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  1. Article: Editorial: Nucleic acid-based aptamers in therapeutics and diagnostics.

    Aviñó, Anna / Fabrega, Carme / Gargallo, Raimundo / Mazzini, Stefania / Riccardi, Claudia

    Frontiers in chemistry

    2024  Volume 11, Page(s) 1355870

    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1355870
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  2. Article ; Online: Editorial

    Anna Aviñó / Carme Fabrega / Raimundo Gargallo / Stefania Mazzini / Claudia Riccardi

    Frontiers in Chemistry, Vol

    Nucleic acid-based aptamers in therapeutics and diagnostics

    2024  Volume 11

    Keywords aptamers ; diagnostics ; therapeutics ; SELEX ; nucleic acids (DNA and RNA) ; Chemistry ; QD1-999
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Activities Carried Out during the First COVID-19 Lockdown by Italian Citizens.

    Paltrinieri, Sara / Bressi, Barbara / Mazzini, Elisa / Fugazzaro, Stefania / Rondini, Ermanno / Giorgi Rossi, Paolo / Costi, Stefania

    International journal of environmental research and public health

    2023  Volume 20, Issue 5

    Abstract: The SARS-CoV-2 pandemic has altered how citizens engage in activities. This study describes the new activities citizens engaged in during the first lockdown, factors that helped them cope with the confinement, the supports they used the most, and which ... ...

    Abstract The SARS-CoV-2 pandemic has altered how citizens engage in activities. This study describes the new activities citizens engaged in during the first lockdown, factors that helped them cope with the confinement, the supports they used the most, and which supports they would have liked to receive. This cross-sectional study consists of an online survey made of 49 questions that was completed by the citizens of the province of Reggio Emilia (Italy) from 4 May until 15 June 2020. The outcomes of this study were explored by focusing on four of the survey questions. Of the 1826 citizens who responded, 84.2% had started new leisure activities. Males, participants who lived in the plain or foothills, and those who experienced nervousness engaged less in new activities, while those whose employment status changed, whose lifestyle worsened, or whose use of alcohol increased engaged in more activities. The support of family and friends, leisure activities, continuing to work, and an optimistic attitude were perceived to be of help. Grocery delivery and hotlines providing any type of information and mental health support were used frequently; a lack of health and social care services and of support in reconciling work with childcare was perceived. Findings may help institutions and policy makers to better support citizens in any future circumstances requiring prolonged confinement.
    MeSH term(s) Male ; Humans ; COVID-19 ; SARS-CoV-2 ; Cross-Sectional Studies ; Communicable Disease Control ; Surveys and Questionnaires
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20053906
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  4. Article ; Online: Exploring the stabilizing effect on the i-motif of neighboring structural motifs and drugs.

    Rodriguez, Judit / Domínguez, Arnau / Aviñó, Anna / Borgonovo, Gigliola / Eritja, Ramon / Mazzini, Stefania / Gargallo, Raimundo

    International journal of biological macromolecules

    2023  Volume 242, Issue Pt 2, Page(s) 124794

    Abstract: Cytosine-rich DNA sequences may fold into a structure known as i-motif, with potential in vivo modulation of gene expression. The stability of the i-motif is residual at neutral pH values. To increase it, the addition of neighboring moieties, such as ... ...

    Abstract Cytosine-rich DNA sequences may fold into a structure known as i-motif, with potential in vivo modulation of gene expression. The stability of the i-motif is residual at neutral pH values. To increase it, the addition of neighboring moieties, such as Watson-Crick stabilized loops, tetrads, or non-canonical base pairs have been proposed. Taking a recently described i-motif structure as a model, the relative effect of these structural moieties, as well as several DNA ligands, on the stabilization of the i-motif has been studied. To this end, not only the original sequence but different mutants were considered. Spectroscopic techniques, PAGE, and multivariate data analysis methods have been used to model the folding/unfolding equilibria induced by changes of pH, temperature, and the presence of ligands. The results have shown that the duplex is the moiety that is responsible of the stabilization of the i-motif structure at neutral pH. The T:T base pair, on the contrary, shows little stabilization of the i-motif. From several selected DNA-binding ligands, the G-quadruplex ligand BA41 is shown to interact with the duplex moiety, whereas non-specific interaction and little stabilization has been observed within the i-motif.
    MeSH term(s) Ligands ; DNA/chemistry ; G-Quadruplexes ; Base Pairing ; Hydrogen-Ion Concentration ; Nucleic Acid Conformation
    Chemical Substances Ligands ; DNA (9007-49-2)
    Language English
    Publishing date 2023-05-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124794
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  5. Article ; Online: Activities Carried Out during the First COVID-19 Lockdown by Italian Citizens

    Sara Paltrinieri / Barbara Bressi / Elisa Mazzini / Stefania Fugazzaro / Ermanno Rondini / Paolo Giorgi Rossi / Stefania Costi

    International Journal of Environmental Research and Public Health, Vol 20, Iss 3906, p

    2023  Volume 3906

    Abstract: The SARS-CoV-2 pandemic has altered how citizens engage in activities. This study describes the new activities citizens engaged in during the first lockdown, factors that helped them cope with the confinement, the supports they used the most, and which ... ...

    Abstract The SARS-CoV-2 pandemic has altered how citizens engage in activities. This study describes the new activities citizens engaged in during the first lockdown, factors that helped them cope with the confinement, the supports they used the most, and which supports they would have liked to receive. This cross-sectional study consists of an online survey made of 49 questions that was completed by the citizens of the province of Reggio Emilia (Italy) from 4 May until 15 June 2020. The outcomes of this study were explored by focusing on four of the survey questions. Of the 1826 citizens who responded, 84.2% had started new leisure activities. Males, participants who lived in the plain or foothills, and those who experienced nervousness engaged less in new activities, while those whose employment status changed, whose lifestyle worsened, or whose use of alcohol increased engaged in more activities. The support of family and friends, leisure activities, continuing to work, and an optimistic attitude were perceived to be of help. Grocery delivery and hotlines providing any type of information and mental health support were used frequently; a lack of health and social care services and of support in reconciling work with childcare was perceived. Findings may help institutions and policy makers to better support citizens in any future circumstances requiring prolonged confinement.
    Keywords COVID-19 ; SARS-CoV-2 ; confinement ; pandemic ; quarantine ; work ; Medicine ; R
    Subject code 300
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Investigation of the Interaction between Aloe vera Anthraquinone Metabolites and c-Myc and C-Kit G-Quadruplex DNA Structures

    Dallavalle, Sabrina / Artali, Roberto / Princiotto, Salvatore / Musso, Loana / Borgonovo, Gigliola / Mazzini, Stefania

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: G-quadruplexes are nucleotide sequences present in the promoter region of numerous oncogenes, having a key role in the suppression of gene transcription. Recently, the binding of anthraquinones ... ...

    Abstract G-quadruplexes are nucleotide sequences present in the promoter region of numerous oncogenes, having a key role in the suppression of gene transcription. Recently, the binding of anthraquinones from
    MeSH term(s) Aloe/chemistry ; G-Quadruplexes ; Ligands ; Anthraquinones ; Proto-Oncogene Proteins c-kit/genetics ; Nucleotides
    Chemical Substances aloe emodin (C8IYT9CR7C) ; Ligands ; Anthraquinones ; 9,10-anthraquinone (030MS0JBDO) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Nucleotides
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232416018
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  7. Article ; Online: Evaluating the potential of hydrochar as a soil amendment.

    Bona, Daniela / Bertoldi, Daniela / Borgonovo, Gigliola / Mazzini, Stefania / Ravasi, Stefano / Silvestri, Silvia / Zaccone, Claudio / Giannetta, Beatrice / Tambone, Fulvia

    Waste management (New York, N.Y.)

    2023  Volume 159, Page(s) 75–83

    Abstract: In this study, hydrochar (HC), a carbon-rich product originated from hydrothermal conversion treatment (HTC), was obtained from wastes of the wine and dairy industries. The effect of mixing secondary char and compost was tested, before and after the ... ...

    Abstract In this study, hydrochar (HC), a carbon-rich product originated from hydrothermal conversion treatment (HTC), was obtained from wastes of the wine and dairy industries. The effect of mixing secondary char and compost was tested, before and after the aerobic mixing of compost (COM) and HC at increasing doses (from 15 to 75 Mg ha
    MeSH term(s) Soil/chemistry ; Carbon ; Composting ; Organic Chemicals ; Dissolved Organic Matter
    Chemical Substances Soil ; Carbon (7440-44-0) ; Organic Chemicals ; Dissolved Organic Matter
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2001471-5
    ISSN 1879-2456 ; 0956-053X
    ISSN (online) 1879-2456
    ISSN 0956-053X
    DOI 10.1016/j.wasman.2023.01.024
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  8. Article ; Online: Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region.

    Princiotto, Salvatore / Karelou, Maria / Ioannidi, Rachel / Beretta, Giovanni Luca / Zaffaroni, Nadia / Artali, Roberto / Kostakis, Ioannis K / Mazzini, Stefania / Dallavalle, Sabrina

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Novel amino-substituted pyridoquinazolinone derivatives have been designed and synthesized as potential c-MYC G-quadruplex (G4) ligands, employing an efficient methodology. All the new compounds exhibited moderate to good antiproliferative activity ... ...

    Abstract Novel amino-substituted pyridoquinazolinone derivatives have been designed and synthesized as potential c-MYC G-quadruplex (G4) ligands, employing an efficient methodology. All the new compounds exhibited moderate to good antiproliferative activity against the human osteosarcoma U2OS cell line. NMR and docking experiments revealed that the recently synthesized compounds interact with the Pu22 G-quadruplex in the c-MYC promoter region, establishing a 2:1 complex, with each molecule positioned over the tetrads at the 3'- and 5'-ends.
    MeSH term(s) Humans ; Cell Line ; G-Quadruplexes ; Osteosarcoma ; Bone Neoplasms ; Promoter Regions, Genetic
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814346
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  9. Article ; Online: A social-healthcare pathway to facilitate return to work of cancer survivors in Italy: The UNAMANO project.

    Paltrinieri, Sara / Ricchi, Elena / Mazzini, Elisa / Cervi, Elena / Sandri, Elisa / Fugazzaro, Stefania / Costi, Stefania

    Work (Reading, Mass.)

    2021  Volume 70, Issue 4, Page(s) 1243–1253

    Abstract: Background: Return to work (RTW) is a major goal to promote cancer survivors' social participation.: Objective: This study describes the multidisciplinary social-healthcare pathway called UNAMANO, conceived to support RTW in this population.: ... ...

    Abstract Background: Return to work (RTW) is a major goal to promote cancer survivors' social participation.
    Objective: This study describes the multidisciplinary social-healthcare pathway called UNAMANO, conceived to support RTW in this population.
    Methods: UNAMANO was developed by the Azienda USL-IRCCS di Reggio Emilia, in partnership with the local branch of the Italian Medical Association, nonprofit associations, vocational training institutions, social cooperatives, a labour union, and a chartered accounting firm.
    Results: UNAMANO is directed towards employed individuals diagnosed with cancer living in the province of RE. It was developed through four actions: A) training healthcare professionals on work-related occupational rehabilitation; B) dissemination among community and stakeholders; C) recruitment and training of volunteers; D) cancer survivor engagement and provision of a personalized comprehensive intervention. This consists in providing information and either occupational therapy to overcome barriers and facilitate RTW or social support through re-training and tailored job search strategies based on individual risk of job loss.
    Conclusions: UNAMANO is the first Italian multidisciplinary social-healthcare pathway supporting RTW of cancer survivors. Addressing a wide area of cancer survivors' needs, it provides personalized intervention to resolve work-related issues. We propose this patient-centred RTW model to promote an easier transition from hospital to community.
    MeSH term(s) Cancer Survivors ; Delivery of Health Care ; Humans ; Motivation ; Neoplasms ; Return to Work
    Language English
    Publishing date 2021-11-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-205249
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  10. Article ; Online: Poor Sleep during the First Peak of the SARS-CoV-2 Pandemic: A Cross-Sectional Study.

    Costi, Stefania / Paltrinieri, Sara / Bressi, Barbara / Fugazzaro, Stefania / Giorgi Rossi, Paolo / Mazzini, Elisa

    International journal of environmental research and public health

    2021  Volume 18, Issue 1

    Abstract: The restrictions enacted during lockdown to limit the spread of the novel coronavirus (SARS-CoV-2) have led to changes in people's lifestyle habits. In Italy, these restrictions have dramatically changed the way people work and spend their leisure time, ... ...

    Abstract The restrictions enacted during lockdown to limit the spread of the novel coronavirus (SARS-CoV-2) have led to changes in people's lifestyle habits. In Italy, these restrictions have dramatically changed the way people work and spend their leisure time, also with repercussions on diet and physical activity. An anonymous survey was disseminated via websites and social media to a convenience sample of the Italian population during and immediately after the first lockdown (10 March-18 May 2020). Data collected on 1826 individuals show that lockdown might have worsened the quality of sleep of almost half of the participants in this cross-sectional study. This worsening was associated with a deterioration in crucial determinants of health, such as physical activity and diet (OR 1.68; 95% CI 1.18-2.40 and OR 4.19; 95% CI 2.51-6.96, respectively), with symptoms of psychological distress, such as tension (OR 3.88; 95% CI 2.74-5.52) and loneliness (OR 3.27; 95% CI 2.23-4.79), and with the presence of financial problems (some OR 1.86; 95% CI 1.27-2.72; many OR 7.27; 95% CI 3.59-14.73). The multivariate regression analysis models confirmed these associations. This impact on sleep quality was seen especially among females, those with low education level, and those who experienced financial problems.
    MeSH term(s) COVID-19/epidemiology ; Communicable Disease Control ; Cross-Sectional Studies ; Diet ; Exercise ; Female ; Humans ; Italy/epidemiology ; Loneliness ; Male ; Pandemics ; Quarantine ; Sleep ; Stress, Psychological ; Surveys and Questionnaires
    Language English
    Publishing date 2021-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18010306
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