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Article: How to Cope With Heavy Metal Ions: Cellular and Proteome-Level Stress Response to Divalent Copper and Nickel in

Völkel, Sabrina / Hein, Sascha / Benker, Nathalie / Pfeifer, Felicitas / Lenz, Christof / Losensky, Gerald

2020 Volume 10, Page(s) 3056

Abstract: Halobacterium ... ...

Abstract	Halobacterium salinarum
Language	English
Publishing date	2020-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.03056
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Article: How to build up big team science: a practical guide for large-scale collaborations.

Baumgartner, Heidi A / Alessandroni, Nicolás / Byers-Heinlein, Krista / Frank, Michael C / Hamlin, J Kiley / Soderstrom, Melanie / Voelkel, Jan G / Willer, Robb / Yuen, Francis / Coles, Nicholas A

Royal Society open science

2023 Volume 10, Issue 6, Page(s) 230235

Abstract: The past decade has witnessed a proliferation of big team science (BTS), endeavours where a comparatively large number of researchers pool their intellectual and/or material resources in pursuit of a common goal. Despite this burgeoning interest, there ... ...

Abstract	The past decade has witnessed a proliferation of big team science (BTS), endeavours where a comparatively large number of researchers pool their intellectual and/or material resources in pursuit of a common goal. Despite this burgeoning interest, there exists little guidance on how to create, manage and participate in these collaborations. In this paper, we integrate insights from a multi-disciplinary set of BTS initiatives to provide a how-to guide for BTS. We first discuss initial considerations for launching a BTS project, such as building the team, identifying leadership, governance, tools and open science approaches. We then turn to issues related to running and completing a BTS project, such as study design, ethical approvals and issues related to data collection, management and analysis. Finally, we address topics that present special challenges for BTS, including authorship decisions, collaborative writing and team decision-making.
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230235
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Article ; Online: Reconciling paradigms of abnormal pulmonary blood flow and quasi-malignant cellular alterations in pulmonary arterial hypertension.

Happé, C M / Szulcek, R / Voelkel, N F / Bogaard, H J

Vascular pharmacology

2016 Volume 83, Page(s) 17–25

Abstract: In pulmonary arterial hypertension (PAH) structural and functional abnormalities of the small lung vessels interact and lead to a progressive increase in pulmonary vascular resistance and right heart failure. A current pathobiological concept ... ...

Abstract	In pulmonary arterial hypertension (PAH) structural and functional abnormalities of the small lung vessels interact and lead to a progressive increase in pulmonary vascular resistance and right heart failure. A current pathobiological concept characterizes PAH as a 'quasi-malignant' disease focusing on cancer-like alterations in endothelial cells (EC) and the importance of their acquired apoptosis-resistant, hyper-proliferative phenotype in the process of vascular remodeling. While changes in pulmonary blood flow (PBF) have been long-since recognized and linked to the development of PAH, little is known about a possible relationship between an altered PBF and the quasi-malignant cell phenotype in the pulmonary vascular wall. This review summarizes recognized and hypothetical effects of an abnormal PBF on the pulmonary vascular bed and links these to quasi-malignant changes found in the pulmonary endothelium. Here we describe that abnormal PBF does not only trigger a pulmonary vascular cell growth program, but may also maintain the cancer-like phenotype of the endothelium. Consequently, normalization of PBF and EC response to abnormal PBF may represent a treatment strategy in patients with established PAH.
MeSH term(s)	Angiogenic Proteins/metabolism ; Animals ; Apoptosis ; Cell Proliferation ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Energy Metabolism ; Humans ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/physiopathology ; Mechanotransduction, Cellular ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic ; Phenotype ; Pulmonary Artery/metabolism ; Pulmonary Artery/pathology ; Pulmonary Artery/physiopathology ; Pulmonary Circulation ; Regional Blood Flow ; Stress, Mechanical
Chemical Substances	Angiogenic Proteins
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2082846-9
ISSN	1879-3649 ; 1537-1891 ; 1879-3649
ISSN (online)	1879-3649 ; 1537-1891
ISSN	1879-3649
DOI	10.1016/j.vph.2016.01.004
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Article: Hidden inflammatory potential of the red blood cell.

Voelkel, N F

Critical care medicine

2000 Volume 28, Issue 6, Page(s) 2149–2150

MeSH term(s)	Erythrocytes/physiology ; Humans ; Inflammation/blood
Language	English
Publishing date	2000-06
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/00003246-200006000-00090
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Article: COPD: Working towards a greater understanding. Introduction.

Voelkel, N F

Chest

2000 Volume 117, Issue 5 Suppl 2, Page(s) 325S

MeSH term(s)	Consensus Development Conferences as Topic ; Education, Medical, Continuing ; Health Personnel/education ; Health Personnel/standards ; Humans ; Incidence ; Lung Diseases, Obstructive/diagnosis ; Lung Diseases, Obstructive/epidemiology ; Lung Diseases, Obstructive/prevention & control ; Patient Education as Topic ; Practice Patterns, Physicians' ; Survival Rate ; United States/epidemiology
Language	English
Publishing date	2000-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.117.5_suppl_2.325s
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Article ; Online: Internal exposure to perfluoroalkyl substances (PFASs) and biological markers in 101 healthy 1-year-old children: associations between levels of perfluorooctanoic acid (PFOA) and vaccine response.

Abraham, Klaus / Mielke, Hans / Fromme, Hermann / Völkel, Wolfgang / Menzel, Juliane / Peiser, Matthias / Zepp, Fred / Willich, Stefan N / Weikert, Cornelia

Archives of toxicology

2020 Volume 94, Issue 6, Page(s) 2131–2147

Abstract: Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) ...

Abstract	Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the lead compounds. They are immunotoxic in experimental animals, and epidemiological studies provided evidence of a diminished production of vaccine antibodies in young children. However, information on children of the first year of age is missing but relevant, as they have a relatively high exposure if breastfed, and may have a higher susceptibility as their immune system is developing. In a cross-sectional study with 101 healthy 1-year-old children, internal levels of persistent organic pollutants and a broad panel of biological parameters were investigated at the end of the 1990s. Additional analysis of PFASs resulted in plasma levels (mean ± SD) of PFOA and PFOS of 3.8 ± 1.1 and 6.8 ± 3.4 µg/L, respectively, in the 21 formula-fed children, and of 16.8 ± 6.6 and 15.2 ± 6.9 µg/L in the 80 children exclusively breastfed for at least 4 months. The study revealed significant associations between levels of PFOA, but not of PFOS, and adjusted levels of vaccine antibodies against Haemophilus influenza type b (Hib, r = 0.32), tetanus (r = 0.25) and diphtheria (r = 0.23), with no observed adverse effect concentrations (NOAECs) determined by fitting a 'knee' function of 12.2, 16.9 and 16.2 µg/L, respectively. The effect size (means for PFOA quintiles Q1 vs. Q5) was quantified to be - 86, - 54 and - 53%, respectively. Furthermore, levels of PFOA were inversely associated with the interferon gamma (IFNɣ) production of ex-vivo lymphocytes after stimulation with tetanus and diphtheria toxoid, with an effect size of - 64 and - 59% (means Q1 vs. Q5), respectively. The study revealed no influence of PFOA and PFOS on infections during the first year of life and on levels of cholesterol. Our results confirmed the negative associations of PFAS levels and parameters of immune response observed in other epidemiological studies, with high consistency as well as comparable NOAECs and effects sizes for the three vaccine antibodies investigated, but for PFOA only. Due to reduction of background levels of PFASs during the last 20 years, children in Germany nowadays breastfed for a long duration are for the most part not expected to reach PFOA levels at the end of the breastfeeding period above the NOAECs determined.
MeSH term(s)	Alkanesulfonic Acids/adverse effects ; Alkanesulfonic Acids/blood ; Antibodies, Bacterial/blood ; Bacterial Infections/immunology ; Bacterial Infections/microbiology ; Bacterial Infections/prevention & control ; Bacterial Vaccines/administration & dosage ; Body Burden ; Bottle Feeding ; Breast Feeding ; Caprylates/adverse effects ; Caprylates/blood ; Cells, Cultured ; Cross-Sectional Studies ; Diphtheria Toxoid/administration & dosage ; Environmental Pollutants/adverse effects ; Environmental Pollutants/blood ; Female ; Fluorocarbons/adverse effects ; Fluorocarbons/blood ; Haemophilus Vaccines/administration & dosage ; Humans ; Immunity, Cellular/drug effects ; Immunogenicity, Vaccine/drug effects ; Infant ; Infant Formula ; Interferon-gamma/metabolism ; Lymphocytes/drug effects ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Male ; No-Observed-Adverse-Effect Level ; Tetanus Toxoid/administration & dosage ; Vaccination
Chemical Substances	Alkanesulfonic Acids ; Antibodies, Bacterial ; Bacterial Vaccines ; Caprylates ; Diphtheria Toxoid ; Environmental Pollutants ; Fluorocarbons ; Haemophilus Vaccines ; IFNG protein, human ; Tetanus Toxoid ; Interferon-gamma (82115-62-6) ; perfluorooctanoic acid (947VD76D3L) ; perfluorooctane sulfonic acid (9H2MAI21CL)
Language	English
Publishing date	2020-03-29
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-020-02715-4
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Article: Raising awareness of COPD in primary care.

Voelkel, N F

Chest

2000 Volume 117, Issue 5 Suppl 2, Page(s) 372S–5S

Abstract: COPD is a major cause of mortality and a significant drain on health-care resources but is widely underdiagnosed in the primary-care setting. There is an urgent need to raise the profile of the disease among both primary-care physicians and patients. At ... ...

Abstract	COPD is a major cause of mortality and a significant drain on health-care resources but is widely underdiagnosed in the primary-care setting. There is an urgent need to raise the profile of the disease among both primary-care physicians and patients. At the workshop "COPD: Working Towards a Greater Understanding," a panel of COPD experts from Europe and the United States discussed ways in which awareness of COPD could be raised. Access to spirometry, and education in its use and relevance, was identified as a major goal for primary-care physicians. Simple questionnaires can promote patient awareness and provide feedback to physicians. COPD needs to be identified as not just a disease of smokers.
MeSH term(s)	Europe/epidemiology ; Humans ; International Cooperation ; Lung Diseases, Obstructive/diagnosis ; Lung Diseases, Obstructive/epidemiology ; Lung Diseases, Obstructive/therapy ; Patient Education as Topic ; Physician-Patient Relations ; Physicians, Family/standards ; Practice Patterns, Physicians' ; Prevalence ; Primary Health Care/methods ; Primary Health Care/standards ; Spirometry ; Survival Rate ; United States/epidemiology
Language	English
Publishing date	2000-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.117.5_suppl_2.372s
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Article: The harmonics of rodent pulmonary hypertension models.

Voelkel, N F / Gomez-Arroyo, J

International journal of clinical practice. Supplement

2011 , Issue 172, Page(s) 1–2

MeSH term(s)	Animals ; Cause of Death ; Disease Models, Animal ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy
Language	English
Publishing date	2011-08
Publishing country	England
Document type	Comment ; Editorial
ISSN	1368-504X
ISSN	1368-504X
DOI	10.1111/j.1742-1241.2011.02712.x
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Article ; Online: Cell Tracking Suggests Pathophysiological and Therapeutic Role of Bone Marrow Cells in Sugen5416/Hypoxia Rat Model of Pulmonary Arterial Hypertension.

Miwa, Hideki / Sakao, Seiichiro / Sanada, Takayuki Jujo / Suzuki, Hidemi / Hata, Atsushi / Shiina, Yuki / Kobayashi, Takayuki / Kato, Fumiaki / Nishimura, Rintaro / Tanabe, Nobuhiro / Voelkel, Norbert / Yoshino, Ichiro / Tatsumi, Koichiro

The Canadian journal of cardiology

2021 Volume 37, Issue 6, Page(s) 913–923

Abstract: Background: The mechanism of vascular remodelling in pulmonary arterial hypertension (PAH) remains unclear. Hence, defining the origin of cells constituting intractable vascular lesions in PAH is expected to facilitate therapeutic progress. Herein, we ... ...

Abstract	Background: The mechanism of vascular remodelling in pulmonary arterial hypertension (PAH) remains unclear. Hence, defining the origin of cells constituting intractable vascular lesions in PAH is expected to facilitate therapeutic progress. Herein, we aimed to evaluate the origin of intractable vascular lesions in PAH rodent models via bone marrow (BM) and orthotopic lung transplantation (LT). Methods: To trace BM-derived cells, we prepared chimeric rats transplanted with BM cells from green fluorescent protein (GFP) transgenic rats. Male rats were transplanted with lungs obtained from female rats and vice versa. Pulmonary hypertension was induced in the transplanted rats via Sugen5416 treatment and subsequent chronic hypoxia (Su/Hx). Results: In the chimeric Su/Hx models, GFP-positive cells were observed in the pulmonary vascular area. Moreover, the right ventricular systolic pressure was significantly lower compared with wild-type Su/Hx rats without BM transplantation (P = 0.009). PAH suppression was also observed in rats that received allograft transplanted BM transplantation. In male rats that received LT and Su/Hx, BM-derived cells carrying the Y chromosome were also detected in neointimal occlusive lesions of the transplanted lungs received from female rats. Conclusions: BM-derived cells participate in pulmonary vascular remodelling in the Su/Hx rat model, whereas BM transplantation may contribute to suppression of development of PAH.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Bone Marrow Transplantation/methods ; Cell Tracking/methods ; Disease Models, Animal ; Female ; Hypoxia/complications ; Hypoxia/metabolism ; Indoles/pharmacology ; Lung/metabolism ; Lung/physiopathology ; Male ; Neointima/etiology ; Neointima/physiopathology ; Pulmonary Arterial Hypertension/etiology ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Artery/pathology ; Pyrroles/pharmacology ; Rats ; Transplantation Chimera ; Vascular Remodeling/drug effects ; Vascular Remodeling/physiology
Chemical Substances	Angiogenesis Inhibitors ; Indoles ; Pyrroles ; Semaxinib (71IA9S35AJ)
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2021.02.006
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Article: Appetite suppressants and pulmonary hypertension.

Voelkel, N F

Thorax

1997 Volume 52 Suppl 3, Page(s) S63–7

MeSH term(s)	Appetite Depressants/adverse effects ; Appetite Depressants/pharmacology ; Female ; Humans ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/etiology ; Obesity/complications ; Serotonin/metabolism
Chemical Substances	Appetite Depressants ; Serotonin (333DO1RDJY)
Language	English
Publishing date	1997-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thx.52.2008.s63
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