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Article ; Online: Incidental Thalamic Lesions Identified on Brain MRI in Pediatric and Young Adult Patients: Imaging Features and Natural History.

Alves, Vinicius de Padua V / Care, Marguerite M / Leach, James L

AJNR. American journal of neuroradiology

2024 Volume 45, Issue 2, Page(s) 211–217

Abstract: Background and purpose: Nonspecific, localized thalamic signal abnormalities of uncertain significance are occasionally found on pediatric brain MR imaging. The goal of this study is to describe the MR imaging appearance and natural history of these ... ...

Abstract	Background and purpose: Nonspecific, localized thalamic signal abnormalities of uncertain significance are occasionally found on pediatric brain MR imaging. The goal of this study is to describe the MR imaging appearance and natural history of these lesions in children and young adults. Materials and methods: This retrospective study evaluated clinically acquired brain MR imaging examinations obtained from February 1995 to March 2022 at a large, tertiary care pediatric hospital. Examinations with non-mass-like and nonenhancing thalamic lesions were identified based on term search of MR imaging reports. A total of 221 patients formed the initial group for imaging assessment. Additional exclusions during imaging review resulted in 171 patients. Imaging appearance and size changes were assessed at baseline and at follow-up examinations. Results: A total of 171 patients (102 male) at a median age of 11 years (range: 1-23 years), 568 MR imaging examinations, and 180 thalamic lesions were included. Median time from baseline to the last follow-up MR imaging was 542 days (range: 46-5730 days). No lesion enhanced at any time point. On imaging follow-up, 11% of lesions (18/161) became smaller, 10% (16/161) resolved, 73% (118/161) remained stable, and 6% (9/161) increased in size at some point during evaluation. Median time interval from baseline to enlargement was 430 days (range: 136-1074 days). Conclusions: Most incidental, non-mass-like thalamic signal abnormalities were stable, decreased in size, or resolved on follow-up imaging and are likely of no clinical significance. Surveillance strategies with longer follow-up intervals may be adequate in the management of such findings.
MeSH term(s)	Humans ; Child ; Young Adult ; Male ; Infant ; Child, Preschool ; Adolescent ; Adult ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Brain/pathology ; Neuroimaging ; Thalamus/diagnostic imaging
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A8090
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Article ; Online: Cheminformatics-driven discovery of hit compounds against

de Oliveira, Amanda Alves / Carmo Silva, Lívia do / Neves, Bruno Junior / Fiaia Costa, Vinícius Alexandre / Muratov, Eugene N / Andrade, Carolina Horta / de Almeida Soares, Célia Maria / Alves, Vinicius M / Pereira, Maristela

Future medicinal chemistry

2023 Volume 15, Issue 17, Page(s) 1553–1567

Abstract: Aims: ...

Abstract	Aims:
MeSH term(s)	Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Paracoccidioides ; Cheminformatics ; Paracoccidioidomycosis/drug therapy ; Microbial Sensitivity Tests
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2022-0288
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Article ; Online: Sampling effort and the drivers of plant species richness in the Brazilian coastal regions.

Oliveira, Eduardo Vinícius S / Alves, Davi M C / Landim, Myrna F / Gouveia, Sidney F

Oecologia

2021 Volume 195, Issue 1, Page(s) 163–171

Abstract: The causes of the gradients in species richness remain contentious because of multiple competing hypotheses, significant knowledge gaps, and regional effects of environmental and historical factors on species pools. Coastal zones are subject to ... ...

Abstract	The causes of the gradients in species richness remain contentious because of multiple competing hypotheses, significant knowledge gaps, and regional effects of environmental and historical factors on species pools. Coastal zones are subject to particular sets of environmental constraints, thus identifying the drivers of species richness therein should shed light on the regional gradients of species diversity. Here, we investigate the geographic patterns and drivers of plant diversity across coastal regions while allowing for pervasive sampling deficiencies. Based on 142708 records of flowering plant occurrences, we mapped species richness and estimated the level of knowledge across the coastal zone of Brazil. Based on inventory completeness, we used linear regression models to test the predictive power of environmental variables that represent different environmental hypotheses. Few cells (25%) were well-surveyed, reflecting little knowledge about the distribution and diversity of flowering plants on the highly-populated Brazilian coast. Still, we found support for the habitat heterogeneity hypothesis as the best explanation of the variation in species richness of flowering plants in this region. Soil properties and water constraints are also important factors. Although our work emphasises the paucity of information on plant diversity in tropical and human-dominated areas, we show that knowledge limitations should not curb our capability of addressing hypotheses about species diversity.
Language	English
Publishing date	2021-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123369-5
ISSN	1432-1939 ; 0029-8549
ISSN (online)	1432-1939
ISSN	0029-8549
DOI	10.1007/s00442-020-04805-7
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Article ; Online: The blockage of downstream P2Y

Cardoso, Tassya Cataldi / Rocha, Marianna Araujo / Monteiro, Matheus M L V / Alves, Vinícius Santos / Savio, Luiz Eduardo Baggio / Silva, Claudia Lucia Martins

Life sciences

2022 Volume 306, Page(s) 120793

Abstract: Aims: Prostate cancer is the second most frequently malignancy in men worldwide. Most deaths are caused by metastasis, and tumor cell dissemination involves the interaction with endothelial cells. However, the endothelial cell signaling involved in such ...

Abstract	Aims: Prostate cancer is the second most frequently malignancy in men worldwide. Most deaths are caused by metastasis, and tumor cell dissemination involves the interaction with endothelial cells. However, the endothelial cell signaling involved in such interaction is not entirely understood. The tumor microenvironment contains extracellular ATP, an endogenous agonist of the purinergic P2Y Main methods: For adhesion assays, confluent endothelial cells EA.hy926 were treated with P2Y Key findings: Endothelial P2Y Significance: Endothelial P2Y
MeSH term(s)	Adenosine Triphosphate/metabolism ; Atorvastatin/metabolism ; Cell Adhesion ; Endothelial Cells/metabolism ; Humans ; Male ; Prostatic Neoplasms/pathology ; Tumor Microenvironment ; Uridine Triphosphate/metabolism
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Atorvastatin (A0JWA85V8F) ; Uridine Triphosphate (UT0S826Z60)
Language	English
Publishing date	2022-07-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120793
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Article: Sampling effort and the drivers of plant species richness in the Brazilian coastal regions

Oliveira, Eduardo Vinícius S / Alves, Davi M. C / Landim, Myrna F / Gouveia, Sidney F

Oecologia. 2021 Jan., v. 195, no. 1

2021

Abstract	The causes of the gradients in species richness remain contentious because of multiple competing hypotheses, significant knowledge gaps, and regional effects of environmental and historical factors on species pools. Coastal zones are subject to particular sets of environmental constraints, thus identifying the drivers of species richness therein should shed light on the regional gradients of species diversity. Here, we investigate the geographic patterns and drivers of plant diversity across coastal regions while allowing for pervasive sampling deficiencies. Based on 142708 records of flowering plant occurrences, we mapped species richness and estimated the level of knowledge across the coastal zone of Brazil. Based on inventory completeness, we used linear regression models to test the predictive power of environmental variables that represent different environmental hypotheses. Few cells (25%) were well-surveyed, reflecting little knowledge about the distribution and diversity of flowering plants on the highly-populated Brazilian coast. Still, we found support for the habitat heterogeneity hypothesis as the best explanation of the variation in species richness of flowering plants in this region. Soil properties and water constraints are also important factors. Although our work emphasises the paucity of information on plant diversity in tropical and human-dominated areas, we show that knowledge limitations should not curb our capability of addressing hypotheses about species diversity.
Keywords	coasts ; habitats ; inventories ; regression analysis ; species richness ; Brazil
Language	English
Dates of publication	2021-01
Size	p. 163-171.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	123369-5
ISSN	1432-1939 ; 0029-8549
ISSN (online)	1432-1939
ISSN	0029-8549
DOI	10.1007/s00442-020-04805-7
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Article ; Online: Insights on the Synthesis of Al-MCM-41 with Optimized Si/Al Ratio for High-Performance Antibiotic Adsorption

Vinicius M. S. Macedo / Eliezer L. Gomes / Juan C. Moreno-Piraján / Liliana Giraldo / Laura P. Tovar / Sarah I. P. M. N. Alves / Luís A. M. Ruotolo / Romilda Fernandez-Felisbino

ACS Omega, Vol 8, Iss 50, Pp 48181-

2023 Volume 48190

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Novel Ostial Angioplasty Technique.

Caied, Fabricio / Cortes, Leandro A / Souza, Vinicius B / Leandro, Sergio M / Paula, Tarso A / Alves, Luiz Felipe M F / Silveira, Gustavo M

JACC. Cardiovascular interventions

2021 Volume 14, Issue 21, Page(s) e293–e295

MeSH term(s)	Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/methods ; Coronary Angiography ; Humans ; Stents ; Treatment Outcome
Language	English
Publishing date	2021-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2021.08.019
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Article ; Online: Development of a Mobile Application with Health Guidelines for TB Patients Care.

Reis, Manoela / Bernardi, Filipe / Lima, Vinicius / Alves, Domingos

Studies in health technology and informatics

2023 Volume 305, Page(s) 373–376

Abstract: Health guidelines inform recommendations for different clinical practices or public health policies. They are a simple way to organize and retrieve relevant information that can impact patient care. Although these documents are easy to use, most are not ... ...

Abstract	Health guidelines inform recommendations for different clinical practices or public health policies. They are a simple way to organize and retrieve relevant information that can impact patient care. Although these documents are easy to use, most are not user-friendly because they are difficult to access. Our work aims to present the developing approach for a decision-making tool based on health guidelines to assist health professionals in caring for patients with tuberculosis. This tool is being developed for use on mobile devices and as a web-based system, which will transform a passive and declarative health guideline document into an interactive tool that will provide data, information, and knowledge. User tests with functional prototypes developed for the Android platform show that this application has the potential to be applied in TB healthcare facilities in the future.
MeSH term(s)	Humans ; Mobile Applications ; Computers, Handheld ; Health Facilities ; Health Personnel ; Knowledge
Language	English
Publishing date	2023-06-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230509
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Article ; Online: Comparative analyses of Theobroma cacao and T. grandiflorum mitogenomes reveal conserved gene content embedded within complex and plastic structures.

de Abreu, Vinicius A C / Moysés Alves, Rafael / Silva, Saura R / Ferro, Jesus A / Domingues, Douglas S / Miranda, Vitor F O / Varani, Alessandro M

Gene

2022 Volume 849, Page(s) 146904

Abstract: Unlike the chloroplast genomes (ptDNA), the plant mitochondrial genomes (mtDNA) are much more plastic in structure and size but maintain a conserved and essential gene set related to oxidative phosphorylation. Moreover, the plant mitochondrial genes and ... ...

Abstract	Unlike the chloroplast genomes (ptDNA), the plant mitochondrial genomes (mtDNA) are much more plastic in structure and size but maintain a conserved and essential gene set related to oxidative phosphorylation. Moreover, the plant mitochondrial genes and mtDNA are good markers for phylogenetic, evolutive, and comparative analyses. The two most known species in Theobroma L. (Malvaceae s.l.) genus are T. cacao, and T. grandiflorum. Besides the economic value, both species also show considerable biotechnology potential due to their other derived products, thus, aggregating additional economic value for the agroindustry. Here, we assembled and compared the mtDNA of Theobroma cacao and T. grandiflorum to generate a new genomics resource and unravel evolutionary trends. Graph-based analyses revealed that both mtDNA exhibit multiple alternative arrangements, confirming the dynamism commonly observed in plant mtDNA. The disentangled assembly graph revealed potential predominant circular molecules. The master circle molecules span 543,794 bp for T. cacao and 501,598 bp for T. grandiflorum, showing 98.9% of average sequence identity. Both mtDNA contains the same set of 39 plant mitochondrial genes, commonly found in other rosid mitogenomes. The main features are a duplicated copy of atp4, the absence of rpl6, rps2, rps8, and rps11, and the presence of two chimeric open-reading frames. Moreover, we detected few ptDNA integrations mainly represented by tRNAs, and no viral sequences were detected. Phylogenomics analyses indicate Theobroma spp. are nested in Malvaceae family. The main mtDNA differences are related to distinct structural rearrangements and exclusive regions associated with relics of Transposable Elements, supporting the hypothesis of dynamic mitochondrial genome maintenance and divergent evolutionary paths and pressures after species differentiation.
MeSH term(s)	Cacao/genetics ; Genome, Mitochondrial/genetics ; Phylogeny ; DNA Transposable Elements ; Plastics ; DNA, Mitochondrial
Chemical Substances	DNA Transposable Elements ; Plastics ; DNA, Mitochondrial
Language	English
Publishing date	2022-09-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146904
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Article: Comparative analyses of Theobroma cacao and T. grandiflorum mitogenomes reveal conserved gene content embedded within complex and plastic structures

de Abreu, Vinicius A.C. / Moysés Alves, Rafael / Silva, Saura R. / Ferro, Jesus A. / Domingues, Douglas S. / Miranda, Vitor F.O. / Varani, Alessandro M.

Gene. 2023 Jan. 15, v. 849

2023

Abstract	Unlike the chloroplast genomes (ptDNA), the plant mitochondrial genomes (mtDNA) are much more plastic in structure and size but maintain a conserved and essential gene set related to oxidative phosphorylation. Moreover, the plant mitochondrial genes and mtDNA are good markers for phylogenetic, evolutive, and comparative analyses. The two most known species in Theobroma L. (Malvaceae s.l.) genus are T. cacao, and T. grandiflorum. Besides the economic value, both species also show considerable biotechnology potential due to their other derived products, thus, aggregating additional economic value for the agroindustry. Here, we assembled and compared the mtDNA of Theobroma cacao and T. grandiflorum to generate a new genomics resource and unravel evolutionary trends. Graph-based analyses revealed that both mtDNA exhibit multiple alternative arrangements, confirming the dynamism commonly observed in plant mtDNA. The disentangled assembly graph revealed potential predominant circular molecules. The master circle molecules span 543,794 bp for T. cacao and 501,598 bp for T. grandiflorum, showing 98.9% of average sequence identity. Both mtDNA contains the same set of 39 plant mitochondrial genes, commonly found in other rosid mitogenomes. The main features are a duplicated copy of atp4, the absence of rpl6, rps2, rps8, and rps11, and the presence of two chimeric open-reading frames. Moreover, we detected few ptDNA integrations mainly represented by tRNAs, and no viral sequences were detected. Phylogenomics analyses indicate Theobroma spp. are nested in Malvaceae family. The main mtDNA differences are related to distinct structural rearrangements and exclusive regions associated with relics of Transposable Elements, supporting the hypothesis of dynamic mitochondrial genome maintenance and divergent evolutionary paths and pressures after species differentiation.
Keywords	Theobroma cacao ; agricultural industry ; biotechnology ; chloroplast genome ; economic valuation ; genes ; genomics ; mitochondria ; mitochondrial genome ; oxidative phosphorylation ; phylogeny ; sequence analysis
Language	English
Dates of publication	2023-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146904
Database	NAL-Catalogue (AGRICOLA)

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