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Book ; Conference proceedings: Proceedings of the Symposium on Pulsatile Insulin Release

Hellman, Bo

held in Uppsala, Sweden, [1997] in honor of Bo Hellman ... on the occasion of his retirement

1998

Title variant	Pulsatile insulin release
Institution	Symposium on Pulsatile Insulin Release
Keywords	Insulin / secretion / congresses ; Islets of Langerhans / physiology / congresses ; Islets of Langerhans / metabolism / congresses ; Calcium / metabolism / congresses
Language	English
Publishing country	France
Document type	Book ; Conference proceedings
Note	In: Diabetes & metabolism. - ISSN 0338-1684. - 24 (1998),1, S. 9 - 45
HBZ-ID	HT008502306
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling.

Bivehed, Erik / Hellman, Björn / Wenson, Leonie / Stenerlöw, Bo / Söderberg, Ola / Heldin, Johan

Nucleic acids research

2024 Volume 52, Issue 4, Page(s) e22

Abstract: In the comet assay, tails are formed after single-cell gel electrophoresis if the cells have been exposed to genotoxic agents. These tails include a mixture of both DNA single-strand breaks (SSBs) and double-strand breaks (DSBs). However, these two types ...

Abstract	In the comet assay, tails are formed after single-cell gel electrophoresis if the cells have been exposed to genotoxic agents. These tails include a mixture of both DNA single-strand breaks (SSBs) and double-strand breaks (DSBs). However, these two types of strand breaks cannot be distinguished using comet assay protocols with conventional DNA stains. Since DSBs are more problematic for the cells, it would be useful if the SSBs and DSBs could be differentially identified in the same comet. In order to be able to distinguish between SSBs and DSBs, we designed a protocol for polymerase-assisted DNA damage analysis (PADDA) to be used in combination with the Flash comet protocol, or on fixed cells. By using DNA polymerase I to label SSBs and terminal deoxynucleotidyl transferase to label DSBs with fluorophore-labelled nucleotides. Herein, TK6-cells or HaCat cells were exposed to either hydrogen peroxide (H2O2), ionising radiation (X-rays) or DNA cutting enzymes, and then subjected to a comet protocol followed by PADDA. PADDA offers a wider detection range, unveiling previously undetected DNA strand breaks.
MeSH term(s)	Comet Assay/methods ; DNA/genetics ; DNA Damage ; DNA-Directed DNA Polymerase ; Hydrogen Peroxide/toxicity
Chemical Substances	DNA (9007-49-2) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkae009
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Book: EUROTOX '93

Hellman, Bo

Uppsala, Sweden, June 30 - July 3, 1993 ; [abstract volume]

(Pharmacology & toxicology ; 73, Suppl. 2)

1993

Institution	EUROTOX Swedish Society of Toxicology
Author's details	in cooperation with the Swedish Society of Toxicology. [Ed. by B. Hellman ...]
Series title	Pharmacology & toxicology ; 73, Suppl. 2
Collection
Keywords	Toxicology / congresses ; Toxikologie
Subject	Giftkunde ; Klinische Toxikologie
Language	English
Size	163 S.
Publisher	Munksgaard
Publishing place	Copenhagen
Publishing country	Denmark
Document type	Book
HBZ-ID	HT004935154
ISBN	87-16-15050-3 ; 978-87-16-15050-9
Database	Catalogue ZB MED Medicine, Health

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Uf I Zs 144 -73,Suppl.2-	verfügbar in Königswinter	Königswinter

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Article ; Online: Pulsatility of insulin release--a clinically important phenomenon.

Hellman, Bo

Upsala journal of medical sciences

2009 Volume 114, Issue 4, Page(s) 193–205

Abstract: The mechanisms and clinical importance of pulsatile insulin release are presented against the background of more than half a century of companionship with the islets of Langerhans. The insulin-secreting beta-cells are oscillators with intrinsic ... ...

Abstract	The mechanisms and clinical importance of pulsatile insulin release are presented against the background of more than half a century of companionship with the islets of Langerhans. The insulin-secreting beta-cells are oscillators with intrinsic variations of cytoplasmic ATP and Ca(2+). Within the islets the beta-cells are mutually entrained into a common rhythm by gap junctions and diffusible factors (ATP). Synchronization of the different islets in the pancreas is supposed to be due to adjustment of the oscillations to the same phase by neural output of acetylcholine and ATP. Studies of hormone secretion from the perfused pancreas of rats and mice revealed that glucose induces pulses of glucagon anti-synchronous with pulses of insulin and somatostatin. The anti-synchrony may result from a paracrine action of somatostatin on the glucagon-producing alpha-cells. Purinoceptors have a key function for pulsatile release of islet hormones. It was possible to remove the glucagon and somatostatin pulses with maintenance of those of insulin with an inhibitor of the P2Y(1) receptors. Knock-out of the adenosine A(1) receptor prolonged the pulses of glucagon and somatostatin without affecting the duration of the insulin pulses. Studies of isolated human islets indicate similar relations between pulses of insulin, glucagon, and somatostatin as found during perfusion of the rodent pancreas. The observation of reversed cycles of insulin and glucagon adds to the understanding how the islets regulate hepatic glucose production. Current protocols for pulsatile intravenous infusion therapy (PIVIT) should be modified to mimic the anti-synchrony between insulin and glucagon normally seen in the portal blood.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Biological Clocks/physiology ; Calcium Signaling ; Cell Communication ; Glucagon/metabolism ; Glucose/pharmacology ; Humans ; In Vitro Techniques ; Insulin/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Mice ; Models, Biological ; Rats ; Somatostatin/metabolism
Chemical Substances	Insulin ; Somatostatin (51110-01-1) ; Adenosine Triphosphate (8L70Q75FXE) ; Glucagon (9007-92-5) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2009-12-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	183949-4
ISSN	2000-1967 ; 0300-9734
ISSN (online)	2000-1967
ISSN	0300-9734
DOI	10.3109/03009730903366075
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Article ; Online: Somatostatin promotes glucose generation of Ca

Hellman, Bo / Dansk, Heléne / Grapengiesser, Eva

Cell calcium

2018 Volume 74, Page(s) 35–42

Abstract: Many cellular processes, including pulsatile release of insulin, are triggered by increase of cytoplasmic ... ...

Abstract	Many cellular processes, including pulsatile release of insulin, are triggered by increase of cytoplasmic Ca
MeSH term(s)	Animals ; Calcium Signaling/drug effects ; Calcium Signaling/physiology ; Cells, Cultured ; Drug Synergism ; Female ; Glucose/pharmacology ; Hormones/pharmacology ; Hypoglycemic Agents/pharmacology ; Islets of Langerhans/drug effects ; Islets of Langerhans/physiology ; Mice ; Mice, Inbred C57BL ; Somatostatin/pharmacology ; Tolbutamide/pharmacology
Chemical Substances	Hormones ; Hypoglycemic Agents ; Somatostatin (51110-01-1) ; Tolbutamide (982XCM1FOI) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-06-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2018.05.007
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Zs.A 1596: Show issues

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Article ; Online: SAUNA Q

Ringbom, Anders / Fritioff, Tomas / Aldener, Mattias / Axelsson, Anders / Elmgren, Klas / Hellesen, Carl / Karlkvist, Lindsay / Kastlander, Johan / Olsson, Henrik / Berglund, Helena / Hellman, Bo / Pettersson, Ola

Journal of environmental radioactivity

2023 Volume 261, Page(s) 107136

Abstract: We introduce a new concept in radioxenon detection - the radioxenon Array, defined as a system where air sampling and activity measurement is performed at multiple locations, using measurement units that are less sensitive, but on the other hand less ... ...

Abstract	We introduce a new concept in radioxenon detection - the radioxenon Array, defined as a system where air sampling and activity measurement is performed at multiple locations, using measurement units that are less sensitive, but on the other hand less costly, and easier to install and operate, compared to current state-of-the-art radioxenon systems. The inter-unit distance in the Array is typically hundreds of kilometres. Using synthetic nuclear explosions together with a parametrized measurement system model, we argue that, when such measurement units are combined into an Array, the aggregated verification performance (detection, location, and characterization) can be high. The concept has been realized by developing a measurement unit named SAUNA Q
MeSH term(s)	Air Pollutants, Radioactive/analysis ; Xenon Radioisotopes/analysis ; Radiation Monitoring ; Steam Bath ; Sweden
Chemical Substances	Air Pollutants, Radioactive ; Xenon Radioisotopes
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1483112-0
ISSN	1879-1700 ; 0265-931X
ISSN (online)	1879-1700
ISSN	0265-931X
DOI	10.1016/j.jenvrad.2023.107136
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Article ; Online: Sulfonylurea Blockade of KATP Channels Unmasks a Distinct Type of Glucose-Induced Ca2+ Decrease in Pancreatic β-Cells.

Hellman, Bo / Dansk, Heléne / Grapengiesser, Eva

Pancreas

2017 Volume 46, Issue 4, Page(s) 467–475

Abstract: Objectives: This study aimed to explore how sulfonylurea blockade of KATP channels affects the early Ca signals for glucose generation of insulin release.: Methods: Cytoplasmic Ca was measured with ratiometric microfluorometry in isolated mouse ... ...

Abstract	Objectives: This study aimed to explore how sulfonylurea blockade of KATP channels affects the early Ca signals for glucose generation of insulin release. Methods: Cytoplasmic Ca was measured with ratiometric microfluorometry in isolated mouse islets loaded with Fura-PE3. Results: After sulfonylurea blockade of the KATP channels (50 μM-1 mM tolbutamide or 1 μM-1 mM gliclazide), increase of glucose from 3 to 20 mM resulted in suppression of elevated Ca during a 3- to 5-minute period. The Ca decrease was shorter after inhibition of the Na/K pump with ouabain (10 and 100 μM) but prolonged when the α2A adrenoceptors were activated with clonidine (1 and 10 nM) or epinephrine (10 nM). Inhibition of the sarco/endoplasmic reticulum Ca-ATPase pump with 10 μM cyclopiazonic acid counteracted the action of 10 nM clonidine, making the Ca decrease shorter than in controls. Extended superfusion of islets with a medium containing 20 mM glucose and 1 mM tolbutamide sometimes resulted in delayed appearance of Ca oscillations mediated by periodic interruption of elevated Ca. Conclusions: Increase of glucose generates prompt suppression of cytoplasmic Ca in β-cells lacking functional KATP channels. Activation of α2A adrenoceptors markedly prolongs the period of glucose-induced Ca decrease, an effect counteracted by cyclopiazonic acid.
MeSH term(s)	Adrenergic alpha-2 Receptor Agonists/pharmacology ; Animals ; Calcium/metabolism ; Cells, Cultured ; Clonidine/pharmacology ; Female ; Gliclazide/pharmacology ; Glucose/pharmacology ; Hypoglycemic Agents/pharmacology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; KATP Channels/antagonists & inhibitors ; KATP Channels/metabolism ; Mice, Inbred C57BL ; Receptors, Adrenergic, alpha-2/metabolism ; Sulfonylurea Compounds/pharmacology ; Time Factors ; Tolbutamide/pharmacology
Chemical Substances	Adrenergic alpha-2 Receptor Agonists ; Hypoglycemic Agents ; KATP Channels ; Receptors, Adrenergic, alpha-2 ; Sulfonylurea Compounds ; Tolbutamide (982XCM1FOI) ; Gliclazide (G4PX8C4HKV) ; Glucose (IY9XDZ35W2) ; Clonidine (MN3L5RMN02) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000000777
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Zs.A 2160: Show issues

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Article ; Online: Effectiveness of the massed delivery of unified protocol for emotional disorders within an intensive outpatient program for military service members and veterans.

Sherrill, Andrew M / Mehta, Mansi / Patton, Samantha C / Sprang Jones, Kelsey / Hellman, Natalie / Chrysosferidis, Julie / Yasinski, Carly W / Rothbaum, Barbara O / Rauch, Sheila A M

Psychological services

2024

Abstract: Recent evidence supports the implementation of massed delivery of disorder-specific treatments in the military service member and veteran population. However, many treatment settings serve patients with a wide range of diagnoses, and often patients ... ...

Abstract	Recent evidence supports the implementation of massed delivery of disorder-specific treatments in the military service member and veteran population. However, many treatment settings serve patients with a wide range of diagnoses, and often patients present with comorbid conditions. Growing evidence suggests transdiagnostic cognitive behavioral treatments are effective for a wide range of emotional disorders and may reduce barriers to access. Little is known about the feasibility and outcomes of the massed delivery of transdiagnostic treatments. The present study examined real-world outcomes of a 2-week intensive outpatient program using the Unified Protocol for emotional disorders (UP-IOP). The sample included military service members and veterans diagnosed with a range of emotional disorders, namely trauma- and stressor-related disorders, unipolar depressive disorders, and anxiety disorders. The present study examined outcomes of UP-IOP (depression, trauma-related symptom severity, and emotion dysregulation). Participants included all patients who sought UP-IOP in its first 15 months of operation (
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2156662-8
ISSN	1939-148X ; 1541-1559
ISSN (online)	1939-148X
ISSN	1541-1559
DOI	10.1037/ser0000833
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Article ; Online: Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells.

Lau, Joey / Grapengiesser, Eva / Hellman, Bo

Journal of diabetes research

2016 Volume 2016, Page(s) 4930741

Abstract: Small and big mouse islets were compared with special reference to their content of glucagon-producing α-cells and somatostatin-producing δ-cells. Areas stained for glucagon and somatostatin were measured in the largest cross section of small (diameter < ...

Abstract	Small and big mouse islets were compared with special reference to their content of glucagon-producing α-cells and somatostatin-producing δ-cells. Areas stained for glucagon and somatostatin were measured in the largest cross section of small (diameter < 60 μm) and big (diameter > 100 μm) islets. Comparison of the areas indicated proportionally more δ- than α-cells in the small islets. After isolation with collagenase these islets were practically devoid of α-cells. We evaluated the functional importance of the islet size by measuring the Ca(2+) signal for insulin release. A majority of the small islets responded to the hyperpolarization action of somatostatin with periodic decrease of cytoplasmic Ca(2+) when glucose was elevated after tolbutamide blockade of the KATP channels.
MeSH term(s)	Animals ; Calcium Signaling/drug effects ; Glucagon/metabolism ; Glucagon-Secreting Cells/cytology ; Glucagon-Secreting Cells/metabolism ; Glucose/metabolism ; Hypoglycemic Agents/pharmacology ; Immunohistochemistry ; In Vitro Techniques ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/cytology ; Islets of Langerhans/metabolism ; Islets of Langerhans/pathology ; Mice ; Organ Size ; Somatostatin/metabolism ; Somatostatin-Secreting Cells/cytology ; Somatostatin-Secreting Cells/metabolism ; Tolbutamide/pharmacology
Chemical Substances	Hypoglycemic Agents ; Insulin ; Somatostatin (51110-01-1) ; Glucagon (9007-92-5) ; Tolbutamide (982XCM1FOI) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2016-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6745
ISSN (online)	2314-6753
ISSN	2314-6745
DOI	10.1155/2016/4930741
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Article ; Online: Ärftliga hjärt–kärlsjukdomar – ett multidisciplinärt arbetssätt krävs.

Mörner, Stellan / Carlberg, Bo / Rydberg, Annika / Jensen, Steen / Lundström, Anna / Nyberg, Peter / Diamant, Ulla-Britt / Hellman, Urban / Johnson, Owe / Näslund, Ulf

Lakartidningen

2021 Volume 118

Abstract: Comprehensive genetic and clinical care of families with monogenic cardiovascular diseases requires competences from different medical specialties. Genetic assessment, cascade screening, risk estimation, treatment and follow-up is difficult to cover. ... ...

Title translation	Experiences from a multidisciplinary cardiogenetic clinic.
Abstract	Comprehensive genetic and clinical care of families with monogenic cardiovascular diseases requires competences from different medical specialties. Genetic assessment, cascade screening, risk estimation, treatment and follow-up is difficult to cover. Fourteen years ago, a center for cardiovascular diseases was created in our hospital, to improve the care of families with monogenic cardiovascular diseases. At our center, clinical geneticists, cardiologists, angiologists, pediatric cardiologists and genetic counselors work together in a seamless organization, while still having different clinic affiliations. A key feature of this organization are the family outpatient clinics, where the proband and his/her relatives at genetic risk are invited to take part. When the family or relatives live in other parts of the country, they are invited to participate through video conference. In this paper we report our experiences and working routines from more than 300 families and 2000 individuals.
MeSH term(s)	Ambulatory Care Facilities ; Child ; Family ; Female ; Humans ; Male ; Risk Factors
Language	Swedish
Publishing date	2021-10-06
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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