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Article ; Online: Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis.

Shi, Yihui / Wu, Chengkun / Shi, Jiayi / Gao, Taotao / Ma, Huabin / Li, Long / Zhao, Yufen

2024 Volume 970, Page(s) 176508

Abstract: Necroptosis is a pivotal contributor to the pathogenesis of various human diseases, including those affecting the nervous system, cardiovascular system, pulmonary system, and kidneys. Extensive investigations have elucidated the mechanisms and ... ...

Abstract	Necroptosis is a pivotal contributor to the pathogenesis of various human diseases, including those affecting the nervous system, cardiovascular system, pulmonary system, and kidneys. Extensive investigations have elucidated the mechanisms and physiological ramifications of necroptosis. Among these, protein phosphorylation emerges as a paramount regulatory process, facilitating the activation or inhibition of specific proteins through the addition of phosphate groups to their corresponding amino acid residues. Currently, the targeting of kinases has gained recognition as a firmly established and efficacious therapeutic approach for diverse diseases, notably cancer. In this comprehensive review, we elucidate the intricate role of phosphorylation in governing key molecular players in the necroptotic pathway. Moreover, we provide an in-depth analysis of recent advancements in the development of kinase inhibitors aimed at modulating necroptosis. Lastly, we deliberate on the prospects and challenges associated with the utilization of kinase inhibitors to modulate necroptotic processes.
MeSH term(s)	Humans ; Phosphorylation ; Protein Kinases/metabolism ; Necroptosis ; Neoplasms/drug therapy ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Apoptosis
Chemical Substances	Protein Kinases (EC 2.7.-) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-03-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2024.176508
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Article: Non-linear association of fasting C-peptide and uric acid levels with renal dysfunction based on restricted cubic spline in patients with type 2 diabetes: A real-world study.

Chen, Lu / Hu, Yifei / Ma, Yongjun / Wang, Huabin

Frontiers in endocrinology

2023 Volume 14, Page(s) 1157123

Abstract: Background: Previous studies had showed divergent findings on the associations of C-peptide and/or uric acid (UA) with renal dysfunction odds in patients with type 2 diabetes mellitus (T2DM). We hypothesized that there were non-linear relationships ... ...

Abstract	Background: Previous studies had showed divergent findings on the associations of C-peptide and/or uric acid (UA) with renal dysfunction odds in patients with type 2 diabetes mellitus (T2DM). We hypothesized that there were non-linear relationships between C-peptide, UA and renal dysfunction odds. This study aimed to further investigate the relationships of different stratification of C-peptide and UA with renal dysfunction in patients with T2DM. Method: We conducted a cross-sectional real-world observational study of 411 patients with T2DM. The levels of fasting C-peptide, 2h postprandial C-peptide, the ratio of fasting C-peptide to 2h postprandial C-peptide (C0/C2 ratio), UA and other characteristics were recorded. Restricted cubic spline (RCS) curves was performed to evaluated the associations of stratified C-peptide and UA with renal dysfunction odds. Results: Fasting C-peptide, C0/C2 ratio and UA were independently and significantly associated with renal dysfunction in patients with T2DM as assessed by multivariate analyses (p < 0.05). In especial, non-linear relationships with threshold effects were observed among fasting C-peptide, UA and renal dysfunction according to RCS analyses. Compared with patients with 0.28 ≤ fasting C-peptide ≤ 0.56 nmol/L, patients with fasting C-peptide < 0.28 nmol/L (OR = 1.38, p = 0.246) or fasting C-peptide > 0.56 nmol/L (OR = 1.85, p = 0.021) had relatively higher renal dysfunction odds after adjusting for confounding factors. Similarly, compared with patients with 276 ≤ UA ≤ 409 μmol/L, patients with UA < 276 μmol/L (OR = 1.32, p = 0.262) or UA > 409 μmol/L (OR = 6.24, p < 0.001) had relatively higher odds of renal dysfunction. Conclusion: The renal dysfunction odds in patients with T2DM was non-linearly associated with the levels of serum fasting C-peptide and UA. Fasting C-peptide and UA might have the potential role in odds stratification of renal dysfunction.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; C-Peptide ; Uric Acid ; Cross-Sectional Studies ; Fasting ; Kidney Diseases
Chemical Substances	C-Peptide ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1157123
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Article: Predictive role of serum C-peptide in new-onset renal dysfunction in type 2 diabetes: a longitudinal observational study.

Sun, Dongmei / Hu, Yifei / Ma, Yongjun / Wang, Huabin

Frontiers in endocrinology

2023 Volume 14, Page(s) 1227260

Abstract: Background: Our previous cross-sectional study has demonstrated the independently non-linear relationship between fasting C-peptide with renal dysfunction odds in patients with type 2 diabetes (T2D) in China. This longitudinal observational study aims ... ...

Abstract	Background: Our previous cross-sectional study has demonstrated the independently non-linear relationship between fasting C-peptide with renal dysfunction odds in patients with type 2 diabetes (T2D) in China. This longitudinal observational study aims to explore the role of serum C-peptide in risk prediction of new-onset renal dysfunction, then construct a predictive model based on serum C-peptide and other clinical parameters. Methods: The patients with T2D and normal renal function at baseline were recruited in this study. The LASSO algorithm was performed to filter potential predictors from the baseline variables. Logistic regression (LR) was performed to construct the predictive model for new-onset renal dysfunction risk. Power analysis was performed to assess the statistical power of the model. Results: During a 2-year follow-up period, 21.08% (35/166) of subjects with T2D and normal renal function at baseline progressed to renal dysfunction. Six predictors were determined using LASSO regression, including baseline albumin-to-creatinine ratio, glycated hemoglobin, hypertension, retinol-binding protein-to-creatinine ratio, quartiles of fasting C-peptide, and quartiles of fasting C-peptide to 2h postprandial C-peptide ratio. These 6 predictors were incorporated to develop model for renal dysfunction risk prediction using LR. Finally, the LR model achieved a high efficiency, with an AUC of 0.83 (0.76 - 0.91), an accuracy of 75.80%, a sensitivity of 88.60%, and a specificity of 70.80%. According to the power analysis, the statistical power of the LR model was found to be 0.81, which was at a relatively high level. Finally, a nomogram was developed to make the model more available for individualized prediction in clinical practice. Conclusion: Our results indicated that the baseline level of serum C-peptide had the potential role in the risk prediction of new-onset renal dysfunction. The LR model demonstrated high efficiency and had the potential to guide individualized risk assessments for renal dysfunction in clinical practice.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; C-Peptide ; Creatinine ; Glycated Hemoglobin ; Kidney Diseases
Chemical Substances	C-Peptide ; Creatinine (AYI8EX34EU) ; Glycated Hemoglobin
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1227260
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Article ; Online: A discussion on PM

Bilal, Muhammad / de Leeuw, Gerrit / Nichol, Janet E / Bleiweiss, Max P / Mhawish, Alaa / Yang, Leiku / Chai, Huabin / Ali, Md Arfan

Journal of hazardous materials

2023 Volume 448, Page(s) 130924

Language	English
Publishing date	2023-02-02
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.130924
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Article ; Online: Hybrid Dynamic Covalent Network-Based Protecting Layer for Stable Li-Metal Batteries.

Feng, Hao / He, Yayue / Ma, Mengxiang / Gao, Shilun / Zhao, Sheng / Shan, Xinyuan / Yang, Huabin / Cao, Peng-Fei

ACS applied materials & interfaces

2024 Volume 16, Issue 10, Page(s) 12374–12384

Abstract: Metallic lithium (Li) is considered as the "Holy Grail" anode material for next-generation energy storage systems due to its extremely high theoretical capacity and low electrochemical potential. Before the commercialization of the Li electrode, ... ...

Abstract	Metallic lithium (Li) is considered as the "Holy Grail" anode material for next-generation energy storage systems due to its extremely high theoretical capacity and low electrochemical potential. Before the commercialization of the Li electrode, dendritic Li growth and the unstable solid electrolyte interphase layer should be conquered. Herein, a hybrid covalent adaptable polymer network (HCAPN) is prepared via the random copolymerization of poly(ethylene glycol) methyl ether methacrylate and -acetoacetoxyethyl methacrylate, followed by chemical cross-linking with polyethylenimine (PEI) and amine-modified silicon dioxide (SiO
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c15690
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Article ; Online: Correction for Zheng et al., "G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2".

Zheng, Huabin / Ma, Liping / Gui, Rui / Lin, Xian / Ke, Xianliang / Jian, Xiaoqin / Ye, Chang / Chen, Quanjiao

Journal of virology

2023 Volume 97, Issue 6, Page(s) e0054623

Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00546-23
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Article ; Online: Comment on Abdul Jabbar et al. Air Quality, Pollution and Sustainability Trends in South Asia: A Population-Based Study.

Bilal, Muhammad / de Leeuw, Gerrit / Nichol, Janet E / Bleiweiss, Max P / Yang, Leiku / Chai, Huabin / Mhawish, Alaa / Ali, Md Arfan

International journal of environmental research and public health

2023 Volume 20, Issue 6

Abstract: This comment discusses the use of ... ...

Abstract	This comment discusses the use of PM
MeSH term(s)	Air Pollution/statistics & numerical data ; Asia, Southern ; Particulate Matter/analysis
Chemical Substances	Particulate Matter
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20065075
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Article ; Online: Allosteric Probe Recognition Initiated Cascade Transcription Amplification for Sensitive Analysis of Exosomes.

Lei, Huabin / Ma, Yaru / Zhang, Hui / Cao, Zenghui / Zhang, Heng

Chembiochem : a European journal of chemical biology

2022 Volume 23, Issue 10, Page(s) e202200067

Abstract: Sensitive and accurate analysis of exosomes is important for many biological processes including as a biomarker for cerebral venous thrombosis (CVT) diagnosis and therapy. Herein, we established a sensitive and specific exosome detection approach based ... ...

Abstract	Sensitive and accurate analysis of exosomes is important for many biological processes including as a biomarker for cerebral venous thrombosis (CVT) diagnosis and therapy. Herein, we established a sensitive and specific exosome detection approach based on target recognition initiated cascade signal amplification. In this method, an allosteric probe was designed with a hairpin structure for specific recognition of the exosome followed by signal amplification. After the cascade signal amplification process, spinach RNA sequences bind to DFHBI ((Z)-4-(3,5-difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one) to produce enhanced fluorescence signal (approximate 2000 fold than that of inactive DFHBI). Compared with former proposed exosome detection techniques, this method exhibited a comparable detection range, but with an easy-to-design toolbox. Therefore, we believe that the proposed approach holds great potential for exosome based early diagnosis and prognosis of disease.
MeSH term(s)	Biosensing Techniques/methods ; Exosomes/genetics ; Exosomes/metabolism ; Fluorescence ; Nucleic Acid Amplification Techniques
Language	English
Publishing date	2022-03-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202200067
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Article ; Online: Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication.

Ma, Liping / Zheng, Huabin / Ke, Xianliang / Gui, Rui / Yao, Zhongzi / Xiong, Jiasong / Chen, Quanjiao

Virologica Sinica

2023 Volume 39, Issue 1, Page(s) 56–70

Abstract: Avian H9N2 viruses have wide host range among the influenza A viruses. However, knowledge of H9N2 mammalian adaptation is limited. To explore the molecular basis of the adaptation to mammals, we performed serial lung passaging of the H9N2 strain A/ ... ...

Abstract	Avian H9N2 viruses have wide host range among the influenza A viruses. However, knowledge of H9N2 mammalian adaptation is limited. To explore the molecular basis of the adaptation to mammals, we performed serial lung passaging of the H9N2 strain A/chicken/Hunan/8.27 YYGK3W3-OC/2018 (3W3) in mice and identified six mutations in the hemagglutinin (HA) and polymerase acidic (PA) proteins. Mutations L226Q, T511I, and A528V of HA were responsible for enhanced pathogenicity and viral replication in mice; notably, HA-L226Q was the key determinant. Mutations T97I, I545V, and S594G of PA contributed to enhanced polymerase activity in mammalian cells and increased viral replication levels in vitro and in vivo. PA-T97I increased viral polymerase activity by accelerating the viral polymerase complex assembly. Our findings revealed that the viral replication was affected by the presence of PA-97I and/or PA-545V in combination with a triple-point HA mutation. Furthermore, the double- and triple-point PA mutations demonstrated antagonistic effect on viral replication when combined with HA-226Q. Notably, any combination of PA mutations, along with double-point HA mutations, resulted in antagonistic effect on viral replication. We also observed antagonism in viral replication between PA-545V and PA-97I, as well as between HA-528V and PA-545V. Our findings demonstrated that several antagonistic mutations in HA and PA proteins affect viral replication, which may contribute to the H9N2 virus adaptation to mice and mammalian cells. These findings can potentially contribute to the monitoring of H9N2 field strains for assessing their potential risk in mammals.
MeSH term(s)	Animals ; Mice ; Influenza A Virus, H9N2 Subtype/genetics ; Orthomyxoviridae Infections ; Hemagglutinins ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Mutation ; Virus Replication/genetics ; Nucleotidyltransferases ; Chickens ; Mammals/metabolism ; Influenza in Birds
Chemical Substances	Hemagglutinins ; Viral Proteins ; Nucleotidyltransferases (EC 2.7.7.-)
Language	English
Publishing date	2023-11-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1016/j.virs.2023.11.004
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Article: Three-stage pattern of rapid increase, plateau, and subsequent decline in vitamin D concentration during pregnancy among Chinese women: a large-scale survey.

Wang, Huabin / Zhang, Feifang / Li, Bingxian / Fu, Miao / Shan, Xiaoyun / Ma, Yongjun

Frontiers in nutrition

2023 Volume 10, Page(s) 1238389

Abstract: Background: There is an incomplete understanding of fluctuations in vitamin D (VitD) concentration during pregnancy among Chinese women. Furthermore, previous research has yielded conflicting results in this area. This study aims to investigate the ... ...

Abstract	Background: There is an incomplete understanding of fluctuations in vitamin D (VitD) concentration during pregnancy among Chinese women. Furthermore, previous research has yielded conflicting results in this area. This study aims to investigate the changes in VitD status and deficiency in Chinese pregnant women across various age groups, gestational weeks, and as well as seasonal variations through conducting a large-scale survey. Methods: A toal of 11,220 Chinese pregnant women between 2021 and April 2023 were included in this study. Generalized additive models (GAM), stratified analysis, and restricted cubic splines (RCS) were used to analyze changes in VitD status and deficiency risk during pregnancy. Results: Of the participants, 45.2% had deficient concentration of 25-hydroxyvitamin D. VitD concentration and deficiency rate do not show linear changes with age and gestational weeks. With increasing gestational weeks, VitD concentration rapidly increased in women with gestational age < 20 weeks, remained stable between 20 and 30 weeks, and decreased beyond 30 weeks; however, the odds of VitD deficiency showed three different patterns: a rapid decline, a stable period, and a mild increase, respectively. Based on the stratified regression analysis, VitD deficiency odds increased by 16% with each additional week of gestation in pregnant women with gestational age > 30 weeks, OR = 1.16 (1.10-1.22), Conclusion: VitD concentration undergo three phases during pregnancy: rapid increase, plateau, and subsequent decrease. VitD deficiency odds was highest in pregnant women under 25 with gestational ages <20 and lowest in pregnant women over 35 with gestational ages between 20 and 30. The odds of deficiency increase slightly in pregnant women with gestational ages beyond 30 weeks, indicating that they may require additional VitD supplementation.
Language	English
Publishing date	2023-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1238389
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