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Article ; Online: AutomAted RepeaT Identifier (AARTI): A tool to identify common, polymorphic, and unique microsatellites.

Kumar, Sonu / Singh, Ashutosh / Kumar, Nitish / Choudhary, Mamta / Kumar Choudhary, Binod / Shanker, Asheesh

2022 Volume 65, Page(s) 161–165

Abstract: ... AutomAted RepeaT Identifier (AARTI). The AARTI is the only tool till date, which identifies common ... Metazoa) and 130 (Viridiplantae) mitochondrial genomes. The AARTI is freely available at https://lms.snu ... edu.in/aarti/ and will certainly accelerate the studies of length variation in microsatellites between ...

Abstract	Here we are presenting an automated computational pipeline used to mine 5976 mitochondrial genomes to identify common, polymorphic, and unique microsatellites also known as simple sequence repeats (SSRs). Microsatellites are repetitive motifs of 1-6 bases in a DNA sequence. Due to their abundance and highly polymorphic nature, microsatellites have become one of the widely used molecular/genetic markers valuable for many studies including gene tagging, genetic diversity, and species identification. Several computational tools dedicated to mine and categorize microsatellites in nucleotide sequences were developed; however, there is no tool which can identify unique, common and polymorphic microsatellites between each pair of nucleotide sequences. To explore such microsatellites, we have developed a fully automated computational pipeline named AutomAted RepeaT Identifier (AARTI). The AARTI is the only tool till date, which identifies common, polymorphic, and unique microsatellites between each pair of nucleotide sequences. The computational pipeline was constructed using the PERL programming language and the web server for the pipeline was developed with the help of PHP, HTML, CSS, and JavaScript. It was successfully tested to reproduce the results of previous study on 7 mitochondrial genomes of genus Orthotrichum. Moreover, the pipeline was also applied on 5846 (Metazoa) and 130 (Viridiplantae) mitochondrial genomes. The AARTI is freely available at https://lms.snu.edu.in/aarti/ and will certainly accelerate the studies of length variation in microsatellites between species. Additionally, it will be useful in comparative genomic studies, for the computational characterization of microsatellites, and has the potential to be a routine genome analysis pipeline for mitochondrial genomes.
MeSH term(s)	Genetic Markers ; Genomics/methods ; Microsatellite Repeats
Chemical Substances	Genetic Markers
Language	English
Publishing date	2022-06-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2022.06.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unraveling Interaction of Rhenium-188 Microspheres with Primary Hepatic Cancer Cell: A Breakthrough Study.

Aggarwal, Aarti / Kaur, Gurjeet / Jassal, Ravjit Singh / Medhi, Bikash / Mittal, Bhagwant Rai / Shukla, Jaya

Cancer biotherapy & radiopharmaceuticals

2024 Volume 39, Issue 3, Page(s) 188–195

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Microspheres ; Fluorescein-5-isothiocyanate ; Apoptosis ; Radioisotopes/therapeutic use ; Radioisotopes/metabolism ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/metabolism ; Fluorescein ; Annexin A5/metabolism ; Rhenium
Chemical Substances	Rhenium-188 (229C124H5I) ; Fluorescein-5-isothiocyanate (I223NX31W9) ; Radioisotopes ; Fluorescein (TPY09G7XIR) ; Annexin A5 ; Rhenium (7440-15-5)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1315649-4
ISSN	1557-8852 ; 1084-9785
ISSN (online)	1557-8852
ISSN	1084-9785
DOI	10.1089/cbr.2023.0146
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Article: Morphological and physiological changes induced by

Sharma, Aarti / Mishra, Monika / Dagar, Vinay Singh / Kumar, Sarita

Frontiers in physiology

2022 Volume 13, Page(s) 1031285

Abstract: ... Aedes ... ...

Abstract	Aedes aegypti
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.1031285
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Book ; Online: Adaptation to Misspecified Kernel Regularity in Kernelised Bandits

Liu, Yusha / Singh, Aarti

2023

Abstract: In continuum-armed bandit problems where the underlying function resides in a reproducing kernel Hilbert space (RKHS), namely, the kernelised bandit problems, an important open problem remains of how well learning algorithms can adapt if the regularity ... ...

Abstract	In continuum-armed bandit problems where the underlying function resides in a reproducing kernel Hilbert space (RKHS), namely, the kernelised bandit problems, an important open problem remains of how well learning algorithms can adapt if the regularity of the associated kernel function is unknown. In this work, we study adaptivity to the regularity of translation-invariant kernels, which is characterized by the decay rate of the Fourier transformation of the kernel, in the bandit setting. We derive an adaptivity lower bound, proving that it is impossible to simultaneously achieve optimal cumulative regret in a pair of RKHSs with different regularities. To verify the tightness of this lower bound, we show that an existing bandit model selection algorithm applied with minimax non-adaptive kernelised bandit algorithms matches the lower bound in dependence of $T$, the total number of steps, except for log factors. By filling in the regret bounds for adaptivity between RKHSs, we connect the statistical difficulty for adaptivity in continuum-armed bandits in three fundamental types of function spaces: RKHS, Sobolev space, and H\"older space. Comment: 9 main pages, 1 table, 12 appendix pages. Accepted to the 26th International Conference on Artificial Intelligence and Statistics 2023
Keywords	Statistics - Machine Learning ; Computer Science - Machine Learning ; Statistics - Methodology
Subject code	510
Publishing date	2023-04-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Lesions Misdiagnosed as Endodontic Pathosis: A Narrative Review.

Patil, Amit Hemraj / Singh, Shruti / Bedia, Aarti S / Sharma, Deepak / Sinha, Anamika / Dahiya, Nitesh

Journal of pharmacy & bioallied sciences

2024 Volume 16, Issue Suppl 1, Page(s) S11–S13

Abstract: In daily practice, clinicians come across certain radiographic abnormalities which may or may not be asymptomatic. This abstract discusses radiographic abnormalities encountered by clinicians in daily practice, some of which resemble endodontic lesions. ... ...

Abstract	In daily practice, clinicians come across certain radiographic abnormalities which may or may not be asymptomatic. This abstract discusses radiographic abnormalities encountered by clinicians in daily practice, some of which resemble endodontic lesions. Prompt attention is crucial as these lesions can be benign or malignant. The article emphasizes the importance of differential diagnosis for accurate identification of periapical pathosis.
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_461_23
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Book ; Online: Web semantics for textual and visual information retrieval

Singh, Aarti

2017

Abstract: ... in information retrieval"--Provideding and ass by publisher ... Singh -- Technique for transformation of data From RDB to XML then to RDF / Kaleem Razzaq Malik, Tauqir A ...

Author's details	Aarti Singh, Nilanjan Dey, Amira S. Ashour, and V. Santhi [editors]
Abstract	"[This book] is a pivotal reference source for the latest academic research on embedding and associating semantics with multimedia information to improve data retrieval techniques. Highlighting a range of pertinent topics such as automation, knowledge discovery, and social networking, this book is ideally designed for researchers, practitioners, students, and professionals interested in emerging trends in information retrieval"--Provided by publisher Scope of automation in semantics-driven multimedia information retrieval from web / Aarti Singh, Nilanjan Dey, Amira S. Ashour -- Information retrieval models: trends and techniques / Saruladha Krishnamurthy, Akila V -- A study on models and methods of information retrieval system / Manisha Malhotra, Aarti Singh -- Technique for transformation of data From RDB to XML then to RDF / Kaleem Razzaq Malik, Tauqir Ahmad -- Conversion of higher into lower language using machine translation / Raghvendra Kumar, Prasant Kumar Pattnaik, Priyanka Pandey -- Knowledge discovery from massive data streams / Sushil Kumar Narang, Sushil Kumar, Vishal Verma -- Knowledge discovery and big data analytics: issues, challenges, and opportunities / Vinoth Kumar Jambulingam, V. Santhi -- Web semantics for personalized information retrieval / Aarti Singh, Anu Sharma -- Semantic web-based framework for scientific workflows in e-science / Singanamalla Vijayakumar [and 3 others] -- State-of-the-art information retrieval tools for biological resources / Shashi Bhushan Lal [and 6 others] -- Role of social networking sites in enhancing teaching environment / Singanamalla Vijayakumar [and 3 others]
Keywords	Content-based image retrieval ; Information retrieval ; Semantic Web ; Information Retrieval
Language	English
Size	Online-Ressource(PDFs (290 pages))
Document type	Book ; Online
Note	Includes bibliographical references and index ; Restricted to subscribers or individual electronic text purchasers
ISBN	1522524835 ; 9781522524830 ; 9781522524847 ; 1522524843
Database	ECONomics Information System

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Article: Development of Deltamethrin-Laced Attractive Toxic Sugar Bait to Control

Kumar, Sarita / Sharma, Aarti / Samal, Roopa Rani / Verma, Vaishali / Sagar, Ravinder Kumar / Singh, Shri Pati / Raghavendra, Kamaraju

Journal of tropical medicine

2024 Volume 2024, Page(s) 6966205

Abstract: Background: The attractive toxic sugar bait (ATSB) is a promising strategy for controlling mosquitoes at the adult stage. The strategy is based on the use of a combination of fruit juice, sugar, and a toxin in order to attract and kill the adult ... ...

Abstract	Background: The attractive toxic sugar bait (ATSB) is a promising strategy for controlling mosquitoes at the adult stage. The strategy is based on the use of a combination of fruit juice, sugar, and a toxin in order to attract and kill the adult mosquitoes. The selection of the components and optimization of their concentrations is significant for the formulation of an effective ATSB. Methods: The present study formulated nine ATSBs and evaluated their efficacy against two laboratory strains (AND- Results: The ATSB formulations registered 8.33-97.44% mortality against AND- Conclusions: The ATSBs formulated with guava juice-ASB and deltamethrin (9 : 1) showed toxin dose-dependent toxicity by all the four strains of
Language	English
Publishing date	2024-01-06
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2546526-0
ISSN	1687-9694 ; 1687-9686
ISSN (online)	1687-9694
ISSN	1687-9686
DOI	10.1155/2024/6966205
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Article ; Online: Development and Evaluation of Celecoxib Emulgel by Using Natural Oil.

Rajput, Aarti / Gaur, Rishabh / Kulshreshtha, Mayank / Jadaun, Sumedha Singh / Kumari, Vibha

Anti-inflammatory & anti-allergy agents in medicinal chemistry

2024

Abstract: Background: Emulgel combines the qualities of an emulsion with those of a gel. In order to create an emulgel w/o or o/w, emulsions have to be formulated, which are then combined with a gelling agent, resulting in a dual-control drug release. Celecoxib ... ...

Abstract	Background: Emulgel combines the qualities of an emulsion with those of a gel. In order to create an emulgel w/o or o/w, emulsions have to be formulated, which are then combined with a gelling agent, resulting in a dual-control drug release. Celecoxib exhibits analgesic, antipyretic and anti-inflammatory activities and is used to treat osteoarthritis, severe pain, rheumatoid arthritis, and other medical conditions. Methods: Celecoxib Emulgel was developed and evaluated by using natural oil and carbopol-940 as a gelling agent in different concentrations. The screening of various oils, co-surfactants and surfactants was performed to determine the solubility. The essential oils (eucalyptus oil and turpentine oil) were used as penetration modifiers. Studies on compatibility with polymers have been conducted, and the results indicate that there should be no physical or chemical interactions between the polymers and the drug substance. For the preparation of emulgel, various emulsions were prepared with Smix (cosurfactant and surfactant) ratios (1:1, 2:1 and 3:1). The selection of a gelling agent was done by incorporating the selected emulsion system ratio of 1:1 with the combinations of polymers carbapol 940, carbapol 934, and HPMC (0:1:0, 0:0.5:1, 0:0:3, 0.5:0:1, 1:0:0) gel base to make a homogenous emulgel. Results: The emulgel was examined visually to see if it had any phase behaviour, feel, spread-ability, and grittiness by applying its thin layer to a slide. Then, all six formulations of emulgel were prepared with the selected gelling agent. All emulgels were evaluated for pH, physical properties (consistency, homogeneity, colour, texture), drug content, spreadability, extrudability, swelling index, viscosity, stability and centrifugation. A Franz diffusion cell and an egg membrane were used to perform in-vitro drug release. Conclusion: Among all prepared formulations, EG1 had a better release, higher viscosity, higher drug content, and a higher swelling index than the others. The formulation EG1 showed higher drug release (91.25%) within 8 hours.
Language	English
Publishing date	2024-02-21
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2227189-2
ISSN	1875-614X ; 1871-5230
ISSN (online)	1875-614X
ISSN	1871-5230
DOI	10.2174/0118715230276597240207070306
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Article ; Online: Potassium ion channel Kir2.1 negatively regulates protective responses to Mycobacterium bovis BCG.

Sinha, Vishal / Singh, Akshita / Singh, Aarti / Saraswati, Shakuntala Surender Kumar / Rana, Ankush Kumar / Kalra, Kanika / Natarajan, Krishnamurthy

Journal of leukocyte biology

2024

Abstract: Tuberculosis caused by the pathogen Mycobacterium tuberculosis leads to increased mortality and morbidity worldwide. The prevalence of highly drug resistant strains has reinforced the need for greater understanding of host-pathogen interactions at the ... ...

Abstract	Tuberculosis caused by the pathogen Mycobacterium tuberculosis leads to increased mortality and morbidity worldwide. The prevalence of highly drug resistant strains has reinforced the need for greater understanding of host-pathogen interactions at the cellular and molecular levels. Our previous work demonstrated critical roles of calcium ion channels in regulating protective responses to mycobacteria. In this report we deciphered the roles of inwardly rectifying K+ ion channel Kir2.1 in epithelial cells. Data showed that infection of epithelial cells (and macrophages) increases the surface expression of Kir2.1. This increased expression of Kir2.1 results in higher intracellular mycobacterial survival, since either inhibiting or knocking down Kir2.1 results in mounting of a higher oxidative burst leading to a significant attenuation of mycobacterial survival. Further, inhibiting Kir2.1 also led to increased expression of T cell costimulatory molecules accompanied with increased activation of MAP Kinases and transcription factors NF-κB and pCREB. Furthermore, inhibiting Kir2.1 induced increased autophagy and apoptosis that could also contribute to decreased bacterial survival. Interestingly, an increased association of heat shock protein-70 with Kir2.1 was observed. The above results showed that mycobacteria modulate the expression and function of Kir2.1 in epithelial cells to its advantage.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiae068
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Article ; Online: Simultaneous axial and radial swelling studies from 2D stereozoom images of tablet compacts composed of superdisintegrants.

Arora, Sagar / Sangwan, Aarti / Kaur, Harmeet / Singh, Jasbir

Journal of microscopy

2022 Volume 288, Issue 1, Page(s) 16–27

Abstract: Swelling-based disintegration is considered important for drug release from tablets and can be modified with excipients called tablet disintegrants. Swelling of tablets occurs axially and radially, and most researchers have observed both these events ... ...

Abstract	Swelling-based disintegration is considered important for drug release from tablets and can be modified with excipients called tablet disintegrants. Swelling of tablets occurs axially and radially, and most researchers have observed both these events separately using 2D images. In the current work, we have studied these events simultaneously instead of separately under a stereozoom microscope for tablet compacts composed of high proportions of disintegrants (sodium starch glycolate, SSG and croscarmellose sodium, CCS), using water as the disintegrating medium. A hypothesis is proposed for the measurements of radial and axial swellings from a single 2D image, as horizontal lengths based on trigonometric functions for a right-angle triangle. All predicted axial and radial lengths (as per proposed hypothesis) are found validated with respect to vernier calliper measurements for dry-tablet compacts with a minute error of 3.809%. The axial swelling is approximately fivefolds more than that of radial swelling on the basis of normalised lengths. No particular trend can be spotted exclusively in favour of a superdisintegrant; however, the CCS-based tablets have shown higher swelling as compared to SSG-based tablets. From the current studies, it is evident that both axial and radial dimensions are obtainable from single 2D stereozoom images and can be successfully implemented for swelling studies of tablets.
MeSH term(s)	Carboxymethylcellulose Sodium ; Excipients ; Solubility ; Starch ; Tablets ; Water
Chemical Substances	Excipients ; Tablets ; Water (059QF0KO0R) ; Starch (9005-25-8) ; Carboxymethylcellulose Sodium (K679OBS311)
Language	English
Publishing date	2022-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	219263-9
ISSN	1365-2818 ; 0022-2720
ISSN (online)	1365-2818
ISSN	0022-2720
DOI	10.1111/jmi.13138
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