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  1. Article ; Online: [Characteristics of olfactory epithelium and manipulations of neural functions in the brain by the intranasal administration].

    Kashiwayanagi, Makoto

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2012  Volume 132, Issue 11, Page(s) 1247–1253

    Abstract: Olfactory cells receive numerous odorants including toxic substances. To avoid complete loss of the olfactory function by toxic odorants, continuous neurogenesis of olfactory cells occurs even at adulthood. Newly generated olfactory neurons extend their ... ...

    Abstract Olfactory cells receive numerous odorants including toxic substances. To avoid complete loss of the olfactory function by toxic odorants, continuous neurogenesis of olfactory cells occurs even at adulthood. Newly generated olfactory neurons extend their axons to the olfactory bulb. Various molecules including polypeptides, proteins, polynucleotides, virus, and cells administrated intranasally have been reported to move from the olfactory epithelium to the brain tissue via the olfactory epithelium-olfactory bulb pathway. I discuss the pathway of substances intranasally administrated to the brain from the view point of characteristics of the olfactory epithelium.
    MeSH term(s) Administration, Intranasal ; Animals ; Biological Transport ; Blood-Brain Barrier ; Brain/metabolism ; Brain/physiology ; Drug Carriers ; Drug Delivery Systems ; Humans ; Olfactory Bulb/metabolism ; Olfactory Mucosa/metabolism ; Olfactory Pathways/metabolism ; Pharmaceutical Preparations/administration & dosage ; Pharmacokinetics
    Chemical Substances Drug Carriers ; Pharmaceutical Preparations
    Language Japanese
    Publishing date 2012-10-22
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.12-00229-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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  2. Article ; Online: Changes in gaseous concentration of alkylpyrazine analogs affect mouse avoidance behavior.

    Osada, Kazumi / Miyazono, Sadaharu / Ohata, Motoko / Noguchi, Tomohiro / Kashiwayanagi, Makoto

    Bioscience, biotechnology, and biochemistry

    2021  Volume 85, Issue 12, Page(s) 2343–2351

    Abstract: We developed a rapid and accurate method for quantifying gaseous phase odorants using headspace solid-phase microextraction (HS-SPME) in conjunction with GC-MS and used our system to quantify alkylpyrazine analogs in the Y-maze. Rapid extraction of ... ...

    Abstract We developed a rapid and accurate method for quantifying gaseous phase odorants using headspace solid-phase microextraction (HS-SPME) in conjunction with GC-MS and used our system to quantify alkylpyrazine analogs in the Y-maze. Rapid extraction of volatile compounds in the vapor phase achieved accurate quantitative analysis of gaseous alkylpyrazine analogs at several locations in the Y-maze. We also used a series of three SPME fibers to quantify changes in the concentration over time. We conducted a behavioral test of mice in response to these alkylpyrazines and identified a positive relationship between the rate of increase in gaseous concentration and the avoidance rate induced. Our results demonstrate that the Y-maze is a simple but reliable apparatus for behavioral studies of olfaction. The HS-SPME fast extraction method can quantify how gaseous concentrations of alkylpyrazines change over time, and the time-dependent increase of alkylpyrazine concentration is correlated with induction of aversive behavior in mice.
    MeSH term(s) Avoidance Learning
    Language English
    Publishing date 2021-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbab178
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    Zs.A 4647: Show issues Location:
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  3. Article: Pyrazine analogues from wolf urine induced unlearned fear in rats.

    Kashiwayanagi, Makoto / Miyazono, Sadaharu / Osada, Kazumi

    Heliyon

    2017  Volume 3, Issue 8, Page(s) e00391

    Abstract: Urine excreted from the common grey wolf ( ...

    Abstract Urine excreted from the common grey wolf (
    Language English
    Publishing date 2017-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2017.e00391
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  4. Article ; Online: Stimulus dynamics-dependent information transfer of olfactory and vomeronasal sensory neurons in mice.

    Noguchi, Tomohiro / Miyazono, Sadaharu / Kashiwayanagi, Makoto

    Neuroscience

    2018  Volume 400, Page(s) 48–61

    Abstract: The parallel processing of chemical signals by the main olfactory system and the vomeronasal system has been known to control animal behavior. The physiological significance of peripheral parallel pathways consisting of olfactory sensory neurons and ... ...

    Abstract The parallel processing of chemical signals by the main olfactory system and the vomeronasal system has been known to control animal behavior. The physiological significance of peripheral parallel pathways consisting of olfactory sensory neurons and vomeronasal sensory neurons is not well understood. Here, we show complementary characteristics of the information transfer of the olfactory sensory neurons and vomeronasal sensory neurons. A difference in excitability between the sensory neurons was revealed by patch-clamp experiments. The olfactory and vomeronasal sensory neurons showed phasic and tonic firing, respectively. Intrinsic channel kinetics determining firing patterns was demonstrated by a Hodgkin-Huxley-style computation. Our estimation of the information carried by action potentials during one cycle of sinusoidal stimulation with variable durations revealed distinct characteristics of information transfer between the sensory neurons. Phasic firing of the olfactory sensory neurons was suitable to carry information about rapid changes in a shorter cycle (<200 ms). In contrast, tonic firing of the vomeronasal sensory neurons was able to convey information about smaller stimuli changing slowly with longer cycles (>500 ms). Thus, the parallel pathways of the two types of sensory neurons can convey information about a wide range of dynamic stimuli. A combination of complementary characteristics of olfactory information transfer may enhance the synergy of the interaction between the main olfactory system and the vomeronasal system.
    MeSH term(s) Action Potentials ; Animals ; Electric Stimulation ; Information Theory ; Male ; Mice, Inbred BALB C ; Models, Neurological ; Olfactory Pathways/physiology ; Olfactory Receptor Neurons/physiology ; Vomeronasal Organ/physiology
    Language English
    Publishing date 2018-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2018.12.043
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    Zs.A 1215: Show issues Location:
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  5. Article ; Online: Soft-diet feeding impairs neural transmission between mitral cells and interneurons in the mouse olfactory bulb.

    Noguchi, Tomohiro / Utsugi, Chizuru / Kashiwayanagi, Makoto

    Archives of oral biology

    2017  Volume 83, Page(s) 209–213

    Abstract: Objective) The subventricular zone in mice generates a lot of neuroblasts even during adulthood. These neuroblasts migrate to the olfactory bulb and differentiate into inhibitory interneurons such as granule cells and periglomerular cells. Olfactory ... ...

    Abstract (Objective) The subventricular zone in mice generates a lot of neuroblasts even during adulthood. These neuroblasts migrate to the olfactory bulb and differentiate into inhibitory interneurons such as granule cells and periglomerular cells. Olfactory sensory neurons receive information from various odorants and transmit it to the olfactory bulb. Our previous study showed that soft-diet feeding impairs neurogenesis in the subventricular zone, in turn leading to the reduction of odor-induced behaviors and Fos-immunoreactivities, the latter of which are markers of neural activity, at the olfactory bulb after exposure to odors. Release of GABA from inhibitory interneurons at the olfactory bulb induces inhibitory currents at the mitral cells, which are output neurons from the olfactory bulb. (Design) In the present study, we measured spontaneous inhibitory postsynaptic currents (sIPSCs) at the mitral cells of mice fed a soft diet in order to explore the effects of changes in texture of diets on neural function at the olfactory bulb. (Results) The soft-diet feeding extended the intervals between sIPSCs and reduced their peak amplitudes. (Conclusions) The present results suggest that soft-diet feeding in mice attenuates the neural functions of inhibitory interneurons at the olfactory bulb.
    MeSH term(s) Animals ; Bicuculline/pharmacology ; Diet ; Male ; Mastication/physiology ; Mice ; Mice, Inbred BALB C ; Neurogenesis/physiology ; Olfactory Bulb/cytology ; Olfactory Bulb/physiology ; Synaptic Transmission/physiology
    Chemical Substances Bicuculline (Y37615DVKC)
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2017.07.015
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    Ul III Zs.151: Show issues Location:
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  6. Article ; Online: Augmentation of sensitivity to urinary pheromone and excreting of urinary pheromone by sexual experiences.

    Kashiwayanagi, Makoto

    Chemical senses

    2005  Volume 30 Suppl 1, Page(s) i138–9

    MeSH term(s) Animals ; Female ; Humans ; Immunohistochemistry ; Male ; Models, Biological ; Olfactory Bulb/metabolism ; Pheromones/metabolism ; Pheromones/urine ; Proto-Oncogene Proteins c-fos/chemistry ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Sexual Behavior, Animal ; Urine ; Vomeronasal Organ/physiology
    Chemical Substances Pheromones ; Proto-Oncogene Proteins c-fos
    Language English
    Publishing date 2005-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 754122-3
    ISSN 1464-3553 ; 0379-864X
    ISSN (online) 1464-3553
    ISSN 0379-864X
    DOI 10.1093/chemse/bjh152
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    Zs.B 1631: Show issues Location:
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  7. Article ; Online: Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra.

    Sasajima, Hitoshi / Miyazono, Sadaharu / Noguchi, Tomohiro / Kashiwayanagi, Makoto

    Biological & pharmaceutical bulletin

    2017  Volume 40, Issue 1, Page(s) 108–112

    Abstract: Exposure to environmental neurotoxins is suspected to be a risk factor for sporadic progressive neurodegenerative diseases. Parkinson's disease has been associated with exposure to the pesticide rotenone, a mitochondrial respiration inhibitor. We ... ...

    Abstract Exposure to environmental neurotoxins is suspected to be a risk factor for sporadic progressive neurodegenerative diseases. Parkinson's disease has been associated with exposure to the pesticide rotenone, a mitochondrial respiration inhibitor. We previously reported that intranasal administration of rotenone in mice induced dopaminergic (DA) neurodegeneration in the olfactory bulb (OB) and reduced olfactory functions. In the present study, we investigated the DA neurons in the brains of mice that were administered rotenone intranasally for an extended period. We found that the olfactory function of mice was attenuated by rotenone administration. Electrophysiological analysis of the mitral cells, which are output neurons in the OB, revealed that the inhibitory input into the mitral cells was retarded. In the immunohistochemical analysis, neurite degeneration of DA neurons in the substantia nigra was observed in rotenone-administered mice, indicating that rotenone progressively initiated the degeneration of cerebral DA neurons via the nasal route.
    MeSH term(s) Administration, Intranasal ; Animals ; Behavior, Animal/drug effects ; Brain/cytology ; Brain/drug effects ; Brain/metabolism ; Brain/physiology ; Butyric Acid ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Female ; Mice, Inbred BALB C ; Neurites/drug effects ; Neurites/pathology ; Neurotoxins/administration & dosage ; Neurotoxins/toxicity ; Rotenone/administration & dosage ; Rotenone/toxicity ; Smell/drug effects ; Tyrosine 3-Monooxygenase/metabolism
    Chemical Substances Neurotoxins ; Rotenone (03L9OT429T) ; Butyric Acid (107-92-6) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
    Language English
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b16-00654
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    Zs.A 1474: Show issues Location:
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  8. Article ; Online: Structure-Activity Relationships of Alkylpyrazine Analogs and Fear-Associated Behaviors in Mice.

    Osada, Kazumi / Miyazono, Sadaharu / Kashiwayanagi, Makoto

    Journal of chemical ecology

    2017  Volume 43, Issue 3, Page(s) 263–272

    Abstract: Our previous studies identified alkyl pyrazine analogs in wolf urine that act as novel kairomones and induce a series of fear-associated behaviors in mice. A mixture of these alkyl pyrazines also effectively suppressed the approach of deer to a feeding ... ...

    Abstract Our previous studies identified alkyl pyrazine analogs in wolf urine that act as novel kairomones and induce a series of fear-associated behaviors in mice. A mixture of these alkyl pyrazines also effectively suppressed the approach of deer to a feeding area, and animals that did approach the marked area exhibited fear-associated behaviors. To investigate structure-activity relationships of alkyl pyrazines, four fear-associated behaviors - freezing, locomotion activity, odor investigation, and avoidance - were measured in experiments on female C57BL/6 J mice. Of the 17 compounds tested, 2,3-diethylpyrazine, 3-ethyl-2,5-dimethylpyrazine, and 3-ethyl-2,5-dimethylpyrazine induced all four fear-associated behaviors. 2,3,5-Trimethylpyrazine also induced three of the fear-associated behaviors, but did not decrease locomotion. Multivalent analysis of behaviors clearly demonstrated that these four compounds formed an independent cluster and were the most active. Structure-activity relationships revealed that active alkyl pyrazines inducing all four fear-associated behaviors had methyl or ethyl group(s), but not longer carbon chains, and alkyl side chains consisting of four carbon atoms in total were present in the most potent analogs. This study is the first experimental investigation of structure-activity relationships between alkyl pyrazine analogs and fear-associated behaviors in mice.
    MeSH term(s) Animals ; Avoidance Learning/drug effects ; Behavior, Animal/drug effects ; Fear/drug effects ; Fear/physiology ; Fear/psychology ; Female ; Locomotion/drug effects ; Maze Learning/drug effects ; Mice ; Mice, Inbred C57BL ; Pyrazines/chemistry ; Pyrazines/pharmacology ; Structure-Activity Relationship ; Time Factors
    Chemical Substances Pyrazines
    Language English
    Publishing date 2017-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800130-3
    ISSN 1573-1561 ; 0098-0331
    ISSN (online) 1573-1561
    ISSN 0098-0331
    DOI 10.1007/s10886-017-0822-3
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  9. Article: Pyrazine analogues from wolf urine induced unlearned fear in rats

    Kashiwayanagi, Makoto / Miyazono, Sadaharu / Osada, Kazumi

    Heliyon. 2017 Aug., v. 3, no. 8

    2017  

    Abstract: Urine excreted from the common grey wolf (Canis lupus) contains a kairomone, inducing fear-related behaviors in various mammals. Numerous fear-inducing substances activate neurons at the main and/or accessory olfactory bulb (AOB), medial and central ... ...

    Abstract Urine excreted from the common grey wolf (Canis lupus) contains a kairomone, inducing fear-related behaviors in various mammals. Numerous fear-inducing substances activate neurons at the main and/or accessory olfactory bulb (AOB), medial and central amygdala, and hypothalamus. Our previous study showed that the mixture of pyrazine analogues (P-mix) contained in wolf urine induced avoidance and fear-related behaviors in laboratory mice and Hokkaido deer (Cervus nippon yesoensis), a species native to Japan. Exposure to wolf urine or P-mix induced expression of Fos, a marker of neuronal excitation, in the AOB of mice. In the present study, we explored the effects of P-mix on fear-related behaviors and Fos-expression in rats. Exposure to P-mix induced avoidance and immobilization in rats, while that to a mixture of i-amyl acetate, linalool and R(+)-limonene (O-mix), which generate floral and fruity odors, induced avoidance but not immobilization. P-mix but not O-mix increased Fos-immunoreactivity of the AOB, medial and central amygdala, and hypothalamus of rats. The present results suggest that P-mix odor induces unlearned fear-related behaviors in rats.
    Keywords Canis lupus ; Cervus nippon ; Japan ; acetates ; amygdala ; deer ; fearfulness ; hypothalamus ; indigenous species ; kairomones ; linalool ; neurons ; odors ; olfactory bulb ; pyrazines ; urine ; wolves
    Language English
    Dates of publication 2017-08
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2017.e00391
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  10. Article ; Online: [Possibility of therapy of brain functions by intranasal administration].

    Kashiwayanagi, Makoto / Iseki, Ken

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2012  Volume 132, Issue 11, Page(s) 1245–1246

    MeSH term(s) Administration, Intranasal ; Biological Transport ; Blood-Brain Barrier/physiology ; Brain/metabolism ; Brain Diseases/drug therapy ; Drug Delivery Systems ; Humans ; Olfactory Mucosa/metabolism ; Olfactory Pathways/metabolism ; Pharmaceutical Preparations/administration & dosage ; Pharmacokinetics
    Chemical Substances Pharmaceutical Preparations
    Language Japanese
    Publishing date 2012-10-22
    Publishing country Japan
    Document type Introductory Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.12-00229-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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