LIVIVO - Search results -

Search results

Result 1 - 10 of total 79

Search options

Book ; Online: Gonadotropin-Releasing Hormone Receptor Signaling and Functions

Bjelobaba, Ivana / Naor, Zvi / Stojilkovic, Stanko S.

2018

Abstract: This eBook provides a comprehensive overview of our current knowledge on Gonadotropin-releasing hormone receptor evolution, structure, signaling and functions. Apart from review articles, it comprises exciting new research, as well as hypotheses and ... ...

Abstract	This eBook provides a comprehensive overview of our current knowledge on Gonadotropin-releasing hormone receptor evolution, structure, signaling and functions. Apart from review articles, it comprises exciting new research, as well as hypotheses and perspectives, all of which are valuable in guiding our further research in this field
Keywords	Medicine (General) ; Diseases of the endocrine glands. Clinical endocrinology
Size	1 electronic resource (170 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020101794
ISBN	9782889454792 ; 2889454797
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Editorial overview: Endocrine and metabolic diseases (2023).

Bjelobaba, Ivana / Constantin, Stephanie

Current opinion in pharmacology

2024 Volume 75, Page(s) 102436

MeSH term(s)	Humans ; Metabolic Diseases ; Endocrine System ; Endocrine System Diseases/therapy
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Editorial
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2024.102436
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5608: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pituitary gonadotroph-specific patterns of gene expression and hormone secretion.

Constantin, Stephanie / Bjelobaba, Ivana / Stojilkovic, Stanko S

Current opinion in pharmacology

2022 Volume 66, Page(s) 102274

Abstract: Pituitary gonadotrophs play a key role in reproductive functions by secreting luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The LH secretory activity of gonadotroph is controlled by hypothalamic gonadotropin-releasing hormone (GnRH) ... ...

Abstract	Pituitary gonadotrophs play a key role in reproductive functions by secreting luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The LH secretory activity of gonadotroph is controlled by hypothalamic gonadotropin-releasing hormone (GnRH) via GnRH receptors and is accompanied by only minor effects on high basal Lhb gene expression. The secretory profiles of GnRH and LH are highly synchronized, with the latter reflecting a depletion of prestored LH in secretory vesicles by regulated exocytosis. In contrast, FSH is predominantly released by constitutive exocytosis, and secretory activity reflects the kinetics of Fshb gene expression controlled by GnRH, activin, and inhibin. Here is a review of recent data to improve the understanding of multiple patterns of gonadotroph gene expression and hormone secretion.
MeSH term(s)	Activins/genetics ; Activins/metabolism ; Follicle Stimulating Hormone/genetics ; Follicle Stimulating Hormone/metabolism ; Gene Expression ; Gonadotrophs/metabolism ; Gonadotropin-Releasing Hormone/genetics ; Gonadotropin-Releasing Hormone/metabolism ; Humans ; Inhibins/genetics ; Inhibins/metabolism ; Luteinizing Hormone/genetics ; Luteinizing Hormone/metabolism ; Receptors, LHRH/genetics ; Receptors, LHRH/metabolism
Chemical Substances	Receptors, LHRH ; Activins (104625-48-1) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Inhibins (57285-09-3) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2022.102274
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5608: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Collaborative Learning Supported by Blockchain Technology as a Model for Improving the Educational Process

Goran Bjelobaba / Ana Savić / Teodora Tošić / Ivana Stefanović / Bojan Kocić

Sustainability, Vol 15, Iss 4780, p

2023 Volume 4780

Abstract: After COVID-19, new accreditation standards include the need for developing better learning and teaching environments. This will be supported and connected with digitization, entrepreneurship, social inclusion, and a circular economy. The orientation ... ...

Abstract	After COVID-19, new accreditation standards include the need for developing better learning and teaching environments. This will be supported and connected with digitization, entrepreneurship, social inclusion, and a circular economy. The orientation towards equity and quality in education clearly imposes the need for an individual approach to each student separately. This situation is especially pronounced in higher education institutions in the field of technology, whose primary goal is very often individual training for use of highly specialized software and hardware tools. In such a situation, it is necessary to move away from the classical ex-cathedra methodology and develop student-centered learning environments. Global accreditation systems for teaching, learning, practice, and business communication can be simplified using blockchain. On the basis of blockchain technology (BCTs), this paper proposes a Collaborative Learning and Student Work Evaluation (CLSW) model that includes a multi-frontal teaching method (VFN) and combines scientific peer-review standards. BCTs are used to protect student project and assessment data storage and transmission. Assisting higher education institutions in finding “employable capabilities” of proactive students is the idea of CLSW. Before implementing the CLSW paradigm, a poll of lecturers’ views on BCTs was conducted. The poll results show a desire and willingness to teach with BCTs. The model’s fundamental capabilities and the key participants’ duties were described in a project framework. Additionally, this research and proposed model can improve educational process sustainability in general, as it is an open platform easily accessible by all the interested parties, thus contributing to life-long learning.
Keywords	blockchain ; digitization ; education ; multi-frontal teaching method ; peer assessment ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	370
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Hyperbaric Oxygenation Prevents Loss of Immature Neurons in the Adult Hippocampal Dentate Gyrus Following Brain Injury.

Jeremic, Rada / Pekovic, Sanja / Lavrnja, Irena / Bjelobaba, Ivana / Djelic, Marina / Dacic, Sanja / Brkic, Predrag

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: A growing body of evidence suggests that hyperbaric oxygenation (HBO) may affect the activity of adult neural stem cells (NSCs). Since the role of NSCs in recovery from brain injury is still unclear, the purpose of this study was to investigate the ... ...

Abstract	A growing body of evidence suggests that hyperbaric oxygenation (HBO) may affect the activity of adult neural stem cells (NSCs). Since the role of NSCs in recovery from brain injury is still unclear, the purpose of this study was to investigate the effects of sensorimotor cortex ablation (SCA) and HBO treatment (HBOT) on the processes of neurogenesis in the adult dentate gyrus (DG), a region of the hippocampus that is the site of adult neurogenesis. Ten-week-old Wistar rats were divided into groups: Control (C, intact animals), Sham control (S, animals that underwent the surgical procedure without opening the skull), SCA (animals in whom the right sensorimotor cortex was removed via suction ablation), and SCA + HBO (operated animals that passed HBOT). HBOT protocol: pressure applied at 2.5 absolute atmospheres for 60 min, once daily for 10 days. Using immunohistochemistry and double immunofluorescence labeling, we show that SCA causes significant loss of neurons in the DG. Newborn neurons in the subgranular zone (SGZ), inner-third, and partially mid-third of the granule cell layer are predominantly affected by SCA. HBOT decreases the SCA-caused loss of immature neurons, prevents reduction of dendritic arborization, and increases proliferation of progenitor cells. Our results suggest a protective effect of HBO by reducing the vulnerability of immature neurons in the adult DG to SCA injury.
MeSH term(s)	Rats ; Animals ; Hyperbaric Oxygenation ; Rats, Wistar ; Neural Stem Cells/physiology ; Hippocampus ; Neurons/physiology ; Neurogenesis/physiology ; Dentate Gyrus ; Brain Injuries
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054261
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Hyperbaric Oxygenation Prevents Loss of Immature Neurons in the Adult Hippocampal Dentate Gyrus Following Brain Injury

Rada Jeremic / Sanja Pekovic / Irena Lavrnja / Ivana Bjelobaba / Marina Djelic / Sanja Dacic / Predrag Brkic

International Journal of Molecular Sciences, Vol 24, Iss 4261, p

2023 Volume 4261

Abstract	A growing body of evidence suggests that hyperbaric oxygenation (HBO) may affect the activity of adult neural stem cells (NSCs). Since the role of NSCs in recovery from brain injury is still unclear, the purpose of this study was to investigate the effects of sensorimotor cortex ablation (SCA) and HBO treatment (HBOT) on the processes of neurogenesis in the adult dentate gyrus (DG), a region of the hippocampus that is the site of adult neurogenesis. Ten-week-old Wistar rats were divided into groups: Control (C, intact animals), Sham control (S, animals that underwent the surgical procedure without opening the skull), SCA (animals in whom the right sensorimotor cortex was removed via suction ablation), and SCA + HBO (operated animals that passed HBOT). HBOT protocol: pressure applied at 2.5 absolute atmospheres for 60 min, once daily for 10 days. Using immunohistochemistry and double immunofluorescence labeling, we show that SCA causes significant loss of neurons in the DG. Newborn neurons in the subgranular zone (SGZ), inner-third, and partially mid-third of the granule cell layer are predominantly affected by SCA. HBOT decreases the SCA-caused loss of immature neurons, prevents reduction of dendritic arborization, and increases proliferation of progenitor cells. Our results suggest a protective effect of HBO by reducing the vulnerability of immature neurons in the adult DG to SCA injury.
Keywords	traumatic brain injury ; hyperbaric oxygenation ; adult neurogenesis ; dentate gyrus ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	590
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Agmatine Mitigates Inflammation-Related Oxidative Stress in BV-2 Cells by Inducing a Pre-Adaptive Response.

Milosevic, Katarina / Stevanovic, Ivana / Bozic, Iva D / Milosevic, Ana / Janjic, Marija M / Laketa, Danijela / Bjelobaba, Ivana / Lavrnja, Irena / Savic, Danijela

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: Neuroinflammation and microglial activation, common components of most neurodegenerative diseases, can be imitated in vitro by challenging microglia cells with Lps. We here aimed to evaluate the effects of agmatine pretreatment on Lps-induced oxidative ... ...

Abstract	Neuroinflammation and microglial activation, common components of most neurodegenerative diseases, can be imitated in vitro by challenging microglia cells with Lps. We here aimed to evaluate the effects of agmatine pretreatment on Lps-induced oxidative stress in a mouse microglial BV-2 cell line. Our findings show that agmatine suppresses nitrosative and oxidative burst in Lps-stimulated microglia by reducing iNOS and XO activity and decreasing O
MeSH term(s)	Agmatine/metabolism ; Agmatine/pharmacology ; Animals ; Glutathione/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Microglia/metabolism ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Oxidative Stress
Chemical Substances	Lipopolysaccharides ; NF-E2-Related Factor 2 ; NF-kappa B ; Agmatine (70J407ZL5Q) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073561
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis.

Milosevic, Ana / Lavrnja, Irena / Savic, Danijela / Milosevic, Katarina / Skuljec, Jelena / Bjelobaba, Ivana / Janjic, Marija M

Cells

2023 Volume 12, Issue 7

Abstract: Multiple sclerosis (MS) is an autoimmune disease affecting the CNS and occurring far more prevalently in women than in men. In both MS and its animal models, sex hormones play important immunomodulatory roles. We have previously shown that experimental ... ...

Abstract	Multiple sclerosis (MS) is an autoimmune disease affecting the CNS and occurring far more prevalently in women than in men. In both MS and its animal models, sex hormones play important immunomodulatory roles. We have previously shown that experimental autoimmune encephalomyelitis (EAE) affects the hypothalamic-pituitary-gonadal axis in rats of both sexes and induces an arrest in the estrous cycle in females. To investigate the gonadal status in female rats with EAE, we explored ovarian morphometric parameters, circulating and intraovarian sex steroid levels, and the expression of steroidogenic machinery components in the ovarian tissue. A prolonged state of diestrus was recorded during the peak of EAE, with maintenance of the corpora lutea, elevated intraovarian progesterone levels, and increased gene and protein expression of StAR, similar to the state of pseudopregnancy. The decrease in CYP17A1 protein expression was followed by a decrease in ovarian testosterone and estradiol levels. On the contrary, serum testosterone levels were slightly increased. With unchanged serum estradiol levels, these results point at extra-gonadal sites of sex steroid biosynthesis and catabolism as important regulators of their circulating levels. Our study suggests alterations in the function of the female reproductive system during central autoimmunity and highlights the bidirectional relationships between hormonal status and EAE.
MeSH term(s)	Male ; Rats ; Female ; Animals ; Encephalomyelitis, Autoimmune, Experimental ; Gonadal Steroid Hormones/metabolism ; Ovary/metabolism ; Multiple Sclerosis ; Testosterone/metabolism ; Estradiol/metabolism
Chemical Substances	Gonadal Steroid Hormones ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12071045
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction.

Sokanovic, Srdjan J / Constantin, Stephanie / Lamarca Dams, Aloa / Mochimaru, Yuta / Smiljanic, Kosara / Bjelobaba, Ivana / Prévide, Rafael M / Stojilkovic, Stanko S

Scientific reports

2023 Volume 13, Issue 1, Page(s) 355

Abstract: Simultaneous knockout of the neuroendocrine marker genes Ptprn and Ptprn2, which encode the protein tyrosine phosphatase receptors N and N2, causes infertility in female mice while males are fertile. To elucidate the mechanism of the sex-specific roles ... ...

Abstract	Simultaneous knockout of the neuroendocrine marker genes Ptprn and Ptprn2, which encode the protein tyrosine phosphatase receptors N and N2, causes infertility in female mice while males are fertile. To elucidate the mechanism of the sex-specific roles of Ptprn and Ptprn2 in mouse reproduction, we analyzed the effects of their double knockout (DKO) on the hypothalamic-pituitary-gonadal axis. In DKO females, delayed puberty and lack of ovulation were observed, complemented by changes in ovarian gene expression and steroidogenesis. In contrast, testicular gene expression, steroidogenesis, and reproductive organs development were not significantly affected in DKO males. However, in both sexes, pituitary luteinizing hormone (LH) beta gene expression and LH levels were reduced, as well as follicle-stimulating hormone beta gene and gonadotropin-releasing hormone (GnRH) gene, while the calcium-mobilizing and LH secretory actions of GnRH were preserved. Hypothalamic Gnrh1 and Kiss1 gene expression was also reduced in DKO females and males. In parallel, a significant decrease in the density of immunoreactive GnRH and kisspeptin fibers was detected in the hypothalamic arcuate nucleus of DKO females and males. The female-specific kisspeptin immunoreactivity in the rostral periventricular region of the third ventricle was also reduced in DKO females, but not in DKO males. These data indicate a critical role of Ptprn and Ptprn2 in kisspeptin-GnRH neuronal function and sexual dimorphism in the threshold levels of GnRH required to preserve reproductive functions.
MeSH term(s)	Male ; Female ; Mice ; Animals ; Kisspeptins/metabolism ; Gonadotropin-Releasing Hormone/genetics ; Gonadotropin-Releasing Hormone/metabolism ; Reproduction ; Hypothalamus/metabolism ; Protein Tyrosine Phosphatases/metabolism
Chemical Substances	Kisspeptins ; Gonadotropin-Releasing Hormone (33515-09-2) ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
Language	English
Publishing date	2023-01-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-27497-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Brain inflammation in experimental autoimmune encephalomyelitis induced in Dark Agouti rats with spinal cord homogenate.

Stegnjaić, Goran / Jevtić, Bojan / Lazarević, Milica / Ignjatović, Đurđica / Tomić, Mirko / Nikolovski, Neda / Bjelobaba, Ivana / Momčilović, Miljana / Dimitrijević, Mirjana / Miljković, Đorđe / Stanisavljević, Suzana

Immunology letters

2024 Volume 267, Page(s) 106852

Abstract: We have recently characterized experimental autoimmune encephalomyelitis (EAE) induced in DA rats with spinal cord homogenate without complete Freund's adjuvant (CFA). The main advantage of this multiple sclerosis model is the lack of CFA-related ... ...

Abstract	We have recently characterized experimental autoimmune encephalomyelitis (EAE) induced in DA rats with spinal cord homogenate without complete Freund's adjuvant (CFA). The main advantage of this multiple sclerosis model is the lack of CFA-related confounding effects which represent the major obstacles in translating findings from EAE to multiple sclerosis. Here, antigen specificity of the cellular and humoral immune response directed against the central nervous system was explored. The reactivity of T and B cells to myelin basic protein, myelin oligodendrocyte glycoprotein, and β-synuclein was detected. Having in mind that reactivity against β-synuclein was previously associated with autoimmunity against the brain, the infiltration of immune cells into different brain compartments, i.e. pons, cerebellum, hippocampus, and cortex was determined. T cell infiltration was observed in all structures examined. This finding stimulated investigation of the effects of immunization on DA rat behavior using the elevated plus maze and the open field test. Rats recovered from EAE displayed increased anxiety-like behavior. These data support CFA-free EAE in DA rats as a useful model for multiple sclerosis research.
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/j.imlet.2024.106852
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1512: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito