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Article ; Online: From Local Covalent Bonding to Extended Electric Field Interactions in Proton Hydration.

Ekimova, Maria / Kleine, Carlo / Ludwig, Jan / Ochmann, Miguel / Agrenius, Thomas E G / Kozari, Eve / Pines, Dina / Pines, Ehud / Huse, Nils / Wernet, Philippe / Odelius, Michael / Nibbering, Erik T J

Angewandte Chemie (International ed. in English)

2022 Volume 61, Issue 46, Page(s) e202211066

Abstract: Seemingly simple yet surprisingly difficult to probe, excess protons in water constitute complex quantum objects with strong interactions with the extended and dynamically changing hydrogen-bonding network of the liquid. Proton hydration plays pivotal ... ...

Abstract	Seemingly simple yet surprisingly difficult to probe, excess protons in water constitute complex quantum objects with strong interactions with the extended and dynamically changing hydrogen-bonding network of the liquid. Proton hydration plays pivotal roles in energy transport in hydrogen fuel cells and signal transduction in transmembrane proteins. While geometries and stoichiometry have been widely addressed in both experiment and theory, the electronic structure of these specific hydrated proton complexes has remained elusive. Here we show, layer by layer, how utilizing novel flatjet technology for accurate x-ray spectroscopic measurements and combining infrared spectral analysis and calculations, we find orbital-specific markers that distinguish two main electronic-structure effects: Local orbital interactions determine covalent bonding between the proton and neigbouring water molecules, while orbital-energy shifts measure the strength of the extended electric field of the proton.
MeSH term(s)	Protons ; Hydrogen Bonding ; Water/chemistry ; Spectrum Analysis ; Electricity
Chemical Substances	Protons ; Water (059QF0KO0R)
Language	English
Publishing date	2022-10-25
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202211066
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Article: Pyoderma Gangrenosum in the Urologist Clinic.

Ludwig, Dina J / Roshani, Hossain / Steffens, Martijn G / Moll, Frederik C / Teepe, Robertus G

Current urology

2016 Volume 9, Issue 3, Page(s) 159–162

Abstract: Pyoderma gangrenosum is a rare non-infectious skin disorder. It is often associated with systemic diseases, like the inflammatory bowel disease, rheumatological disease and (hematological) malignancy. The diagnosis is affirmed through a process of ... ...

Abstract	Pyoderma gangrenosum is a rare non-infectious skin disorder. It is often associated with systemic diseases, like the inflammatory bowel disease, rheumatological disease and (hematological) malignancy. The diagnosis is affirmed through a process of elimination and is principally based on clinical presentation and course. We present a 59-year-old male with T-cell large granular lymphocyte leukemia and pyoderma gangrenosum of penis and scrotum. Finally the patient was successfully treated with systemic prednisolone.
Language	English
Publishing date	2016-09-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2253664-4
ISSN	1661-7657 ; 1661-7649
ISSN (online)	1661-7657
ISSN	1661-7649
DOI	10.1159/000447133
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Article ; Online: Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor.

Laboratory investigation; a journal of technical methods and pathology

2022 Volume 102, Issue 6, Page(s) 658–666

Abstract: Undifferentiated pleomorphic sarcoma (UPS) and malignant peripheral nerve sheath tumor (MPNST) are aggressive soft tissue sarcomas that do not respond well to current treatment modalities. The limited availability of UPS and MPNST cell lines makes it ... ...

Abstract	Undifferentiated pleomorphic sarcoma (UPS) and malignant peripheral nerve sheath tumor (MPNST) are aggressive soft tissue sarcomas that do not respond well to current treatment modalities. The limited availability of UPS and MPNST cell lines makes it challenging to identify potential therapeutic targets in a laboratory setting. Understanding the urgent need for improved treatments for these tumors and the limited cellular models available, we generated additional cell lines to study these rare cancers. Patient-derived tumors were used to establish 4 new UPS models, including one radiation-associated UPS-UPS271.1, UPS511, UPS0103, and RIS620, one unclassified spindle cell sarcoma-USC060.1, and 3 new models of MPNST-MPNST007, MPNST3813E, and MPNST4970. This study examined the utility of the new cell lines as sarcoma models by assessing their tumorigenic potential and mutation status for known sarcoma-related genes. All the cell lines formed colonies and migrated in vitro. The in vivo tumorigenic potential of the cell lines and corresponding xenografts was determined by subcutaneous injection or xenograft re-passaging into immunocompromised mice. USC060.1 and UPS511 cells formed tumors in mice upon subcutaneous injection. UPS0103 and RIS620 tumor implants formed tumors in vivo, as did MPNST007 and MPNST3813E tumor implants. Targeted sequencing analysis of a panel of genes frequently mutated in sarcomas identified TP53, RB1, and ATRX mutations in a subset of the cell lines. These new cellular models provide the scientific community with powerful tools for detailed studies of tumorigenesis and for investigating novel therapies for UPS and MPNST.
MeSH term(s)	Animals ; Humans ; Mice ; Models, Theoretical ; Mutation ; Neurofibrosarcoma/genetics ; Sarcoma/genetics ; Sarcoma/pathology ; Soft Tissue Neoplasms/genetics
Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1038/s41374-022-00734-6
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Article: Pyoderma Gangrenosum in the Urologist Clinic

Ludwig, Dina J. / Roshani, Hossain / Steffens, Martijn G. / Moll, Frederik C. / Teepe, Robertus G.

Current Urology

2016 Volume 9, Issue 3, Page(s) 159–162

Institution	Department of Urology and Dermatology , Haga Teaching Hospital, The Hague Department of Urology and Pathology, Isala Clinics, Zwolle, Netherlands
Abstract	Pyoderma gangrenosum is a rare non-infectious skin disorder. It is often associated with systemic diseases, like the inflammatory bowel disease, rheumatological disease and (hematological) malignancy. The diagnosis is affirmed through a process of elimination and is principally based on clinical presentation and course. We present a 59-year-old male with T-cell large granular lymphocyte leukemia and pyoderma gangrenosum of penis and scrotum. Finally the patient was successfully treated with systemic prednisolone.
Keywords	Penis ; Pyoderma gangrenosum ; Scrotum ; Ulcer ; Urology
Language	English
Publishing date	2016-09-20
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Case Report
ZDB-ID	2253664-4
ISSN	1661-7657 ; 1661-7649
ISSN (online)	1661-7657
ISSN	1661-7649
DOI	10.1159/000447133
Database	Karger publisher's database

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Article ; Online: Current practices in nutrition management and disease incidence of common marmosets (Callithrix jacchus).

Goodroe, Anna / Wachtman, Lynn / Benedict, William / Allen-Worthington, Krystal / Bakker, Jaco / Burns, Monika / Diaz, Leslie Lynn / Dick, Edward / Dickerson, Mary / Eliades, Steven J / Gonzalez, Olga / Graf, Dina-Jo / Haroush, Keren / Inoue, Takashi / Izzi, Jessica / Laudano, Allison / Layne-Colon, Donna / Leblanc, Mathias / Ludwig, Brian /

Mejia, Andres / Miller, Cory / Sarfaty, Anna / Sosa, Megan / Vallender, Eric / Brown, Celeste / Forney, Larry / Schultz-Darken, Nancy / Colman, Ricki / Power, Michael / Capuano, Saverio / Ross, Corinna / Tardif, Suzette

Journal of medical primatology

2021 Volume 50, Issue 3, Page(s) 164–175

Abstract: Background: A survey was developed to characterize disease incidence, common pathology lesions, environmental characteristics, and nutrition programs within captive research marmoset colonies.: Methods: Seventeen research facilities completed the ... ...

Abstract	Background: A survey was developed to characterize disease incidence, common pathology lesions, environmental characteristics, and nutrition programs within captive research marmoset colonies. Methods: Seventeen research facilities completed the electronic survey. Results: Nutritional management programs varied amongst research institutions housing marmosets; eight primary base diets were reported. The most common clinical syndromes reported were gastrointestinal disease (i.e. inflammatory bowel disease like disease, chronic lymphocytic enteritis, chronic malabsorption, chronic diarrhea), metabolic bone disease or fracture, infectious diarrhea, and oral disease (tooth root abscesses, gingivitis, tooth root resorption). The five most common pathology morphologic diagnoses were colitis, nephropathy/nephritis, enteritis, chronic lymphoplasmacytic enteritis, and cholecystitis. Obesity was more common (average 20% of a reporting institution's population) than thin body condition (average 5%). Conclusions: Through review of current practices, we aim to inspire development of evidence-based practices to standardize husbandry and nutrition practices for marmoset research colonies.
MeSH term(s)	Animals ; Bone Diseases, Metabolic ; Callithrix ; Diet/veterinary ; Incidence ; Obesity
Language	English
Publishing date	2021-04-28
Publishing country	Denmark
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	121206-0
ISSN	1600-0684 ; 0047-2565
ISSN (online)	1600-0684
ISSN	0047-2565
DOI	10.1111/jmp.12525
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Zs.A 819: Show issues

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Article: Treatment and outcome of fibroepithelial ureteral polyps: A systematic literature review.

Ludwig, Dina J / Buddingh, Karel T / Kums, Jan J M / Kropman, René F / Roshani, Hossain / Hirdes, Willem H

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2015 Volume 9, Issue 9-10, Page(s) E631–7

Abstract: Introduction: Fibroepithelial polyps of the ureter are rare. Cases and small series are reported in the literature. The treatment of choice, outcome and appropriate follow-up regimen remain unclear.: Methods: We conducted a systematic literature ... ...

Abstract	Introduction: Fibroepithelial polyps of the ureter are rare. Cases and small series are reported in the literature. The treatment of choice, outcome and appropriate follow-up regimen remain unclear. Methods: We conducted a systematic literature review of papers reporting fibroepithelial polyps of the ureter in adult patients. Articles published before 1980 were excluded. Results: The search yielded 144 papers, of which 68 met the inclusion criteria. A reference scan from the included 68 yielded an additional 7 new articles. In total, our study included 75 articles (68 + 7). A total of 134 patients were described. Most patients had a single lesion (range: 1-10). The median length of the polyp was 4.0 cm (range: 0.4-17.0). The percentage of polyps resected endoscopically increased from 0% before 1985 to 67% after 2005. Two perioperative complications were reported in 72 procedures (2.8%): a deep venous thrombosis and a case of mesenteric lymphadenopathy. Both of these occurred after open surgery. Follow-up data were available for 57 patients. The median follow-up was 12 months (range: 1-180). Four patients (7.0%) developed recurrent complaints: 2 had urinary stones, 1 had a ureteral stricture and 1 had recurrence of the polyp. Three of these events followed endoscopic resection, and occurred within a year after the procedure. Conclusion: Endoscopic resection of fibroepithelial polyps seems to be safe and effective. It is minimally invasive and should be considered the gold standard where endoscopic expertise is available. We advise follow-up imaging by computed tomographic intravenous urography after 3 months and ultrasound after 1 year to detect late complications.
Language	English
Publishing date	2015-09-09
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.2878
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Article: Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival.

Clinical cancer research : an official journal of the American Association for Cancer Research

2018 Volume 24, Issue 19, Page(s) 4865–4873

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Adult ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Desmoplastic Small Round Cell Tumor/drug therapy ; Desmoplastic Small Round Cell Tumor/genetics ; Desmoplastic Small Round Cell Tumor/pathology ; Desmoplastic Small Round Cell Tumor/surgery ; Disease-Free Survival ; Female ; Humans ; Male ; RNA-Binding Protein EWS/genetics ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/pathology ; Sarcoma, Ewing/surgery ; Young Adult
Chemical Substances	EWSR1 protein, human ; RNA-Binding Protein EWS
Language	English
Publishing date	2018-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-18-0202
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Zs.A 4223: Show issues

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Article ; Online: Erratum to: Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma.

Drugs

2016 Volume 76, Issue 9, Page(s) 989–990

Language	English
Publishing date	2016-06
Publishing country	New Zealand
Document type	Published Erratum
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.1007/s40265-016-0590-3
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Article ; Online: The Value of Molecular vs. Morphometric and Acoustic Information for Species Identification Using Sympatric Molossid Bats.

Gager, Yann / Tarland, Emilia / Lieckfeldt, Dietmar / Ménage, Matthieu / Botero-Castro, Fidel / Rossiter, Stephen J / Kraus, Robert H S / Ludwig, Arne / Dechmann, Dina K N

PloS one

2016 Volume 11, Issue 3, Page(s) e0150780

Abstract: A fundamental condition for any work with free-ranging animals is correct species identification. However, in case of bats, information on local species assemblies is frequently limited especially in regions with high biodiversity such as the Neotropics. ...

Abstract	A fundamental condition for any work with free-ranging animals is correct species identification. However, in case of bats, information on local species assemblies is frequently limited especially in regions with high biodiversity such as the Neotropics. The bat genus Molossus is a typical example of this, with morphologically similar species often occurring in sympatry. We used a multi-method approach based on molecular, morphometric and acoustic information collected from 962 individuals of Molossus bondae, M. coibensis, and M. molossus captured in Panama. We distinguished M. bondae based on size and pelage coloration. We identified two robust species clusters composed of M. molossus and M. coibensis based on 18 microsatellite markers but also on a more stringently determined set of four markers. Phylogenetic reconstructions using the mitochondrial gene co1 (DNA barcode) were used to diagnose these microsatellite clusters as M. molossus and M. coibensis. To differentiate species, morphological information was only reliable when forearm length and body mass were combined in a linear discriminant function (95.9% correctly identified individuals). When looking in more detail at M. molossus and M. coibensis, only four out of 13 wing parameters were informative for species differentiation, with M. coibensis showing lower values for hand wing area and hand wing length and higher values for wing loading. Acoustic recordings after release required categorization of calls into types, yielding only two informative subsets: approach calls and two-toned search calls. Our data emphasizes the importance of combining morphological traits and independent genetic data to inform the best choice and combination of discriminatory information used in the field. Because parameters can vary geographically, the multi-method approach may need to be adjusted to local species assemblies and populations to be entirely informative.
MeSH term(s)	Acoustics ; Animals ; Body Weight ; Chiroptera/anatomy & histology ; Chiroptera/genetics ; Echolocation ; Extremities/anatomy & histology ; Female ; Genetic Loci ; Male ; Microsatellite Repeats/genetics ; Multigene Family ; Phylogeny ; Principal Component Analysis ; Sample Size ; Skin Pigmentation ; Sound Spectrography ; Species Specificity ; Sympatry ; Wings, Animal/anatomy & histology
Language	English
Publishing date	2016-03-04
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0150780
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Article ; Online: The Value of Molecular vs. Morphometric and Acoustic Information for Species Identification Using Sympatric Molossid Bats.

Yann Gager / Emilia Tarland / Dietmar Lieckfeldt / Matthieu Ménage / Fidel Botero-Castro / Stephen J Rossiter / Robert H S Kraus / Arne Ludwig / Dina K N Dechmann

PLoS ONE, Vol 11, Iss 3, p e

2016 Volume 0150780

Abstract	A fundamental condition for any work with free-ranging animals is correct species identification. However, in case of bats, information on local species assemblies is frequently limited especially in regions with high biodiversity such as the Neotropics. The bat genus Molossus is a typical example of this, with morphologically similar species often occurring in sympatry. We used a multi-method approach based on molecular, morphometric and acoustic information collected from 962 individuals of Molossus bondae, M. coibensis, and M. molossus captured in Panama. We distinguished M. bondae based on size and pelage coloration. We identified two robust species clusters composed of M. molossus and M. coibensis based on 18 microsatellite markers but also on a more stringently determined set of four markers. Phylogenetic reconstructions using the mitochondrial gene co1 (DNA barcode) were used to diagnose these microsatellite clusters as M. molossus and M. coibensis. To differentiate species, morphological information was only reliable when forearm length and body mass were combined in a linear discriminant function (95.9% correctly identified individuals). When looking in more detail at M. molossus and M. coibensis, only four out of 13 wing parameters were informative for species differentiation, with M. coibensis showing lower values for hand wing area and hand wing length and higher values for wing loading. Acoustic recordings after release required categorization of calls into types, yielding only two informative subsets: approach calls and two-toned search calls. Our data emphasizes the importance of combining morphological traits and independent genetic data to inform the best choice and combination of discriminatory information used in the field. Because parameters can vary geographically, the multi-method approach may need to be adjusted to local species assemblies and populations to be entirely informative.
Keywords	Medicine ; R ; Science ; Q
Subject code	590
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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