Result 1 - 5 of total 5
Mental welfare
2017 Volume 17, Issue 4, Page(s) 97–103
| Language | English |
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| Publishing date | 2017-09-14 |
| Publishing country | England |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Environmental and experimental botany. 2020 Aug., v. 176
2020
Abstract: Highbush blueberry (Vaccinium corymbosum L.) is an important crop well adapted to acid soils, but sensitive to Al³⁺ toxicity. Gypsum amendments are frequently used to reduce Al³⁺ toxicity in V. corymbosum. However, little is known about the physiological ...
| Abstract | Highbush blueberry (Vaccinium corymbosum L.) is an important crop well adapted to acid soils, but sensitive to Al³⁺ toxicity. Gypsum amendments are frequently used to reduce Al³⁺ toxicity in V. corymbosum. However, little is known about the physiological and metabolic responses to gypsum application in plants growing in the presence of Al³⁺ toxicity. Thus, we evaluated the mechanisms displayed by gypsum application at the metabolite levels in V. corymbosum cultivars growing under Al³⁺ toxicity. We characterized three cultivars (Brigitta, Legacy, and Bluegold) with different response mechanisms to Al³⁺ toxicity. Furthermore, four treatments were applied: (i) Acid substrate without Al (Control), (ii) Acid substrate + 1.4 g CaSO₄ kg⁻¹, (iii) Acid substrate + 0.9 g AlCl₃ kg⁻¹ and (iv) Acid substrate + 0.9 g AlCl₃ kg⁻¹ + 1.4 g CaSO₄ kg⁻¹. After ten days of treatment exposition, leaves, and roots were harvested for metabolite profiling analyses. Starch and amino acid concentrations in leaves and roots decreased in all cultivars growing under toxic Al³⁺ levels. However, gypsum amendment reduced Al concentration in leaves and roots, as well as increased Ca concentrations in leaves, and recovered amino acid and starch levels. In addition, metabolite profiling and multivariate analyses indicated that in roots, gamma-aminobutyric acid (GABA) might be a metabolite related to Al³⁺ toxicity. Taken together that gypsum amendment ameliorates the Al³⁺ toxicity, mainly in the cultivar Al-sensitive, Bluegold. The two Al-resistant cultivars (Legacy and Brigitta) showed distinct Al mechanisms (tolerance and exclusion, respectively). |
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| Keywords | Vaccinium corymbosum ; acid soils ; aluminum ; aluminum chloride ; amino acid composition ; biochemical pathways ; calcium ; calcium sulfate ; cultivars ; gamma-aminobutyric acid ; gypsum ; leaves ; metabolites ; multivariate analysis ; roots ; starch ; toxicity |
| Language | English |
| Dates of publication | 2020-08 |
| Publishing place | Elsevier B.V. |
| Document type | Article |
| ZDB-ID | 195968-2 |
| ISSN | 0098-8472 |
| ISSN | 0098-8472 |
| DOI | 10.1016/j.envexpbot.2020.104119 |
| Database | NAL-Catalogue (AGRICOLA) |
| Z 1950: Show issues |
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1944
| Author's details | by Alfred E. Barclay ; Kenneth J. Franklin and Marjorie M. L. Prichard |
|---|---|
| Language | English |
| Size | xvi, 275 Seiten, Illustrationen |
| Publisher | Blackwell Scientific Publicatiions |
| Publishing place | Oxford |
| Publishing country | Great Britain |
| Document type | Book |
| HBZ-ID | HT007870125 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2012 A 6156 | order for loan | Magazin |
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2020 Volume 29, Issue 21, Page(s) 3516–3531
Abstract: Neurodevelopmental disorder with microcephaly, hypotonia and variable brain anomalies (NMIHBA) is an autosomal recessive neurodevelopmental and neurodegenerative disorder characterized by global developmental delay and severe intellectual disability. ... ...
| Abstract | Neurodevelopmental disorder with microcephaly, hypotonia and variable brain anomalies (NMIHBA) is an autosomal recessive neurodevelopmental and neurodegenerative disorder characterized by global developmental delay and severe intellectual disability. Microcephaly, progressive cortical atrophy, cerebellar hypoplasia and delayed myelination are neurological hallmarks in affected individuals. NMIHBA is caused by biallelic variants in PRUNE1 encoding prune exopolyphosphatase 1. We provide in-depth clinical description of two affected siblings harboring compound heterozygous variant alleles, c.383G > A (p.Arg128Gln), c.520G > T (p.Gly174*) in PRUNE1. To gain insights into disease biology, we biochemically characterized missense variants within the conserved N-terminal aspartic acid-histidine-histidine (DHH) motif and provide evidence that they result in the destabilization of protein structure and/or loss of exopolyphosphatase activity. Genetic ablation of Prune1 results in midgestational lethality in mice, associated with perturbations to embryonic growth and vascular development. Our findings suggest that NMIHBA results from hypomorphic variant alleles in humans and underscore the potential key role of PRUNE1 exopolyphoshatase activity in neurodevelopment. |
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| MeSH term(s) | Acid Anhydride Hydrolases/deficiency ; Alleles ; Animals ; Child, Preschool ; Female ; Humans ; Infant ; Intellectual Disability/etiology ; Intellectual Disability/metabolism ; Intellectual Disability/pathology ; Male ; Mice ; Microcephaly/etiology ; Microcephaly/metabolism ; Microcephaly/pathology ; Muscle Hypotonia/etiology ; Muscle Hypotonia/metabolism ; Muscle Hypotonia/pathology ; Mutation ; Neurodevelopmental Disorders/etiology ; Neurodevelopmental Disorders/metabolism ; Neurodevelopmental Disorders/pathology ; Pedigree ; Phenotype ; Phosphoric Monoester Hydrolases/genetics |
| Chemical Substances | PRUNE1 protein, human (EC 3.1.3.2) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Acid Anhydride Hydrolases (EC 3.6.-) ; exopolyphosphatase (EC 3.6.1.11) |
| Language | English |
| Publishing date | 2020-10-25 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1108742-0 |
| ISSN | 1460-2083 ; 0964-6906 |
| ISSN (online) | 1460-2083 |
| ISSN | 0964-6906 |
| DOI | 10.1093/hmg/ddaa237 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3469: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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executive summary and overview
1979
| Institution | Solid Waste Council of the Paper Industry |
|---|---|
| Author's details | by William E. Franklin, Marjorie A. Franklin, and Mary Ellen Weber. -- |
| Keywords | Paper industry/Waste disposal. ; Factory and trade waste. |
| Language | English |
| Size | xiv, 279 p. :, ill. |
| Publisher | Franklin Associates |
| Publishing place | Prairie Village, Kan |
| Document type | Book |
| Note | "The study was sponsored by the Solid Waste Council of the Paper Industry." |
| Database | NAL-Catalogue (AGRICOLA) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.