COPD.

Blanco, Isabel / Tura-Ceide, Olga / Peinado, Victor Ivo / Barberà, Joan Albert

International journal of chronic obstructive pulmonary disease

2020 Volume 15, Page(s) 1315–1324

Abstract: Pulmonary hypertension (PH) is a frequent and important complication of chronic obstructive pulmonary disease (COPD). It is associated with worse clinical courses with more frequent exacerbation episodes, shorter survival, and greater need of health ... ...

Abstract	Pulmonary hypertension (PH) is a frequent and important complication of chronic obstructive pulmonary disease (COPD). It is associated with worse clinical courses with more frequent exacerbation episodes, shorter survival, and greater need of health resources. PH is usually of moderate severity and progresses slowly, without altering right ventricular function in the majority of cases. Nevertheless, a reduced subgroup of patients may present disproportionate PH, with pulmonary artery pressure (PAP) largely exceeding the severity of respiratory impairment. These patients may represent a group with an exaggerated vascular impairment (pulmonary vascular phenotype) to factors that induce PH in COPD or be patients in whom idiopathic pulmonary arterial hypertension (PAH) coexist. The present review addresses the current definition and classification of PH in COPD, the distinction among the different phenotypes of pulmonary vascular disease that might present in COPD patients, and the therapeutic approach to PH in COPD based on the available scientific evidence.
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Lung ; Pulmonary Circulation ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/therapy ; Ventricular Function, Right
Language	English
Publishing date	2020-06-09
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	1178-2005
ISSN (online)	1178-2005
DOI	10.2147/COPD.S211841
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Article ; Online: ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles.

Cardeñes, Beatriz / Clares, Irene / Bezos, Tamara / Toribio, Víctor / López-Martín, Soraya / Rocha, Almudena / Peinado, Héctor / Yáñez-Mó, María / Cabañas, Carlos

International journal of molecular sciences

2022 Volume 23, Issue 10

Abstract: Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal metastasis, a condition associated with a very poor prognosis. In these cancers, tumor-derived extracellular vesicles (EVs) cause immunosuppression, facilitate the ... ...

Abstract	Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal metastasis, a condition associated with a very poor prognosis. In these cancers, tumor-derived extracellular vesicles (EVs) cause immunosuppression, facilitate the direct attachment and invasion of cancer cells through the mesothelium, induce the conversion of peritoneal mesothelial cells (PMCs) into cancer-associated fibroblasts (CAFs) and transfer a more aggressive phenotype amongst cancer cells. Although the promoting role of EVs in CRC and OvC peritoneal metastasis is well established, the specific molecules that mediate the interactions between tumor-derived EVs and immune and non-immune target cells remain elusive. Here, we employed the SKOV-3 (ovarian adenocarcinoma) and Colo-320 (colorectal adenocarcinoma) human cell lines as model systems to study the interactions and uptake of EVs produced by ovarian carcinoma and colorectal carcinoma cells, respectively. We established that the adhesion molecule ALCAM/CD166 is involved in the interaction of cancer-derived EVs with recipient cancer cells (a process termed "EV binding" or "EV docking") and in their subsequent uptake by these cells. The identification of ALCAM/CD166 as a molecule mediating the docking and uptake of CRC and OvC-derived EVs may be potentially exploited to block the peritoneal metastasis cascade promoted by EVs in CRC and OvC patients.
MeSH term(s)	Activated-Leukocyte Cell Adhesion Molecule/metabolism ; Adenocarcinoma/pathology ; Antigens, CD/metabolism ; Carcinoma, Ovarian Epithelial/pathology ; Cell Adhesion Molecules, Neuronal/metabolism ; Extracellular Vesicles/metabolism ; Female ; Fetal Proteins/metabolism ; Humans ; Ovarian Neoplasms/pathology ; Peritoneal Neoplasms/metabolism
Chemical Substances	ALCAM protein, human ; Activated-Leukocyte Cell Adhesion Molecule ; Antigens, CD ; Cell Adhesion Molecules, Neuronal ; Fetal Proteins
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23105753
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Article: Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways.

Aguilar, Daniel / Bosacoma, Adelaida / Blanco, Isabel / Tura-Ceide, Olga / Serrano-Mollar, Anna / Barberà, Joan Albert / Peinado, Victor Ivo

Life (Basel, Switzerland)

2022 Volume 12, Issue 6

Abstract: Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease associated with high morbidity and mortality. Although many patients recover, long-term sequelae after infection have become increasingly recognized and concerning. Among other ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease associated with high morbidity and mortality. Although many patients recover, long-term sequelae after infection have become increasingly recognized and concerning. Among other sequelae, the available data indicate that many patients who recover from COVID-19 could develop fibrotic abnormalities over time. To understand the basic pathophysiology underlying the development of long-term pulmonary fibrosis in COVID-19, as well as the higher mortality rates in patients with pre-existing lung diseases, we compared the transcriptomic fingerprints among patients with COVID-19, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) using interactomic analysis. Patients who died of COVID-19 shared some of the molecular biological processes triggered in patients with IPF, such as those related to immune response, airway remodeling, and wound healing, which could explain the radiological images seen in some patients after discharge. However, other aspects of this transcriptomic profile did not resemble the profile associated with irreversible fibrotic processes in IPF. Our mathematical approach instead showed that the molecular processes that were altered in COVID-19 patients more closely resembled those observed in COPD. These data indicate that patients with COPD, who have overcome COVID-19, might experience a faster decline in lung function that will undoubtedly affect global health.
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12060887
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Article ; Online: Reply to: COVID-19 and Coagulopathy.

Rodríguez, Cristina / Luque, Neus / Blanco, Isabel / Sebastian, Laura / Barberà, Joan Albert / Peinado, Víctor I / Tura-Ceide, Olga

American journal of respiratory cell and molecular biology

2021 Volume 64, Issue 6, Page(s) 764–766

MeSH term(s)	Blood Coagulation ; Blood Coagulation Disorders ; COVID-19 ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-03-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2021-0103LE
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Zs.A 2851: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Identification of intergenerational epigenetic inheritance by whole genome DNA methylation analysis in trios.

Díez-Villanueva, Anna / Martín, Berta / Moratalla-Navarro, Ferran / Morón-Duran, Francisco D / Galván-Femenía, Iván / Obón-Santacana, Mireia / Carreras, Anna / de Cid, Rafael / Peinado, Miguel A / Moreno, Victor

Scientific reports

2023 Volume 13, Issue 1, Page(s) 21266

Abstract: Genome-wide association studies have identified thousands of loci associated with common diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic modifications, such as the observed in DNA methylation have been ... ...

Abstract	Genome-wide association studies have identified thousands of loci associated with common diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic modifications, such as the observed in DNA methylation have been proposed as a mechanism of intergenerational inheritance. To investigate the potential contribution of DNA methylation to the missing heritability, we analysed the methylomes of four healthy trios (two parents and one offspring) using whole genome bisulphite sequencing. Of the 1.5 million CpGs (19%) with over 20% variability between parents in at least one family and compatible with a Mendelian inheritance pattern, only 3488 CpGs (0.2%) lacked correlation with any SNP in the genome, marking them as potential sites for intergenerational epigenetic inheritance. These markers were distributed genome-wide, with some preference to be located in promoters. They displayed a bimodal distribution, being either fully methylated or unmethylated, and were often found at the boundaries of genomic regions with high/low GC content. This analysis provides a starting point for future investigations into the missing heritability of simple and complex traits.
MeSH term(s)	DNA Methylation ; Genome-Wide Association Study ; Epigenesis, Genetic ; Genome ; Multifactorial Inheritance ; CpG Islands/genetics
Language	English
Publishing date	2023-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48517-3
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Book ; Online: A free convection heat transfer correlation for very thin horizontal wires in rarefied atmospheres

Peinado, Lilian / Muntean, Victor / Pérez-Grande, Isabel

2020

Abstract: Mars and upper Earth atmosphere missions are booming in recent years increasing the interest in heat transfer in rarefied gases. At these low pressures, the heat transfer problems involving small geometries whose characteristic length is of the order of ... ...

Abstract	Mars and upper Earth atmosphere missions are booming in recent years increasing the interest in heat transfer in rarefied gases. At these low pressures, the heat transfer problems involving small geometries whose characteristic length is of the order of the mean free path of the gas molecules, raises new difficulties. This being especially severe in the case of free convection, where the velocity of the gas is closely linked to the heat transfer problem. Experiments with horizontal wires with diameters of $12.7\ \mu\mathrm{m}$ and $25\ \mu\mathrm{m}$ were conducted in a tailored vacuum chamber with pressures from $0.03$ milibar to ambient pressure, reaching temperature differences of up to $80$ K between the wire and the air. Experimental data is comprised of Rayleigh numbers from $10^{-13}$ to $10^{-5}$ that cover a wide range from free molecular flow to continuum regime. Particularly for the transition regime, with Knudsen numbers ranging between 0.1 and 10, the experimental data shows that the free convection heat transfer cannot be represented solely as a function of the Rayleigh number, but a dependence on Knudsen number must be introduced into the correlation as well. The presented results for the Nusselt number below Rayleigh numbers of $10^{-8}$ exhibit a clear departure from the available correlations in the literature. A new empirical correlation for free convection from horizontal thin wires from the transition to continuum regime is presented. The present work sheds light on current thermal engineering problems which involves very thin wires in their systems which interact with a surrounding environment with a significant level of rarefaction.
Keywords	Physics - Fluid Dynamics
Subject code	621
Publishing date	2020-06-05
Publishing country	us
Document type	Book ; Online
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