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  1. Book ; Online ; E-Book: The 15 minute case conceptualization

    Sperry, Len / Sperry, Jonathan J.

    mastering the pattern-focused approach

    2021  

    Abstract: Therapists need an effective approach to case conceptualization that has three key functions. It must explain and guide treatment, and it must predict challenges and obstacles that are likely to arise over the course of treatment. This allows therapists ... ...

    Author's details Len Sperry and Jonathan Sperry
    Abstract Therapists need an effective approach to case conceptualization that has three key functions. It must explain and guide treatment, and it must predict challenges and obstacles that are likely to arise over the course of treatment. This allows therapists to proactively respond. The 15 Minute Case Conceptualization is a clinician-friendly approach that is quick to use and easy to learn and master.
    Keywords Psychotherapy ; Psychotherapy/Methodology
    Subject code 616.8914
    Language English
    Size 1 online resource (193 pages)
    Publisher Oxford University Press
    Publishing place New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-19-751800-1 ; 0-19-760871-X ; 0-19-751799-4 ; 0-19-751798-6 ; 978-0-19-751800-7 ; 978-0-19-760871-5 ; 978-0-19-751799-4 ; 978-0-19-751798-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Case conceptualization

    Sperry, Len / Sperry, Jonathan J.

    mastering this competency with ease and confidence

    (Core competencies in psychotherapy series)

    2012  

    Author's details Len Sperry and Jonathan J. Sperry
    Series title Core competencies in psychotherapy series
    Keywords Psychology, Clinical / methods ; Psychotherapy / methods ; Diagnosis, Differential
    Subject code 616.89/14
    Language English
    Size XVI, 232 S. : Ill., graph. Darst.
    Publisher Routledge
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; Preface -- Part I. Introduction to the chapters in part I -- Case conceptualizations: an overview -- Assessment and diagnostic formulations -- Explanations and clinical and cultural formulations -- Treatment planning and treatment formulations -- Part II. Introduction to the chapters in part II -- Biopsychosocial case conceptualizations -- Cognitive-behavioral case conceptualizations -- Brief dynamic case conceptualizations -- Solution-focused case conceptualizations -- Adlerian case conceptualizations -- Appendix
    HBZ-ID HT017812521
    ISBN 978-0-415-89730-3 ; 0-415-89730-0 ; 9780203110010 ; 0203110013
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 3347 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Biomimetic synthetic studies on the hicksoane alkaloids

    Stephanie Lee / Tilo Söhnel / Jonathan Sperry

    Tetrahedron Chem, Vol 9, Iss , Pp 100060- (2024)

    1481  

    Abstract: The hicksoane alkaloids contain an unusual propane-2,2-diamine unit embedded within a 1,3,6-triazocane, the only natural product known to possess this eight-membered heterocycle. Herein, we report the results examining a biosynthesis proposal that this ... ...

    Abstract The hicksoane alkaloids contain an unusual propane-2,2-diamine unit embedded within a 1,3,6-triazocane, the only natural product known to possess this eight-membered heterocycle. Herein, we report the results examining a biosynthesis proposal that this heterocycle emerges from a late-stage reaction of a dipeptide with acetone. Ile-Trp-CONH2 and Trp-Ile-CONH2 dipeptides were trialled as substrates; in both cases, the intermediate iminium ion did not engage with the primary amide to form the triazocane, reacting instead to generate an imidazolidinone and a β-carboline, respectively. The results from this study infer the triazocane present in these alkaloids is unlikely to be biosynthesised by the late-stage reaction of a dipeptide with biogenic acetone.
    Keywords Organic chemistry ; QD241-441
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Support studies toward the hicksoane alkaloids reveal cascade reactions of a (tryptophanamido)methylglycinate.

    Lee, Stephanie / Söhnel, Tilo / Sperry, Jonathan

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 43, Page(s) 8708–8715

    Abstract: Herein we report unanticipated results that emerged from a synthetic study targeting the unique triazocane present in the hicksoane alkaloids. An initial strategy focused on the cyclisation-ring expansion of a 3-(tryptophyl)imidazolidin-4-one failed due ... ...

    Abstract Herein we report unanticipated results that emerged from a synthetic study targeting the unique triazocane present in the hicksoane alkaloids. An initial strategy focused on the cyclisation-ring expansion of a 3-(tryptophyl)imidazolidin-4-one failed due to the high reactivity of the imide unit; passing a methanolic solution of this compound through a weakly basic ion exchange resin led to methanolysis to form a (tryptophanamido)methylglycinate. Attempted lactamisation of this (tryptophanamido)methylglycinate led to the formation of a (tryptophyl)imidazolidin-4-one, a rare imidazopyrido[3,4-
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01596c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis of lysiformine, a marine-derived 3-hydroxypyridine alkaloid

    Lin, Simon X. / Sperry, Jonathan

    Tetrahedron Letters. 2023 Sept., v. 127 p.154671-

    2023  

    Abstract: A synthesis of the bisindole alkaloid lysiformine is reported. The heterocyclic skeleton of the natural product was assembled from a kojic acid-derived pyridine using iterative Suzuki coupling and reductive alkylation reactions. The NMR spectroscopic ... ...

    Abstract A synthesis of the bisindole alkaloid lysiformine is reported. The heterocyclic skeleton of the natural product was assembled from a kojic acid-derived pyridine using iterative Suzuki coupling and reductive alkylation reactions. The NMR spectroscopic data of the synthetic sample was in excellent agreement to the natural product, confirming that lysiformine is a rare example of a marine natural product harbouring a 3-hydroxypyridine.
    Keywords alkaloids ; alkylation ; pyridines ; spectral analysis ; Natural product ; Indole ; 3-hydroxypyridine ; Alkaloid
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2023.154671
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Isolation and biological activity of azocine and azocane alkaloids.

    Lee, Stephanie / Sperry, Jonathan

    Bioorganic & medicinal chemistry

    2021  Volume 54, Page(s) 116560

    Abstract: Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N- ... ...

    Abstract Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate.
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Antimalarials/chemistry ; Antimalarials/isolation & purification ; Antimalarials/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Azabicyclo Compounds/chemistry ; Azabicyclo Compounds/isolation & purification ; Azabicyclo Compounds/pharmacology ; Azocines/chemistry ; Azocines/isolation & purification ; Azocines/pharmacology ; Humans ; Insecticides/chemistry ; Insecticides/isolation & purification ; Insecticides/pharmacology ; Molecular Structure
    Chemical Substances Alkaloids ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Antimalarials ; Antineoplastic Agents, Phytogenic ; Azabicyclo Compounds ; Azocines ; Insecticides
    Language English
    Publishing date 2021-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2021.116560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The curious yellow colouring matter of the Iceland poppy.

    Devlin, Rory / Sperry, Jonathan

    Organic & biomolecular chemistry

    2020  Volume 18, Issue 28, Page(s) 5278–5286

    Abstract: The pigment responsible for the yellow colour of the Iceland poppy (Papaver nudicaule) has fascinated chemists for decades. Named nudicaulin by Sir Robert Robinson in 1939, this flavoalkaloid has been the subject of several structural elucidation, ... ...

    Abstract The pigment responsible for the yellow colour of the Iceland poppy (Papaver nudicaule) has fascinated chemists for decades. Named nudicaulin by Sir Robert Robinson in 1939, this flavoalkaloid has been the subject of several structural elucidation, biosynthesis, total synthesis and chemical ecology investigations. This account provides a chronological overview of the fascinating history of this natural product.
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d0ob01162b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Haber-independent, asymmetric synthesis of the marine alkaloid

    Neville, Jessica C / Lau, Michelle Y / Söhnel, Tilo / Sperry, Jonathan

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 33, Page(s) 6562–6565

    Abstract: Chitin-derived platforms are emerging as valuable chemical entities for the construction of nitrogenous fine chemicals in processes independent of Haber ammonia. However, much of the work in this area has focused on achiral platforms that limit routine ... ...

    Abstract Chitin-derived platforms are emerging as valuable chemical entities for the construction of nitrogenous fine chemicals in processes independent of Haber ammonia. However, much of the work in this area has focused on achiral platforms that limit routine entry into enantiopure, bio-based N-chemical space. Herein, dihydroxyethyl acetamidofuran (Di-HAF), a chiral synthon readily available from chitin, has been transformed into the marine alkaloid
    MeSH term(s) Alkaloids ; Antineoplastic Agents ; Chitin ; Nitrogen ; Stereoisomerism
    Chemical Substances Alkaloids ; Antineoplastic Agents ; Chitin (1398-61-4) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01251k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Electrochemical oxidation of 3-substituted indoles.

    Arteaga Giraldo, Juan J / Lindsay, Ashley C / Seo, Rachel Chae-Young / Kilmartin, Paul A / Sperry, Jonathan

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 27, Page(s) 5609–5615

    Abstract: 2-Oxindoles are an abundant heteroaromatic motif in natural products and pharmaceuticals. An appealing method for accessing 2-oxindoles is by oxidation of the corresponding indole, a transformation currently executed using stoichiometric quantities of ... ...

    Abstract 2-Oxindoles are an abundant heteroaromatic motif in natural products and pharmaceuticals. An appealing method for accessing 2-oxindoles is by oxidation of the corresponding indole, a transformation currently executed using stoichiometric quantities of unsafe chemical oxidants that can also form unwanted side-products. Herein, we report that 3-substituted indoles undergo a logistically straightforward, electrochemical oxidation to the corresponding 2-oxindole in the presence of potassium bromide (>20 examples), with only traces of the oxidative dimer detected. Cyclic voltammetry and control studies infer that the reaction proceeds by electrochemical generation of elemental bromine (Br
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00831b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Synthesis of 3-nitroindoles by sequential paired electrolysis.

    Lindsay, Ashley C / Kilmartin, Paul A / Sperry, Jonathan

    Organic & biomolecular chemistry

    2021  Volume 19, Issue 36, Page(s) 7903–7913

    Abstract: 3-Nitroindoles are synthetically versatile intermediates but current methods for the preparation hinder their widespread application. Herein, we report that nitroenamines undergo electrochemical cyclisation to 3-nitroindoles in the presence of potassium ... ...

    Abstract 3-Nitroindoles are synthetically versatile intermediates but current methods for the preparation hinder their widespread application. Herein, we report that nitroenamines undergo electrochemical cyclisation to 3-nitroindoles in the presence of potassium iodide. Detailed control experiments and cyclic voltammogram studies infer the reaction proceeds
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d1ob01453f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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