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  1. Article ; Online: Activity and toxicity of intramuscular 1000 iu/m

    Sidhu, Jasmeet / Masurekar, Ashish Narayan / Gogoi, Manash Pratim / Fong, Caroline / Ioannou, Tasos / Lodhi, Taha / Parker, Catriona / Liu, Jizhong / Kirkwood, Amy A / Moorman, Anthony V / Das, Kiranmoy / Goulden, Nicholas J / Vora, Ajay / Saha, Vaskar / Krishnan, Shekhar

    British journal of haematology

    2022  Volume 198, Issue 1, Page(s) 142–150

    Abstract: ... acute lymphoblastic leukaemia (ALL), polyethylene glycol-conjugated E. coli L-asparaginase (PEG-EcASNase) 1000 iu/m ...

    Abstract In successive UK clinical trials (UKALL 2003, UKALL 2011) for paediatric acute lymphoblastic leukaemia (ALL), polyethylene glycol-conjugated E. coli L-asparaginase (PEG-EcASNase) 1000 iu/m
    MeSH term(s) Antibodies/therapeutic use ; Antineoplastic Agents/therapeutic use ; Asparaginase ; Child ; Drug Monitoring ; Escherichia coli ; Humans ; Polyethylene Glycols ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/chemically induced ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
    Chemical Substances Antibodies ; Antineoplastic Agents ; Polyethylene Glycols (3WJQ0SDW1A) ; Asparaginase (EC 3.5.1.1)
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways.

    Das, Bhaba K / Gogoi, Jyoti / Kannan, Aarthi / Gao, Ling / Xing, Weirong / Mohan, Subburaman / Zhao, Haibo

    Cells

    2021  Volume 11, Issue 1

    Abstract: Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including ... ...

    Abstract Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including lysosomes along the microtubules. LIS1, NDE1, and NDEL1 belong to an evolutionary conserved pathway that regulates dynein functions. Disruption of the cytoplasmic dynein complex and deletion of LIS1 in osteoclast precursors arrest osteoclastogenesis. Nonetheless, the role of NDE1 and NDEL1 in osteoclast biology remains elusive. In this study, we found that knocking-down Nde1 expression by lentiviral transduction of specific shRNAs markedly inhibited osteoclastogenesis
    MeSH term(s) Actin Cytoskeleton/metabolism ; Animals ; Bone Marrow/pathology ; Bone Resorption/pathology ; Bone and Bones/pathology ; Cell Differentiation ; Cell Proliferation ; Cell Survival ; Cytoplasmic Dyneins/metabolism ; Homeostasis ; Macrophage Colony-Stimulating Factor/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubule-Associated Proteins/metabolism ; Microtubules/metabolism ; Monocytes/metabolism ; Osteoclasts/metabolism ; Osteoclasts/pathology ; Osteogenesis ; RANK Ligand/metabolism ; Signal Transduction ; Mice
    Chemical Substances Microtubule-Associated Proteins ; Nde1 protein, mouse ; RANK Ligand ; Macrophage Colony-Stimulating Factor (81627-83-0) ; Cytoplasmic Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2021-12-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11010013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways

    Bhaba K. Das / Jyoti Gogoi / Aarthi Kannan / Ling Gao / Weirong Xing / Subburaman Mohan / Haibo Zhao

    Cells, Vol 11, Iss 13, p

    2022  Volume 13

    Abstract: ... of signaling pathways downstream of M-CSF and RANKL as well as osteoclast differentiation transcription factor NFATc1 ...

    Abstract Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including lysosomes along the microtubules. LIS1, NDE1, and NDEL1 belong to an evolutionary conserved pathway that regulates dynein functions. Disruption of the cytoplasmic dynein complex and deletion of LIS1 in osteoclast precursors arrest osteoclastogenesis. Nonetheless, the role of NDE1 and NDEL1 in osteoclast biology remains elusive. In this study, we found that knocking-down Nde1 expression by lentiviral transduction of specific shRNAs markedly inhibited osteoclastogenesis in vitro by attenuating the proliferation, survival, and differentiation of osteoclast precursor cells via suppression of signaling pathways downstream of M-CSF and RANKL as well as osteoclast differentiation transcription factor NFATc1. To dissect how NDEL1 regulates osteoclasts and bone homeostasis, we generated Ndel1 conditional knockout mice in myeloid osteoclast precursors ( Ndel1 ΔlysM ) by crossing Ndel1- floxed mice with LysM -Cre mice on C57BL/6J background. The Ndel1 ΔlysM mice developed normally. The µCT analysis of distal femurs and in vitro osteoclast differentiation and functional assays in cultures unveiled the similar bone mass in both trabecular and cortical bone compartments as well as intact osteoclastogenesis, cytoskeleton organization, and bone resorption in Ndel1 ΔlysM mice and cultures. Therefore, our results reveal a novel role of NDE1 in regulation of osteoclastogenesis and demonstrate that NDEL1 is dispensable for osteoclast differentiation and function.
    Keywords osteoclast ; bone resorption ; bone remodeling ; cytoplasmic dynein ; NDE1 ; NDEL1 ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Aryne insertion into the P[double bond, length as m-dash]O bond: one-pot synthesis of quaternary phosphonium triflates.

    Neog, Kashmiri / Dutta, Dhiraj / Das, Babulal / Gogoi, Pranjal

    Organic & biomolecular chemistry

    2019  Volume 17, Issue 26, Page(s) 6450–6460

    Abstract: A novel transition-metal free synthetic strategy has been developed for the direct synthesis of quaternary phosphonium triflates via insertion of aryne into phosphine oxide. This methodology provides good yields of quaternary phosphonium salts and one of ...

    Abstract A novel transition-metal free synthetic strategy has been developed for the direct synthesis of quaternary phosphonium triflates via insertion of aryne into phosphine oxide. This methodology provides good yields of quaternary phosphonium salts and one of the synthesized phosphonium salts has been unambiguously established by single crystal XRD study. Preliminary mechanistic studies suggest that the reaction proceeds via a sequential [2 + 2] cycloaddition followed by the o-arylation and protonation pathway.
    Language English
    Publishing date 2019-06-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c9ob01157a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A taxonomic study of Musa flaviflora and M. thomsonii (Musaceae)

    Häkkinen, Markku / Gogoi, Rajib / Borah, Souravjyoti

    Nordic journal of botany. 2014 Oct., v. 32, no. 5

    2014  

    Abstract: The taxonomic identity of Musa flaviflora Simmonds (1956a) and Musa thomsonii (King ex Baker) A. M ... distributions, viz. M. flaviflora from the northeastern parts of India and M. thomsonii from Bhutan, Sikkim ...

    Abstract The taxonomic identity of Musa flaviflora Simmonds (1956a) and Musa thomsonii (King ex Baker) A. M. Cowan & Cowan (1929) have been uncertain to most botanists and have fallen towards oblivion. These two species have also been erroneously synonymized by many botanists but are distinct species with different distributions, viz. M. flaviflora from the northeastern parts of India and M. thomsonii from Bhutan, Sikkim, the Himalayan hills of India and Yunnan, China. The aim of this study is to settle the true identity of those ‘lost species’ and to update their descriptions. These studies are based on morphological characteristics observed in the field in northeast India, and Yunnan, China, in various herbaria as well as in the literature on Musaceae.
    Keywords Musa ; herbaria ; hills ; Bhutan ; China ; India
    Language English
    Dates of publication 2014-10
    Size p. 578-583.
    Publishing place Blackwell Publishing Ltd
    Document type Article
    ZDB-ID 2406507-9
    ISSN 1756-1051 ; 0107-055X
    ISSN (online) 1756-1051
    ISSN 0107-055X
    DOI 10.1111/j.1756-1051.2013.00370.x
    Database NAL-Catalogue (AGRICOLA)

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  6. Book ; Online ; E-Book: Sustainable agriculture and the environment

    Farooq, Muhammad / Gogoi, Nirmali / Pisante, Michele

    2023  

    Author's details edited by Muhammad Farooq, Nirmali Gogoi, Michele Pisante
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xviii, 567 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030010384
    ISBN 978-0-323-90501-5 ; 9780323905008 ; 0-323-90501-3 ; 0323905005
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Reduction-enhanced water flux through layered graphene oxide (GO) membranes stabilized with H

    Gogoi, Abhijit / Neyts, Erik C / Peeters, François M

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 13, Page(s) 10265–10272

    Abstract: Graphene oxide (GO) is one of the most promising candidates for next generation of atomically thin membranes. Nevertheless, one of the major issues for real world application of GO membranes is their undesirable swelling in an aqueous environment. ... ...

    Abstract Graphene oxide (GO) is one of the most promising candidates for next generation of atomically thin membranes. Nevertheless, one of the major issues for real world application of GO membranes is their undesirable swelling in an aqueous environment. Recently, we demonstrated that generation of H
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04097f
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  8. Article ; Online: Pool vs single sample determination of serum prolactin to explore venipuncture associated stress induced variation.

    Das, Madhumita / Gogoi, Chitralekha

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 113

    Abstract: Stress is identified as a cause of transient hyperprolactinemia, whereas venipuncture is considered a source of stress for patient. The aim of this study was to investigate the association of venipuncture-induced stress with elevation of serum prolactin. ...

    Abstract Stress is identified as a cause of transient hyperprolactinemia, whereas venipuncture is considered a source of stress for patient. The aim of this study was to investigate the association of venipuncture-induced stress with elevation of serum prolactin. This was a cross-sectional observational study conducted on a group of 150 outdoor patients visiting a tertiary care hospital. Serial sampling was performed by drawing venous blood at different time intervals (0, 30 and 60 min) by single venipuncture to measure serum prolactin to diagnose stress-induced hyperprolactinemia. The study was conducted in two phases, namely, Phase 1 and Phase 2, at different times. The Phase 1 results were divided into two groups: Group 1 (0 min) and Group 5 (pool prepared from samples collected at 0 + 30 + 60 min). Likewise, the results of Phase 2 were segregated into five groups; Group 1 (0 min), Group 2 (30 min), Group 3 (60 min), Group 4 (average of three groups), and Group 5 (pool from samples collected at 0 + 30 + 60 min). In both Phase 1 and Phase 2 of the study, there was a statistically significant (p = 0.0003 in Phase 1 and p = 0.02 in Phase 2) decrease in the mean prolactin (17.99 ± 24.76 ng/mL in Phase 1 and 19.61 ± 23.42 ng/mL in Phase 2) in the pooled samples (Group 5) in comparison to the mean prolactin (19.67 ± 27.69 ng/mL in Phase 1 and 21.06 ± 25.06 ng/mL in Phase 2) of the serum collected at 0 h (Group 1). There was no significant difference in the mean prolactin measured from the pooled samples and average prolactin calculated after individual testing from each sample collected at 0 h, 30 min and 60 min. Venipuncture-triggered fear and apprehension may result in transient hyperprolactinemia. In comparison to performing multiple testing on the samples collected at different time intervals and determining the mean, measurement of the analyte from the pooled serum is the better alternative as it can conserve both time and resources.
    MeSH term(s) Humans ; Prolactin ; Hyperprolactinemia ; Phlebotomy/adverse effects ; Cross-Sectional Studies ; Time Factors
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-27051-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An overview of anti-Hepatitis B virus flavonoids and their mechanisms of action.

    Naderi, Malihe / Salavatiha, Zahra / Gogoi, Urvashee / Mohebbi, Alireza

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1356003

    Abstract: Flavonoids, a diverse group of polyphenolic compounds found in various plant-based foods, have garnered attention for their potential in combating Hepatitis B Virus (HBV) infection. Flavonoids have demonstrated promising anti-HBV activities by ... ...

    Abstract Flavonoids, a diverse group of polyphenolic compounds found in various plant-based foods, have garnered attention for their potential in combating Hepatitis B Virus (HBV) infection. Flavonoids have demonstrated promising anti-HBV activities by interfering with multiple stages of the HBV life cycle, making them promising candidates for novel antiviral agents. Certain plant families, such as
    MeSH term(s) Humans ; Hepatitis B virus/physiology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Hepatitis B/drug therapy ; Hepatitis B, Chronic/drug therapy ; Flavonoids/pharmacology ; Virus Replication
    Chemical Substances Antiviral Agents ; Flavonoids
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1356003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Roles of transmembrane protein 135 in mitochondrial and peroxisomal functions - implications for age-related retinal disease.

    Landowski, Michael / Gogoi, Purnima / Ikeda, Sakae / Ikeda, Akihiro

    Frontiers in ophthalmology

    2024  Volume 4

    Abstract: Aging is the most significant risk factor for age-related diseases in general, which is true for age-related diseases in the eye including age-related macular degeneration (AMD). Therefore, in order to identify potential therapeutic targets for these ... ...

    Abstract Aging is the most significant risk factor for age-related diseases in general, which is true for age-related diseases in the eye including age-related macular degeneration (AMD). Therefore, in order to identify potential therapeutic targets for these diseases, it is crucial to understand the normal aging process and how its mis-regulation could cause age-related diseases at the molecular level. Recently, abnormal lipid metabolism has emerged as one major aspect of age-related symptoms in the retina. Animal models provide excellent means to identify and study factors that regulate lipid metabolism in relation to age-related symptoms. Central to this review is the role of transmembrane protein 135 (TMEM135) in the retina. TMEM135 was identified through the characterization of a mutant mouse strain exhibiting accelerated retinal aging and positional cloning of the responsible mutation within the gene, indicating the crucial role of TMEM135 in regulating the normal aging process in the retina. Over the past decade, the molecular functions of TMEM135 have been explored in various models and tissues, providing insights into the regulation of metabolism, particularly lipid metabolism, through its action in multiple organelles. Studies indicated that TMEM135 is a significant regulator of peroxisomes, mitochondria, and their interaction. Here, we provide an overview of the molecular functions of TMEM135 which is crucial for regulating mitochondria, peroxisomes, and lipids. The review also discusses the age-dependent phenotypes in mice with TMEM135 perturbations, emphasizing the importance of a balanced TMEM135 function for the health of the retina and other tissues including the heart, liver, and adipose tissue. Finally, we explore the potential roles of TMEM135 in human age-related retinal diseases, connecting its functions to the pathobiology of AMD.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3123828-2
    ISSN 2674-0826 ; 2674-0826
    ISSN (online) 2674-0826
    ISSN 2674-0826
    DOI 10.3389/fopht.2024.1355379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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